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The map label for this gene is uvrB [H]

Identifier: 157962112

GI number: 157962112

Start: 2775396

End: 2777381

Strand: Reverse

Name: uvrB [H]

Synonym: Spea_2291

Alternate gene names: 157962112

Gene position: 2777381-2775396 (Counterclockwise)

Preceding gene: 157962113

Following gene: 157962111

Centisome position: 53.67

GC content: 45.47

Gene sequence:

>1986_bases
ATGTCTAAAAATACCTTTATCTTACATTCGAACTATACGCCTTCAGGCGATCAGCCTGAAGCCATCGCTCGCTTAGTCGA
TGGGATTGATAGTGGAAGCAGCCATCAAACCTTAAAAGGTGTTACGGGTTCGGGTAAAACCTTCACTGTGGCCAATATCA
TTCATAGGTTAAAACGGCCAACGATTATTCTGGCTCATAACAAGACATTAGCCGCGCAGCTATATAGTGAAATGAGGCAT
TTTTTCCCTGAAAATGCCGTTGAATTCTTTGTATCTTATTACGATTATTATCAGCCTGAAGTGTACCTTCCCGGTAGCGA
TCGTTTCATTCGTAAAGACTCAGCCATTAACGAGCACTTAGAGCGGCTGCGATTATCAACCACTAAGGCCTTGATTGAGC
GTAGAGATGTTATCGTCGTGGCGTCTGTCTCGTCGATATATGGTTTAGGAGATCCTGATGCCTACCGTTCCTTGCAAGTT
AAGCTCTGGCTAGGACAAGAAATAGACCTTGATGATTTAATCCAGCGGTTGGAGCGGTTGCAGTACACGCGTTGTAATCG
CACTATCAATCGGGCGACGTTTTTAGTACGTGAGGGAGTGATTGATATCTTTCCTGCTGATTCCGAGCATCAGGCGCTGA
CAGTTGAAATTGAAGCTGGCCGAGTCAATCAATTGTATTGGATTGATGCCATCAGTGGCCAGCAACTCGAGACAATCGCT
GAATATTGTGTCTCGCCAAAAACCTTGTATTCGGTATCTATAGAGCAGGTGGAATTGGCCTGCGGGCAGATAATGAGCGA
TATGGAGCAACAGGTCGCCATACTCAATGCAGATAATAGACTGACTGAGGCGGCGAGGTTATATGAGCGCACAGTGTCAG
ATCTCGAGTTGCTGCGATTACAGGGCTATTGTCCAGGTATTGAGAACTATGCTTCCTATCTAAATCAACGCGACCCACAG
TTACCGCCAACAACCTTGTTCGACTATCTCCCTAAAGATGGCTTACTGTTTATTGACGAGTCACATGTGATGATCCCGCA
GATATCGGCCATGTATAAGAGTGATCAGAGCCGTAAGAACACTCTAATCGATTTTGGGTTTCGTCTCCCTTCTGCCCGTA
ACAACCGTCCTTTGAGCTTCACTGAGTTTGAGAGCATTAAACCACAAACCATTTTTGTGTCAGCCACTCCGAGCAACTAC
GAGCTATCAAAATCAAAACAGCAGGTATTTAAGCAGATTATACGTCCTACAGGTTTACTCGATCCTGAAATTGAAATTCG
TCCTTCTGACAATAATCTTGAGGATCTCGTTCAAGAGATAGCCCTTAGACTTGCCCGCAACGAGCGGACACTGGTGACCA
CGTTAACTAAAAAAAGCGCTGAATCGTTAAATGACTTTTTGTCTGCCAAAGGGATTAAAGTCAGCTATTTACATTCAGAT
ATCAAAACCAACGATAGGGTCGAGATCATAAAAGCTCTGCGTGTGGGAGAGATTGATGTGCTGATAGGCATTAACCTATT
GCGTGAAGGTTTAGATATTCCTGAGGCATCCTTGGTGGCGGTACTCGATGCCGATACAGCCGGTTTCTTACGTTCTGAAC
AGGCGCTGATTCAAATTATCGGCCGAGCTGCGCGTAACGAGAACGGCAAAGCGATTCTATATGCAGATAAGGTGACAACT
GCGATGCAAAGTGCCATCGACGAGTCTGCTGAGCGACGAGGCCATCAAATTATCTATAACATGGCCAATGGCATAGTGCC
TAGTTCATCTAAGCGTAGACTCGACTCTGGTAGTCAAACTCAGGTTGCAGTTAGCCACATGGATAGGGCGCAATTTTGTG
AGAATTTGTCAGCCCTGTGTCAGCAGATCACAGCCAAGGAGAAGGAGTTACTCCTGTGTGTCGATGAAGGTGAAGGTGGC
GCGGATCAGGCTAAGATCATTCGACAGCAGCTTATTGCGCTTTATCGTCAGTTTATCTTTATGTAA

Upstream 100 bases:

>100_bases
CCTCCTAGCCATCGACTAAGCTTGATACTCTATAGTTAATCTAAGCTGCTGTGAGCTGTACTACAGACACGCAGCGAGAC
TTGATTAAAGGCGAGTGCTT

Downstream 100 bases:

>100_bases
TTACAGTATGTTTATCGTGGTTGATTAACTCATTACTCAGGGGCCTGTATGGGCTCCTTTTTACTGACTTTCAAAACAGG
TGATACCGGATAGTTGTTGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSKNTFILHSNYTPSGDQPEAIARLVDGIDSGSSHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLYSEMRH
FFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINEHLERLRLSTTKALIERRDVIVVASVSSIYGLGDPDAYRSLQV
KLWLGQEIDLDDLIQRLERLQYTRCNRTINRATFLVREGVIDIFPADSEHQALTVEIEAGRVNQLYWIDAISGQQLETIA
EYCVSPKTLYSVSIEQVELACGQIMSDMEQQVAILNADNRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLNQRDPQ
LPPTTLFDYLPKDGLLFIDESHVMIPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFTEFESIKPQTIFVSATPSNY
ELSKSKQQVFKQIIRPTGLLDPEIEIRPSDNNLEDLVQEIALRLARNERTLVTTLTKKSAESLNDFLSAKGIKVSYLHSD
IKTNDRVEIIKALRVGEIDVLIGINLLREGLDIPEASLVAVLDADTAGFLRSEQALIQIIGRAARNENGKAILYADKVTT
AMQSAIDESAERRGHQIIYNMANGIVPSSSKRRLDSGSQTQVAVSHMDRAQFCENLSALCQQITAKEKELLLCVDEGEGG
ADQAKIIRQQLIALYRQFIFM

Sequences:

>Translated_661_residues
MSKNTFILHSNYTPSGDQPEAIARLVDGIDSGSSHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLYSEMRH
FFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINEHLERLRLSTTKALIERRDVIVVASVSSIYGLGDPDAYRSLQV
KLWLGQEIDLDDLIQRLERLQYTRCNRTINRATFLVREGVIDIFPADSEHQALTVEIEAGRVNQLYWIDAISGQQLETIA
EYCVSPKTLYSVSIEQVELACGQIMSDMEQQVAILNADNRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLNQRDPQ
LPPTTLFDYLPKDGLLFIDESHVMIPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFTEFESIKPQTIFVSATPSNY
ELSKSKQQVFKQIIRPTGLLDPEIEIRPSDNNLEDLVQEIALRLARNERTLVTTLTKKSAESLNDFLSAKGIKVSYLHSD
IKTNDRVEIIKALRVGEIDVLIGINLLREGLDIPEASLVAVLDADTAGFLRSEQALIQIIGRAARNENGKAILYADKVTT
AMQSAIDESAERRGHQIIYNMANGIVPSSSKRRLDSGSQTQVAVSHMDRAQFCENLSALCQQITAKEKELLLCVDEGEGG
ADQAKIIRQQLIALYRQFIFM
>Mature_660_residues
SKNTFILHSNYTPSGDQPEAIARLVDGIDSGSSHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLYSEMRHF
FPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINEHLERLRLSTTKALIERRDVIVVASVSSIYGLGDPDAYRSLQVK
LWLGQEIDLDDLIQRLERLQYTRCNRTINRATFLVREGVIDIFPADSEHQALTVEIEAGRVNQLYWIDAISGQQLETIAE
YCVSPKTLYSVSIEQVELACGQIMSDMEQQVAILNADNRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLNQRDPQL
PPTTLFDYLPKDGLLFIDESHVMIPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFTEFESIKPQTIFVSATPSNYE
LSKSKQQVFKQIIRPTGLLDPEIEIRPSDNNLEDLVQEIALRLARNERTLVTTLTKKSAESLNDFLSAKGIKVSYLHSDI
KTNDRVEIIKALRVGEIDVLIGINLLREGLDIPEASLVAVLDADTAGFLRSEQALIQIIGRAARNENGKAILYADKVTTA
MQSAIDESAERRGHQIIYNMANGIVPSSSKRRLDSGSQTQVAVSHMDRAQFCENLSALCQQITAKEKELLLCVDEGEGGA
DQAKIIRQQLIALYRQFIFM

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=594, Percent_Identity=57.9124579124579, Blast_Score=687, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 74455; Mature: 74323

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNTFILHSNYTPSGDQPEAIARLVDGIDSGSSHQTLKGVTGSGKTFTVANIIHRLKRP
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEHHHHHHHHCCC
TIILAHNKTLAAQLYSEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINEHL
EEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEECHHHHHHHH
ERLRLSTTKALIERRDVIVVASVSSIYGLGDPDAYRSLQVKLWLGQEIDLDDLIQRLERL
HHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
QYTRCNRTINRATFLVREGVIDIFPADSEHQALTVEIEAGRVNQLYWIDAISGQQLETIA
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHH
EYCVSPKTLYSVSIEQVELACGQIMSDMEQQVAILNADNRLTEAARLYERTVSDLELLRL
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QGYCPGIENYASYLNQRDPQLPPTTLFDYLPKDGLLFIDESHVMIPQISAMYKSDQSRKN
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCEECHHHHHHHHCCCCCCC
TLIDFGFRLPSARNNRPLSFTEFESIKPQTIFVSATPSNYELSKSKQQVFKQIIRPTGLL
CEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DPEIEIRPSDNNLEDLVQEIALRLARNERTLVTTLTKKSAESLNDFLSAKGIKVSYLHSD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECC
IKTNDRVEIIKALRVGEIDVLIGINLLREGLDIPEASLVAVLDADTAGFLRSEQALIQII
CCCCCHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
GRAARNENGKAILYADKVTTAMQSAIDESAERRGHQIIYNMANGIVPSSSKRRLDSGSQT
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHEEEHHHCCCCCCCCHHHCCCCCCC
QVAVSHMDRAQFCENLSALCQQITAKEKELLLCVDEGEGGADQAKIIRQQLIALYRQFIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
M
C
>Mature Secondary Structure 
SKNTFILHSNYTPSGDQPEAIARLVDGIDSGSSHQTLKGVTGSGKTFTVANIIHRLKRP
CCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEHHHHHHHHCCC
TIILAHNKTLAAQLYSEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINEHL
EEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEECHHHHHHHH
ERLRLSTTKALIERRDVIVVASVSSIYGLGDPDAYRSLQVKLWLGQEIDLDDLIQRLERL
HHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
QYTRCNRTINRATFLVREGVIDIFPADSEHQALTVEIEAGRVNQLYWIDAISGQQLETIA
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHH
EYCVSPKTLYSVSIEQVELACGQIMSDMEQQVAILNADNRLTEAARLYERTVSDLELLRL
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QGYCPGIENYASYLNQRDPQLPPTTLFDYLPKDGLLFIDESHVMIPQISAMYKSDQSRKN
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCEECHHHHHHHHCCCCCCC
TLIDFGFRLPSARNNRPLSFTEFESIKPQTIFVSATPSNYELSKSKQQVFKQIIRPTGLL
CEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DPEIEIRPSDNNLEDLVQEIALRLARNERTLVTTLTKKSAESLNDFLSAKGIKVSYLHSD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECC
IKTNDRVEIIKALRVGEIDVLIGINLLREGLDIPEASLVAVLDADTAGFLRSEQALIQII
CCCCCHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
GRAARNENGKAILYADKVTTAMQSAIDESAERRGHQIIYNMANGIVPSSSKRRLDSGSQT
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHEEEHHHCCCCCCCCHHHCCCCCCC
QVAVSHMDRAQFCENLSALCQQITAKEKELLLCVDEGEGGADQAKIIRQQLIALYRQFIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
M
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]