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The map label for this gene is emrA [H]

Identifier: 157962012

GI number: 157962012

Start: 2656332

End: 2657396

Strand: Reverse

Name: emrA [H]

Synonym: Spea_2191

Alternate gene names: 157962012

Gene position: 2657396-2656332 (Counterclockwise)

Preceding gene: 157962016

Following gene: 157962011

Centisome position: 51.35

GC content: 50.14

Gene sequence:

>1065_bases
ATGAGCGAAAATTTAGCAGAAACATCAGCACCAGCAGAGCTAGAACCAAAATCCCACCTAATACGTAACCTTATCATTGC
CGCCACAGTGCTCGCGGCACTTGTTACTCTTAGTTATTTCTATATTCAGCATCAAAAGAACTACCCGAGTACCGATGACT
CCTATGTTCATGCCAACATCATTTACATTGCACCACAAGTCCATGGCAAGGTGATCAGCGTTAATGCATCTGATTATCAA
GAGGTCAGCCAAGGTGACTTACTGGTACAGATCGATCCAGCCCCCTTTCAGGCACAACTCGATGAAGCTCGCGCCGCTTA
CGAGGTGGCGATACAGAATAATGCCGCCAGTGATGATGCGATCCTGGCTGCCAGTGCCAACGTTAGAAGCGCCGTGGCTC
AACTGACCGATGCTCAGGCAACCTACCAACGTATTAAGCAACTGGTAGCAAAACAGTTACTGCCAGCGCAGCAACTCGAT
GATGCCCGCGCCAAGCTCTCCTCCGCTGAAGAGAATGTGATTGCCGCCCGCGCAACCATGTCACAACTCATTAAAACCCA
AGGCGCGCAAGGTAATGCCGCACCGGAAGTGAAAAAGGCCGCGGCGGCGCTCAGTCAGGCCAGTCTGTCTCTTTCATACA
CCAATATCTTTGCTCCCAAAAGTGGCACCTTAGGTAAGTTAACCGCCCATGCGGGTAGCGTGGTGTCTGTTGGCCAAGCA
TTGGTGCCCTTGGTTGAGGCCAATACCTATTGGGTACAAGCTAACTTTAAAGAAACCCAGCTAGAATTGATCACTAAGGG
AATGCAGGCAACAATCACCTTAGATCTCTACCCGAGTGTGGATTATCACGGCACCATTGAAGCCATATCTCCCGCTAGCG
GCTCATCATTTTCACTGCTGCCTCCAGAAAATGCCACCGGTAACTGGGTAAAGGTCCCGCAACGTTTCCCTATACTCATT
CGTCTTGCTAACGAAAGTGAACACCCTGACACTCCGTTACGGGTGGGCGCTAGCGCGAATGTCACCATAGATACAGTTAG
CACAGCAAACAAACAAGAGCAGTAA

Upstream 100 bases:

>100_bases
AGTATTTGTGAAACGAATGAATGTTTCGCCGAGCTATCAGCTTCTTAAGTACAGGTTCAACCGCTCGGCTTACGTCAAAT
AACCTAATTGGGTTAAAATA

Downstream 100 bases:

>100_bases
CATGACCGAGCTCTCTCAAGCATCGTCAAGCCCTGGTGATGCTCAAGTATTAAGTGAAGGCAGTCGTAAACTGGTGACCT
TGGCGGTGATGTTATCCGCT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSENLAETSAPAELEPKSHLIRNLIIAATVLAALVTLSYFYIQHQKNYPSTDDSYVHANIIYIAPQVHGKVISVNASDYQ
EVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDAILAASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLD
DARAKLSSAEENVIAARATMSQLIKTQGAQGNAAPEVKKAAAALSQASLSLSYTNIFAPKSGTLGKLTAHAGSVVSVGQA
LVPLVEANTYWVQANFKETQLELITKGMQATITLDLYPSVDYHGTIEAISPASGSSFSLLPPENATGNWVKVPQRFPILI
RLANESEHPDTPLRVGASANVTIDTVSTANKQEQ

Sequences:

>Translated_354_residues
MSENLAETSAPAELEPKSHLIRNLIIAATVLAALVTLSYFYIQHQKNYPSTDDSYVHANIIYIAPQVHGKVISVNASDYQ
EVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDAILAASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLD
DARAKLSSAEENVIAARATMSQLIKTQGAQGNAAPEVKKAAAALSQASLSLSYTNIFAPKSGTLGKLTAHAGSVVSVGQA
LVPLVEANTYWVQANFKETQLELITKGMQATITLDLYPSVDYHGTIEAISPASGSSFSLLPPENATGNWVKVPQRFPILI
RLANESEHPDTPLRVGASANVTIDTVSTANKQEQ
>Mature_353_residues
SENLAETSAPAELEPKSHLIRNLIIAATVLAALVTLSYFYIQHQKNYPSTDDSYVHANIIYIAPQVHGKVISVNASDYQE
VSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDAILAASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLDD
ARAKLSSAEENVIAARATMSQLIKTQGAQGNAAPEVKKAAAALSQASLSLSYTNIFAPKSGTLGKLTAHAGSVVSVGQAL
VPLVEANTYWVQANFKETQLELITKGMQATITLDLYPSVDYHGTIEAISPASGSSFSLLPPENATGNWVKVPQRFPILIR
LANESEHPDTPLRVGASANVTIDTVSTANKQEQ

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=334, Percent_Identity=32.3353293413174, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789041, Length=327, Percent_Identity=32.1100917431193, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790519, Length=322, Percent_Identity=30.1242236024845, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI87081951, Length=330, Percent_Identity=28.1818181818182, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789637, Length=312, Percent_Identity=26.6025641025641, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789929, Length=178, Percent_Identity=29.2134831460674, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37786; Mature: 37655

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENLAETSAPAELEPKSHLIRNLIIAATVLAALVTLSYFYIQHQKNYPSTDDSYVHANI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEE
IYIAPQVHGKVISVNASDYQEVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDA
EEEEECCCCEEEEECCHHHHHHCCCCEEEEECCCCCHHHHHHHHHEEEEEECCCCCCCCE
ILAASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLDDARAKLSSAEENVIAARATM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
SQLIKTQGAQGNAAPEVKKAAAALSQASLSLSYTNIFAPKSGTLGKLTAHAGSVVSVGQA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEHHCCCCHHHHHHH
LVPLVEANTYWVQANFKETQLELITKGMQATITLDLYPSVDYHGTIEAISPASGSSFSLL
HHHEEECCEEEEEECCCHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCCCCEEEEE
PPENATGNWVKVPQRFPILIRLANESEHPDTPLRVGASANVTIDTVSTANKQEQ
CCCCCCCCEEECCCCCCEEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SENLAETSAPAELEPKSHLIRNLIIAATVLAALVTLSYFYIQHQKNYPSTDDSYVHANI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEE
IYIAPQVHGKVISVNASDYQEVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDA
EEEEECCCCEEEEECCHHHHHHCCCCEEEEECCCCCHHHHHHHHHEEEEEECCCCCCCCE
ILAASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLDDARAKLSSAEENVIAARATM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
SQLIKTQGAQGNAAPEVKKAAAALSQASLSLSYTNIFAPKSGTLGKLTAHAGSVVSVGQA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEHHCCCCHHHHHHH
LVPLVEANTYWVQANFKETQLELITKGMQATITLDLYPSVDYHGTIEAISPASGSSFSLL
HHHEEECCEEEEEECCCHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCCCCEEEEE
PPENATGNWVKVPQRFPILIRLANESEHPDTPLRVGASANVTIDTVSTANKQEQ
CCCCCCCCEEECCCCCCEEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]