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The map label for this gene is uvrY [H]

Identifier: 157961776

GI number: 157961776

Start: 2376525

End: 2377169

Strand: Direct

Name: uvrY [H]

Synonym: Spea_1953

Alternate gene names: 157961776

Gene position: 2376525-2377169 (Clockwise)

Preceding gene: 157961773

Following gene: 157961777

Centisome position: 45.93

GC content: 42.17

Gene sequence:

>645_bases
TTGATCTCAGTATATTTAGTTGATGACCATGAGTTAGTAAGAACCGGTATTAGACGGATCCTCGAAGATGAGAGGGGTAT
TAAAGTCATCGGTGAGGCTGGCGATGGCGAAACTGCTGTGCAGTGGTGCCGCAAAAATGAAGCTGACGTGATTTTGATGG
ATATGAATATGCCGGGTATTGGCGGTTTAGAGGCGACACGTAAGATCTTACGTTTTCAAGCCCATGCCAAGATTATTGTG
CTAACCATTCATACTGAAGATCCTTTTCCGACCAAAGTTATGCAAGCAGGGGCTTCAGGTTATCTAACTAAAGGGGCGAC
TTCTCCAGAAGTACTGCAGGCAATTAGACAAGTGGCTCATGGACAAAGATATTTGTCACCTGAGATTGCTCAACAGATGG
CTCTGAGTCAGTTCAATCAATCTGAAGATAATCCATTTAAGACGTTATCGGAGAGAGAGCTGCAGATCATGCTGATGATC
ACCAATGGTGAAAAAGTGAGTGAGATCTCTGAGCAGTTAAATTTAAGTCCTAAAACAGTCAATAGTTATCGTTATCGTCT
GTTTGCTAAGTTAGGCATTGGTGGAGATGTAGAGCTGACTCGTTTAGCTATTCGATATAAAATGTTGGATACTGGACAAT
TCTAA

Upstream 100 bases:

>100_bases
CTATATGCAGTTAGATGCGATAAATTAACCTTTATAACATTATCAATTTAAGTCTGTTCAATAGCAGAGTTTAAGTTGAG
CTGCGAAAGGTAAGGCGACT

Downstream 100 bases:

>100_bases
ATAATTAGCCCCAAACTTTATGTCTGATGAGTTTAATGCCAATCAATTTTTAAAGACGGTGACATCATCTCCCGGTGTAT
ATCGGATGTATGATGCTAAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVIGEAGDGETAVQWCRKNEADVILMDMNMPGIGGLEATRKILRFQAHAKIIV
LTIHTEDPFPTKVMQAGASGYLTKGATSPEVLQAIRQVAHGQRYLSPEIAQQMALSQFNQSEDNPFKTLSERELQIMLMI
TNGEKVSEISEQLNLSPKTVNSYRYRLFAKLGIGGDVELTRLAIRYKMLDTGQF

Sequences:

>Translated_214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVIGEAGDGETAVQWCRKNEADVILMDMNMPGIGGLEATRKILRFQAHAKIIV
LTIHTEDPFPTKVMQAGASGYLTKGATSPEVLQAIRQVAHGQRYLSPEIAQQMALSQFNQSEDNPFKTLSERELQIMLMI
TNGEKVSEISEQLNLSPKTVNSYRYRLFAKLGIGGDVELTRLAIRYKMLDTGQF
>Mature_214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVIGEAGDGETAVQWCRKNEADVILMDMNMPGIGGLEATRKILRFQAHAKIIV
LTIHTEDPFPTKVMQAGASGYLTKGATSPEVLQAIRQVAHGQRYLSPEIAQQMALSQFNQSEDNPFKTLSERELQIMLMI
TNGEKVSEISEQLNLSPKTVNSYRYRLFAKLGIGGDVELTRLAIRYKMLDTGQF

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=70.6161137440758, Blast_Score=309, Evalue=8e-86,
Organism=Escherichia coli, GI1788521, Length=204, Percent_Identity=34.8039215686275, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=35.8208955223881, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=25.6038647342995, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=26.2135922330097, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=28.9617486338798, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23996; Mature: 23996

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVYLVDDHELVRTGIRRILEDERGIKVIGEAGDGETAVQWCRKNEADVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCC
GGLEATRKILRFQAHAKIIVLTIHTEDPFPTKVMQAGASGYLTKGATSPEVLQAIRQVAH
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHCCCCCCEECCCCCHHHHHHHHHHHC
GQRYLSPEIAQQMALSQFNQSEDNPFKTLSERELQIMLMITNGEKVSEISEQLNLSPKTV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCHH
NSYRYRLFAKLGIGGDVELTRLAIRYKMLDTGQF
HHHHEEEEEEECCCCCCHHHHHEEHHEECCCCCC
>Mature Secondary Structure
MISVYLVDDHELVRTGIRRILEDERGIKVIGEAGDGETAVQWCRKNEADVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCC
GGLEATRKILRFQAHAKIIVLTIHTEDPFPTKVMQAGASGYLTKGATSPEVLQAIRQVAH
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHCCCCCCEECCCCCHHHHHHHHHHHC
GQRYLSPEIAQQMALSQFNQSEDNPFKTLSERELQIMLMITNGEKVSEISEQLNLSPKTV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCHH
NSYRYRLFAKLGIGGDVELTRLAIRYKMLDTGQF
HHHHEEEEEEECCCCCCHHHHHEEHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]