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The map label for this gene is lpxB [H]

Identifier: 157962691

GI number: 157962691

Start: 3509820

End: 3510971

Strand: Reverse

Name: lpxB [H]

Synonym: Spea_2872

Alternate gene names: 157962691

Gene position: 3510971-3509820 (Counterclockwise)

Preceding gene: 157962692

Following gene: 157962690

Centisome position: 67.85

GC content: 46.53

Gene sequence:

>1152_bases
ATGAGTTCAAACAATCCTCGTGTATTTGCAATGGTTGCCGGAGAGATCTCGGGTGACATTTTAGGTGCAGGCTTAATTAA
AGCACTGCAAAAGCAGTACCCAGATGCTAAATTTGTTGGCATTGGTGGGCCCCGCATGGAAGCCCTTGGTTTTGAGTCAA
TCTTCTCTTATGAAGAGTTGGCTGTTATGGGCATTGTGGAAGTTTTATCGCGTTTGCCAAGATTACTAAAAGTACGGGCA
ACGCTGATCGATGAGTTGGTTAAGACACAACCAGACTGTTTTATCGGTATCGATGCGCCAGACTTTAATATTGGACTAGA
GCTAAAGCTTAAGAACCGCGGTATTAAAACGGTTCATTACGTTAGCCCATCTGTGTGGGCATGGCGACCAAAGCGTATTT
TCAAAATTGCCAAGGCAACCGACATGGTGTTGTCACTGCTGCCTTTTGAAAAAGCGTTTTATGATGAATATCAGGTGCCT
TGTACCTTTGTTGGTCATACGTTAGCCGATGATATTGAGCTTGAAAGTGATAAAGCACAGGCCCGTGAATTACTTGGGCT
TGATAAAGAAGCCGAGTACTTAGCAATATTACCCGGATCTCGCGGTGGCGAGCTCAAGATGTTGGCCGAGCCGTTTGTCA
AAGCGGCTAGCCTAATCAAGCTGCGCTATCCTGATATTAAGTTCGTCACGCCATTAGTTAACCAGAAGCGTCGCGATCAA
TTTGAGCAAGCGTTACGTGAGCATGCACCGGATCTAGAGATCCATTTAATTGAAGGTCATTCACGAGAGGTAATGGCTGC
CGCTGACTGCATACTGTTGGCCTCGGGGACGGCAACATTAGAGGCCATGCTTGTTAAGCGCCCTATGGTAGTGGCTTATC
GAGTCAGCCCAATCACTTATCGCATTGCTAAAGGCATGATGCTCACTAAGCGTTACTCCTTGCCAAATCTCCTTGCGGAT
GATGATGTGGTTGAGGAGCTTATTCAAGCTGACTGTACGCCAGAGAAAATAGCGGCGGCTGTTGCAACTCAGCTAGATAA
TGACTTTACCCCAATGTATGACCGCTTTATGCAGATGCATAAGGGCCTTCGCTGTGATGCCAGCGCACGAGCCGCTGATG
CAGTGATTAAGTTAGTAGAGGATAATGTCTAA

Upstream 100 bases:

>100_bases
GTTGCTTCCTCTCAACGAGGCATCATTCGCTAGTCCAAGACCTGAACCCGTGTAAAAGCGGGTTCTTTGTTTTCATCTCA
TCAGTGACAGACGCCTTTCT

Downstream 100 bases:

>100_bases
TGGCGGTGATTAAAGGTATTACACCTGAGCAGATAGCTCAAATTTGTGTCGGACAATATGCCGGTGTCGATGAAGTAGGC
CGTGGGCCTTTGATTGGCAA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSSNNPRVFAMVAGEISGDILGAGLIKALQKQYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRA
TLIDELVKTQPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDEYQVP
CTFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKLRYPDIKFVTPLVNQKRRDQ
FEQALREHAPDLEIHLIEGHSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLAD
DDVVEELIQADCTPEKIAAAVATQLDNDFTPMYDRFMQMHKGLRCDASARAADAVIKLVEDNV

Sequences:

>Translated_383_residues
MSSNNPRVFAMVAGEISGDILGAGLIKALQKQYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRA
TLIDELVKTQPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDEYQVP
CTFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKLRYPDIKFVTPLVNQKRRDQ
FEQALREHAPDLEIHLIEGHSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLAD
DDVVEELIQADCTPEKIAAAVATQLDNDFTPMYDRFMQMHKGLRCDASARAADAVIKLVEDNV
>Mature_382_residues
SSNNPRVFAMVAGEISGDILGAGLIKALQKQYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRAT
LIDELVKTQPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDEYQVPC
TFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKLRYPDIKFVTPLVNQKRRDQF
EQALREHAPDLEIHLIEGHSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLADD
DVVEELIQADCTPEKIAAAVATQLDNDFTPMYDRFMQMHKGLRCDASARAADAVIKLVEDNV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=56.5445026178011, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42615; Mature: 42484

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNPRVFAMVAGEISGDILGAGLIKALQKQYPDAKFVGIGGPRMEALGFESIFSYEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRATLIDELVKTQPDCFIGIDAPDFNIGLELKLKNRGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCEEEEE
VSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDEYQVPCTFVGHTLADDIELESDKAQ
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHCCHHHCCCCCCCHHHH
ARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKLRYPDIKFVTPLVNQKRRDQ
HHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEECHHHCHHHHHH
FEQALREHAPDLEIHLIEGHSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITY
HHHHHHHCCCCEEEEEECCCCCCHHHHHCEEEEECCHHHHHHHHHCCCEEEEEEECCHHH
RIAKGMMLTKRYSLPNLLADDDVVEELIQADCTPEKIAAAVATQLDNDFTPMYDRFMQMH
HHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KGLRCDASARAADAVIKLVEDNV
CCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSNNPRVFAMVAGEISGDILGAGLIKALQKQYPDAKFVGIGGPRMEALGFESIFSYEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRATLIDELVKTQPDCFIGIDAPDFNIGLELKLKNRGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCEEEEE
VSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDEYQVPCTFVGHTLADDIELESDKAQ
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHCCHHHCCCCCCCHHHH
ARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKLRYPDIKFVTPLVNQKRRDQ
HHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEECHHHCHHHHHH
FEQALREHAPDLEIHLIEGHSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITY
HHHHHHHCCCCEEEEEECCCCCCHHHHHCEEEEECCHHHHHHHHHCCCEEEEEEECCHHH
RIAKGMMLTKRYSLPNLLADDDVVEELIQADCTPEKIAAAVATQLDNDFTPMYDRFMQMH
HHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KGLRCDASARAADAVIKLVEDNV
CCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA