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The map label for this gene is galK [H]

Identifier: 157961458

GI number: 157961458

Start: 1977417

End: 1978601

Strand: Direct

Name: galK [H]

Synonym: Spea_1632

Alternate gene names: 157961458

Gene position: 1977417-1978601 (Clockwise)

Preceding gene: 157961457

Following gene: 157961461

Centisome position: 38.21

GC content: 47.0

Gene sequence:

>1185_bases
ATGGATGAACTTACAATACGCGATAGGTTCAAGCAGCTCTACCAAGTCGAGGCCGACATAGTCGCCTATGCACCTGGGCG
GGTTAATATTATTGGCGATCATACCGATTATAACGATGGCTTTGTATTGCCTGCCGCCATTGATATGGGGACCTATGTTG
CGGCGCAAAAGCGTGATGATCTTGGTATTAATGTGATAGCAAATGATCTTAATGGCGTGAGAGTTAGCTTTAGTCTGGAT
GCGATTAGCTTTGACGAGCAAGTAGGCTGGGGTCATTACGTTAAAGGTGTAATACAAGCCTTATTAAGCCATTTTGATTC
ACTCGATAGCCCCTTTAGTAAACCTATTGATAGAACTGGAACGATGCAAGGTTGCAACCTCTTGATCAGCGGCAACATTC
CACAGGGAGCAGGGTTAAGCTCGTCGGCTTCTCTCGAAATCGCACTGATCAAAGCCATTACTCAGCTATATGACCTTCCT
ATGGACGGTATTGGTGCTGCATTGATTGGTCAGCAAGCCGAAAATGTTTATGTGGGTTGTAACTGCGGCATCATGGATCA
GCTTATTTCGGCATTGGGACAAGATCATCAAGCCATGCTGCTCGACTGTAATGACTTAAGTTATCGTTACGTCACCATTG
ATGAATCGTTGCAAGTGCTGGTGATTAACTCCAATGTCCAGCGCCAGCTCGTGGGAAGCGAATACAACGATAGGCGAGAA
CAGTGCAATCAAGTCGCGCAATTTTTTAATCAGTCTTCGTTACGCCATATCAGTATACAAGAGTTAGAGGCGGCAGAAGG
GGATCTTCCTGAGCTGTTATTTAAGCGTGCACGGCACGTGATCCTAGAAAGCAGTCGAACCTTACAGGCATTTGAGGCGC
TAGCCTTAGGTGATATTGCTAAGATGAGTCAGTTAATGCAAGACTCGCATGCTTCCCTGAGAGAAGATTTTGAGGTGACC
ACTGCAGAGGTCGATTACCTGGTTAACTGTGTTTCTGAGGTTATTGGCAGTCATGGCGGCGTGAGAATGACAGGTGGGGG
CTTTGGAGGCTGTGTTATTGCTCTAGTGCCCCATGGTCTGGTCGATGCTGTTACAGCTGTGATTGAGCGTGATTACCACA
GAGAAACCGGTCTCAAGGCCGATATATATAGCTGCTCGGCTAAAGCGGGCGCCTTTAGCGCTTAA

Upstream 100 bases:

>100_bases
TTACGCCTGAGCAGGCCGCGTCACGCCTACGGGGTGCCCGTGGTATTCATTACAAATTGAAGCCATACAAATTGAAGCCA
TGCAAATTGGAGCAAGAGTA

Downstream 100 bases:

>100_bases
GGGGGAGCGCTTAATGGATAGTTCTTAAGGGGTGGTTCTTAAGAGAGAGTGTCTCAGGATTTAATTAGTTAAATGTTGTT
GTATCAACGAGGCTTATATT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MDELTIRDRFKQLYQVEADIVAYAPGRVNIIGDHTDYNDGFVLPAAIDMGTYVAAQKRDDLGINVIANDLNGVRVSFSLD
AISFDEQVGWGHYVKGVIQALLSHFDSLDSPFSKPIDRTGTMQGCNLLISGNIPQGAGLSSSASLEIALIKAITQLYDLP
MDGIGAALIGQQAENVYVGCNCGIMDQLISALGQDHQAMLLDCNDLSYRYVTIDESLQVLVINSNVQRQLVGSEYNDRRE
QCNQVAQFFNQSSLRHISIQELEAAEGDLPELLFKRARHVILESSRTLQAFEALALGDIAKMSQLMQDSHASLREDFEVT
TAEVDYLVNCVSEVIGSHGGVRMTGGGFGGCVIALVPHGLVDAVTAVIERDYHRETGLKADIYSCSAKAGAFSA

Sequences:

>Translated_394_residues
MDELTIRDRFKQLYQVEADIVAYAPGRVNIIGDHTDYNDGFVLPAAIDMGTYVAAQKRDDLGINVIANDLNGVRVSFSLD
AISFDEQVGWGHYVKGVIQALLSHFDSLDSPFSKPIDRTGTMQGCNLLISGNIPQGAGLSSSASLEIALIKAITQLYDLP
MDGIGAALIGQQAENVYVGCNCGIMDQLISALGQDHQAMLLDCNDLSYRYVTIDESLQVLVINSNVQRQLVGSEYNDRRE
QCNQVAQFFNQSSLRHISIQELEAAEGDLPELLFKRARHVILESSRTLQAFEALALGDIAKMSQLMQDSHASLREDFEVT
TAEVDYLVNCVSEVIGSHGGVRMTGGGFGGCVIALVPHGLVDAVTAVIERDYHRETGLKADIYSCSAKAGAFSA
>Mature_394_residues
MDELTIRDRFKQLYQVEADIVAYAPGRVNIIGDHTDYNDGFVLPAAIDMGTYVAAQKRDDLGINVIANDLNGVRVSFSLD
AISFDEQVGWGHYVKGVIQALLSHFDSLDSPFSKPIDRTGTMQGCNLLISGNIPQGAGLSSSASLEIALIKAITQLYDLP
MDGIGAALIGQQAENVYVGCNCGIMDQLISALGQDHQAMLLDCNDLSYRYVTIDESLQVLVINSNVQRQLVGSEYNDRRE
QCNQVAQFFNQSSLRHISIQELEAAEGDLPELLFKRARHVILESSRTLQAFEALALGDIAKMSQLMQDSHASLREDFEVT
TAEVDYLVNCVSEVIGSHGGVRMTGGGFGGCVIALVPHGLVDAVTAVIERDYHRETGLKADIYSCSAKAGAFSA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=369, Percent_Identity=40.650406504065, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI4503897, Length=429, Percent_Identity=25.4079254079254, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI48527957, Length=431, Percent_Identity=26.2180974477958, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786972, Length=383, Percent_Identity=48.8250652741514, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71989053, Length=416, Percent_Identity=28.8461538461538, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319494, Length=210, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=210, Percent_Identity=31.4285714285714, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661292, Length=435, Percent_Identity=26.2068965517241, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355577, Length=435, Percent_Identity=26.2068965517241, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24661285, Length=435, Percent_Identity=26.2068965517241, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42787; Mature: 42787

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELTIRDRFKQLYQVEADIVAYAPGRVNIIGDHTDYNDGFVLPAAIDMGTYVAAQKRDD
CCCCCHHHHHHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEEEEHHCCCHHHHHCCCCC
LGINVIANDLNGVRVSFSLDAISFDEQVGWGHYVKGVIQALLSHFDSLDSPFSKPIDRTG
CCEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TMQGCNLLISGNIPQGAGLSSSASLEIALIKAITQLYDLPMDGIGAALIGQQAENVYVGC
CCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEC
NCGIMDQLISALGQDHQAMLLDCNDLSYRYVTIDESLQVLVINSNVQRQLVGSEYNDRRE
CCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCCHHHHHCCCCHHHHH
QCNQVAQFFNQSSLRHISIQELEAAEGDLPELLFKRARHVILESSRTLQAFEALALGDIA
HHHHHHHHHCCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KMSQLMQDSHASLREDFEVTTAEVDYLVNCVSEVIGSHGGVRMTGGGFGGCVIALVPHGL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEHHCCHH
VDAVTAVIERDYHRETGLKADIYSCSAKAGAFSA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MDELTIRDRFKQLYQVEADIVAYAPGRVNIIGDHTDYNDGFVLPAAIDMGTYVAAQKRDD
CCCCCHHHHHHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEEEEHHCCCHHHHHCCCCC
LGINVIANDLNGVRVSFSLDAISFDEQVGWGHYVKGVIQALLSHFDSLDSPFSKPIDRTG
CCEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TMQGCNLLISGNIPQGAGLSSSASLEIALIKAITQLYDLPMDGIGAALIGQQAENVYVGC
CCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEC
NCGIMDQLISALGQDHQAMLLDCNDLSYRYVTIDESLQVLVINSNVQRQLVGSEYNDRRE
CCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCCHHHHHCCCCHHHHH
QCNQVAQFFNQSSLRHISIQELEAAEGDLPELLFKRARHVILESSRTLQAFEALALGDIA
HHHHHHHHHCCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KMSQLMQDSHASLREDFEVTTAEVDYLVNCVSEVIGSHGGVRMTGGGFGGCVIALVPHGL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEHHCCHH
VDAVTAVIERDYHRETGLKADIYSCSAKAGAFSA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA