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The map label for this gene is zraS [C]

Identifier: 157963416

GI number: 157963416

Start: 4396185

End: 4397579

Strand: Reverse

Name: zraS [C]

Synonym: Spea_3602

Alternate gene names: 157963416

Gene position: 4397579-4396185 (Counterclockwise)

Preceding gene: 157963417

Following gene: 157963415

Centisome position: 84.98

GC content: 47.74

Gene sequence:

>1395_bases
ATGCCAGTATTTGTCACATTCAATATCTACCTTTTTTACGGCCTCGTGTTTTTCTCTATGGGCTGTGCCGTTGTTTTTCG
TAATTTTCGCTATAGCCAATTAAAGGTTGCACCGACGCTATGGGCGCTGGCCGCCTTCGGGTTCTCCCATGCTTTTCATG
AGTGGTCTGAGCTATATGTACTCATTTTTACAGACCATATCGCGCCTGAGTATCGCCTGCTGACACAGTGGCTCTGCTTG
GCAAAATTATTTCTATCTTACGCCGCCTTGATGGTATTTGCTTGGCAGATCTTAACCATCAATAATAAGCGTCTAGCGCA
TATAGGCCATGGTGTGATTATCACTCTATTACTCTGCTATGCCTATTTAGTGATCCCGGATTTGCATCATCTCGCGGTTA
ATCAAACTGGTTTTGCTGAGGCCAGCCAGTACACACGAATACTGATAGGCTTCGGTAGTGCGATGCTAGCGGGTGTGGGT
ATGGTGATTTACGGCAATAGCTTGCGGCAAGAAGAGCATAGCTACGGACTTTACTTTGCACTCTGTGGTTTCGGCCTAAT
GGTTTATGGTGTGCTGTCGGGACTCGTGCCGACAGAGTATCACTACAGCGTGCCAATCTATCGAACACTGGCGGGTGGTC
TTATCTTAGTCGCCCTATTTAAGGCGCTGAAAGTGTTTGACTTAGAAAAGGAGCAGGCAACAGCCGCAAAGCTTAAACGC
GCCATCGAAGCGGATAAGTATAAAGCCATTGGTCAGCTCGCTATGGGAGTCGCTCATGAGATCAATAACCCCTTAGCATC
GTCGACATTGGCTTTGGATCTATGGGAGCGAAAGCATCCCCACCAGTCTGACTCAGAAGCAGATTACCTAAGCCGTGTTC
GCCTAGGCATTGAGCGCGCCTCCTCAATAAGTAAAGAGCTACTCAGCTACGCAAGGCCTGCCTCTGGCAGACGCTGCTTT
GTCTCTTTGAGGGAGGTGTTAGATTCTGCAGCCAAGCTGTTGTCACACCGCACTAAGCAGCATTCTATTGAGTTTGATTG
CAGTGATAATATTGTGCTCTATGCCGAGAAGGTGAAGTTAGAGGAGCTATTTATCAATCTTTTATGTAATGCCCTTGATG
CATCGAGTCCGCAGAGTTCGATTATCGTGAGTGCGACGCAAGATGAGCACAAGGTCTGTGTGTATGTCGAGGACTCAGGC
TGTGGCATGACTGAGGAGGAGCTTGCTCACGCGACAGAATTATTTTATTCCACCAAGGCCTTAGGCCATGGCACTGGCTT
AGGTTTGGCGATTTGTGAGCAGATAGTCGCACTACATAATGGGAAGATGCATATTGTGAGCAGTAAACAGAAGGGCACTC
GTGTGGAGCTAACCTTTTATCGGGAGCAAGATTAA

Upstream 100 bases:

>100_bases
TTAAGTGGCTTTTTTGTTTTATGAACTAGCGCAAATTGCTGAGTTATAAAATCAGAAGCAGATCAAGTCATACTTTATAG
GTAGATGTTATGTTTATCTA

Downstream 100 bases:

>100_bases
TGGTGACAGTTTTGCTAGCTGAGGATGATAGAGAGCTTAGCCAAAATATGGTTGAAATTCTTGAACTTGAGGGTTTTAGT
GTTACCGCGGTTGAAAGTGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPVFVTFNIYLFYGLVFFSMGCAVVFRNFRYSQLKVAPTLWALAAFGFSHAFHEWSELYVLIFTDHIAPEYRLLTQWLCL
AKLFLSYAALMVFAWQILTINNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFAEASQYTRILIGFGSAMLAGVG
MVIYGNSLRQEEHSYGLYFALCGFGLMVYGVLSGLVPTEYHYSVPIYRTLAGGLILVALFKALKVFDLEKEQATAAKLKR
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPHQSDSEADYLSRVRLGIERASSISKELLSYARPASGRRCF
VSLREVLDSAAKLLSHRTKQHSIEFDCSDNIVLYAEKVKLEELFINLLCNALDASSPQSSIIVSATQDEHKVCVYVEDSG
CGMTEEELAHATELFYSTKALGHGTGLGLAICEQIVALHNGKMHIVSSKQKGTRVELTFYREQD

Sequences:

>Translated_464_residues
MPVFVTFNIYLFYGLVFFSMGCAVVFRNFRYSQLKVAPTLWALAAFGFSHAFHEWSELYVLIFTDHIAPEYRLLTQWLCL
AKLFLSYAALMVFAWQILTINNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFAEASQYTRILIGFGSAMLAGVG
MVIYGNSLRQEEHSYGLYFALCGFGLMVYGVLSGLVPTEYHYSVPIYRTLAGGLILVALFKALKVFDLEKEQATAAKLKR
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPHQSDSEADYLSRVRLGIERASSISKELLSYARPASGRRCF
VSLREVLDSAAKLLSHRTKQHSIEFDCSDNIVLYAEKVKLEELFINLLCNALDASSPQSSIIVSATQDEHKVCVYVEDSG
CGMTEEELAHATELFYSTKALGHGTGLGLAICEQIVALHNGKMHIVSSKQKGTRVELTFYREQD
>Mature_463_residues
PVFVTFNIYLFYGLVFFSMGCAVVFRNFRYSQLKVAPTLWALAAFGFSHAFHEWSELYVLIFTDHIAPEYRLLTQWLCLA
KLFLSYAALMVFAWQILTINNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFAEASQYTRILIGFGSAMLAGVGM
VIYGNSLRQEEHSYGLYFALCGFGLMVYGVLSGLVPTEYHYSVPIYRTLAGGLILVALFKALKVFDLEKEQATAAKLKRA
IEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPHQSDSEADYLSRVRLGIERASSISKELLSYARPASGRRCFV
SLREVLDSAAKLLSHRTKQHSIEFDCSDNIVLYAEKVKLEELFINLLCNALDASSPQSSIIVSATQDEHKVCVYVEDSGC
GMTEEELAHATELFYSTKALGHGTGLGLAICEQIVALHNGKMHIVSSKQKGTRVELTFYREQD

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=28.5106382978723, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788393, Length=126, Percent_Identity=32.5396825396825, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=236, Percent_Identity=26.6949152542373, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=325, Percent_Identity=23.3846153846154, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790551, Length=217, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51809; Mature: 51677

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFVTFNIYLFYGLVFFSMGCAVVFRNFRYSQLKVAPTLWALAAFGFSHAFHEWSELYV
CCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEE
LIFTDHIAPEYRLLTQWLCLAKLFLSYAALMVFAWQILTINNKRLAHIGHGVIITLLLCY
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEHHCCHHHHHHHHHH
AYLVIPDLHHLAVNQTGFAEASQYTRILIGFGSAMLAGVGMVIYGNSLRQEEHSYGLYFA
HHHHHCCHHHHHCCCCCCHHHHHHHEEEEECCHHHHHHCCCEEECCCHHHHHHCCCHHHH
LCGFGLMVYGVLSGLVPTEYHYSVPIYRTLAGGLILVALFKALKVFDLEKEQATAAKLKR
HHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPHQSDSEADYLSRVRLGIERA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SSISKELLSYARPASGRRCFVSLREVLDSAAKLLSHRTKQHSIEFDCSDNIVLYAEKVKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHH
EELFINLLCNALDASSPQSSIIVSATQDEHKVCVYVEDSGCGMTEEELAHATELFYSTKA
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGHGTGLGLAICEQIVALHNGKMHIVSSKQKGTRVELTFYREQD
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCC
>Mature Secondary Structure 
PVFVTFNIYLFYGLVFFSMGCAVVFRNFRYSQLKVAPTLWALAAFGFSHAFHEWSELYV
CEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEE
LIFTDHIAPEYRLLTQWLCLAKLFLSYAALMVFAWQILTINNKRLAHIGHGVIITLLLCY
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEHHCCHHHHHHHHHH
AYLVIPDLHHLAVNQTGFAEASQYTRILIGFGSAMLAGVGMVIYGNSLRQEEHSYGLYFA
HHHHHCCHHHHHCCCCCCHHHHHHHEEEEECCHHHHHHCCCEEECCCHHHHHHCCCHHHH
LCGFGLMVYGVLSGLVPTEYHYSVPIYRTLAGGLILVALFKALKVFDLEKEQATAAKLKR
HHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPHQSDSEADYLSRVRLGIERA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SSISKELLSYARPASGRRCFVSLREVLDSAAKLLSHRTKQHSIEFDCSDNIVLYAEKVKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHH
EELFINLLCNALDASSPQSSIIVSATQDEHKVCVYVEDSGCGMTEEELAHATELFYSTKA
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGHGTGLGLAICEQIVALHNGKMHIVSSKQKGTRVELTFYREQD
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]