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The map label for this gene is alr

Identifier: 157963394

GI number: 157963394

Start: 4370968

End: 4372044

Strand: Reverse

Name: alr

Synonym: Spea_3580

Alternate gene names: 157963394

Gene position: 4372044-4370968 (Counterclockwise)

Preceding gene: 157963395

Following gene: 157963393

Centisome position: 84.49

GC content: 48.0

Gene sequence:

>1077_bases
TTGAAACCATTCCCACGAGCAGAAATCAGCCGCCATGCATTGAAGAATAATCTTGCTCGGCTGCATGAATTAGCCCCATC
GAGTAAAGTGATGGCGGTTGTTAAAGCTAATGGCTATGGCCATGGCTTACTCAATGTCGCTCAATGTTTAGATAATGCCG
ACGGTTTTGGCCTAGCCCGGCTCGAAGAAGCATTAGCGCTTCGAGCGGGCGGTGTTAAGGCCAAGCTTTTATTATTGGAA
GGCTTTTTCCGAGCGACTGATTTAGTCACCTTAGTTGAGCATGATATTGAAACTGTGGTTCACCACGAGTCACAAATCGA
AATGCTCGAGCAGGCAGAGTTGAACAAACCCGTCACAGTGTGGATGAAAGTAGACTCTGGTATGCATCGACTCGGGTTTG
TACCTGATGAATTTCATCAGATTTATCAGCGTCTATTAGCCTGTGACAATATCGCCAAGCCAATTAACTTGATGACCCAC
TTTGCCTGTGCCGATGAACCAGATAATGACTGTACTGCCAAGCAGATTGCTGTTTTCGAAGAACTAACTAAAGACTTACT
TGGCGATCGTACTCTAGCCAACTCGGCTGGCGCACTCTTTTGGCAGCAAAGCCAAGCAAGTTGGATCCGCCCTGGTATTG
CGCTCTATGGTGTATCTCCTGTGGTTGGCGATCTAGGTACCAAACACGGGCTTATTCCTGCGATGGAGCTAGTGTCGCAG
CTGATTGCGATTCGCGATCATAAAGCTGGACAACCCGTTGGTTATGGTAGTCATTGGGTTGCAGAGAAAGATACCAAACT
TGGAGTTGTTGCTATCGGTTATGGTGATGGTTATCCAAGAAATGCGCCGTTAGGAACCCCAGTACTGATAAACGGTCGAT
TAGCACCTATCGTTGGTCGCGTCTCAATGGACATGTTGACGGTGGATCTTGGCGCTGGTGCTAAGGATAATGTTGGCGAT
AAAGCCGTGCTTTGGGGGAAAGACCTTCCGGTAGAGGAGGTGGCAGAGCATATTGGGACTATCGCCTACGAACTTGTGAC
TAAATTGACTCCCCGAGTCGCTGTTTGCCTAGATTGA

Upstream 100 bases:

>100_bases
AGATTAATTATTGGTCATCATCACTTTTTTTACACAGTGATAAAATACAATAGAGCCTCAATGAGGCTCTTATTTTTAGA
TTAGATAAACAAGGTTACTC

Downstream 100 bases:

>100_bases
GCAAATAAACACCTTATTCTGTAGTGGTGATTGAGGCTGGATGCCCTTCATCAGAATGAAGATCTTTTAAATTGAAAACT
TATTTATTGCGTACTTTTAC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKPFPRAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLARLEEALALRAGGVKAKLLLLE
GFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTVWMKVDSGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTH
FACADEPDNDCTAKQIAVFEELTKDLLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGTKHGLIPAMELVSQ
LIAIRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGRVSMDMLTVDLGAGAKDNVGD
KAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRVAVCLD

Sequences:

>Translated_358_residues
MKPFPRAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLARLEEALALRAGGVKAKLLLLE
GFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTVWMKVDSGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTH
FACADEPDNDCTAKQIAVFEELTKDLLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGTKHGLIPAMELVSQ
LIAIRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGRVSMDMLTVDLGAGAKDNVGD
KAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRVAVCLD
>Mature_358_residues
MKPFPRAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLARLEEALALRAGGVKAKLLLLE
GFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTVWMKVDSGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTH
FACADEPDNDCTAKQIAVFEELTKDLLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGTKHGLIPAMELVSQ
LIAIRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGRVSMDMLTVDLGAGAKDNVGD
KAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRVAVCLD

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=348, Percent_Identity=57.7586206896552, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1787439, Length=352, Percent_Identity=42.8977272727273, Blast_Score=280, Evalue=9e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_SHEPA (A8H8K6)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001503428.1
- ProteinModelPortal:   A8H8K6
- STRING:   A8H8K6
- GeneID:   5663966
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_3580
- NMPDR:   fig|398579.3.peg.3090
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- BioCyc:   SPEA398579:SPEA_3580-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38794; Mature: 38794

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFPRAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLAR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHHH
LEEALALRAGGVKAKLLLLEGFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTV
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
WMKVDSGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTHFACADEPDNDCTAKQIAVFE
EEEECCCCHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ELTKDLLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGTKHGLIPAMELVSQ
HHHHHHHCCCHHHCCCCCEEEECCCCCHHCCCEEEEECCHHHHHCCCCCCCHHHHHHHHH
LIAIRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGR
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHH
VSMDMLTVDLGAGAKDNVGDKAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRVAVCLD
HHHEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKPFPRAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLAR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHHH
LEEALALRAGGVKAKLLLLEGFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTV
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
WMKVDSGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTHFACADEPDNDCTAKQIAVFE
EEEECCCCHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ELTKDLLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGTKHGLIPAMELVSQ
HHHHHHHCCCHHHCCCCCEEEECCCCCHHCCCEEEEECCHHHHHCCCCCCCHHHHHHHHH
LIAIRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGR
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHH
VSMDMLTVDLGAGAKDNVGDKAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRVAVCLD
HHHEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA