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The map label for this gene is melA [H]

Identifier: 157961697

GI number: 157961697

Start: 2283981

End: 2285021

Strand: Reverse

Name: melA [H]

Synonym: Spea_1873

Alternate gene names: 157961697

Gene position: 2285021-2283981 (Counterclockwise)

Preceding gene: 157961698

Following gene: 157961693

Centisome position: 44.16

GC content: 43.32

Gene sequence:

>1041_bases
ATGGCAAGCGAACAAAACCCACTGGGTCTACTCGGTATCGAATTCACTGAGTTTGCAACACCCGAACAAGACTTTATGCA
TCAGGTCTTTATTGATTTCGGCTTTTCATTGTTGAAAAAGTCAAAGTCCAAAGAGATTTTGTACTACAAACAAAACGATA
TTAACTTTCTATTGAATACCGAACGTAAAGGGTTTTCAGCAGAGTTTGCCAAGAGCCATGGTCCGGCAATATGTTCAATG
GGCTGGCGTGTAGAAGACGCCCAATTTGCGTTCGAAAATGCCGTTGCTCGTGGTGCAAAACCTGCAGATGATGCAGCAAA
AGATATGCCTTACCCTGCAATTTATGGCATTGGCGATAGCTTAATTTACTTTATCGATACCTTCGGCGAAAACGATAATA
TCTATGCCACAGATTTTGACGATCTAGACGAGCAAGTTATTGTTGAGGAGAAAGGCTTTATCGAAGTCGACCACCTTACC
AACAATGTCTACAAAGGCACCATGGAGTACTGGTCAAATTTCTATAAAGATATCTTTGGCTTTACCGAAGTGCGTTACTT
TGACATTAAAGGCTCGCAAACCGCGCTTATCTCTTACGCGCTGCGCTCACCCGATGGCAGCTTCTGTATTCCGATCAACG
AAGGTAAAGGCAACGACAAAAATCAGATTGATGAATACTTACGTGAATACGACGGTCCAGGTGTACAGCACCTTGCCTTT
AGAAGCCGCGATATTGTTGGTTCACTCGATGCGATGGAAGGCACATCGATTCAAACCTTAGATATTATTCCTGAGTATTA
CGACACCATTTTCGACAAGTTGCCACAGGTAACCGAAGATCGTGACCGCATTAAGCATCACCAAATTCTGGTCGACGGCG
ATGAAGATGGTTACCTACTGCAGATCTTTACTAAGAATCTTTTTGGGCCAATTTTTATCGAGATCATCCAGCGTAAAAAT
AATCTCGGCTTCGGTGAAGGTAACTTTACCGCACTGTTTGAGTCGATTGAGCGTGATCAAAAGCGCCGTGGCGTGCTTTA
A

Upstream 100 bases:

>100_bases
TTGAAAGCTAACAAAACGATTTTTCAAGACTTTAAGCCATCATCAGAAGCCATCGACAGAGTGGCTGGTATGTAGCAACA
AATTGACAGAGGATATAACA

Downstream 100 bases:

>100_bases
ATAGTAGATAAAGCAATTCACCACAGAGGACACGAAGCTCACGGAGAAAAGCAACAACCAAGGTCTAGTAGACTCTTTAC
CTTGGCATTCTTTGTGTTCT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MASEQNPLGLLGIEFTEFATPEQDFMHQVFIDFGFSLLKKSKSKEILYYKQNDINFLLNTERKGFSAEFAKSHGPAICSM
GWRVEDAQFAFENAVARGAKPADDAAKDMPYPAIYGIGDSLIYFIDTFGENDNIYATDFDDLDEQVIVEEKGFIEVDHLT
NNVYKGTMEYWSNFYKDIFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGNDKNQIDEYLREYDGPGVQHLAF
RSRDIVGSLDAMEGTSIQTLDIIPEYYDTIFDKLPQVTEDRDRIKHHQILVDGDEDGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFESIERDQKRRGVL

Sequences:

>Translated_346_residues
MASEQNPLGLLGIEFTEFATPEQDFMHQVFIDFGFSLLKKSKSKEILYYKQNDINFLLNTERKGFSAEFAKSHGPAICSM
GWRVEDAQFAFENAVARGAKPADDAAKDMPYPAIYGIGDSLIYFIDTFGENDNIYATDFDDLDEQVIVEEKGFIEVDHLT
NNVYKGTMEYWSNFYKDIFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGNDKNQIDEYLREYDGPGVQHLAF
RSRDIVGSLDAMEGTSIQTLDIIPEYYDTIFDKLPQVTEDRDRIKHHQILVDGDEDGYLLQIFTKNLFGPIFIEIIQRKN
NLGFGEGNFTALFESIERDQKRRGVL
>Mature_345_residues
ASEQNPLGLLGIEFTEFATPEQDFMHQVFIDFGFSLLKKSKSKEILYYKQNDINFLLNTERKGFSAEFAKSHGPAICSMG
WRVEDAQFAFENAVARGAKPADDAAKDMPYPAIYGIGDSLIYFIDTFGENDNIYATDFDDLDEQVIVEEKGFIEVDHLTN
NVYKGTMEYWSNFYKDIFGFTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGNDKNQIDEYLREYDGPGVQHLAFR
SRDIVGSLDAMEGTSIQTLDIIPEYYDTIFDKLPQVTEDRDRIKHHQILVDGDEDGYLLQIFTKNLFGPIFIEIIQRKNN
LGFGEGNFTALFESIERDQKRRGVL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=335, Percent_Identity=28.6567164179104, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI4504477, Length=335, Percent_Identity=28.6567164179104, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI14249394, Length=212, Percent_Identity=26.8867924528302, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=203, Percent_Identity=39.4088669950739, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=210, Percent_Identity=37.6190476190476, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356105, Length=301, Percent_Identity=33.5548172757475, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24667510, Length=301, Percent_Identity=33.5548172757475, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39527; Mature: 39395

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEQNPLGLLGIEFTEFATPEQDFMHQVFIDFGFSLLKKSKSKEILYYKQNDINFLLNT
CCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC
ERKGFSAEFAKSHGPAICSMGWRVEDAQFAFENAVARGAKPADDAAKDMPYPAIYGIGDS
CCCCCCHHHHHCCCCEEEECCCEECHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEECCCC
LIYFIDTFGENDNIYATDFDDLDEQVIVEEKGFIEVDHLTNNVYKGTMEYWSNFYKDIFG
EEEEEEECCCCCCEEECCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHC
FTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGNDKNQIDEYLREYDGPGVQHLAF
CCEEEEEECCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVGSLDAMEGTSIQTLDIIPEYYDTIFDKLPQVTEDRDRIKHHQILVDGDEDGYLL
HCCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEECCCCCEEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFESIERDQKRRGVL
EEEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASEQNPLGLLGIEFTEFATPEQDFMHQVFIDFGFSLLKKSKSKEILYYKQNDINFLLNT
CCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC
ERKGFSAEFAKSHGPAICSMGWRVEDAQFAFENAVARGAKPADDAAKDMPYPAIYGIGDS
CCCCCCHHHHHCCCCEEEECCCEECHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEECCCC
LIYFIDTFGENDNIYATDFDDLDEQVIVEEKGFIEVDHLTNNVYKGTMEYWSNFYKDIFG
EEEEEEECCCCCCEEECCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHC
FTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGNDKNQIDEYLREYDGPGVQHLAF
CCEEEEEECCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHH
RSRDIVGSLDAMEGTSIQTLDIIPEYYDTIFDKLPQVTEDRDRIKHHQILVDGDEDGYLL
HCCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEECCCCCEEE
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFTALFESIERDQKRRGVL
EEEHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756973 [H]