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The map label for this gene is gcvR [H]

Identifier: 157961802

GI number: 157961802

Start: 2403476

End: 2404012

Strand: Reverse

Name: gcvR [H]

Synonym: Spea_1979

Alternate gene names: 157961802

Gene position: 2404012-2403476 (Counterclockwise)

Preceding gene: 157961807

Following gene: 157961801

Centisome position: 46.46

GC content: 43.39

Gene sequence:

>537_bases
ATGTCCAATCACTTGGTCGTTACTGCAATGGGGCTCGACCGTCCTGGTATTGTAAGTAAATTTGCACGACTCGCGAGTGA
GTGTGACTGCGATATCGTTGATAGTCGCATGGCACTTTTTGGTAACGAATTTACCTTGATTATGATGCTTTCAGGCTCAT
GGCCATCTATCACTAAGATAGAATCGACATTACCTAGCTTAAGTGTTGAGTTAGAATTATTGACAGTGATGAAGCGCACT
TCAAAGCATACACCGCAAAATTACATCTCTAATTTAGAAGTTAACTTCAGCGGTCTCGATCAACGTGGCACGATGAAAAA
GATCACCCAGTTCTTGGCTGACCGCTCCTTAGACCTCGCCGCGGTAAAGTCGCATGCTGAAGCTGACGCAACGGGTAGAC
CGACACAAAATATCAGCCTAACCATTAATGTGCCGGAAAAAGTCGACCTAGATAAGTTAGAAATTGGTTTAAATGAATTG
GCTGATGAATTATCACTAGAATGTGCCATTGAGCGTATGCAAGGTGTCGAAAGCTAA

Upstream 100 bases:

>100_bases
CAATCTGATTAACTTGTGATAGCATTAGCCACCGCAAAGAAAACCGTTATTTATTTGACGCTTTTTTTAAAGTCTAACTA
ATAAGAAAATGGGGTATTGA

Downstream 100 bases:

>100_bases
ACTTTATTAAGGATAACAATATGAAAACCTTAACCGTTGGCGAACAAGCGCCGCTATTTACACTACAAAACCAAAGAGAT
GAAACAGTCAGTTTGGCTGA

Product: amino acid-binding ACT domain-containing protein

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSNHLVVTAMGLDRPGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWPSITKIESTLPSLSVELELLTVMKRT
SKHTPQNYISNLEVNFSGLDQRGTMKKITQFLADRSLDLAAVKSHAEADATGRPTQNISLTINVPEKVDLDKLEIGLNEL
ADELSLECAIERMQGVES

Sequences:

>Translated_178_residues
MSNHLVVTAMGLDRPGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWPSITKIESTLPSLSVELELLTVMKRT
SKHTPQNYISNLEVNFSGLDQRGTMKKITQFLADRSLDLAAVKSHAEADATGRPTQNISLTINVPEKVDLDKLEIGLNEL
ADELSLECAIERMQGVES
>Mature_177_residues
SNHLVVTAMGLDRPGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWPSITKIESTLPSLSVELELLTVMKRTS
KHTPQNYISNLEVNFSGLDQRGTMKKITQFLADRSLDLAAVKSHAEADATGRPTQNISLTINVPEKVDLDKLEIGLNELA
DELSLECAIERMQGVES

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=169, Percent_Identity=37.8698224852071, Blast_Score=115, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 19572; Mature: 19441

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHLVVTAMGLDRPGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWPSITKI
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHHH
ESTLPSLSVELELLTVMKRTSKHTPQNYISNLEVNFSGLDQRGTMKKITQFLADRSLDLA
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHH
AVKSHAEADATGRPTQNISLTINVPEKVDLDKLEIGLNELADELSLECAIERMQGVES
HHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNHLVVTAMGLDRPGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWPSITKI
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHHH
ESTLPSLSVELELLTVMKRTSKHTPQNYISNLEVNFSGLDQRGTMKKITQFLADRSLDLA
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHH
AVKSHAEADATGRPTQNISLTINVPEKVDLDKLEIGLNELADELSLECAIERMQGVES
HHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]