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The map label for this gene is betA [C]

Identifier: 157963317

GI number: 157963317

Start: 4282427

End: 4284022

Strand: Reverse

Name: betA [C]

Synonym: Spea_3503

Alternate gene names: 157963317

Gene position: 4284022-4282427 (Counterclockwise)

Preceding gene: 157963318

Following gene: 157963314

Centisome position: 82.79

GC content: 50.94

Gene sequence:

>1596_bases
ATGGCCATTGAAGATCCTATCGTAACCGGACTCGATTCTGGATGGGCGCATATTAATGCATCTAAGCTCAGTGAAAACCA
AACCTTAGAGGCCGATGTGGTGATTGTCGGCAGTGGCGCGGGAGGCGGCGTCGCGGCAGAAATTCTTACCGAGGCTGGCT
TATCTGTGATCATCGTTGAGGGCGGTCAACTAAAGTCATCGAAAGATTTTGTCATGGAGGAGCGAGTCGCTTATCCAGAT
CTCTACCAGCAAGCGGCGGGGATGAAGACAACCGACAAGGCGATCGGTATTTTTCAGGGCCGCGGCGTAGGTGGCTCCAC
CACAGTCAACTGGACCACTTCTATCCGCACTCCAGAGCCCGCATTGGATTATTGGGCGCAGACAAAATCTGTTGTAGGGC
TCTCTCGCACCGAGCTAGATCCTTGGTTTGAGAAGATGGAGCAACGGCTTAATATCAGCAAGTGGGCCTACGATCCTAAC
CGTAATAATCAAGCCTTAAAGCAAGGCTGTGAGACATTAGGTTGGGAGCACACTGTGATTAAGCGTAACGTCAAAGGTTG
TTGGAATACGGGCTATTGCGGCATGGGCTGCCCGGTAAATGCTAAGCAGTCTATGTTGGTGACCACGATTCCCGCGGCGC
TAGATCGCGGTGCAACACTGGTGAGTCAGGCTCAGGTCATTAAGCTTGAGCATCATAACGACAAGATCTTCGCTGTTAAG
GCTCAAGCGGTCGATAAAAATATGAAGCCTATGCCTGTGGAAGTGATGTTTAAGGCTAAGCACTATATTCTTGCGGCCGG
GGCGATTCATACTCCAAGCATTATGCTGCGCTCCAAGCTACCGGATCCTCATGAGATCATAGGTAAGCGTACTTTCTTAC
ATCCGACCTTGCTCAGCGGTGCTGTTTTTAGCGATCCGATTAATGGTCACAGCGGGGCGCCGCAGTCTATCTATTCTGAT
GAATTTGTCTGGCAAGATGGCGCCGACGGAGAGCTAGGCTACAAGCTTGAAGTGCCACCCATTCACCCAATTCTGATCGC
TTCAAAAACTGTTGGCTATGGCAAGAGTCACGCGCAGCTGATGGAGAAATTTAACCAATTACAGGTCACTATCGCATTAG
TAAGAGACGGTTATCATGACAATAGTCAGGGGGGGCAGGTTAAGCTGACAGACCATGGCTTTACCCTAGATTACCCTCTT
ACCGATGCGTTTTGGCGTGCGGCGCGGCGTGCATATGCCAGCATGGCAGAGTTGCAGTTTGCGGCAGGGGCGCAGCAAGT
GCTGCCAATCAGTGAGGGTATGCCTTACTTGTCGAGCTGGAATGAGGCTAAAAAGGCTATTAGCGAAATGGATTTGGCAC
CGCTGAAAACCGTAGTGGCATCGGCTCATGTGATGGGGGGCTGCCCATTTGGTGAGGACCCCAAGTTAGCTATGGTGAAC
AGCTTTGGTGAATCACACTACTTTGATAACCTGTCAGTGATGGATGGCTCGATATTCCCAACCAGCCTAGGGGCCAATCC
TCAGTTGTCTATCTATGGTATTACCGCCAGAAACGCGACTCGATTGGCTGAGAGGCTTAAGCCCCAAGCTAGTTAA

Upstream 100 bases:

>100_bases
CTGTATTATGCTAAACCGACGTTCCTTGAAGATATGAAGTCTGGAGGATATGAAGTGAAGTTATTTCTTAACTCTGAGCT
AAAAGGGAAGGGGAGCCTAT

Downstream 100 bases:

>100_bases
TAGATAAAAAATATGAACTCAGCACAAACTGAGTTCTTTGCTTTAAAAGCGATAAACCATGAAGTGCTCACTTGGTTTGC
TACACGGAGGACGCGAAGAA

Product: glucose-methanol-choline oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAIEDPIVTGLDSGWAHINASKLSENQTLEADVVIVGSGAGGGVAAEILTEAGLSVIIVEGGQLKSSKDFVMEERVAYPD
LYQQAAGMKTTDKAIGIFQGRGVGGSTTVNWTTSIRTPEPALDYWAQTKSVVGLSRTELDPWFEKMEQRLNISKWAYDPN
RNNQALKQGCETLGWEHTVIKRNVKGCWNTGYCGMGCPVNAKQSMLVTTIPAALDRGATLVSQAQVIKLEHHNDKIFAVK
AQAVDKNMKPMPVEVMFKAKHYILAAGAIHTPSIMLRSKLPDPHEIIGKRTFLHPTLLSGAVFSDPINGHSGAPQSIYSD
EFVWQDGADGELGYKLEVPPIHPILIASKTVGYGKSHAQLMEKFNQLQVTIALVRDGYHDNSQGGQVKLTDHGFTLDYPL
TDAFWRAARRAYASMAELQFAAGAQQVLPISEGMPYLSSWNEAKKAISEMDLAPLKTVVASAHVMGGCPFGEDPKLAMVN
SFGESHYFDNLSVMDGSIFPTSLGANPQLSIYGITARNATRLAERLKPQAS

Sequences:

>Translated_531_residues
MAIEDPIVTGLDSGWAHINASKLSENQTLEADVVIVGSGAGGGVAAEILTEAGLSVIIVEGGQLKSSKDFVMEERVAYPD
LYQQAAGMKTTDKAIGIFQGRGVGGSTTVNWTTSIRTPEPALDYWAQTKSVVGLSRTELDPWFEKMEQRLNISKWAYDPN
RNNQALKQGCETLGWEHTVIKRNVKGCWNTGYCGMGCPVNAKQSMLVTTIPAALDRGATLVSQAQVIKLEHHNDKIFAVK
AQAVDKNMKPMPVEVMFKAKHYILAAGAIHTPSIMLRSKLPDPHEIIGKRTFLHPTLLSGAVFSDPINGHSGAPQSIYSD
EFVWQDGADGELGYKLEVPPIHPILIASKTVGYGKSHAQLMEKFNQLQVTIALVRDGYHDNSQGGQVKLTDHGFTLDYPL
TDAFWRAARRAYASMAELQFAAGAQQVLPISEGMPYLSSWNEAKKAISEMDLAPLKTVVASAHVMGGCPFGEDPKLAMVN
SFGESHYFDNLSVMDGSIFPTSLGANPQLSIYGITARNATRLAERLKPQAS
>Mature_530_residues
AIEDPIVTGLDSGWAHINASKLSENQTLEADVVIVGSGAGGGVAAEILTEAGLSVIIVEGGQLKSSKDFVMEERVAYPDL
YQQAAGMKTTDKAIGIFQGRGVGGSTTVNWTTSIRTPEPALDYWAQTKSVVGLSRTELDPWFEKMEQRLNISKWAYDPNR
NNQALKQGCETLGWEHTVIKRNVKGCWNTGYCGMGCPVNAKQSMLVTTIPAALDRGATLVSQAQVIKLEHHNDKIFAVKA
QAVDKNMKPMPVEVMFKAKHYILAAGAIHTPSIMLRSKLPDPHEIIGKRTFLHPTLLSGAVFSDPINGHSGAPQSIYSDE
FVWQDGADGELGYKLEVPPIHPILIASKTVGYGKSHAQLMEKFNQLQVTIALVRDGYHDNSQGGQVKLTDHGFTLDYPLT
DAFWRAARRAYASMAELQFAAGAQQVLPISEGMPYLSSWNEAKKAISEMDLAPLKTVVASAHVMGGCPFGEDPKLAMVNS
FGESHYFDNLSVMDGSIFPTSLGANPQLSIYGITARNATRLAERLKPQAS

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 57644; Mature: 57513

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEDPIVTGLDSGWAHINASKLSENQTLEADVVIVGSGAGGGVAAEILTEAGLSVIIVE
CCCCCCCEECCCCCCEEEEHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEE
GGQLKSSKDFVMEERVAYPDLYQQAAGMKTTDKAIGIFQGRGVGGSTTVNWTTSIRTPEP
CCCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEECCCCCCCCEEEEEEECCCCCH
ALDYWAQTKSVVGLSRTELDPWFEKMEQRLNISKWAYDPNRNNQALKQGCETLGWEHTVI
HHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHCCCCHHHH
KRNVKGCWNTGYCGMGCPVNAKQSMLVTTIPAALDRGATLVSQAQVIKLEHHNDKIFAVK
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCHHHCCEEEEEEEECCCEEEEEE
AQAVDKNMKPMPVEVMFKAKHYILAAGAIHTPSIMLRSKLPDPHEIIGKRTFLHPTLLSG
EHHHCCCCCCCCCEEEEECCEEEEEECCCCCCHHHEECCCCCHHHHHCCHHEECHHHHCC
AVFSDPINGHSGAPQSIYSDEFVWQDGADGELGYKLEVPPIHPILIASKTVGYGKSHAQL
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHH
MEKFNQLQVTIALVRDGYHDNSQGGQVKLTDHGFTLDYPLTDAFWRAARRAYASMAELQF
HHHHHHHEEEEEEEECCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHH
AAGAQQVLPISEGMPYLSSWNEAKKAISEMDLAPLKTVVASAHVMGGCPFGEDPKLAMVN
HCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
SFGESHYFDNLSVMDGSIFPTSLGANPQLSIYGITARNATRLAERLKPQAS
CCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCC
>Mature Secondary Structure 
AIEDPIVTGLDSGWAHINASKLSENQTLEADVVIVGSGAGGGVAAEILTEAGLSVIIVE
CCCCCCEECCCCCCEEEEHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEE
GGQLKSSKDFVMEERVAYPDLYQQAAGMKTTDKAIGIFQGRGVGGSTTVNWTTSIRTPEP
CCCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEECCCCCCCCEEEEEEECCCCCH
ALDYWAQTKSVVGLSRTELDPWFEKMEQRLNISKWAYDPNRNNQALKQGCETLGWEHTVI
HHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHCCCCHHHH
KRNVKGCWNTGYCGMGCPVNAKQSMLVTTIPAALDRGATLVSQAQVIKLEHHNDKIFAVK
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCHHHCCEEEEEEEECCCEEEEEE
AQAVDKNMKPMPVEVMFKAKHYILAAGAIHTPSIMLRSKLPDPHEIIGKRTFLHPTLLSG
EHHHCCCCCCCCCEEEEECCEEEEEECCCCCCHHHEECCCCCHHHHHCCHHEECHHHHCC
AVFSDPINGHSGAPQSIYSDEFVWQDGADGELGYKLEVPPIHPILIASKTVGYGKSHAQL
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHH
MEKFNQLQVTIALVRDGYHDNSQGGQVKLTDHGFTLDYPLTDAFWRAARRAYASMAELQF
HHHHHHHEEEEEEEECCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHH
AAGAQQVLPISEGMPYLSSWNEAKKAISEMDLAPLKTVVASAHVMGGCPFGEDPKLAMVN
HCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
SFGESHYFDNLSVMDGSIFPTSLGANPQLSIYGITARNATRLAERLKPQAS
CCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]