Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 157963649

GI number: 157963649

Start: 4664896

End: 4666089

Strand: Direct

Name: coaBC [H]

Synonym: Spea_3838

Alternate gene names: 157963649

Gene position: 4664896-4666089 (Clockwise)

Preceding gene: 157963643

Following gene: 157963650

Centisome position: 90.15

GC content: 51.59

Gene sequence:

>1194_bases
ATGGGTCTCAACAACAAAAAAGTATTACTGGGTATTGGTGGTGGCATTGCCGCATACAAATCGGCCGACCTAGTACGCAA
GTTAAAGGAACGCGGCGCCGATGTCCGTGTTGTTATGAGTCAAAGTGCACAAGAGTTTATTACTCCGCTAACTTTGCAGG
CGCTTTCCGGTTATCCAGTGGCGACCGATCTGCTTGATCCTACGGCCGAAGCCTCTATGGGGCACATCGAGCTCGCACGT
TGGGCAGACCTAGTCATCATAGCTCCAGCCACCGCCAACCTTATCGCTCGGGTAAATGCCGGCATGGCAGATGAGTTAAT
TACCACCACCTGCCTAGCCACCGAAGCCCCTGTAGTGATTTGCCCCGCAATGAACCAACAGATGTATCGCAACGCCGCAA
CCCAAGCTAACTTGAAGCAAGTAGCCGAGCGCGGTATCTACATTTGGGGGCCAGATTCAGGCTCGCAAGCCTGTGGCGAA
GTCGGCCCAGGTAGAATGCTTGAGCCTGTGGCGATTGCTGAAAAAGCAGTTGAATTTTTTGGCCCAAAACTGCTGCAAGG
CATGTCATTGCTGCTTACAGCAGGTCCGACTCGTGAGGCTATCGATCCGGTTCGTTATATTTCCAACCATAGCTCAGGCA
AGATGGGCTTTGCCCTTGCCAAAGCCGCAGCAGCAATGGGCGCAGAGGTGACCTTAGTTGCCGGCCCGGTCAATCTAGCG
ACGCCCGCAGGCGTCACCCGAGTCAATGTTGAGTCGGCTCAGCAGATGCTAGATGCGGTAATGCCACAAGTTGAGATGCA
CCAAATATTTATCGGCTGCGCCGCCGTGGCCGATTACCGCATCGCAGAAGTCGCCGAGAGTAAAATCAAGAAATCGGCAG
AGCAGATGCAACTTGCGCTAGTGCGAAATCCTGATATCTTAGCCAGCGTTGCCAGCCATGCTAACCGACCTTTCACCGTT
GGATTTGCCGCTGAAACCAACGATGTAGAGCAATATGCCCGTGGAAAGTTAACAGGTAAAAAGCTCGACATGATTGCCGC
TAATGACGTATCAAATAGCGCCATTGGCTTTAACAGTGACTCCAACGCCCTAAGCGTATTTTGGAGTGATGGTAGCACCG
ACCTACCCGCTGTTGATAAAGACACTTTAGCCAAGCAATTGCTTACTCTAATAGCGAACAAAATAAAAAACTGA

Upstream 100 bases:

>100_bases
AGTTGTTCATCACCATTTTGAGGTTTGTGATATCTTAGGCCAACTTCAGCTGTGTGACATAAAGTTTGGTCCACAACGTG
ATTATCAAAAAGAGTTAACT

Downstream 100 bases:

>100_bases
TGAAAACACCAATCGAATTAAAGATTTTAGACTCACGCATCGGCACCGAGTTTCCACTTCCTGCTTACGCCACACCAGGC
AGTGCAGGCATGGATCTTCG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELAR
WADLVIIAPATANLIARVNAGMADELITTTCLATEAPVVICPAMNQQMYRNAATQANLKQVAERGIYIWGPDSGSQACGE
VGPGRMLEPVAIAEKAVEFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAAMGAEVTLVAGPVNLA
TPAGVTRVNVESAQQMLDAVMPQVEMHQIFIGCAAVADYRIAEVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTV
GFAAETNDVEQYARGKLTGKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVDKDTLAKQLLTLIANKIKN

Sequences:

>Translated_397_residues
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELAR
WADLVIIAPATANLIARVNAGMADELITTTCLATEAPVVICPAMNQQMYRNAATQANLKQVAERGIYIWGPDSGSQACGE
VGPGRMLEPVAIAEKAVEFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAAMGAEVTLVAGPVNLA
TPAGVTRVNVESAQQMLDAVMPQVEMHQIFIGCAAVADYRIAEVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTV
GFAAETNDVEQYARGKLTGKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVDKDTLAKQLLTLIANKIKN
>Mature_396_residues
GLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELARW
ADLVIIAPATANLIARVNAGMADELITTTCLATEAPVVICPAMNQQMYRNAATQANLKQVAERGIYIWGPDSGSQACGEV
GPGRMLEPVAIAEKAVEFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAAMGAEVTLVAGPVNLAT
PAGVTRVNVESAQQMLDAVMPQVEMHQIFIGCAAVADYRIAEVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTVG
FAAETNDVEQYARGKLTGKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVDKDTLAKQLLTLIANKIKN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=33.8888888888889, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=61.6541353383459, Blast_Score=482, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=26.7379679144385, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41892; Mature: 41761

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPV
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHHHHCCCCC
ATDLLDPTAEASMGHIELARWADLVIIAPATANLIARVNAGMADELITTTCLATEAPVVI
CHHHCCCCHHCCCCCEEHCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
CPAMNQQMYRNAATQANLKQVAERGIYIWGPDSGSQACGEVGPGRMLEPVAIAEKAVEFF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHH
GPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAAMGAEVTLVAGPVNLA
CHHHHHCHHEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TPAGVTRVNVESAQQMLDAVMPQVEMHQIFIGCAAVADYRIAEVAESKIKKSAEQMQLAL
CCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNPDILASVASHANRPFTVGFAAETNDVEQYARGKLTGKKLDMIAANDVSNSAIGFNSD
HCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
SNALSVFWSDGSTDLPAVDKDTLAKQLLTLIANKIKN
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPV
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHHHHCCCCC
ATDLLDPTAEASMGHIELARWADLVIIAPATANLIARVNAGMADELITTTCLATEAPVVI
CHHHCCCCHHCCCCCEEHCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
CPAMNQQMYRNAATQANLKQVAERGIYIWGPDSGSQACGEVGPGRMLEPVAIAEKAVEFF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHH
GPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAAMGAEVTLVAGPVNLA
CHHHHHCHHEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TPAGVTRVNVESAQQMLDAVMPQVEMHQIFIGCAAVADYRIAEVAESKIKKSAEQMQLAL
CCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNPDILASVASHANRPFTVGFAAETNDVEQYARGKLTGKKLDMIAANDVSNSAIGFNSD
HCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
SNALSVFWSDGSTDLPAVDKDTLAKQLLTLIANKIKN
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]