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The map label for this gene is lpxA [H]

Identifier: 157962692

GI number: 157962692

Start: 3511039

End: 3511809

Strand: Reverse

Name: lpxA [H]

Synonym: Spea_2873

Alternate gene names: 157962692

Gene position: 3511809-3511039 (Counterclockwise)

Preceding gene: 157962693

Following gene: 157962691

Centisome position: 67.87

GC content: 46.43

Gene sequence:

>771_bases
GTGATTGATAAATTAGCTTACATCCACCCAGATGCCAAGATTGGCAACAATGTGACGATCGGTCCTTGGACTTATATCGG
TGCTGACGTTGAGATTGGTGATGATTGCTGGTTCAGCTCACACGTTGTTGTGAAAGGACCTACCGTTATTGGTAAAGGCA
ATAAGTTCTACCAGTTCGCCTCTGTAGGTGAAGATTGCCAAGATAAAAAGTATGCGGGCGAGGCAACTCGTTTGATAATT
GGTGATAATAACGTGATCCGCGAATCGGTAACGATTCACCGCGGTACGACTCAGGATGAGTGGGAAACACGTATTGGCTC
AAATAACCTATTTATGGCTTATGTGCATATTGCCCATGACTGTGTGGTAGGCAGCAATGTGATTATGGCGAATAACGCTT
CGATCGCAGGCCATGTACACGTTGGTGACTGGGCTATTTTAGGCGGCATGACAGGCGTTCATCAGTTTGTGCATATTGGT
GCACATGCGTTTACCGCTGGTAGTTCATTGATCCTAAATGATGTACCTCCATTTGTAATGGCATCGGGTCAACCAGCCAT
TCCTAGAGGTTTGAATATCGAGGGCATGAAGCGTCGAGGCTTCTCTAAAGAGTCTCAGCTTTCGGTTCGCAGAGCCTATA
AGACTTTGTATCGCAGCAGCTTAACGGTTGCTGAAGCGATTGAGCAGCTTAAAGAGGCTGCAGTGGATGATGAGCAGGTT
GAGTCACTTATAGACTTTGTTGCTTCCTCTCAACGAGGCATCATTCGCTAG

Upstream 100 bases:

>100_bases
AAGAGCGCCGCGGGATTGGCGTGTTTACTGGCGTTGCTAAAGTGGATGGCGAGGTAGTTTGTTCAGCCGAGATCATGTGT
GCACGTAGAGAGATTTCTAA

Downstream 100 bases:

>100_bases
TCCAAGACCTGAACCCGTGTAAAAGCGGGTTCTTTGTTTTCATCTCATCAGTGACAGACGCCTTTCTATGAGTTCAAACA
ATCCTCGTGTATTTGCAATG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIDKLAYIHPDAKIGNNVTIGPWTYIGADVEIGDDCWFSSHVVVKGPTVIGKGNKFYQFASVGEDCQDKKYAGEATRLII
GDNNVIRESVTIHRGTTQDEWETRIGSNNLFMAYVHIAHDCVVGSNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGSSLILNDVPPFVMASGQPAIPRGLNIEGMKRRGFSKESQLSVRRAYKTLYRSSLTVAEAIEQLKEAAVDDEQV
ESLIDFVASSQRGIIR

Sequences:

>Translated_256_residues
MIDKLAYIHPDAKIGNNVTIGPWTYIGADVEIGDDCWFSSHVVVKGPTVIGKGNKFYQFASVGEDCQDKKYAGEATRLII
GDNNVIRESVTIHRGTTQDEWETRIGSNNLFMAYVHIAHDCVVGSNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGSSLILNDVPPFVMASGQPAIPRGLNIEGMKRRGFSKESQLSVRRAYKTLYRSSLTVAEAIEQLKEAAVDDEQV
ESLIDFVASSQRGIIR
>Mature_256_residues
MIDKLAYIHPDAKIGNNVTIGPWTYIGADVEIGDDCWFSSHVVVKGPTVIGKGNKFYQFASVGEDCQDKKYAGEATRLII
GDNNVIRESVTIHRGTTQDEWETRIGSNNLFMAYVHIAHDCVVGSNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGSSLILNDVPPFVMASGQPAIPRGLNIEGMKRRGFSKESQLSVRRAYKTLYRSSLTVAEAIEQLKEAAVDDEQV
ESLIDFVASSQRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=54.5801526717557, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1786376, Length=238, Percent_Identity=26.890756302521, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27884; Mature: 27884

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKLAYIHPDAKIGNNVTIGPWTYIGADVEIGDDCWFSSHVVVKGPTVIGKGNKFYQFA
CCCCEEEECCCCCCCCEEEECCCEEECCEEEECCCCEECCEEEEECCEEEECCCCEEEEC
SVGEDCQDKKYAGEATRLIIGDNNVIRESVTIHRGTTQDEWETRIGSNNLFMAYVHIAHD
CCCCCHHCCCCCCCEEEEEECCCCEEECEEEEECCCCCHHHHHHCCCCCEEEEEEEEHHH
CVVGSNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGSSLILNDVPPFVM
HEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHCHHHHHCCCEEEECCCCCCEE
ASGQPAIPRGLNIEGMKRRGFSKESQLSVRRAYKTLYRSSLTVAEAIEQLKEAAVDDEQV
ECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
ESLIDFVASSQRGIIR
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIDKLAYIHPDAKIGNNVTIGPWTYIGADVEIGDDCWFSSHVVVKGPTVIGKGNKFYQFA
CCCCEEEECCCCCCCCEEEECCCEEECCEEEECCCCEECCEEEEECCEEEECCCCEEEEC
SVGEDCQDKKYAGEATRLIIGDNNVIRESVTIHRGTTQDEWETRIGSNNLFMAYVHIAHD
CCCCCHHCCCCCCCEEEEEECCCCEEECEEEEECCCCCHHHHHHCCCCCEEEEEEEEHHH
CVVGSNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGSSLILNDVPPFVM
HEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHCHHHHHCCCEEEECCCCCCEE
ASGQPAIPRGLNIEGMKRRGFSKESQLSVRRAYKTLYRSSLTVAEAIEQLKEAAVDDEQV
ECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
ESLIDFVASSQRGIIR
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA