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The map label for this gene is phoR [H]

Identifier: 157962786

GI number: 157962786

Start: 3634896

End: 3636215

Strand: Reverse

Name: phoR [H]

Synonym: Spea_2968

Alternate gene names: 157962786

Gene position: 3636215-3634896 (Counterclockwise)

Preceding gene: 157962787

Following gene: 157962785

Centisome position: 70.27

GC content: 46.36

Gene sequence:

>1320_bases
ATGTTTGATTCATATTCTGGGTACCGTTTAATTTCACGTTTGGCGATATATTTGGCCTCGTGTTTGTTGATTGGATTGAT
ATTCGGTGAAGTGCTTTGGATCTTATTGCTAGGGTCGATTCTTCTACTCATTTGGCATTATCGCCAGTTATCCCGTTTAA
ATTTTTGGCTATGGCATGATCGCCGCCTCACGCCCCCTAATGGCAGCGGTAGTTGGGAGGGGGTGTTCAATGGTATCTAT
CGTTTACAAGGGAAGAATCGTAAACGAGTGTCGCAGCTTGCTTTCTTGCTCGGACGTTTCAGGCAAGGCGCAGAAGCGCT
ACCCGATGCCGCTGTAGTATTAGATTCTGAACATAATATTTTATGGTGTAATAAACTGGCGCAATTGCTGCTCGGTTTTG
TATGGCCACAAGATAACGGTCAGCGCATCGATAACCTCATTCGTCATCCTGATTTTTCCGCTTATCTTAAAAATAAAGAA
TACCAAGAGCCCTTAGAGTTGTCATCGCCGCAATCAGAAGGCCATATCCTTGAGATCCGAATCATGGGTTACGGGGCGGG
GCAGCTTTTATTGATTGCCCGAGATATCACTCGAGTACGTCAGTTAGAGGGGATGCGTAAAGAGTTCGTCGCCAATGTAT
CCCATGAGCTAAAAACGCCGCTCACCGTATTGCAAGGCTATTTAGAGATGATGCATTCGATGGCGGAGCCTGATTCGCCA
AATGTTCGCGCCTTGGAGCAGATGCAGCAGCAAACCACGCGCATGCGCTCTATGGTTGAGCAGTTACTTGCATTATCGAG
GATTGAGGATGCTAGCGACGTGAGCTTAGAGGTTAAGGTGAATATGAAGCAGATGATGGATATCTTGCGTGATGAAGCCT
TAGCCTTAGCGCAAGAGCAGTACGAGATCAGTTTTTACTGTGAGCCAGGGCTGAATATATATGGCAATGAATTACAGCTA
AGAAGCGTGTGTTCTAACCTAATTTCTAATGCTATCCGTTACACCGAGCCTGGTGGCAAGGTCGAAATAAGTTGGCGTAA
GATTGCTATCGGCGGTCTATTTAGTGTTAAAGATAATGGTGAGGGAATTGCGCCTCACCATATCGGTCGTTTAACCGAAC
GTTTTTATCGTGTCGATAGCGCTCGTTCACGCCAAAGCGGTGGCACAGGCCTGGGACTTGCCATCACTAAGCATGCTTTA
CATAACCACCAGAGTGAACTTAACATCGCCAGTCAATTGGGGAAGGGCAGTACCTTTAGCTTTGTTATTCCAGCGAATTT
AATCGAGTTTACCCCGCAGGCAAGCAATCAGCAGGGTTAA

Upstream 100 bases:

>100_bases
CTGGTTATCGTTTCTCTACTCGCCTCTAGTTGATAGGTACAAGGTGATTTTTAGCTTATCTTGTGCCGAGCTTTCTATAT
GGCCGATATATTGGTAAAAC

Downstream 100 bases:

>100_bases
GTTTTAAAGATAAGCCGTTACAGATAAGTTTTAAAATAAATGTCATATAAAAACAGGCTGCTGCCTGTTTTTTAGTATAA
AAAGATCCAAATTAGCTTGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFDSYSGYRLISRLAIYLASCLLIGLIFGEVLWILLLGSILLLIWHYRQLSRLNFWLWHDRRLTPPNGSGSWEGVFNGIY
RLQGKNRKRVSQLAFLLGRFRQGAEALPDAAVVLDSEHNILWCNKLAQLLLGFVWPQDNGQRIDNLIRHPDFSAYLKNKE
YQEPLELSSPQSEGHILEIRIMGYGAGQLLLIARDITRVRQLEGMRKEFVANVSHELKTPLTVLQGYLEMMHSMAEPDSP
NVRALEQMQQQTTRMRSMVEQLLALSRIEDASDVSLEVKVNMKQMMDILRDEALALAQEQYEISFYCEPGLNIYGNELQL
RSVCSNLISNAIRYTEPGGKVEISWRKIAIGGLFSVKDNGEGIAPHHIGRLTERFYRVDSARSRQSGGTGLGLAITKHAL
HNHQSELNIASQLGKGSTFSFVIPANLIEFTPQASNQQG

Sequences:

>Translated_439_residues
MFDSYSGYRLISRLAIYLASCLLIGLIFGEVLWILLLGSILLLIWHYRQLSRLNFWLWHDRRLTPPNGSGSWEGVFNGIY
RLQGKNRKRVSQLAFLLGRFRQGAEALPDAAVVLDSEHNILWCNKLAQLLLGFVWPQDNGQRIDNLIRHPDFSAYLKNKE
YQEPLELSSPQSEGHILEIRIMGYGAGQLLLIARDITRVRQLEGMRKEFVANVSHELKTPLTVLQGYLEMMHSMAEPDSP
NVRALEQMQQQTTRMRSMVEQLLALSRIEDASDVSLEVKVNMKQMMDILRDEALALAQEQYEISFYCEPGLNIYGNELQL
RSVCSNLISNAIRYTEPGGKVEISWRKIAIGGLFSVKDNGEGIAPHHIGRLTERFYRVDSARSRQSGGTGLGLAITKHAL
HNHQSELNIASQLGKGSTFSFVIPANLIEFTPQASNQQG
>Mature_439_residues
MFDSYSGYRLISRLAIYLASCLLIGLIFGEVLWILLLGSILLLIWHYRQLSRLNFWLWHDRRLTPPNGSGSWEGVFNGIY
RLQGKNRKRVSQLAFLLGRFRQGAEALPDAAVVLDSEHNILWCNKLAQLLLGFVWPQDNGQRIDNLIRHPDFSAYLKNKE
YQEPLELSSPQSEGHILEIRIMGYGAGQLLLIARDITRVRQLEGMRKEFVANVSHELKTPLTVLQGYLEMMHSMAEPDSP
NVRALEQMQQQTTRMRSMVEQLLALSRIEDASDVSLEVKVNMKQMMDILRDEALALAQEQYEISFYCEPGLNIYGNELQL
RSVCSNLISNAIRYTEPGGKVEISWRKIAIGGLFSVKDNGEGIAPHHIGRLTERFYRVDSARSRQSGGTGLGLAITKHAL
HNHQSELNIASQLGKGSTFSFVIPANLIEFTPQASNQQG

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=428, Percent_Identity=50.4672897196262, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=30.3030303030303, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790346, Length=211, Percent_Identity=31.7535545023697, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=27.6785714285714, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=29.8319327731092, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=27.5303643724696, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=356, Percent_Identity=25.561797752809, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=285, Percent_Identity=27.0175438596491, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=322, Percent_Identity=25.776397515528, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=25.4980079681275, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=278, Percent_Identity=26.6187050359712, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=27.5303643724696, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=275, Percent_Identity=26.1818181818182, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=24.3589743589744, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=28.6343612334802, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=25.6521739130435, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=290, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=25.6302521008403, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=25.4980079681275, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49694; Mature: 49694

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSYSGYRLISRLAIYLASCLLIGLIFGEVLWILLLGSILLLIWHYRQLSRLNFWLWHD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
RRLTPPNGSGSWEGVFNGIYRLQGKNRKRVSQLAFLLGRFRQGAEALPDAAVVLDSEHNI
CEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCCE
LWCNKLAQLLLGFVWPQDNGQRIDNLIRHPDFSAYLKNKEYQEPLELSSPQSEGHILEIR
EHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
IMGYGAGQLLLIARDITRVRQLEGMRKEFVANVSHELKTPLTVLQGYLEMMHSMAEPDSP
EEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
NVRALEQMQQQTTRMRSMVEQLLALSRIEDASDVSLEVKVNMKQMMDILRDEALALAQEQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHC
YEISFYCEPGLNIYGNELQLRSVCSNLISNAIRYTEPGGKVEISWRKIAIGGLFSVKDNG
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEEEEEEEEECCCC
EGIAPHHIGRLTERFYRVDSARSRQSGGTGLGLAITKHALHNHQSELNIASQLGKGSTFS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEE
FVIPANLIEFTPQASNQQG
EEECCHHHHCCCCCCCCCC
>Mature Secondary Structure
MFDSYSGYRLISRLAIYLASCLLIGLIFGEVLWILLLGSILLLIWHYRQLSRLNFWLWHD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
RRLTPPNGSGSWEGVFNGIYRLQGKNRKRVSQLAFLLGRFRQGAEALPDAAVVLDSEHNI
CEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCCE
LWCNKLAQLLLGFVWPQDNGQRIDNLIRHPDFSAYLKNKEYQEPLELSSPQSEGHILEIR
EHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
IMGYGAGQLLLIARDITRVRQLEGMRKEFVANVSHELKTPLTVLQGYLEMMHSMAEPDSP
EEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
NVRALEQMQQQTTRMRSMVEQLLALSRIEDASDVSLEVKVNMKQMMDILRDEALALAQEQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHC
YEISFYCEPGLNIYGNELQLRSVCSNLISNAIRYTEPGGKVEISWRKIAIGGLFSVKDNG
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEEEEEEEEECCCC
EGIAPHHIGRLTERFYRVDSARSRQSGGTGLGLAITKHALHNHQSELNIASQLGKGSTFS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEE
FVIPANLIEFTPQASNQQG
EEECCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]