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The map label for this gene is pgcA [H]

Identifier: 157962548

GI number: 157962548

Start: 3332821

End: 3334554

Strand: Reverse

Name: pgcA [H]

Synonym: Spea_2727

Alternate gene names: 157962548

Gene position: 3334554-3332821 (Counterclockwise)

Preceding gene: 157962550

Following gene: 157962541

Centisome position: 64.44

GC content: 49.6

Gene sequence:

>1734_bases
ATGGATACCCAATTAGCATTGAGAGTCAAACATTGGATGGCTAGCGACCCAGACCCTTTAATGCGACAGCAGCTACAAAC
TCTGCTGAATTCCGGTGATAGCGCTGAACTTGAAGGGCGTTTTGCGGGGCGACTCGCATTTGGTACCGCAGGGTTACGTG
GTGTGGTTGGCGCTGGTCCGACTCGAATGAATCGATTAGTTGTGCAGCAAACATCTGCAGGCTTAGGTGCGTATCTAAAA
GCACAAATTAGCGATGTGGCTACCCGCGGCGTGGTGATTGGTTATGATGGTCGCCATGACTCGAAACAGTTTGCCCATGA
CGCAGCCAGTGTATTAACGGCAATGGGAATAAAGGTTTACCTTACAGCAAATGTTGCTGCAACGCCGCTGGTGGCTTTTG
GTGTGCTGCATTTAGGTACCGCAGCAGGGATTGTTGTCACCGCAAGTCACAACCCGCCACAATATAACGGCTATAAAGTC
TATTGGGGCAATGGCGCGCAGATCATTCCTCCCCACGACAGTGGTATTGCCGCCTGTATCGATAAAGCTGCTACCCAAGT
GATCCCATTACTGGAGATGCCACAAGCAAAAGCCTCGGGTCAGTTAGTGATGCTGGAAGAGGATTTTTATGATGCATATC
GTCAAGGTGTGAAGCTGGCTCCAGTGCTGCAGAATCATACTCAACCAGAAGCTGTGAGCTTAGCCTATACCGCCATGCAT
GGTGTGGGAAATCAGATGGCACTTGATGTATTAAAGGATGCGGGGTTTACAAAAGTGTATTCGGTTGCCGAGCAGGCGCA
GCCTGATGGTGACTTTCCAACGGTCAATTTCCCCAACCCGGAAGAGAAGGGCGCTATGGATATGGTCATGGCTGAGGCGA
AAAAACATGGCGCCATGCTGGCTTGTGCAAATGATCCCGATGCCGACCGTTTTGCCGTTGCCGTTCGTACTGACAGCGGA
GATTATCAGATGCTCACCGGCGATCAGGTCGGGGTGTTATTTGGCCACTATCTGCTGACTCATGCCAGTGAAAATCAGCG
GTTAACCTGCACCACCATAGTGTCATCAAGCTTATTATCTAAGGTTGCTCAAAGCTTAAATGCGACATGCAGAACCACGC
TGACCGGCTTTAAATGGTTAACCAACGTGGGTATGAGTGAAGAGACTGATAGTAATCGTTTCCTGTTCGCCTATGAGGAG
GCGTTGGGTTACACCGTTGGCTCTATGGTGTGGGATAAAGATGGCTTATCGGCCTTGGTGGCGTTTGCTCAGTTAACCGC
AGAACTTGCCAGTCAAGGTCAAACCATTTGGGATCGTCTCGAAGCTATCTATCGTGAACATGGTTTTCACATCAATGCTC
AAGTGAGTATTGCATTAAAGCCAACAACACCGAATATCGGTGCTTATCTGCGTGCGAATCCACCGACGGAAATCGCAGGG
CATAAAGTGCTATCGACCGATGATATCAGTTTAGGTAAACGCTTCTTTTTTGAGGGCAGTGCCGATGGCACACAAGAGGA
TATCGCGCTCCCTGCCAGTGACGTGCTGATCTATCGTCTTAAAAACGGTGCTCGAGTGATAGTAAGACCATCGGGTACGG
AACCGAAAATTAAGTGTTACTACGAAGTGGTCGAATCGATGAGCAAGGATGACAGCTTAGCAAGTGCACAACAAAGAGCT
GAGGTTGAAATGGCGCGCTTTATCGAGGCGCATCAGGCGGCGCTACCTAAATAG

Upstream 100 bases:

>100_bases
TAATTTAAGTGTTTAGTCAGGTTCAATCTTAGTAATGTGCTGCGATCGGTTGTTTATTCTTTAGCGGGCATTACCTCATC
GACAGTAAATGGAGCGAGTT

Downstream 100 bases:

>100_bases
TATCTATTTGGTATGAATATCTCTTAGATGATTTTTGGGACTAGCTAAACTGAGATCATTCGAGCATATAACTGAGGGAA
AACTGTAAATTGGACCTTTA

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MDTQLALRVKHWMASDPDPLMRQQLQTLLNSGDSAELEGRFAGRLAFGTAGLRGVVGAGPTRMNRLVVQQTSAGLGAYLK
AQISDVATRGVVIGYDGRHDSKQFAHDAASVLTAMGIKVYLTANVAATPLVAFGVLHLGTAAGIVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATQVIPLLEMPQAKASGQLVMLEEDFYDAYRQGVKLAPVLQNHTQPEAVSLAYTAMH
GVGNQMALDVLKDAGFTKVYSVAEQAQPDGDFPTVNFPNPEEKGAMDMVMAEAKKHGAMLACANDPDADRFAVAVRTDSG
DYQMLTGDQVGVLFGHYLLTHASENQRLTCTTIVSSSLLSKVAQSLNATCRTTLTGFKWLTNVGMSEETDSNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELASQGQTIWDRLEAIYREHGFHINAQVSIALKPTTPNIGAYLRANPPTEIAG
HKVLSTDDISLGKRFFFEGSADGTQEDIALPASDVLIYRLKNGARVIVRPSGTEPKIKCYYEVVESMSKDDSLASAQQRA
EVEMARFIEAHQAALPK

Sequences:

>Translated_577_residues
MDTQLALRVKHWMASDPDPLMRQQLQTLLNSGDSAELEGRFAGRLAFGTAGLRGVVGAGPTRMNRLVVQQTSAGLGAYLK
AQISDVATRGVVIGYDGRHDSKQFAHDAASVLTAMGIKVYLTANVAATPLVAFGVLHLGTAAGIVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATQVIPLLEMPQAKASGQLVMLEEDFYDAYRQGVKLAPVLQNHTQPEAVSLAYTAMH
GVGNQMALDVLKDAGFTKVYSVAEQAQPDGDFPTVNFPNPEEKGAMDMVMAEAKKHGAMLACANDPDADRFAVAVRTDSG
DYQMLTGDQVGVLFGHYLLTHASENQRLTCTTIVSSSLLSKVAQSLNATCRTTLTGFKWLTNVGMSEETDSNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELASQGQTIWDRLEAIYREHGFHINAQVSIALKPTTPNIGAYLRANPPTEIAG
HKVLSTDDISLGKRFFFEGSADGTQEDIALPASDVLIYRLKNGARVIVRPSGTEPKIKCYYEVVESMSKDDSLASAQQRA
EVEMARFIEAHQAALPK
>Mature_577_residues
MDTQLALRVKHWMASDPDPLMRQQLQTLLNSGDSAELEGRFAGRLAFGTAGLRGVVGAGPTRMNRLVVQQTSAGLGAYLK
AQISDVATRGVVIGYDGRHDSKQFAHDAASVLTAMGIKVYLTANVAATPLVAFGVLHLGTAAGIVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATQVIPLLEMPQAKASGQLVMLEEDFYDAYRQGVKLAPVLQNHTQPEAVSLAYTAMH
GVGNQMALDVLKDAGFTKVYSVAEQAQPDGDFPTVNFPNPEEKGAMDMVMAEAKKHGAMLACANDPDADRFAVAVRTDSG
DYQMLTGDQVGVLFGHYLLTHASENQRLTCTTIVSSSLLSKVAQSLNATCRTTLTGFKWLTNVGMSEETDSNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELASQGQTIWDRLEAIYREHGFHINAQVSIALKPTTPNIGAYLRANPPTEIAG
HKVLSTDDISLGKRFFFEGSADGTQEDIALPASDVLIYRLKNGARVIVRPSGTEPKIKCYYEVVESMSKDDSLASAQQRA
EVEMARFIEAHQAALPK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=609, Percent_Identity=34.9753694581281, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI31377548, Length=602, Percent_Identity=32.2259136212625, Blast_Score=300, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71993870, Length=561, Percent_Identity=33.5115864527629, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71993878, Length=314, Percent_Identity=35.9872611464968, Blast_Score=202, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6323934, Length=593, Percent_Identity=35.2445193929174, Blast_Score=286, Evalue=6e-78,
Organism=Drosophila melanogaster, GI20129809, Length=578, Percent_Identity=35.4671280276817, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24651977, Length=562, Percent_Identity=34.8754448398576, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24653722, Length=574, Percent_Identity=31.3588850174216, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62163; Mature: 62163

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQLALRVKHWMASDPDPLMRQQLQTLLNSGDSAELEGRFAGRLAFGTAGLRGVVGAGP
CCCCEEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCEEECEEEECCCCCCCCCCCCH
TRMNRLVVQQTSAGLGAYLKAQISDVATRGVVIGYDGRHDSKQFAHDAASVLTAMGIKVY
HHHHHEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
LTANVAATPLVAFGVLHLGTAAGIVVTASHNPPQYNGYKVYWGNGAQIIPPHDSGIAACI
EEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
DKAATQVIPLLEMPQAKASGQLVMLEEDFYDAYRQGVKLAPVLQNHTQPEAVSLAYTAMH
HHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHHHH
GVGNQMALDVLKDAGFTKVYSVAEQAQPDGDFPTVNFPNPEEKGAMDMVMAEAKKHGAML
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEE
ACANDPDADRFAVAVRTDSGDYQMLTGDQVGVLFGHYLLTHASENQRLTCTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
KVAQSLNATCRTTLTGFKWLTNVGMSEETDSNRFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCHHHHHEECCCCHHHHH
AFAQLTAELASQGQTIWDRLEAIYREHGFHINAQVSIALKPTTPNIGAYLRANPPTEIAG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCCEEEECCCCCHHCC
HKVLSTDDISLGKRFFFEGSADGTQEDIALPASDVLIYRLKNGARVIVRPSGTEPKIKCY
CEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHH
YEVVESMSKDDSLASAQQRAEVEMARFIEAHQAALPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDTQLALRVKHWMASDPDPLMRQQLQTLLNSGDSAELEGRFAGRLAFGTAGLRGVVGAGP
CCCCEEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCEEECEEEECCCCCCCCCCCCH
TRMNRLVVQQTSAGLGAYLKAQISDVATRGVVIGYDGRHDSKQFAHDAASVLTAMGIKVY
HHHHHEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
LTANVAATPLVAFGVLHLGTAAGIVVTASHNPPQYNGYKVYWGNGAQIIPPHDSGIAACI
EEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
DKAATQVIPLLEMPQAKASGQLVMLEEDFYDAYRQGVKLAPVLQNHTQPEAVSLAYTAMH
HHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHHHH
GVGNQMALDVLKDAGFTKVYSVAEQAQPDGDFPTVNFPNPEEKGAMDMVMAEAKKHGAML
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEE
ACANDPDADRFAVAVRTDSGDYQMLTGDQVGVLFGHYLLTHASENQRLTCTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
KVAQSLNATCRTTLTGFKWLTNVGMSEETDSNRFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCHHHHHEECCCCHHHHH
AFAQLTAELASQGQTIWDRLEAIYREHGFHINAQVSIALKPTTPNIGAYLRANPPTEIAG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCCEEEECCCCCHHCC
HKVLSTDDISLGKRFFFEGSADGTQEDIALPASDVLIYRLKNGARVIVRPSGTEPKIKCY
CEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHH
YEVVESMSKDDSLASAQQRAEVEMARFIEAHQAALPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]