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The map label for this gene is sdaC [H]

Identifier: 157962218

GI number: 157962218

Start: 2921392

End: 2922684

Strand: Reverse

Name: sdaC [H]

Synonym: Spea_2397

Alternate gene names: 157962218

Gene position: 2922684-2921392 (Counterclockwise)

Preceding gene: 157962220

Following gene: 157962217

Centisome position: 56.48

GC content: 43.7

Gene sequence:

>1293_bases
ATGGACTCTGTAATTAACAAAACTGAAAATACCTCGGCACAACTCAAGGTAAAATCAAGCTGGAACAAGAGCGATACTCT
ATGGGTATTGGGGCTTTATGGTACGGCAGTGGGGGCTGGCACCCTTTTCCTGCCAATTAATGCGGCGCAAGGTGGCTTGG
TCCCGCTCATTCTTATGGCTCTACTGGCACTGCCAATGACCTTCTTCGCTCATCGCGGCTTAACACGTTTTGTGTTATCG
GGATCAAACCCAGAAGCAGGGATCACCGAAGTGGTAGAGGAGCATTTTGGTGTAGGCATGGGTAAGGTCATCACCTTACT
CTATTTCTTTGCTATTTACCCGATTTTACTCGTCTACAGTGTTGCACTTACCAATACTGTTGAAAGCTTTATGCAACATC
AGCTGGGCATGACTCCGCCTAACCGTGCAACATTGGCCTTAATCTTGATTATTGGCTTGATTGCCGTAGTTCGTTTAGGT
GAACAGTTAATTATCAAAGCGATGAGTATACTGGTTTTCCCGTTCGTTGCCGTGCTTCTGCTGCTCTCTGTTTACCTGAT
CCCTTACTGGAACACGTCAATATTTAGCAATGTGATGCCTGCAGAAGGTGGAATAAGTACCATTTTAATGGCTTTGTGGT
TGATACTGCCTGTGATGGTATTTTCATTTAACCACTCTCCGGTTATCTCCTCCTTTGCGGTCGATCGTAGAAAATTTCAC
GGTGATGATGCTGAAAAACAGTGTTCACGGATCTTAGCTTTTAGCCATATTCTTATGGTTGTAACAGTGATGTTTTTCGT
GTTTAGTTGTGTGTTTAGCCTATCGCCTGCCAATCTAGCTGAGGCTAAAGCGCAAAATGTTTCGATATTAACTTATCTAG
CGAACCATTTTGATACGCCGATTATCGCTTATGTTGCGCCAATTGTTGCGATCATCGCTATCACTAAGTCATTCTTTGGC
CACTATATCGGGGCGAGTGAAGGCTTTAATGGTTTAATCATCAAGGCTGCACGCGGTAAGGGCAAAGAGGTCAACCCTGT
TACTCTGAATCGTGTTACTGCAGGTTTTATGCTACTGACCACTTGGGCTGTAGCAACTATCAACCCCAATATTTTGGGAA
TGATTGAAAGCTTAGGTGGACCAATCATCGCTCTGCTGTTGTTTATCATGCCTATGTACGCCATCATGAAAGTACCAGCG
ATGAAGCAATACTCAGGTACCATCAGTAATGTTTTTGTAGTGATTATCGGATTAGTTTCAATCTCGGCAATCTTCTATTC
ATTGGTACAGTAA

Upstream 100 bases:

>100_bases
TGCTTTGGTTGATATTTTCAGCGGCTACGTGATGTGAAGTTAGGTATGAAAACAGAACCCTTAAAAGGTCATATAAGAAC
CGTCTAAGGAGATGTCCATA

Downstream 100 bases:

>100_bases
AATAAAAAGAGGACAGGAGCCATGGGCTTTTGTTCTCTTTAGCCATCAGAGATGGACCTCCCTTACTGATTTCAAGAGCA
GTATTGATCTTTGAACTATT

Product: putative serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDSVINKTENTSAQLKVKSSWNKSDTLWVLGLYGTAVGAGTLFLPINAAQGGLVPLILMALLALPMTFFAHRGLTRFVLS
GSNPEAGITEVVEEHFGVGMGKVITLLYFFAIYPILLVYSVALTNTVESFMQHQLGMTPPNRATLALILIIGLIAVVRLG
EQLIIKAMSILVFPFVAVLLLLSVYLIPYWNTSIFSNVMPAEGGISTILMALWLILPVMVFSFNHSPVISSFAVDRRKFH
GDDAEKQCSRILAFSHILMVVTVMFFVFSCVFSLSPANLAEAKAQNVSILTYLANHFDTPIIAYVAPIVAIIAITKSFFG
HYIGASEGFNGLIIKAARGKGKEVNPVTLNRVTAGFMLLTTWAVATINPNILGMIESLGGPIIALLLFIMPMYAIMKVPA
MKQYSGTISNVFVVIIGLVSISAIFYSLVQ

Sequences:

>Translated_430_residues
MDSVINKTENTSAQLKVKSSWNKSDTLWVLGLYGTAVGAGTLFLPINAAQGGLVPLILMALLALPMTFFAHRGLTRFVLS
GSNPEAGITEVVEEHFGVGMGKVITLLYFFAIYPILLVYSVALTNTVESFMQHQLGMTPPNRATLALILIIGLIAVVRLG
EQLIIKAMSILVFPFVAVLLLLSVYLIPYWNTSIFSNVMPAEGGISTILMALWLILPVMVFSFNHSPVISSFAVDRRKFH
GDDAEKQCSRILAFSHILMVVTVMFFVFSCVFSLSPANLAEAKAQNVSILTYLANHFDTPIIAYVAPIVAIIAITKSFFG
HYIGASEGFNGLIIKAARGKGKEVNPVTLNRVTAGFMLLTTWAVATINPNILGMIESLGGPIIALLLFIMPMYAIMKVPA
MKQYSGTISNVFVVIIGLVSISAIFYSLVQ
>Mature_430_residues
MDSVINKTENTSAQLKVKSSWNKSDTLWVLGLYGTAVGAGTLFLPINAAQGGLVPLILMALLALPMTFFAHRGLTRFVLS
GSNPEAGITEVVEEHFGVGMGKVITLLYFFAIYPILLVYSVALTNTVESFMQHQLGMTPPNRATLALILIIGLIAVVRLG
EQLIIKAMSILVFPFVAVLLLLSVYLIPYWNTSIFSNVMPAEGGISTILMALWLILPVMVFSFNHSPVISSFAVDRRKFH
GDDAEKQCSRILAFSHILMVVTVMFFVFSCVFSLSPANLAEAKAQNVSILTYLANHFDTPIIAYVAPIVAIIAITKSFFG
HYIGASEGFNGLIIKAARGKGKEVNPVTLNRVTAGFMLLTTWAVATINPNILGMIESLGGPIIALLLFIMPMYAIMKVPA
MKQYSGTISNVFVVIIGLVSISAIFYSLVQ

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=421, Percent_Identity=70.3087885985748, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1789504, Length=435, Percent_Identity=50.3448275862069, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=36.4963503649635, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI145693183, Length=417, Percent_Identity=24.9400479616307, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1789961, Length=405, Percent_Identity=25.4320987654321, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46663; Mature: 46663

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSVINKTENTSAQLKVKSSWNKSDTLWVLGLYGTAVGAGTLFLPINAAQGGLVPLILMA
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCHHHHHHHH
LLALPMTFFAHRGLTRFVLSGSNPEAGITEVVEEHFGVGMGKVITLLYFFAIYPILLVYS
HHHHHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VALTNTVESFMQHQLGMTPPNRATLALILIIGLIAVVRLGEQLIIKAMSILVFPFVAVLL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSVYLIPYWNTSIFSNVMPAEGGISTILMALWLILPVMVFSFNHSPVISSFAVDRRKFH
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GDDAEKQCSRILAFSHILMVVTVMFFVFSCVFSLSPANLAEAKAQNVSILTYLANHFDTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCH
IIAYVAPIVAIIAITKSFFGHYIGASEGFNGLIIKAARGKGKEVNPVTLNRVTAGFMLLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHH
TWAVATINPNILGMIESLGGPIIALLLFIMPMYAIMKVPAMKQYSGTISNVFVVIIGLVS
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
ISAIFYSLVQ
HHHHHHHHHC
>Mature Secondary Structure
MDSVINKTENTSAQLKVKSSWNKSDTLWVLGLYGTAVGAGTLFLPINAAQGGLVPLILMA
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCHHHHHHHH
LLALPMTFFAHRGLTRFVLSGSNPEAGITEVVEEHFGVGMGKVITLLYFFAIYPILLVYS
HHHHHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VALTNTVESFMQHQLGMTPPNRATLALILIIGLIAVVRLGEQLIIKAMSILVFPFVAVLL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSVYLIPYWNTSIFSNVMPAEGGISTILMALWLILPVMVFSFNHSPVISSFAVDRRKFH
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GDDAEKQCSRILAFSHILMVVTVMFFVFSCVFSLSPANLAEAKAQNVSILTYLANHFDTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCH
IIAYVAPIVAIIAITKSFFGHYIGASEGFNGLIIKAARGKGKEVNPVTLNRVTAGFMLLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHH
TWAVATINPNILGMIESLGGPIIALLLFIMPMYAIMKVPAMKQYSGTISNVFVVIIGLVS
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
ISAIFYSLVQ
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]