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The map label for this gene is umuC [H]

Identifier: 157962016

GI number: 157962016

Start: 2664091

End: 2665344

Strand: Reverse

Name: umuC [H]

Synonym: Spea_2195

Alternate gene names: 157962016

Gene position: 2665344-2664091 (Counterclockwise)

Preceding gene: 157962017

Following gene: 157962012

Centisome position: 51.51

GC content: 47.45

Gene sequence:

>1254_bases
ATGTATGCACTTGTGGATGCAAACTCATTTTATTGCAGCGCCGAGCAGGTATTTAGGCCTGACTGGCGTAACCGCCCTAT
CGTAGTGCTCAGTAACAACGACGGGATGATTGTTGCGGCGAACAGATTGGCCAAAGAGGCTGGAATTAACAAGTTTGGTC
CCTACTTTGAAGCACAGAAACTGTGTGAGCAGAAAGGCGTTATCGCGCTGTCTTCAAACTATGAGCTCTATGGCTCGTTA
TCTGCAGCAATGATGGAGGTAATTGGCCGTTTTGCACCGGAGCAGCATATCTACAGCATCGATGAGTCATTTCTATCATT
TAAGCACTGTTACCCCGCTATCCCTTGTTTAACTGAGCATGCGATGAAAATAAGGCGCGCCGTGTGGAAAGAAACTCGGC
TTCCGGTCTGTGTTGGGATTGGCCCCACGCTCACTTTGGCTAAGGTTGCCAATCATGCCGCCAAGAGAATCGCCGGATAT
AACGGTGTATGCGCTATTAGCAGTGATGAGCAGCGCATTTCGATTTTAAAGACCATGAAAACTAACGATGTATGGGGCGT
TGGCAATCGAATCGCTAAACGACTCGGGATGATGAATATCCACAATGCTTTTGCTTTGTCACAAATGAAAACCGGCATCG
CTAGTAAGCAATTTAGCATCGAGCTTGAACGTACAATTCGTGAGTTAAATGGTGAAGTGTGCAAAACTTGGGATGAGGCC
CGCGCAGACAAGAAACAGATATTTTCAACCCGCAGCGTAGGCAATAGAGTCACCGACTCAACCTCCTTGTGTCAGGCGTT
AAGCAAGCATGCTTCAACCGCAGCAGCAAAGGCCAGAACCCAAGGTTCGCTATGTAAAAGCATGCTGATTTTTGCCTCAA
ACTCGCCTTTTGATGAGCAGCCCGGCGGATTTAAGTTTGTTCATCATTTTAATTATCCAACAAATGACACCTGTGAGCTG
ATTGAGGCAGCAACAAGAGCCGCTATCGTCAGATTCAACCCCGCTATACGTTATTACAAAATTGGTGTGGGCCTGATCAA
CCTGTGCAGCGAGGCCAACTTACAAGGCGACCTATTCGAGAAGTGCAGGAACCCAAACAAGATGTTGGTGCTAGATAGCA
TTAATGCAAAGTACGGCACAGACTCTCTGTTTCTGGCCGCCCAAGGCATATCACAGAAATGGGGCATGCGCAGAGAGATG
CTCACACCACAGTATACGACGCGGTGGAAAGACATTCCCTTGATTAAGTGTTAA

Upstream 100 bases:

>100_bases
GCACGCCCATTCTTGAACACGATACTTTTAGTGTTGAAGGCGTGGTTATACGTTCTATTCGCTGTCATCGTAGAAGCTCA
ATTTTAGAGAACGATTAATC

Downstream 100 bases:

>100_bases
CCGAGCAGTGGCAAAATTAGCATGTTTTCGGGGGCAGTGCGGAGTTGTAGTAACTGAATTGTAGGAGCTGAGTTAGGAGC
TTAGTTGTAGGAGCAGTGTA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MYALVDANSFYCSAEQVFRPDWRNRPIVVLSNNDGMIVAANRLAKEAGINKFGPYFEAQKLCEQKGVIALSSNYELYGSL
SAAMMEVIGRFAPEQHIYSIDESFLSFKHCYPAIPCLTEHAMKIRRAVWKETRLPVCVGIGPTLTLAKVANHAAKRIAGY
NGVCAISSDEQRISILKTMKTNDVWGVGNRIAKRLGMMNIHNAFALSQMKTGIASKQFSIELERTIRELNGEVCKTWDEA
RADKKQIFSTRSVGNRVTDSTSLCQALSKHASTAAAKARTQGSLCKSMLIFASNSPFDEQPGGFKFVHHFNYPTNDTCEL
IEAATRAAIVRFNPAIRYYKIGVGLINLCSEANLQGDLFEKCRNPNKMLVLDSINAKYGTDSLFLAAQGISQKWGMRREM
LTPQYTTRWKDIPLIKC

Sequences:

>Translated_417_residues
MYALVDANSFYCSAEQVFRPDWRNRPIVVLSNNDGMIVAANRLAKEAGINKFGPYFEAQKLCEQKGVIALSSNYELYGSL
SAAMMEVIGRFAPEQHIYSIDESFLSFKHCYPAIPCLTEHAMKIRRAVWKETRLPVCVGIGPTLTLAKVANHAAKRIAGY
NGVCAISSDEQRISILKTMKTNDVWGVGNRIAKRLGMMNIHNAFALSQMKTGIASKQFSIELERTIRELNGEVCKTWDEA
RADKKQIFSTRSVGNRVTDSTSLCQALSKHASTAAAKARTQGSLCKSMLIFASNSPFDEQPGGFKFVHHFNYPTNDTCEL
IEAATRAAIVRFNPAIRYYKIGVGLINLCSEANLQGDLFEKCRNPNKMLVLDSINAKYGTDSLFLAAQGISQKWGMRREM
LTPQYTTRWKDIPLIKC
>Mature_417_residues
MYALVDANSFYCSAEQVFRPDWRNRPIVVLSNNDGMIVAANRLAKEAGINKFGPYFEAQKLCEQKGVIALSSNYELYGSL
SAAMMEVIGRFAPEQHIYSIDESFLSFKHCYPAIPCLTEHAMKIRRAVWKETRLPVCVGIGPTLTLAKVANHAAKRIAGY
NGVCAISSDEQRISILKTMKTNDVWGVGNRIAKRLGMMNIHNAFALSQMKTGIASKQFSIELERTIRELNGEVCKTWDEA
RADKKQIFSTRSVGNRVTDSTSLCQALSKHASTAAAKARTQGSLCKSMLIFASNSPFDEQPGGFKFVHHFNYPTNDTCEL
IEAATRAAIVRFNPAIRYYKIGVGLINLCSEANLQGDLFEKCRNPNKMLVLDSINAKYGTDSLFLAAQGISQKWGMRREM
LTPQYTTRWKDIPLIKC

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=426, Percent_Identity=39.4366197183099, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1786425, Length=203, Percent_Identity=26.6009852216749, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46543; Mature: 46543

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALVDANSFYCSAEQVFRPDWRNRPIVVLSNNDGMIVAANRLAKEAGINKFGPYFEAQK
CEEEEECCCCEECHHHHHCCCCCCCCEEEEECCCCEEEEHHHHHHHCCCCCCCCHHHHHH
LCEQKGVIALSSNYELYGSLSAAMMEVIGRFAPEQHIYSIDESFLSFKHCYPAIPCLTEH
HHHHCCEEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AMKIRRAVWKETRLPVCVGIGPTLTLAKVANHAAKRIAGYNGVCAISSDEQRISILKTMK
HHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHC
TNDVWGVGNRIAKRLGMMNIHNAFALSQMKTGIASKQFSIELERTIRELNGEVCKTWDEA
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCHHHHCHHHH
RADKKQIFSTRSVGNRVTDSTSLCQALSKHASTAAAKARTQGSLCKSMLIFASNSPFDEQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
PGGFKFVHHFNYPTNDTCELIEAATRAAIVRFNPAIRYYKIGVGLINLCSEANLQGDLFE
CCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCEEEEEECHHHHHHHHCCCCCCHHHH
KCRNPNKMLVLDSINAKYGTDSLFLAAQGISQKWGMRREMLTPQYTTRWKDIPLIKC
HHCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHCCHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MYALVDANSFYCSAEQVFRPDWRNRPIVVLSNNDGMIVAANRLAKEAGINKFGPYFEAQK
CEEEEECCCCEECHHHHHCCCCCCCCEEEEECCCCEEEEHHHHHHHCCCCCCCCHHHHHH
LCEQKGVIALSSNYELYGSLSAAMMEVIGRFAPEQHIYSIDESFLSFKHCYPAIPCLTEH
HHHHCCEEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
AMKIRRAVWKETRLPVCVGIGPTLTLAKVANHAAKRIAGYNGVCAISSDEQRISILKTMK
HHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHC
TNDVWGVGNRIAKRLGMMNIHNAFALSQMKTGIASKQFSIELERTIRELNGEVCKTWDEA
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCHHHHCHHHH
RADKKQIFSTRSVGNRVTDSTSLCQALSKHASTAAAKARTQGSLCKSMLIFASNSPFDEQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
PGGFKFVHHFNYPTNDTCELIEAATRAAIVRFNPAIRYYKIGVGLINLCSEANLQGDLFE
CCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCEEEEEECHHHHHHHHCCCCCCHHHH
KCRNPNKMLVLDSINAKYGTDSLFLAAQGISQKWGMRREMLTPQYTTRWKDIPLIKC
HHCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHCCHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]