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The map label for this gene is uvrC [H]

Identifier: 157961777

GI number: 157961777

Start: 2377189

End: 2379018

Strand: Direct

Name: uvrC [H]

Synonym: Spea_1954

Alternate gene names: 157961777

Gene position: 2377189-2379018 (Clockwise)

Preceding gene: 157961776

Following gene: 157961778

Centisome position: 45.94

GC content: 44.21

Gene sequence:

>1830_bases
ATGTCTGATGAGTTTAATGCCAATCAATTTTTAAAGACGGTGACATCATCTCCCGGTGTATATCGGATGTATGATGCTAA
AGACGCTGTTATCTATGTGGGTAAGGCCAAAGATTTAAAAAAGCGCCTTTCCTCCTACTTTCGTAAAAACCTAGCCAATG
TCAAGACTCAGGCATTGGTCTCCCATATTGCGAATATCGATGTCACGGTAACACACAGTGAAACCGATGCGCTGATCCTA
GAAAATGATTACATCAAGCAGTACATGCCTAAATATAATGTACTGCTTCGCGATGATAAATCTTACCCCTATATTCTTCT
CAGTAACCATCAACATCCTCGTTTGGCGTATCACCGCGGTCCCAAACGCGATAAAGGTCAGTATTTCGGACCTTACCCCA
ATGGGGGGGCTGTGCGAGAAAGCCTGCATCTTATGCAGAAAATCTTCCCTATTCGGCAGTGTGACGACCTTTACTATAAG
TCACGTTCACGCCCTTGCCTGCAGTATCAGATAGGAAGGTGTAGTGCGCCTTGCGTCGATTTAGTGTCTGAGGAAGATTA
TCAAGAGCAGGTAAGGTTAGCGACTTTGTTCTTGAAGGGTAAGAATCAGCAAGTGATGTCTGTGCTTGTACAAAAGATGG
AACAAGCCTCTAGTGATATGCGTTATGAACAAGCTGCCTTATACCGGGATCAAATTACTGCCTTAAGACGAGTCTCTGAG
CAGCAGGAAGTATCGAATGCATCAGGAGACATGGATGTTATTGGAGCTTATTATGCTTCTGGTGTTGCTTGTTTTCACCT
GTTGTTTATCCGAGAGGGAAAGATCTTTGGTAGCCGAAGTTACTATCCAAAAGTCCCTGTTAATACTGAAGTGTCCGAAG
TTCTTCGTTCATTTATGCTGCAGTTTTATCTCAACTCTGATAGTCAACGACTAACGCCGAAAGAGATCTTAATCAGCGAT
GCCTTTGAGGAACAAGCGGAACTCGCGGATGCGATTCAAAGCGCACAAAATAAGAAAGTTGAGATAAAAACTCAGGTTCG
TGGTGAAAGGGCGAGTTTTTTACGCTTAGCCTTAACCAATGCCACGAATGCAGTTAATACTCGCCTGTCGCATAAGAACA
CTATCGAGCAGCGTTTTTTATTATTAGAGGAAGCTATCGAGTCGACTAATAAAATCCAGCGGATGGAATGTTTCGATATT
AGCCATACTATGGGCGAGAGCACTGTGGCATCTTGCGTGGTGTTTAATCGAGAGGGGCCAAGCAAAGCTGACTACCGACG
CTATAATATTACTGGGATCACGCCCGGTGATGATTACGCCGCAATGAAGCAGGCGATAACAAGGCGCTTCGATAAAATTA
CTGAGAAAGGAAAGATCCCCGATATATTGTTTATCGACGGTGGTATAGGTCAGTTACGCATCGCTCAGAAAGTGGTGGAT
GAGCAATTTGTAGCGCTAGACAATGCACCGACACTGATAGGTGTGGCAAAGGGGGAGGGACGAAAGCCTGGGCTTGAAAC
GCTTATCTACGGTGAGAGTGAAGAGTCATTTTCACTCCCCGCAGATTCCGGAGCCTTACACCTTATCCAACATATTCGTG
ATGAGTCTCATCGTTTTGCGATTACTGGCCATAGAAATAAACGACAGAAAACACGTAATACTTCTACTCTAGAGACGATT
GCAGGAGTGGGACCTAAACGTCGTAAAGCATTACTGCAATATTTAGGCGGATTGCAAGAAGTTAAAGGTGCAAGTGTATC
TGAATTGGCAAAAGTACCCGGTATTAGCTTAGAAATGGCACAAACGATACATGATGCATTGCGAGGGTAA

Upstream 100 bases:

>100_bases
GCTAAGTTAGGCATTGGTGGAGATGTAGAGCTGACTCGTTTAGCTATTCGATATAAAATGTTGGATACTGGACAATTCTA
AATAATTAGCCCCAAACTTT

Downstream 100 bases:

>100_bases
CAAAATTAAGGCAAGATTGGCGCTGCTTTTGAATATTAGGTTCTAAAATGCCGTTTAACATTCCTATTGCGTTAACACTT
TTCAGGTTAGCTCTGCTTCC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALVSHIANIDVTVTHSETDALIL
ENDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRGPKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYK
SRSRPCLQYQIGRCSAPCVDLVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSE
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISD
AFEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDI
SHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVD
EQFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLETI
AGVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMAQTIHDALRG

Sequences:

>Translated_609_residues
MSDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALVSHIANIDVTVTHSETDALIL
ENDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRGPKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYK
SRSRPCLQYQIGRCSAPCVDLVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSE
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISD
AFEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDI
SHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVD
EQFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLETI
AGVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMAQTIHDALRG
>Mature_608_residues
SDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALVSHIANIDVTVTHSETDALILE
NDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRGPKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYKS
RSRPCLQYQIGRCSAPCVDLVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSEQ
QEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISDA
FEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDIS
HTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVDE
QFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLETIA
GVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMAQTIHDALRG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=60.327868852459, Blast_Score=765, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68702; Mature: 68571

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALV
CCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
SHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRG
HHHCCCEEEEEECCCCEEEEECHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCCHHCCC
PKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHEECCCCCCCHHH
LVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSE
HHCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFML
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHH
QFYLNSDSQRLTPKEILISDAFEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTN
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHC
ATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGP
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCC
SKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
EQFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFA
HHHHEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
ITGHRNKRQKTRNTSTLETIAGVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMA
EECCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCHHHHH
QTIHDALRG
HHHHHHHCC
>Mature Secondary Structure 
SDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALV
CCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
SHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRG
HHHCCCEEEEEECCCCEEEEECHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCCHHCCC
PKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHEECCCCCCCHHH
LVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSE
HHCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFML
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHH
QFYLNSDSQRLTPKEILISDAFEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTN
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHC
ATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGP
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCC
SKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
EQFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFA
HHHHEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
ITGHRNKRQKTRNTSTLETIAGVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMA
EECCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCHHHHH
QTIHDALRG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA