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The map label for this gene is aceA [C]

Identifier: 157961862

GI number: 157961862

Start: 2470491

End: 2472074

Strand: Reverse

Name: aceA [C]

Synonym: Spea_2041

Alternate gene names: 157961862

Gene position: 2472074-2470491 (Counterclockwise)

Preceding gene: 157961865

Following gene: 157961861

Centisome position: 47.77

GC content: 44.57

Gene sequence:

>1584_bases
ATGACAAATTACAGATCAAACATCGATGAAGCTGCTACCTTGATTAATGCCGAAGGTAGTGCATGGAGCGCAATTAACCC
TGAATCTGTAGCACGCATGCGTCTGCAAAATCAATTTAAGACCGGGCTTGATATTGCTAAATATACGGCAAAAATTATGC
GCGAAGATATGGACAACTACGACAAGGATTCGTCTCAATACACGCAATCTTTAGGTTGTTGGCATGGTTTTATCGGTCAG
CAGAAGATGATCTCAATTAAGAAACATCTACTGACCACTAAGCGTCGCTACCTTTACCTTTCTGGCTGGATGGTTGCCGC
ACTTCGCAGTGAGTTTGGTCCTCTACCGGATCAGTCTATGCATGAGAAGACCTCTGTTGCGTCACTGATCAAAGAGCTTT
ACACCTTCTTACGTCAAGCCGATGCCCGTGAATTAGGTGGTCTATTCCGTCAATTAGACGCTGCGAATGAAAGCGAAAAA
GCAGTTATCCAAGCAAAAATTGATAACTTTGAAACCCATGTTGTACCGATTATTGCCGACATTGATGCCGGTTTTGGTAA
CGAAGAAGCCACCTATCTAATGGCTAAGCAGATGATTGAAGCCGGGGCTTGTTGTATTCAGCTTGAAAACCAAGTGTCTG
ATGTTAAGCAATGTGGTCACCAAGACGGTAAAGTTACCGTACCTCATGTTGAGTTCCTCGCTAAAATTAACGCCGTTCGT
TATGCATTCTTAGAACTCGGTATTGATGATGGTGTTATCGTTGCTCGTACAGACTCATTAGGTGCTGGCCTAACGCAAAA
AATTGCTGTAACGAGCGAGGTTGGCGATTTAGGCGACCAATACAACTCATTCCTAGAAGTAGAATCTGTAGATGCGGCCA
ATCTTGCAAATGGCGATGTTGTATTCCAGCAAAACGGTCAACTTGTTAAGCCCGCGCGTTTACCAAATGGCCTATTTAAG
TTCCGAGCGGGTACAGGCGAAGAACGCTGTGTACTCGATTGTATTACCTCATTACAAAATGGTGCGGATCTGCTTTGGAT
TGAAACAGAAAAGCCTCACGTTGCTCAGATTGGCGGTATGGTAAATAAGATCCGTGAGACTATTCCAAATGCAAAACTGG
TTTATAACAACTCACCTTCGTTTAACTGGACGCTTAACTTCCGTCAGCAAGTGTTCGATATGATGCAAGAGTCAGGTCAA
GACGTATCAACTTATGACCGTGACAAGCTTATGAGCGTCGATTACGACGGCACAGATCTAGCTGTTCAAGCTGATGAGAA
GATCCGAACCTTCCAGGCAGATGCTGCACGTGAAGCGGGTATTTTCCACCACTTAATCACACTTCCTACGTACCATACTG
CGGCGCTATCTACCGATAACTTGGCGAAAGAGTACTTCGGTGACCAAGGCATGCTAGGTTATGTGGCAAACGTTCAACGT
AAAGAGATCCGTCAAGGGATTGCCTGTGTTAGACACCAAAACATGGCTGGCTCAGATATGGGTGATGATCACAAAGAGTA
CTTCTCTGGTGACCAAGCATTGAAGGCATCGGGTAAAGACAACACTATGAACCAATTTAGCTAA

Upstream 100 bases:

>100_bases
CCGGATATAAAAACTATAAATTAGACTTATTTAAACAAATCTTACTAATATTTTCAACGTAATCAATCGCCGCTAATCAT
ATTGTTAAAGGAATAGACAC

Downstream 100 bases:

>100_bases
GCCGTCGTTATCACTGTTAGTTTTTGAAGTGGACTAACTTGTTGTAAACGAGCTAATAACTTAAGGCCTACTCTTTGTAG
GCCTTTTTATTTCCCGGATC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTNYRSNIDEAATLINAEGSAWSAINPESVARMRLQNQFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQ
QKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANESEK
AVIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEVGDLGDQYNSFLEVESVDAANLANGDVVFQQNGQLVKPARLPNGLFK
FRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGGMVNKIRETIPNAKLVYNNSPSFNWTLNFRQQVFDMMQESGQ
DVSTYDRDKLMSVDYDGTDLAVQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
KEIRQGIACVRHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS

Sequences:

>Translated_527_residues
MTNYRSNIDEAATLINAEGSAWSAINPESVARMRLQNQFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQ
QKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANESEK
AVIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEVGDLGDQYNSFLEVESVDAANLANGDVVFQQNGQLVKPARLPNGLFK
FRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGGMVNKIRETIPNAKLVYNNSPSFNWTLNFRQQVFDMMQESGQ
DVSTYDRDKLMSVDYDGTDLAVQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
KEIRQGIACVRHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
>Mature_526_residues
TNYRSNIDEAATLINAEGSAWSAINPESVARMRLQNQFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQQ
KMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANESEKA
VIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVRY
AFLELGIDDGVIVARTDSLGAGLTQKIAVTSEVGDLGDQYNSFLEVESVDAANLANGDVVFQQNGQLVKPARLPNGLFKF
RAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGGMVNKIRETIPNAKLVYNNSPSFNWTLNFRQQVFDMMQESGQD
VSTYDRDKLMSVDYDGTDLAVQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQRK
EIRQGIACVRHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=409, Percent_Identity=27.8728606356968, Blast_Score=129, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71982926, Length=409, Percent_Identity=26.8948655256724, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17561814, Length=409, Percent_Identity=26.8948655256724, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=472, Percent_Identity=26.0593220338983, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58559; Mature: 58427

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYRSNIDEAATLINAEGSAWSAINPESVARMRLQNQFKTGLDIAKYTAKIMREDMDNY
CCCCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DKDSSQYTQSLGCWHGFIGQQKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVASLIKELYTFLRQADARELGGLFRQLDAANESEKAVIQAKIDNFETHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEE
IDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
CCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEVGDLGDQYNSFLEVESVDAANLANGDV
HHHHHCCCCCCEEEEECCCCCCCCHHHEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCE
VFQQNGQLVKPARLPNGLFKFRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGGM
EEECCCCEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
VNKIRETIPNAKLVYNNSPSFNWTLNFRQQVFDMMQESGQDVSTYDRDKLMSVDYDGTDL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCE
AVQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KEIRQGIACVRHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCC
>Mature Secondary Structure 
TNYRSNIDEAATLINAEGSAWSAINPESVARMRLQNQFKTGLDIAKYTAKIMREDMDNY
CCCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DKDSSQYTQSLGCWHGFIGQQKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVASLIKELYTFLRQADARELGGLFRQLDAANESEKAVIQAKIDNFETHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEE
IDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
CCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEVGDLGDQYNSFLEVESVDAANLANGDV
HHHHHCCCCCCEEEEECCCCCCCCHHHEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCE
VFQQNGQLVKPARLPNGLFKFRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGGM
EEECCCCEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
VNKIRETIPNAKLVYNNSPSFNWTLNFRQQVFDMMQESGQDVSTYDRDKLMSVDYDGTDL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCE
AVQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KEIRQGIACVRHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]