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The map label for this gene is hsaA [H]

Identifier: 157961950

GI number: 157961950

Start: 2580214

End: 2581437

Strand: Direct

Name: hsaA [H]

Synonym: Spea_2129

Alternate gene names: 157961950

Gene position: 2580214-2581437 (Clockwise)

Preceding gene: 157961947

Following gene: 157961951

Centisome position: 49.86

GC content: 45.18

Gene sequence:

>1224_bases
ATGAGTGAACATAAAGAAGTATTTTCTGCAGGCTTAATTAAAGAAGACTATATAACCGTAGAGGCTCAAGCGTTGCTTGA
ACTCGCCGCCGCATTAGTTCCTAACCTTGCGGCACGAGCTCGACAAACAGAAATAGACGGTAAGGTGCCCCAAGCATCAA
TTGATGAAATAGCTGAAGCGGGTTTATTTGCTGTTTTACAACCTAAAAGGTGGGGCGGAGCAGAGCTCGACCCTCGTGTA
TTTTATCGAATTCAAATGATTCTGGCTCAAGGTTGCATGTCTACTGCATGGATCTACGGTGTTATTAGTGTTCACAATTG
GCAGCTGCCATTGTTTCCTGAACAAGCTCAACAAGATGTTTGGCAAGAAGATCGCTCAACCTTAATAGCTTCAACTTACA
TGCCAGTGGGTAGAGCTCAAGCTGTTGAAGGCGGATTCACATTTTCCGGTCGCTGGGGCTTTTCAAGTGGCTGTGAGCAT
TGTGAATGGATCTTTTTGGGGGCTTTACTGCCTAAAGAAGATGGCAGTGAAGGTGTTGAGCACACCACATTTTTACTACC
GAAATCCGATTTTAGTATTGAAAAGAACTGGGACGTTCATGGACTGCAGGGGACTGGCAGCCACGATATCGTCGTAGACA
ATGTCTTTGTACCTGCACATCGAACTCAACGTACCAATAACCATAGTGATGCAGGTTGTCCAGGCAGAGTGCTCAATCAA
GGTTGGTTATACAAGATCCCGTTCACTCAAGTGTTCCAGAGAGCAGTTTCAACCGCATGTATTGGCGCATTAGATGGCGC
AATTGAGGTGTTTAAGCAAAGAGCATCAGCTCATGTTGGCAAGCACGGCAGCAAGACCGCTGAAGATCCTAATGCACAGT
TTGCAGTAACTGCGGCAATGATGACGAGTGATCAATTAAAACTAGTTATGATGCGTAATTATGAGCGTATCGTGAATTGT
GCAAAGTCTGGCGAAAACTTGGAAGTAGAAGAGCGATTATTACAGCGGGCTCAAGCAGCATCGGTTCCCAAATTGTGTGG
TGAACATGCCGATGAGTTACTTCGAGCCTGCGCGGGGTCAGGGCTTTATAAATCGAATCCAATTGAAAGGGTATTTAGAG
ATATTCACCAAGCACGTGGACACATAGCTAATAATGGTGATGCCTATATGCGCGCCCACGGTTCAGTCATGCTTGGGTTA
CCAAATCTTGATCCATTTATTTAA

Upstream 100 bases:

>100_bases
AACCTCAACAACATAAATGAAGTGGTAACGCTTGGCTTATCCAAACTTAGCTAGGTAATTCGAAGATTGAAATTGAATGC
AAATTTGGGAGTAAATGTTT

Downstream 100 bases:

>100_bases
TCATCTCATTAGATAACCGTTTTTGGAAAGGAGTTGCCATGTCTTCATCTCGCTATCATCTGTTGACAGTCAGTAAACTG
GTAAATGAAACCTCAGATGC

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSEHKEVFSAGLIKEDYITVEAQALLELAAALVPNLAARARQTEIDGKVPQASIDEIAEAGLFAVLQPKRWGGAELDPRV
FYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQEDRSTLIASTYMPVGRAQAVEGGFTFSGRWGFSSGCEH
CEWIFLGALLPKEDGSEGVEHTTFLLPKSDFSIEKNWDVHGLQGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRVLNQ
GWLYKIPFTQVFQRAVSTACIGALDGAIEVFKQRASAHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMMRNYERIVNC
AKSGENLEVEERLLQRAQAASVPKLCGEHADELLRACAGSGLYKSNPIERVFRDIHQARGHIANNGDAYMRAHGSVMLGL
PNLDPFI

Sequences:

>Translated_407_residues
MSEHKEVFSAGLIKEDYITVEAQALLELAAALVPNLAARARQTEIDGKVPQASIDEIAEAGLFAVLQPKRWGGAELDPRV
FYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQEDRSTLIASTYMPVGRAQAVEGGFTFSGRWGFSSGCEH
CEWIFLGALLPKEDGSEGVEHTTFLLPKSDFSIEKNWDVHGLQGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRVLNQ
GWLYKIPFTQVFQRAVSTACIGALDGAIEVFKQRASAHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMMRNYERIVNC
AKSGENLEVEERLLQRAQAASVPKLCGEHADELLRACAGSGLYKSNPIERVFRDIHQARGHIANNGDAYMRAHGSVMLGL
PNLDPFI
>Mature_406_residues
SEHKEVFSAGLIKEDYITVEAQALLELAAALVPNLAARARQTEIDGKVPQASIDEIAEAGLFAVLQPKRWGGAELDPRVF
YRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQEDRSTLIASTYMPVGRAQAVEGGFTFSGRWGFSSGCEHC
EWIFLGALLPKEDGSEGVEHTTFLLPKSDFSIEKNWDVHGLQGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRVLNQG
WLYKIPFTQVFQRAVSTACIGALDGAIEVFKQRASAHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMMRNYERIVNCA
KSGENLEVEERLLQRAQAASVPKLCGEHADELLRACAGSGLYKSNPIERVFRDIHQARGHIANNGDAYMRAHGSVMLGLP
NLDPFI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 44787; Mature: 44656

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHKEVFSAGLIKEDYITVEAQALLELAAALVPNLAARARQTEIDGKVPQASIDEIAEA
CCCHHHHHHHCCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GLFAVLQPKRWGGAELDPRVFYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDV
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
WQEDRSTLIASTYMPVGRAQAVEGGFTFSGRWGFSSGCEHCEWIFLGALLPKEDGSEGVE
HHHHHHHEEHHHCCCCCCHHEECCCEEEECCCCCCCCCCHHHHHEEECCCCCCCCCCCCC
HTTFLLPKSDFSIEKNWDVHGLQGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRVLNQ
EEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCCCCCCHHHHCC
GWLYKIPFTQVFQRAVSTACIGALDGAIEVFKQRASAHVGKHGSKTAEDPNAQFAVTAAM
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEH
MTSDQLKLVMMRNYERIVNCAKSGENLEVEERLLQRAQAASVPKLCGEHADELLRACAGS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GLYKSNPIERVFRDIHQARGHIANNGDAYMRAHGSVMLGLPNLDPFI
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCC
>Mature Secondary Structure 
SEHKEVFSAGLIKEDYITVEAQALLELAAALVPNLAARARQTEIDGKVPQASIDEIAEA
CCHHHHHHHCCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GLFAVLQPKRWGGAELDPRVFYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDV
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
WQEDRSTLIASTYMPVGRAQAVEGGFTFSGRWGFSSGCEHCEWIFLGALLPKEDGSEGVE
HHHHHHHEEHHHCCCCCCHHEECCCEEEECCCCCCCCCCHHHHHEEECCCCCCCCCCCCC
HTTFLLPKSDFSIEKNWDVHGLQGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRVLNQ
EEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCCCCCCHHHHCC
GWLYKIPFTQVFQRAVSTACIGALDGAIEVFKQRASAHVGKHGSKTAEDPNAQFAVTAAM
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEH
MTSDQLKLVMMRNYERIVNCAKSGENLEVEERLLQRAQAASVPKLCGEHADELLRACAGS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GLYKSNPIERVFRDIHQARGHIANNGDAYMRAHGSVMLGLPNLDPFI
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA