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The map label for this gene is aslA [H]

Identifier: 157961559

GI number: 157961559

Start: 2110589

End: 2112115

Strand: Direct

Name: aslA [H]

Synonym: Spea_1735

Alternate gene names: 157961559

Gene position: 2110589-2112115 (Clockwise)

Preceding gene: 157961551

Following gene: 157961560

Centisome position: 40.79

GC content: 46.95

Gene sequence:

>1527_bases
ATGAAAACATTCACCAAAACGATGTTATCAAAAGCGGTACTAGGCATGGCAGTGGTCTCTACTGCTGTCGCGGCCCCAGC
TATGGCTAAAAATGAATCTGAAAAGCCGAATATTCTAGTCATCATGGCAGACGATATTGGTTGGTCAAATACTTCTGCAT
ATAACATGGGAATGATGGGATATAAAACACCTAACATTGACCGTATCGCCAAAGAGGGGATGTTATTCACCGACCACTAT
GGCCAGCCTAGCTCAACCGCAGGGCGTGCTGCTTTTTTAACGGGTCAGCTACCAATCCGTACCGGACTACTTACTGTCGG
AATGCCGGGTTCGCCAATCGGGATCTCAAAAGAGGATCCCACCCTTGCCGAGGTGATGAAAGATCAAGGTTATATGACGG
TGCAACTAGGTAAAAACCACTTAGGCGACCAGGAGCATATGCTACCTCATCGTCGTGGTTTTGATTATTTCTACGGCAAT
CTTTATCACCTAAATGCAGAGGAGGAGCCTGAGAATGAGGATTACCCGAAAGACCCTGAATTCTTAGAGCGTTTCGGACC
TCGCGGTATTGTTGAGGGGCACGCAGATGGTGAAACTGGCTCTGGCGGACCATTAACGAAGAAGCGTATGGAAACCATCG
ACCGTGAGTTAACGGATATGGCGGTAGATTACATTGAAGAGAGTGCCAAGAAAGATGAGCCATTCTTCATGTGGTATAAC
CCTTCACGTATGCATGTATGGACTCACTTAAGTGAAAAGTGGAAAGGAAAGACAGGTTACGGTCTATATGCTGACGGTAT
GGCTGAGCTAGATAGTTATGTCGGTGAGATTTTAGAAACTCTAGAGAAGACTGGCCAGCGTGATAACACCATTATTATCT
TCACGACCGATAACGGTGCTGAGAAGATGAGTTGGCCAGATGGGGGCAACACGCCATTTAAAGGTGAGAAGGGCTTGACG
ACCGAAGGTGGCGTCCGCGTACCATTTATGGTGAGCTGGCCAGGTAAGATCCCTGCTGGTAGCGTCAATAACGGTATTCA
GTCCCATGAAGACTTGTTTACGACCTTAGCAACCTTTGCCGGAGAAAAAGACATTCAGGAAAGCTTTAAGAAGAAGCACG
ATGTCTATATCGATGGTTATGATCACACCCAAGCTTGGCTAACCAATGAAGATACTCCCCGTAACGAGATCTTCTATTTT
GCTGAAACGGGTAACCTTGAAGCGGTGCGAGTCGGTAAGATTAAGGCGACCTTTATTCAGCCTCTAGAGGAGAGCTGGTT
TGCTCCACGCTTAGCAACTCAGTGGCCACAGCTTGTTGACCTTCGTGCAGACCCTTATGAAGAAGCACCTGAGCACTCAG
GCATGTACCTAAAGTGGTTTGCTGAGCGTATGTACAACTTTGTCCCCGTACAAGTTGAGGTCGCTAAACTACTTGGCACT
TTCCAAGAGTTCCCATTAAGACAGGAGCCTGCTTCGTTTAACTTAGAAAGAGTTATTGAGCAACTTCCATACCGAGAGAA
CCGTTAG

Upstream 100 bases:

>100_bases
ACAAATAATACTAACTGTAATGACTGCTTTAGGAATAGTCCTAGTTCGATTTTGTTTGAGTAGCCTTGATACTAGCTCCA
TCTAAAATGAGGAGTGAACA

Downstream 100 bases:

>100_bases
ACCTCTCTTACCTGAGGGCGCATTAGGCGCCCTCTGTTCCCTGCAAATACAAAAACAGTAAACGCACTTTCCCGTACATA
ATCGAGTCCAAAGGTGAGCT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKTFTKTMLSKAVLGMAVVSTAVAAPAMAKNESEKPNILVIMADDIGWSNTSAYNMGMMGYKTPNIDRIAKEGMLFTDHY
GQPSSTAGRAAFLTGQLPIRTGLLTVGMPGSPIGISKEDPTLAEVMKDQGYMTVQLGKNHLGDQEHMLPHRRGFDYFYGN
LYHLNAEEEPENEDYPKDPEFLERFGPRGIVEGHADGETGSGGPLTKKRMETIDRELTDMAVDYIEESAKKDEPFFMWYN
PSRMHVWTHLSEKWKGKTGYGLYADGMAELDSYVGEILETLEKTGQRDNTIIIFTTDNGAEKMSWPDGGNTPFKGEKGLT
TEGGVRVPFMVSWPGKIPAGSVNNGIQSHEDLFTTLATFAGEKDIQESFKKKHDVYIDGYDHTQAWLTNEDTPRNEIFYF
AETGNLEAVRVGKIKATFIQPLEESWFAPRLATQWPQLVDLRADPYEEAPEHSGMYLKWFAERMYNFVPVQVEVAKLLGT
FQEFPLRQEPASFNLERVIEQLPYRENR

Sequences:

>Translated_508_residues
MKTFTKTMLSKAVLGMAVVSTAVAAPAMAKNESEKPNILVIMADDIGWSNTSAYNMGMMGYKTPNIDRIAKEGMLFTDHY
GQPSSTAGRAAFLTGQLPIRTGLLTVGMPGSPIGISKEDPTLAEVMKDQGYMTVQLGKNHLGDQEHMLPHRRGFDYFYGN
LYHLNAEEEPENEDYPKDPEFLERFGPRGIVEGHADGETGSGGPLTKKRMETIDRELTDMAVDYIEESAKKDEPFFMWYN
PSRMHVWTHLSEKWKGKTGYGLYADGMAELDSYVGEILETLEKTGQRDNTIIIFTTDNGAEKMSWPDGGNTPFKGEKGLT
TEGGVRVPFMVSWPGKIPAGSVNNGIQSHEDLFTTLATFAGEKDIQESFKKKHDVYIDGYDHTQAWLTNEDTPRNEIFYF
AETGNLEAVRVGKIKATFIQPLEESWFAPRLATQWPQLVDLRADPYEEAPEHSGMYLKWFAERMYNFVPVQVEVAKLLGT
FQEFPLRQEPASFNLERVIEQLPYRENR
>Mature_508_residues
MKTFTKTMLSKAVLGMAVVSTAVAAPAMAKNESEKPNILVIMADDIGWSNTSAYNMGMMGYKTPNIDRIAKEGMLFTDHY
GQPSSTAGRAAFLTGQLPIRTGLLTVGMPGSPIGISKEDPTLAEVMKDQGYMTVQLGKNHLGDQEHMLPHRRGFDYFYGN
LYHLNAEEEPENEDYPKDPEFLERFGPRGIVEGHADGETGSGGPLTKKRMETIDRELTDMAVDYIEESAKKDEPFFMWYN
PSRMHVWTHLSEKWKGKTGYGLYADGMAELDSYVGEILETLEKTGQRDNTIIIFTTDNGAEKMSWPDGGNTPFKGEKGLT
TEGGVRVPFMVSWPGKIPAGSVNNGIQSHEDLFTTLATFAGEKDIQESFKKKHDVYIDGYDHTQAWLTNEDTPRNEIFYF
AETGNLEAVRVGKIKATFIQPLEESWFAPRLATQWPQLVDLRADPYEEAPEHSGMYLKWFAERMYNFVPVQVEVAKLLGT
FQEFPLRQEPASFNLERVIEQLPYRENR

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=402, Percent_Identity=32.8358208955224, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229329, Length=402, Percent_Identity=32.8358208955224, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI6005990, Length=402, Percent_Identity=32.8358208955224, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229324, Length=402, Percent_Identity=32.8358208955224, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4503899, Length=412, Percent_Identity=32.7669902912621, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI45430057, Length=456, Percent_Identity=29.1666666666667, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI157266309, Length=434, Percent_Identity=29.0322580645161, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI146229327, Length=328, Percent_Identity=30.4878048780488, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI58743319, Length=403, Percent_Identity=29.7766749379653, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38569407, Length=385, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI38569405, Length=385, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI59797060, Length=484, Percent_Identity=26.4462809917355, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI31742482, Length=163, Percent_Identity=36.1963190184049, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI53831991, Length=143, Percent_Identity=38.4615384615385, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71852586, Length=150, Percent_Identity=37.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71852584, Length=150, Percent_Identity=36.6666666666667, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI109389362, Length=135, Percent_Identity=34.8148148148148, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1790233, Length=404, Percent_Identity=36.1386138613861, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87081924, Length=374, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI115533416, Length=355, Percent_Identity=27.887323943662, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=342, Percent_Identity=27.4853801169591, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559078, Length=274, Percent_Identity=30.2919708029197, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281366397, Length=494, Percent_Identity=28.1376518218623, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI281366395, Length=494, Percent_Identity=28.1376518218623, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24666163, Length=494, Percent_Identity=28.1376518218623, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24666175, Length=368, Percent_Identity=29.3478260869565, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24666109, Length=400, Percent_Identity=28.25, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI281363223, Length=422, Percent_Identity=27.0142180094787, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57246; Mature: 57246

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFTKTMLSKAVLGMAVVSTAVAAPAMAKNESEKPNILVIMADDIGWSNTSAYNMGMMG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCCCEECCCCC
YKTPNIDRIAKEGMLFTDHYGQPSSTAGRAAFLTGQLPIRTGLLTVGMPGSPIGISKEDP
CCCCCHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCEECEEEECCCCCCCCCCCCCC
TLAEVMKDQGYMTVQLGKNHLGDQEHMLPHRRGFDYFYGNLYHLNAEEEPENEDYPKDPE
HHHHHHHCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHH
FLERFGPRGIVEGHADGETGSGGPLTKKRMETIDRELTDMAVDYIEESAKKDEPFFMWYN
HHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PSRMHVWTHLSEKWKGKTGYGLYADGMAELDSYVGEILETLEKTGQRDNTIIIFTTDNGA
CCEEEEEEEHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EKMSWPDGGNTPFKGEKGLTTEGGVRVPFMVSWPGKIPAGSVNNGIQSHEDLFTTLATFA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GEKDIQESFKKKHDVYIDGYDHTQAWLTNEDTPRNEIFYFAETGNLEAVRVGKIKATFIQ
CCHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCEEEEEEECCCEEEEEECCCHHHHHH
PLEESWFAPRLATQWPQLVDLRADPYEEAPEHSGMYLKWFAERMYNFVPVQVEVAKLLGT
HHHHHHCCCHHHHCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
FQEFPLRQEPASFNLERVIEQLPYRENR
HHHCCCCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTFTKTMLSKAVLGMAVVSTAVAAPAMAKNESEKPNILVIMADDIGWSNTSAYNMGMMG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCCCEECCCCC
YKTPNIDRIAKEGMLFTDHYGQPSSTAGRAAFLTGQLPIRTGLLTVGMPGSPIGISKEDP
CCCCCHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCEECEEEECCCCCCCCCCCCCC
TLAEVMKDQGYMTVQLGKNHLGDQEHMLPHRRGFDYFYGNLYHLNAEEEPENEDYPKDPE
HHHHHHHCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHH
FLERFGPRGIVEGHADGETGSGGPLTKKRMETIDRELTDMAVDYIEESAKKDEPFFMWYN
HHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PSRMHVWTHLSEKWKGKTGYGLYADGMAELDSYVGEILETLEKTGQRDNTIIIFTTDNGA
CCEEEEEEEHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EKMSWPDGGNTPFKGEKGLTTEGGVRVPFMVSWPGKIPAGSVNNGIQSHEDLFTTLATFA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GEKDIQESFKKKHDVYIDGYDHTQAWLTNEDTPRNEIFYFAETGNLEAVRVGKIKATFIQ
CCHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCEEEEEEECCCEEEEEECCCHHHHHH
PLEESWFAPRLATQWPQLVDLRADPYEEAPEHSGMYLKWFAERMYNFVPVQVEVAKLLGT
HHHHHHCCCHHHHCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
FQEFPLRQEPASFNLERVIEQLPYRENR
HHHCCCCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]