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The map label for this gene is nanH [H]

Identifier: 157961341

GI number: 157961341

Start: 1838982

End: 1841831

Strand: Direct

Name: nanH [H]

Synonym: Spea_1515

Alternate gene names: 157961341

Gene position: 1838982-1841831 (Clockwise)

Preceding gene: 157961340

Following gene: 157961343

Centisome position: 35.54

GC content: 44.98

Gene sequence:

>2850_bases
ATGCTGAGAACAATTACATTAACGGCGCTATTCATTACTTTATGCTCAATGGGCTTTAGTAGTGGATATGCGCAAGCAAA
TACATTGGTCGCAAATTTTGATGCGATGAATGAAACAAGCCCAACGATCCAAGGTTGGAGTGATTTCCTTTCGGGGCAAG
CAACAGGCTCAGTTGCGCAAGATTTAAATGCCGCAAGTTGGAAGTCAACGGGAAGCAGCGGCAGAGCGCAATGGAATATG
GTTCCAACTACCGAGCTTAATAATGAGGCTAGTCTAAAAGGTTGGCGAATGAGCTGGACTAGTCGCGTTGAGTCTGGCGG
CTATATCACTGATTACTATGCAAATGGTGCTTTGCGTTTTCTACCAATATTGAGTATTAGTGCGTCGGGAGATTTAGTCG
TAAACCTAGTTGGGGGAGGTGAACATACATTAGTTTCAGGAACGGGAGCGGATAGCTATCATCAATACGTTGTTGAGTAT
GATCCACTTACTCAACTTGCTAGTTTCAGCTTTGATGGAGTGATAATTGATCCTGCCTGGGTTGGTGAGGCCAGCAACCA
AAATATGATTGCATGGGGAAATGGTTCATCAAACATTAATGGCGTTGCTTATTATAGAGCTGTCACCTTTGAGACGCTCA
GCGAAACCGTGCCAGAAGAAGCTAAGATTATTGCAGCGTGGGACTCATCTGGGGTCACCTTTGATGGCGAAAGCCAATTT
ATATCGATTAATACCGAGCTTGCATCTGTACAGCAACTGGCCCGAGGTAGCATATTTACCAAGTTTAAAGCCACTGGTAC
AACAGCAACTCTTTTTAGTGCTTCCAATTCAGCCGTAGGTTCAAGTGAATTTGCAATACTGATTAACGGTGATGGCACAT
TACGGGTGCATGCTCGAGAGAACGGCAGTTTTGTCAATGACTCAAAAACCGTCACCACATTCAATAATAATCAAGAGCAC
AAAGCACTGATTATGGTAGATGCAAACGGTACCCAAATCTATGTCGATGGCCGGTTAGCATTCAGTGGTAATGCAACTAG
CTTTCTTAGCGCCATTGCGGGATTAGATAGCATGAATATTGGTCGTAACCATGATAGTAATGGTGGCCAATGGTATTTCA
GCGGCACCATCGATGAAACTCGTATTTATGACAATGTACTGACGGCAGAGCAAGCTGAGGATCTCACTCGGTTATCGACT
GTGGTGGCGACTTTTGATAGTAACCTCAATACCGATCCCCTCTTGGCTGGCTGGACAAATGATAGTGTGGACTCTGGCGC
AGGCAGCTTAGTTAACGAACAAGGTCAAGCTGCTTGGCAGGCTAGAGGTATAAATGGCCGAGCTGAGTGGGAAATACAGC
CTAGCGTGCAAGTTAATCGAGATGCGACAACCTTAGGCTGGAAAATGACCACCACAAGTCGAATCGTGTCGGGCAGTGCG
ATTTCTGATTACTACGCAAATGGTAATAAACGCTTTTTAGCTTTGTTAAGTATCAATGGCAATGGTGACTTAGTCGCAGC
GTTGGAGGGAGGCAGTAGTCATACATTAGTGCCGATGACTGGTGCAGATAAGTACCATACCTATGAAGTGACTTACGATG
TTGAAACGAGCTTAGCGACGTTTTATTTTGACGGTATTGCAATCGAAACTTGGGCTGGTTCTGCTACCAGTCAGAATGTC
ATAGTGTGGGGAAATGGCTCTTCTGGCACAAATGGTGTTGCCAATTACCGTTATGTCAACTTTGAGACCTTTGGTAGTGG
TCCGGCTATCTTTGAAAGTATTGTTTTTCAAGGAGGTCAAGAAGGCGATGATGGTATGAGTCATTATCGAATCCCTTCCA
TGGTCCAATCTGCAGATGGCTCAATACTGGCGTTTATTGAAGGCCGTCCAAGTGGTGGAGATCCTGGGCAAGTGGGTCAG
ATTAACATCTCTTTAAAACGTTCAATTGATAATGGACGTAGCTGGCTACCTGTGCAGATTATTCATCAAGATCCAGCGTT
TGATTATTCAGATCCCCGTCCATTTGTTGATAAATCGACAAATACGGTTTATGTATTTTATGTGCAGTGGCCAGACTTAT
GTGCGCAAAATGGCAACTGTGTCGCCCCTGATGATGCCAACTATTTGTATTATCGAAAAAGTATTGATAATGGACTGACA
TGGTCAGCCGCAGTAGATGTTACTTCGCAAGTTAAAGATCCGACTTGGCGATCAATAAACCCAGGCCCAGGACAAGGGAT
CCAATTGCAATGGCAGACTTTAGCTCAAGGTGAGCACAATGGCAGAATGATTTTTCCAGCCATAGTGCGTGCTGGTAATA
GCCTTTTTTATGTTGCGACAGTGTTTAGTGACGACAATGGCTTAACTTGGCATAAAGGTGAGTTTACGCCTGTTTCTGGA
CCGACCGAAGCTGATATGGTTGAGCTTAATGATGGAACATTATTATTGTCCGCTCGCAATGATGGGGGGGCAGCAGGTAC
TCGTTATCACTTCTTGAGTCATGATGGCGGGATCACCTGGACGCAAACAAGTCATGACTTGGCTGTTTCTAAGGTTGATA
TTGGGCTCACCCGATTTTCAGCGATAAGAGCGGGAGATGCTGAAGATCTTATCATTGCTACTGCGCCCATAGGTACAACA
TCAGGCCCTAATCGTAATAACTTGGGGATTTGGGTCAGTACCGATGAAGGGGCTAATTTTGGCACTCCTCATCAATTAGT
TTATGGCATGAGTGCCTATTCTGATGTGGTAAGGTTAAATGACGGCTCTATTGGTGTGATTTATGAGGCGACGGGAAGCA
CGCTGTTGAAGTTTCTAAACTTTGAGCTGAGCAGCCTTGAGCGGCAGTAG

Upstream 100 bases:

>100_bases
GTGGTTCAGGATGTATAACGTGAGTAAAGGCACCTTTAAATTATCAGCCACTTATTGCTGGCTTTGTCATGGATAACACT
TAATTTATAAAGGTGACATT

Downstream 100 bases:

>100_bases
GCTGGCTGTTTTACAGTGCTATCCATGGCTATGAAATAGAAACTTAGACTGTTAGCTATAAGTATGGCTAACAGTCTAGA
TTTCGAGCCGTTAAGCTAAG

Product: exo-alpha-sialidase

Products: NA

Alternate protein names: Neuraminidase; NANase [H]

Number of amino acids: Translated: 949; Mature: 949

Protein sequence:

>949_residues
MLRTITLTALFITLCSMGFSSGYAQANTLVANFDAMNETSPTIQGWSDFLSGQATGSVAQDLNAASWKSTGSSGRAQWNM
VPTTELNNEASLKGWRMSWTSRVESGGYITDYYANGALRFLPILSISASGDLVVNLVGGGEHTLVSGTGADSYHQYVVEY
DPLTQLASFSFDGVIIDPAWVGEASNQNMIAWGNGSSNINGVAYYRAVTFETLSETVPEEAKIIAAWDSSGVTFDGESQF
ISINTELASVQQLARGSIFTKFKATGTTATLFSASNSAVGSSEFAILINGDGTLRVHARENGSFVNDSKTVTTFNNNQEH
KALIMVDANGTQIYVDGRLAFSGNATSFLSAIAGLDSMNIGRNHDSNGGQWYFSGTIDETRIYDNVLTAEQAEDLTRLST
VVATFDSNLNTDPLLAGWTNDSVDSGAGSLVNEQGQAAWQARGINGRAEWEIQPSVQVNRDATTLGWKMTTTSRIVSGSA
ISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGADKYHTYEVTYDVETSLATFYFDGIAIETWAGSATSQNV
IVWGNGSSGTNGVANYRYVNFETFGSGPAIFESIVFQGGQEGDDGMSHYRIPSMVQSADGSILAFIEGRPSGGDPGQVGQ
INISLKRSIDNGRSWLPVQIIHQDPAFDYSDPRPFVDKSTNTVYVFYVQWPDLCAQNGNCVAPDDANYLYYRKSIDNGLT
WSAAVDVTSQVKDPTWRSINPGPGQGIQLQWQTLAQGEHNGRMIFPAIVRAGNSLFYVATVFSDDNGLTWHKGEFTPVSG
PTEADMVELNDGTLLLSARNDGGAAGTRYHFLSHDGGITWTQTSHDLAVSKVDIGLTRFSAIRAGDAEDLIIATAPIGTT
SGPNRNNLGIWVSTDEGANFGTPHQLVYGMSAYSDVVRLNDGSIGVIYEATGSTLLKFLNFELSSLERQ

Sequences:

>Translated_949_residues
MLRTITLTALFITLCSMGFSSGYAQANTLVANFDAMNETSPTIQGWSDFLSGQATGSVAQDLNAASWKSTGSSGRAQWNM
VPTTELNNEASLKGWRMSWTSRVESGGYITDYYANGALRFLPILSISASGDLVVNLVGGGEHTLVSGTGADSYHQYVVEY
DPLTQLASFSFDGVIIDPAWVGEASNQNMIAWGNGSSNINGVAYYRAVTFETLSETVPEEAKIIAAWDSSGVTFDGESQF
ISINTELASVQQLARGSIFTKFKATGTTATLFSASNSAVGSSEFAILINGDGTLRVHARENGSFVNDSKTVTTFNNNQEH
KALIMVDANGTQIYVDGRLAFSGNATSFLSAIAGLDSMNIGRNHDSNGGQWYFSGTIDETRIYDNVLTAEQAEDLTRLST
VVATFDSNLNTDPLLAGWTNDSVDSGAGSLVNEQGQAAWQARGINGRAEWEIQPSVQVNRDATTLGWKMTTTSRIVSGSA
ISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGADKYHTYEVTYDVETSLATFYFDGIAIETWAGSATSQNV
IVWGNGSSGTNGVANYRYVNFETFGSGPAIFESIVFQGGQEGDDGMSHYRIPSMVQSADGSILAFIEGRPSGGDPGQVGQ
INISLKRSIDNGRSWLPVQIIHQDPAFDYSDPRPFVDKSTNTVYVFYVQWPDLCAQNGNCVAPDDANYLYYRKSIDNGLT
WSAAVDVTSQVKDPTWRSINPGPGQGIQLQWQTLAQGEHNGRMIFPAIVRAGNSLFYVATVFSDDNGLTWHKGEFTPVSG
PTEADMVELNDGTLLLSARNDGGAAGTRYHFLSHDGGITWTQTSHDLAVSKVDIGLTRFSAIRAGDAEDLIIATAPIGTT
SGPNRNNLGIWVSTDEGANFGTPHQLVYGMSAYSDVVRLNDGSIGVIYEATGSTLLKFLNFELSSLERQ
>Mature_949_residues
MLRTITLTALFITLCSMGFSSGYAQANTLVANFDAMNETSPTIQGWSDFLSGQATGSVAQDLNAASWKSTGSSGRAQWNM
VPTTELNNEASLKGWRMSWTSRVESGGYITDYYANGALRFLPILSISASGDLVVNLVGGGEHTLVSGTGADSYHQYVVEY
DPLTQLASFSFDGVIIDPAWVGEASNQNMIAWGNGSSNINGVAYYRAVTFETLSETVPEEAKIIAAWDSSGVTFDGESQF
ISINTELASVQQLARGSIFTKFKATGTTATLFSASNSAVGSSEFAILINGDGTLRVHARENGSFVNDSKTVTTFNNNQEH
KALIMVDANGTQIYVDGRLAFSGNATSFLSAIAGLDSMNIGRNHDSNGGQWYFSGTIDETRIYDNVLTAEQAEDLTRLST
VVATFDSNLNTDPLLAGWTNDSVDSGAGSLVNEQGQAAWQARGINGRAEWEIQPSVQVNRDATTLGWKMTTTSRIVSGSA
ISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGADKYHTYEVTYDVETSLATFYFDGIAIETWAGSATSQNV
IVWGNGSSGTNGVANYRYVNFETFGSGPAIFESIVFQGGQEGDDGMSHYRIPSMVQSADGSILAFIEGRPSGGDPGQVGQ
INISLKRSIDNGRSWLPVQIIHQDPAFDYSDPRPFVDKSTNTVYVFYVQWPDLCAQNGNCVAPDDANYLYYRKSIDNGLT
WSAAVDVTSQVKDPTWRSINPGPGQGIQLQWQTLAQGEHNGRMIFPAIVRAGNSLFYVATVFSDDNGLTWHKGEFTPVSG
PTEADMVELNDGTLLLSARNDGGAAGTRYHFLSHDGGITWTQTSHDLAVSKVDIGLTRFSAIRAGDAEDLIIATAPIGTT
SGPNRNNLGIWVSTDEGANFGTPHQLVYGMSAYSDVVRLNDGSIGVIYEATGSTLLKFLNFELSSLERQ

Specific function: Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infection

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 BNR repeats [H]

Homologues:

Organism=Homo sapiens, GI117190519, Length=411, Percent_Identity=23.6009732360097, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI4557791, Length=236, Percent_Identity=30.0847457627119, Blast_Score=72, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002860
- InterPro:   IPR008985
- InterPro:   IPR013320
- InterPro:   IPR011040
- InterPro:   IPR015344 [H]

Pfam domain/function: PF02012 BNR; PF09264 Sial-lect-inser [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 101904; Mature: 101904

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTITLTALFITLCSMGFSSGYAQANTLVANFDAMNETSPTIQGWSDFLSGQATGSVAQ
CCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHH
DLNAASWKSTGSSGRAQWNMVPTTELNNEASLKGWRMSWTSRVESGGYITDYYANGALRF
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCCEEEE
LPILSISASGDLVVNLVGGGEHTLVSGTGADSYHQYVVEYDPLTQLASFSFDGVIIDPAW
EEEEEECCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEECCHHHHHHCCCCCEEECCCC
VGEASNQNMIAWGNGSSNINGVAYYRAVTFETLSETVPEEAKIIAAWDSSGVTFDGESQF
CCCCCCCCEEEECCCCCCCCEEEEEEEEEHHHHHHCCCCCCEEEEEECCCCCEECCCCCE
ISINTELASVQQLARGSIFTKFKATGTTATLFSASNSAVGSSEFAILINGDGTLRVHARE
EEEECHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEEEC
NGSFVNDSKTVTTFNNNQEHKALIMVDANGTQIYVDGRLAFSGNATSFLSAIAGLDSMNI
CCCEECCCEEEEEECCCCCCEEEEEEECCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCC
GRNHDSNGGQWYFSGTIDETRIYDNVLTAEQAEDLTRLSTVVATFDSNLNTDPLLAGWTN
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCC
DSVDSGAGSLVNEQGQAAWQARGINGRAEWEIQPSVQVNRDATTLGWKMTTTSRIVSGSA
CCCCCCCCCHHCCCCCCEEEECCCCCEEEEEECCCEEECCCCEEEEEEEEEHHHEECCCC
ISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGADKYHTYEVTYDVETSLAT
CHHHHCCCCEEEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCCCEEE
FYFDGIAIETWAGSATSQNVIVWGNGSSGTNGVANYRYVNFETFGSGPAIFESIVFQGGQ
EEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCC
EGDDGMSHYRIPSMVQSADGSILAFIEGRPSGGDPGQVGQINISLKRSIDNGRSWLPVQI
CCCCCCCEEECCHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEE
IHQDPAFDYSDPRPFVDKSTNTVYVFYVQWPDLCAQNGNCVAPDDANYLYYRKSIDNGLT
EECCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHCCCCCEECCCCCCEEEEEECCCCCEE
WSAAVDVTSQVKDPTWRSINPGPGQGIQLQWQTLAQGEHNGRMIFPAIVRAGNSLFYVAT
EEEEECCHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHCCCCEEEEEE
VFSDDNGLTWHKGEFTPVSGPTEADMVELNDGTLLLSARNDGGAAGTRYHFLSHDGGITW
EEECCCCCEEECCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCEEE
TQTSHDLAVSKVDIGLTRFSAIRAGDAEDLIIATAPIGTTSGPNRNNLGIWVSTDEGANF
EECCCCEEEEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCC
GTPHQLVYGMSAYSDVVRLNDGSIGVIYEATGSTLLKFLNFELSSLERQ
CCCHHEEEECCHHCCEEEECCCCEEEEEECCHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MLRTITLTALFITLCSMGFSSGYAQANTLVANFDAMNETSPTIQGWSDFLSGQATGSVAQ
CCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHH
DLNAASWKSTGSSGRAQWNMVPTTELNNEASLKGWRMSWTSRVESGGYITDYYANGALRF
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCCEEEE
LPILSISASGDLVVNLVGGGEHTLVSGTGADSYHQYVVEYDPLTQLASFSFDGVIIDPAW
EEEEEECCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEECCHHHHHHCCCCCEEECCCC
VGEASNQNMIAWGNGSSNINGVAYYRAVTFETLSETVPEEAKIIAAWDSSGVTFDGESQF
CCCCCCCCEEEECCCCCCCCEEEEEEEEEHHHHHHCCCCCCEEEEEECCCCCEECCCCCE
ISINTELASVQQLARGSIFTKFKATGTTATLFSASNSAVGSSEFAILINGDGTLRVHARE
EEEECHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEEEC
NGSFVNDSKTVTTFNNNQEHKALIMVDANGTQIYVDGRLAFSGNATSFLSAIAGLDSMNI
CCCEECCCEEEEEECCCCCCEEEEEEECCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCC
GRNHDSNGGQWYFSGTIDETRIYDNVLTAEQAEDLTRLSTVVATFDSNLNTDPLLAGWTN
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCC
DSVDSGAGSLVNEQGQAAWQARGINGRAEWEIQPSVQVNRDATTLGWKMTTTSRIVSGSA
CCCCCCCCCHHCCCCCCEEEECCCCCEEEEEECCCEEECCCCEEEEEEEEEHHHEECCCC
ISDYYANGNKRFLALLSINGNGDLVAALEGGSSHTLVPMTGADKYHTYEVTYDVETSLAT
CHHHHCCCCEEEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCCCEEE
FYFDGIAIETWAGSATSQNVIVWGNGSSGTNGVANYRYVNFETFGSGPAIFESIVFQGGQ
EEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCC
EGDDGMSHYRIPSMVQSADGSILAFIEGRPSGGDPGQVGQINISLKRSIDNGRSWLPVQI
CCCCCCCEEECCHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEE
IHQDPAFDYSDPRPFVDKSTNTVYVFYVQWPDLCAQNGNCVAPDDANYLYYRKSIDNGLT
EECCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHCCCCCEECCCCCCEEEEEECCCCCEE
WSAAVDVTSQVKDPTWRSINPGPGQGIQLQWQTLAQGEHNGRMIFPAIVRAGNSLFYVAT
EEEEECCHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHCCCCEEEEEE
VFSDDNGLTWHKGEFTPVSGPTEADMVELNDGTLLLSARNDGGAAGTRYHFLSHDGGITW
EEECCCCCEEECCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCEEE
TQTSHDLAVSKVDIGLTRFSAIRAGDAEDLIIATAPIGTTSGPNRNNLGIWVSTDEGANF
EECCCCEEEEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCC
GTPHQLVYGMSAYSDVVRLNDGSIGVIYEATGSTLLKFLNFELSSLERQ
CCCHHEEEECCHHCCEEEECCCCEEEEEECCHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730470; 2832365 [H]