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The map label for this gene is grxD [H]

Identifier: 157961787

GI number: 157961787

Start: 2389726

End: 2390067

Strand: Direct

Name: grxD [H]

Synonym: Spea_1964

Alternate gene names: 157961787

Gene position: 2389726-2390067 (Clockwise)

Preceding gene: 157961782

Following gene: 157961789

Centisome position: 46.18

GC content: 43.57

Gene sequence:

>342_bases
ATGGAAACTGTAGAAAAAATCAAGCAGCAAATTGCCGAAAACCCAATTATCGTTTACATGAAAGGCTCACCAAAGTTACC
AAGCTGTGGCTTTTCATCTCAGGTAGCGCAGATCATGATCAACTGCGAAGCGCAATTTGCTTTCGTTGATATCCTTCAGC
ACCCAGATATCCGCGCCGAATTACCAAAATATGCTAACTGGCCAACGTTCCCGCAGCTATGGGTTGAAGGCGAGTTGATC
GGTGGTTGTGACATTCTGACTGAAATGTACCAGAAGGGTGAGTTACAAACGCTAATCAAAGAAACTGCTGCTAAATATAA
GACTGAAGACGATCAAGGGTAA

Upstream 100 bases:

>100_bases
TTTCTATTACTTATTGCCCCTTTTAAAAGTAGGTTTTTGTTCTGCTAAATACTGACGTACAATGGTGCGATTGTAATGAT
GTTTTAATCAGGAATGAAAA

Downstream 100 bases:

>100_bases
AGCTTTATCCTGTAAAAGTTTTAGCGAATAAAAAGCCCCTATTGGTTTACCAATAGGGGCTTTTTTTAGGTATATCTCGT
CCAGAAATGTGTCCTATATT

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 113; Mature: 113

Protein sequence:

>113_residues
METVEKIKQQIAENPIIVYMKGSPKLPSCGFSSQVAQIMINCEAQFAFVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMYQKGELQTLIKETAAKYKTEDDQG

Sequences:

>Translated_113_residues
METVEKIKQQIAENPIIVYMKGSPKLPSCGFSSQVAQIMINCEAQFAFVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMYQKGELQTLIKETAAKYKTEDDQG
>Mature_113_residues
METVEKIKQQIAENPIIVYMKGSPKLPSCGFSSQVAQIMINCEAQFAFVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMYQKGELQTLIKETAAKYKTEDDQG

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=92, Percent_Identity=39.1304347826087, Blast_Score=93, Evalue=4e-20,
Organism=Homo sapiens, GI95113651, Length=93, Percent_Identity=41.9354838709677, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1787943, Length=108, Percent_Identity=76.8518518518518, Blast_Score=186, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17556042, Length=106, Percent_Identity=32.0754716981132, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988153, Length=84, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988159, Length=75, Percent_Identity=41.3333333333333, Blast_Score=78, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=114, Percent_Identity=36.8421052631579, Blast_Score=94, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321022, Length=74, Percent_Identity=47.2972972972973, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320303, Length=83, Percent_Identity=42.1686746987952, Blast_Score=88, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642023, Length=85, Percent_Identity=44.7058823529412, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=39.5833333333333, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12781; Mature: 12781

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVEKIKQQIAENPIIVYMKGSPKLPSCGFSSQVAQIMINCEAQFAFVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LPKYANWPTFPQLWVEGELIGGCDILTEMYQKGELQTLIKETAAKYKTEDDQG
CCCCCCCCCCCCEEECCCEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
METVEKIKQQIAENPIIVYMKGSPKLPSCGFSSQVAQIMINCEAQFAFVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LPKYANWPTFPQLWVEGELIGGCDILTEMYQKGELQTLIKETAAKYKTEDDQG
CCCCCCCCCCCCEEECCCEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]