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The map label for this gene is csrD [H]

Identifier: 157963585

GI number: 157963585

Start: 4586457

End: 4588364

Strand: Reverse

Name: csrD [H]

Synonym: Spea_3773

Alternate gene names: 157963585

Gene position: 4588364-4586457 (Counterclockwise)

Preceding gene: 157963586

Following gene: 157963584

Centisome position: 88.67

GC content: 45.34

Gene sequence:

>1908_bases
ATGAAATTGACTCGAATTCTAACTAAAAAATTGACTAGCTTTTGGCTGATGTCACTCGCTGGTGTCGCATTTATCTGCTT
TTTGACAGCCATGGTCAGCTTTATCCAGCTAACTTACACCTTTCAACAGCAAAAGGTGACCGAACTCGAGAATCTGATAG
AGCAACAATTTACTCAGCAAGCAAGTGGCCCCCTTGACGCATGGCTGCCGCCTTTGCTACGCGCCTATCGAGCAAATTCT
TTTTCATTATCTCAAAACAGCCAACCCATTTTTGAATATCAGCCATCGACACAAAATGAGGGAGGCGTTCACTACCAGAG
TTCTCTTGCCGATGGAAAGTTAGTGATGCAGCTAACTCTGCCTCAGCCATTTAGTAAAGATGATGTGAGTTGGGATGAAC
TCTTAATTATCATTATCGGCTGCGCGGCCGTATTTGCGTTTGTTCGCTTTGGTTTTCGTTGGTTTGCGGTGCACCTCACA
GGTATTGAAGATCTGGCGCTACGCTCCAGCCTGATCCTGTCGGGTAAGCATGATAAGGCGCTGGCCGAAAAAGGTGATGG
TAAGCCTAGGTTAATTAATCGAGCGCTAACACATCTGTTGTTAGAGTTAGATGACGCCCATAAAGAGCGGGCTCGCTTCG
ATCAGTTTATTCGCTCAAATACTTTTCTCGATGCCAGTACTGGTATTGGTAATCGATTGTTTTTGAAAAACCGACTCGAT
GCCCTGAGTAATCACTCGGGGATGATGACCCCAGGGGTATTATATTTATTAGAGATGGAAGATTTGGATTTGTTAAGCAA
TGAGCTTGGTGAGTACGAGATTGATGAACTGCTATCTCAGCTTATCGCCACCATTAATCAAATCTTAGGGGATAAGGCTA
ACAGTATTTTCTCCCGGCGCTCATACAATCAATTTGCGGTGGTTGTACCGCAGATCTCACAGAACGAAGCGGATCAGCTG
GTGGCCAAGCTATTACGTTTAGTCTTGAATCAGATGAATACGCTGGTTCAGCTACCTGATGATTGTTTCCATATCGGCGG
CGCGTACTTTAAGGTCGGAGACGATAAAGATGCTTTAGTCGAAGAGGCTGAACTCGCATTGCGCTCGGCGCAGTTCCAAG
GTAGCAGTAGTTGGTTTATGTATGATAAAGGTGCCGTTGATGGGGACTTGTCGAAAGGGTCCGTGCGTTGGCGCAGTTTT
CTCGAAAACGTCTTGGTCAGCAAGCGAATTTTCCTATTTTCTCAGCCAGTTGTAGACAGTGACTCCCATGCTCACCATCA
AGAGGTTACTTGTCGATTACGAGATACGCAGGGAAACCTTGTTAGAGCTACACTGTTTCTACCTATGGCGATAAAGTGCG
GTTTAACCCCACAAATTGAGCGTCAGGTCATAGAGATGGTGATGTTTGATTTGTTGCCAAAACATAAAGATAACAGCCTC
AAGTTTAGTATTAATTTGAGCTTAGATACCTTAGTCAGTCGTGCTTTTGTCCGCTGGTTGAAGACCACATTACTCGAGTA
TCGCCATCTAGCTCCTAGGCTTATCTTTGAGGTGAATGAAGACATTTTAGTGAATCATCAGGCACAGCTGGTAGAGCCCT
TGAATATGCTCAATAAAATGGGCGCAAGTATTAGTGTCGATCGTGTGGGTCAACAGGTGGTTAGTACAGAGTATATTCAC
CATTATCCAATCTCTATTATTAAGCTGCATCGTTCTATCGTTAATCAAATCCATCTGCGCGCCGAGAACCAACTGTTTGT
TCGAAGCCTGATTGGAGGTTTGTTCCGGACCGGAGTACAGGTGTGTGCAGAAGGGGTGGAGGTATTCGAGGAGTGGCAAA
CCCTGCAGATTTTAGGGGTGAGTGCAGGCCAGGGAAGTTTCTTTAGTGAGCCGATCGAAGAGGTATAG

Upstream 100 bases:

>100_bases
GGATAACTAGCTAAGGTTGGCTTTATCACCATTTTCCACCTTTTCAGTTTGGAGAAGGCTGATTCAGACACAATAAAAAG
ATCTAGCAGGAAGCGGACAG

Downstream 100 bases:

>100_bases
TTTGTTTTGTATTTGTATTCAATTGTTGCGGACCATTCCTAAATTGGGGTTTTATCTATAATAATCAGGGATAACTCGCT
ACACTAATGGCATAATAAGT

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFIQLTYTFQQQKVTELENLIEQQFTQQASGPLDAWLPPLLRAYRANS
FSLSQNSQPIFEYQPSTQNEGGVHYQSSLADGKLVMQLTLPQPFSKDDVSWDELLIIIIGCAAVFAFVRFGFRWFAVHLT
GIEDLALRSSLILSGKHDKALAEKGDGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDASTGIGNRLFLKNRLD
ALSNHSGMMTPGVLYLLEMEDLDLLSNELGEYEIDELLSQLIATINQILGDKANSIFSRRSYNQFAVVVPQISQNEADQL
VAKLLRLVLNQMNTLVQLPDDCFHIGGAYFKVGDDKDALVEEAELALRSAQFQGSSSWFMYDKGAVDGDLSKGSVRWRSF
LENVLVSKRIFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLVSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQAQLVEPLNMLNKMGASISVDRVGQQVVSTEYIH
HYPISIIKLHRSIVNQIHLRAENQLFVRSLIGGLFRTGVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV

Sequences:

>Translated_635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFIQLTYTFQQQKVTELENLIEQQFTQQASGPLDAWLPPLLRAYRANS
FSLSQNSQPIFEYQPSTQNEGGVHYQSSLADGKLVMQLTLPQPFSKDDVSWDELLIIIIGCAAVFAFVRFGFRWFAVHLT
GIEDLALRSSLILSGKHDKALAEKGDGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDASTGIGNRLFLKNRLD
ALSNHSGMMTPGVLYLLEMEDLDLLSNELGEYEIDELLSQLIATINQILGDKANSIFSRRSYNQFAVVVPQISQNEADQL
VAKLLRLVLNQMNTLVQLPDDCFHIGGAYFKVGDDKDALVEEAELALRSAQFQGSSSWFMYDKGAVDGDLSKGSVRWRSF
LENVLVSKRIFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLVSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQAQLVEPLNMLNKMGASISVDRVGQQVVSTEYIH
HYPISIIKLHRSIVNQIHLRAENQLFVRSLIGGLFRTGVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
>Mature_635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFIQLTYTFQQQKVTELENLIEQQFTQQASGPLDAWLPPLLRAYRANS
FSLSQNSQPIFEYQPSTQNEGGVHYQSSLADGKLVMQLTLPQPFSKDDVSWDELLIIIIGCAAVFAFVRFGFRWFAVHLT
GIEDLALRSSLILSGKHDKALAEKGDGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDASTGIGNRLFLKNRLD
ALSNHSGMMTPGVLYLLEMEDLDLLSNELGEYEIDELLSQLIATINQILGDKANSIFSRRSYNQFAVVVPQISQNEADQL
VAKLLRLVLNQMNTLVQLPDDCFHIGGAYFKVGDDKDALVEEAELALRSAQFQGSSSWFMYDKGAVDGDLSKGSVRWRSF
LENVLVSKRIFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLVSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQAQLVEPLNMLNKMGASISVDRVGQQVVSTEYIH
HYPISIIKLHRSIVNQIHLRAENQLFVRSLIGGLFRTGVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=501, Percent_Identity=31.1377245508982, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1787541, Length=444, Percent_Identity=23.8738738738739, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081921, Length=451, Percent_Identity=22.6164079822616, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081845, Length=242, Percent_Identity=24.7933884297521, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788849, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790496, Length=234, Percent_Identity=24.7863247863248, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71769; Mature: 71769

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFIQLTYTFQQQKVTELENLIEQQFTQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGPLDAWLPPLLRAYRANSFSLSQNSQPIFEYQPSTQNEGGVHYQSSLADGKLVMQLTL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCEEEEEEEC
PQPFSKDDVSWDELLIIIIGCAAVFAFVRFGFRWFAVHLTGIEDLALRSSLILSGKHDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCHHHHHHHHHHHCCCCCCHH
LAEKGDGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDASTGIGNRLFLKNRLD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHH
ALSNHSGMMTPGVLYLLEMEDLDLLSNELGEYEIDELLSQLIATINQILGDKANSIFSRR
HHCCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SYNQFAVVVPQISQNEADQLVAKLLRLVLNQMNTLVQLPDDCFHIGGAYFKVGDDKDALV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHH
EEAELALRSAQFQGSSSWFMYDKGAVDGDLSKGSVRWRSFLENVLVSKRIFLFSQPVVDS
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
DSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
CCCCCCHHEEEEEECCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCE
KFSINLSLDTLVSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQAQLVEPLNMLNKM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCEECCHHHHHHHHHHHHHC
GASISVDRVGQQVVSTEYIHHYPISIIKLHRSIVNQIHLRAENQLFVRSLIGGLFRTGVQ
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
HHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHCC
>Mature Secondary Structure
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFIQLTYTFQQQKVTELENLIEQQFTQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGPLDAWLPPLLRAYRANSFSLSQNSQPIFEYQPSTQNEGGVHYQSSLADGKLVMQLTL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCEEEEEEEC
PQPFSKDDVSWDELLIIIIGCAAVFAFVRFGFRWFAVHLTGIEDLALRSSLILSGKHDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCHHHHHHHHHHHCCCCCCHH
LAEKGDGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDASTGIGNRLFLKNRLD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHH
ALSNHSGMMTPGVLYLLEMEDLDLLSNELGEYEIDELLSQLIATINQILGDKANSIFSRR
HHCCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SYNQFAVVVPQISQNEADQLVAKLLRLVLNQMNTLVQLPDDCFHIGGAYFKVGDDKDALV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHH
EEAELALRSAQFQGSSSWFMYDKGAVDGDLSKGSVRWRSFLENVLVSKRIFLFSQPVVDS
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
DSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
CCCCCCHHEEEEEECCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCE
KFSINLSLDTLVSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQAQLVEPLNMLNKM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCEECCHHHHHHHHHHHHHC
GASISVDRVGQQVVSTEYIHHYPISIIKLHRSIVNQIHLRAENQLFVRSLIGGLFRTGVQ
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
HHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]