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The map label for this gene is acdA [H]

Identifier: 157962602

GI number: 157962602

Start: 3397414

End: 3398571

Strand: Reverse

Name: acdA [H]

Synonym: Spea_2781

Alternate gene names: 157962602

Gene position: 3398571-3397414 (Counterclockwise)

Preceding gene: 157962603

Following gene: 157962601

Centisome position: 65.68

GC content: 49.48

Gene sequence:

>1158_bases
ATGGATTTTAACCTGAATGAAGACCAACGCCAATTTAGCGATCTCGCGCAGCAGTTTGCAGCAGAGGAGTTAGCGCCATT
TGCGGCTAAATGGGATGAAGAGCATCACTTCCCTAAAGATGTGATTCAAAAAGCTGGAGAGCTAGGTTTTTGCTCTCTGT
ACTCGCCAGAGTCCGAAGGTGGAATGGGTCTGTCTCGTTTAGATTCATCGATTATTTTTGAGCAGTTATCCATGGGCTGC
ACAGCAACTACTGCAATGCTAACCATTCATAACATGGCCACTTGGATGGTCACTAGCTTTGGCTCAGAAACACTGCGCCA
AGAGTGGTCTGAATCGTTGACTACAGGTGAGAAGCTTGCGTCATATTGCTTAACTGAGCCTGGGGCGGGGAGTGATGCGG
CGTCGCTGCAAACCAAGGCTATTCGCGAAGGCGATGAGTATGTGATTTCAGGTTCGAAAGTGTTTATCTCTGGCGCTGGG
GCAACCGAACTATTAGTGGTGATGTGCCGCACTGGTGAGGCGGGTCCTAAAGGGATTTCAGCGATTGTGGTTCCAGCCGA
TGCCGCCGGTGTTATCTACGGTAAAGCCGAAGATAAGATGGGCTGGAATGCTCAACCTACCCGCGAAATCACCTTCGAAA
ATGTACGTGTACCCGTGTCATATTTACTAGGTGAAGAGGGACAAGGCTTTACTTTTGCCATGAAGGGGCTAGATGGCGGC
CGTATCAACATCGCCACTTGCTCAATCGGTACCGCGCAAGCCGCGCTTGAGCGAGCGACCAAATATATGAACGAGCGAAA
GCAGTTCGGTAAACCTTTGGCGGCATTTCAGGCGCTGCAATTTAAGCTTGCCGATATGGCGACCGAACTTGTTGCTGCGC
GTCAGTTAGTGCGTTTAGCAGCCTTTAAATTAGATCAGCAAGATCCTGAAGCCACTGCTTATTGCGCCATGGCCAAACGC
TTTGCTACCGATATCGGTTTTCAGGTGTGTGACGCTGCGCTGCAAATTCATGGCGGCTATGGCTACATTCGAGAGTATCC
GTTAGAGCGTTATGTACGCGATGTTAGAGTGCATCAAATTTTAGAGGGAACCAACGAAATCATGCGATTGATTATCTCTC
GCCGTTTATTGGATGAGAACGCAGGCGCGATTCTCTAG

Upstream 100 bases:

>100_bases
AGACCCAAAGCTTTTTGCTTGATGGTACTGGACTAGAACCTAGTATCTAGCACCTAGCACCTAGAGCATAGGCAATTGAC
AGAACAACAGGAGTAGCCTG

Downstream 100 bases:

>100_bases
AGCCTTGGTATTCGGTTTAATTGATTTCAGTTTAGTAAAAGGAGTTTTCATGACGTTAACAACAGAAAAGAGCTTATTGA
AAGAGCAAATTGTTGGTCAC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGSETLRQEWSESLTTGEKLASYCLTEPGAGSDAASLQTKAIREGDEYVISGSKVFISGAG
ATELLVVMCRTGEAGPKGISAIVVPADAAGVIYGKAEDKMGWNAQPTREITFENVRVPVSYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATKYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERYVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL

Sequences:

>Translated_385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGSETLRQEWSESLTTGEKLASYCLTEPGAGSDAASLQTKAIREGDEYVISGSKVFISGAG
ATELLVVMCRTGEAGPKGISAIVVPADAAGVIYGKAEDKMGWNAQPTREITFENVRVPVSYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATKYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERYVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL
>Mature_385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGSETLRQEWSESLTTGEKLASYCLTEPGAGSDAASLQTKAIREGDEYVISGSKVFISGAG
ATELLVVMCRTGEAGPKGISAIVVPADAAGVIYGKAEDKMGWNAQPTREITFENVRVPVSYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATKYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERYVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=57.6, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=41.3333333333333, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=37.9581151832461, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=37.9581151832461, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI21361497, Length=389, Percent_Identity=36.5038560411311, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=35.8288770053476, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=33.6927223719677, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.9148936170213, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=32.7225130890052, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=32.7225130890052, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=31.8452380952381, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=27.2486772486773, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI38505218, Length=355, Percent_Identity=29.5774647887324, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI211971008, Length=369, Percent_Identity=28.7262872628726, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI48976061, Length=369, Percent_Identity=28.7262872628726, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=26.7409470752089, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=29.9479166666667, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=32.0413436692506, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI87082384, Length=291, Percent_Identity=28.8659793814433, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=52.3809523809524, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=39.2764857881137, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=39.0052356020942, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.2204724409449, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=34.2175066312997, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=32.9787234042553, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=32.5459317585302, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=33.7110481586402, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=32.425068119891, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=31.2154696132597, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=35.0877192982456, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=37.117903930131, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=29.0909090909091, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=31.2292358803987, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=27.4151436031332, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562446, Length=356, Percent_Identity=30.6179775280899, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=27.7551020408163, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=38.8020833333333, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=39.0501319261214, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.8297872340425, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=34.4086021505376, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.2036553524804, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=33.1378299120235, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=27.7044854881267, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42070; Mature: 42070

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDSSIIFEQLSMGCTATTAMLTIHNMATWMVTSFGSETLRQEWSESLTTGEKLA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLQTKAIREGDEYVISGSKVFISGAGATELLVVMCRTGEAGPKGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHEEECCCCCCCCCCE
AIVVPADAAGVIYGKAEDKMGWNAQPTREITFENVRVPVSYLLGEEGQGFTFAMKGLDGG
EEEEECCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCEEEEEECCCCC
RINIATCSIGTAQAALERATKYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDQQDPEATAYCAMAKRFATDIGFQVCDAALQIHGGYGYIREYPLERYVRDVRVHQI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENAGAIL
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDSSIIFEQLSMGCTATTAMLTIHNMATWMVTSFGSETLRQEWSESLTTGEKLA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLQTKAIREGDEYVISGSKVFISGAGATELLVVMCRTGEAGPKGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHEEECCCCCCCCCCE
AIVVPADAAGVIYGKAEDKMGWNAQPTREITFENVRVPVSYLLGEEGQGFTFAMKGLDGG
EEEEECCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCEEEEEECCCCC
RINIATCSIGTAQAALERATKYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDQQDPEATAYCAMAKRFATDIGFQVCDAALQIHGGYGYIREYPLERYVRDVRVHQI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENAGAIL
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]