Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 157963130

GI number: 157963130

Start: 4056093

End: 4056761

Strand: Reverse

Name: ung [H]

Synonym: Spea_3314

Alternate gene names: 157963130

Gene position: 4056761-4056093 (Counterclockwise)

Preceding gene: 157963134

Following gene: 157963126

Centisome position: 78.4

GC content: 49.78

Gene sequence:

>669_bases
ATGACGGCGCACTCTAGCTGGTCATCGTTTATAAACGAACAGCAGCAACAAGACTATTTCCAATCCTTACAGCTGTTTGT
TGAAGCCGAACGCGCAGCGGGCAAGGTTATTTATCCGCCTGAGAGCGAAGTGCTGGCCGCATTTGACTCGACGCCATTGG
ATAAGGTACGCGTGGTGCTAATAGGGCAAGACCCTTATCATGGTCCCGGGCAGGCACATGGCTTGTGTTTCTCAGTTAAA
CACGGAGTTAAGACGCCGCCGTCCTTGGTGAATATGTATAAAGAGCTGGCAACAGATATTGATGGTTTCAGTATTCCAGA
GCATGGCAACCTGAGTCACTGGGCCGAGCAGGGAATATTGATGCTCAATACCGTGTTAACCGTCGAGCAGGGCAAGGCGC
ACTCCCACGCTAAATCGGGTTGGGAAACTTTTACTGCCAATGCGCTTGAGTTACTGAATCAACAAGCTCAACCGATAATC
TTTGTGCTTTGGGGCGCTCACGCCATTAAAAAGGGTAAAGTGATTAACGCACCGCAGCATCAGGTTATCTCGGGGCCGCA
CCCATCGCCGTTATCGGCCTATCGTGGATTCTTTGGTTGTCAGCATTTCTCAAAAATTAATGCGATCTTGCAAGCTAGAG
GCGAAGTGCCGATAGACTGGCAGGTATAA

Upstream 100 bases:

>100_bases
TGTACTAGGATTGCATTTTGAGGGGGATTTACAAAACGGTGATTGCATGGGATGCCGCGAGCTTTTAAGCTTAGGCAAAT
TTTTACCTTGAGGTCAGATC

Downstream 100 bases:

>100_bases
TTGTCAGCGATACAAACAAAAAGAGCGCATTGCGCTCTTTTTACTTTATCTAGCTCTGCCTCAATTAGCGTACTTAATTG
TTACCCCACCAAGAAATAGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTAHSSWSSFINEQQQQDYFQSLQLFVEAERAAGKVIYPPESEVLAAFDSTPLDKVRVVLIGQDPYHGPGQAHGLCFSVK
HGVKTPPSLVNMYKELATDIDGFSIPEHGNLSHWAEQGILMLNTVLTVEQGKAHSHAKSGWETFTANALELLNQQAQPII
FVLWGAHAIKKGKVINAPQHQVISGPHPSPLSAYRGFFGCQHFSKINAILQARGEVPIDWQV

Sequences:

>Translated_222_residues
MTAHSSWSSFINEQQQQDYFQSLQLFVEAERAAGKVIYPPESEVLAAFDSTPLDKVRVVLIGQDPYHGPGQAHGLCFSVK
HGVKTPPSLVNMYKELATDIDGFSIPEHGNLSHWAEQGILMLNTVLTVEQGKAHSHAKSGWETFTANALELLNQQAQPII
FVLWGAHAIKKGKVINAPQHQVISGPHPSPLSAYRGFFGCQHFSKINAILQARGEVPIDWQV
>Mature_221_residues
TAHSSWSSFINEQQQQDYFQSLQLFVEAERAAGKVIYPPESEVLAAFDSTPLDKVRVVLIGQDPYHGPGQAHGLCFSVKH
GVKTPPSLVNMYKELATDIDGFSIPEHGNLSHWAEQGILMLNTVLTVEQGKAHSHAKSGWETFTANALELLNQQAQPIIF
VLWGAHAIKKGKVINAPQHQVISGPHPSPLSAYRGFFGCQHFSKINAILQARGEVPIDWQV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=50.9259259259259, Blast_Score=230, Evalue=8e-61,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=50.9259259259259, Blast_Score=229, Evalue=1e-60,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=55.4545454545455, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.1481481481481, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=44.3037974683544, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24486; Mature: 24355

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHSSWSSFINEQQQQDYFQSLQLFVEAERAAGKVIYPPESEVLAAFDSTPLDKVRVVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHEEECCCCCCCCEEEEE
IGQDPYHGPGQAHGLCFSVKHGVKTPPSLVNMYKELATDIDGFSIPEHGNLSHWAEQGIL
EECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEQGKAHSHAKSGWETFTANALELLNQQAQPIIFVLWGAHAIKKGKVINAPQH
EEHHEEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCCCEECCCCC
QVISGPHPSPLSAYRGFFGCQHFSKINAILQARGEVPIDWQV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAHSSWSSFINEQQQQDYFQSLQLFVEAERAAGKVIYPPESEVLAAFDSTPLDKVRVVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHEEECCCCCCCCEEEEE
IGQDPYHGPGQAHGLCFSVKHGVKTPPSLVNMYKELATDIDGFSIPEHGNLSHWAEQGIL
EECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEQGKAHSHAKSGWETFTANALELLNQQAQPIIFVLWGAHAIKKGKVINAPQH
EEHHEEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCCCEECCCCC
QVISGPHPSPLSAYRGFFGCQHFSKINAILQARGEVPIDWQV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]