Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 157962944

GI number: 157962944

Start: 3830048

End: 3831298

Strand: Reverse

Name: hemA [H]

Synonym: Spea_3127

Alternate gene names: 157962944

Gene position: 3831298-3830048 (Counterclockwise)

Preceding gene: 157962948

Following gene: 157962943

Centisome position: 74.04

GC content: 45.0

Gene sequence:

>1251_bases
ATGAGCCTTGTAGCAATCGGAATTAACCATAAAACGGCGACGGTCGACCTGCGAGAAAAAGTCGCATTCGGTCCTGATAA
AATTCATGATGCCATGAAGAGTCTAGCTGCTAGCACTCAGTCGGGCGAAGCCGTCATCATTTCCACCTGTAACCGTACAG
AACTTTACTGTAATAACTGTGAAGCTGCTGACGTAGTTGCTTGGCTGGAAGATTATCATCAACTATCTCATGAAGATGTT
GAACCCTGCTTGTACCAATATAAAGGTCAAGAAGCGGTTAAACATTTAATGCGTGTATCTGCTGGTCTCGATTCACTGAT
TTTGGGTGAACCGCAAATTTTAGGTCAAGTGAAGCAATCTTTTGTGAAAGCAAAAGAAGCGGGTACCGTTGCTGCGACAA
TGGATCGTATGTTTCAGAATACCTTTTCAGTCGCCAAAAAAATTCGAACCGAGACTGAAATTGGTGCAGCGGCCGTATCG
GTAGCCTTTGCAGCAGTGAGTATGGCAAAACATATTTTCTCATCAATCAGTACGACTCAGGTATTATTGGTCGGTGCCGG
TGAGACAATTGAGCTGGTCGCGCGTCACTTAAAAGACAATGGCGTTACAACCATGGTTGTTGCCAACCGAACGATTTCAC
GTGCAGAAGCCATGTGTGAAGAGTTCGGCGCGACAGCAATTACACTCGAACAGATCCCAGATTTTCTCCCTAAGGCCGAT
ATCGTGATATCCTCTACGGCTAGCCCATTACCAATTCTTGGTAAAGGCATGGTAGAAAAAGCGCTTAAGCAGCGTCGTCA
TCAACCTATGTTATTGGTTGATATAGCAGTTCCTCGAGATATCGAGGCTGAAGTCGCGGATTTAGATGATGCATTCCTCT
ATACCGTAGATGACCTGCAAAGCATTATTGAACAGAATATGGCATCTCGAAGAGAAGCCGCCGAGCAAGCAGAATTAATT
GCAGAAGATCAAGCTTATCAATTTATGGAATGGATCCGCTCGCTAGAGTCGGTAGACAGTATCCGTGAATATCGCACAAA
AAGTATGGCGATTAAAGATGAGCTGGTAGAGCGAGCGGTCAACAAATTGGCCCAAGGTGGTAATAGTGAGCAGGTCTTAC
TAGAACTAGCTAATAAGCTTACCAATAAACTGATCCATGCGCCGACACAAGCGCTTACCGCTGCGAGTCGACAAGGGGAC
TTGAATTCCCTTGGACAATTAAGAGCTTTGCTTGGACTAGATAAAGACTAA

Upstream 100 bases:

>100_bases
ATTATTATTCGGTTTTGTTAAGCGTATTCTGTTTTTAACAAAACCAATTCAGTAGAATGGCACCAATAAATGAGATGCCC
AAGAGTCCAGAACGAGTCAA

Downstream 100 bases:

>100_bases
GGTTAGCGTTTTAATGAAGGACAGTGTGATTCGTAAGCTTGAAGGCTTACTTGAACGTAATGAAGAAGTGTTGGCGTTAC
TGAGTGATGCAGGCGTTATT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNCEAADVVAWLEDYHQLSHEDV
EPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVS
VAFAAVSMAKHIFSSISTTQVLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELI
AEDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGD
LNSLGQLRALLGLDKD

Sequences:

>Translated_416_residues
MSLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNCEAADVVAWLEDYHQLSHEDV
EPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVS
VAFAAVSMAKHIFSSISTTQVLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELI
AEDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGD
LNSLGQLRALLGLDKD
>Mature_415_residues
SLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNCEAADVVAWLEDYHQLSHEDVE
PCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSV
AFAAVSMAKHIFSSISTTQVLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKADI
VISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELIA
EDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDL
NSLGQLRALLGLDKD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=419, Percent_Identity=55.3699284009546, Blast_Score=457, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 45425; Mature: 45294

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNC
CCEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC
EAADVVAWLEDYHQLSHEDVEPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQS
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
FVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSVAFAAVSMAKHIFSSISTTQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE
VLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKAD
EEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHEEEHHHHH
SIIEQNMASRREAAEQAELIAEDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDLNSLGQLRALLGLDKD
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLVAIGINHKTATVDLREKVAFGPDKIHDAMKSLAASTQSGEAVIISTCNRTELYCNNC
CEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC
EAADVVAWLEDYHQLSHEDVEPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQS
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
FVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSVAFAAVSMAKHIFSSISTTQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE
VLLVGAGETIELVARHLKDNGVTTMVVANRTISRAEAMCEEFGATAITLEQIPDFLPKAD
EEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHEEEHHHHH
SIIEQNMASRREAAEQAELIAEDQAYQFMEWIRSLESVDSIREYRTKSMAIKDELVERAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDLNSLGQLRALLGLDKD
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA