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The map label for this gene is nanM [H]

Identifier: 157961340

GI number: 157961340

Start: 1837304

End: 1838458

Strand: Direct

Name: nanM [H]

Synonym: Spea_1514

Alternate gene names: 157961340

Gene position: 1837304-1838458 (Clockwise)

Preceding gene: 157961339

Following gene: 157961341

Centisome position: 35.51

GC content: 43.98

Gene sequence:

>1155_bases
ATGCCGCTTGTCGCGCTTGTTTGTGGGCCAGCGTTAGCTGTGGAAAGTCAAACAAAAGTACCTGTTCAGGCCAAGGTGAG
TTGGGTAAAAGCAGGGCAACTACCAGCTCCTAAAGGCTTTAATCAATCTATCGGTATAGCTGGTGCCTATAGCGCATTTG
TCGGTGATTACCTTGTGGTTGCTGGCGGGGCTAATTTTCCTAAGGGCCACCCTTTTTTTGATAAGGGGGTTAAGCAGTAT
TATTCAGATATTTTTGTTTTTGATACCGCAAATAATCAATTTGAGCTAGTAGCTCATGGTCACTTACCCTCCGCAAGAGG
GCATGGTGCAACTGTCGTTGTTGGCAATAGTCTGTATCTTGTTGGAGGTAAAAATAACGACCAAGCCTTCGACTCTATTC
TAAAGCTGACACTAGATGATAACTCTCAACCTGTGGTGAATGCTGTTAATCAACTGCCTTTTACTTGGGATTCTGGCGCG
GCGGCCTGGCAAGACGACTCACTGTTTTTATTTGCTGGTAAGCATAACGGCGTAGTGAGTAATGCTGTGTGTCAGTTTTC
TTTGAAACAGCAAAAATGCATCAATAAAGATAAGATAGCGCCAATCCCGGGGCTTGCGAGAGCCGATTTCCCTTCCATAA
AGCATCACAAACAATTTTATGTATTTGGTGGTGCCAATGTGTTGGCAGGAAAAGGACGTTATGTTCTAACCGACGCTTAT
GCGTTTGACTTTGAAGCACTAAGCTGGAGAACACTTACGCCGATTACGGTTAAAGACCAACCCTATTCTGTCGCTGGTGG
AGGGGTTGCGGTGATTAACGATGAGCAGTTCATTTTGCTTGGTGGTGTAAACAGGCAAGTGTTTAACGATGCTATTTTTC
AATTGACCACGAGTGCACAGGATAGGCTATCTAAGTTCAAACAATATTATTTTAGTTTGAATGAGCAAGAGGTTAACTTT
AGCCGCCAACAGCTTATTTATGATCTCAATAAAGATAACTGGTCAACTTTAAGTAAGGAAGTGCCTTTTACGGGGGGAGC
GGGCCCCCTTGCGATATCGCAAAAAGAGAACCAAATATATTGGATTTCTGGCGAGATAAGGCCGGTGATCCGTACCCCTA
ATGTCTATCAAGCCACAATCGAACCTGTTCAATAA

Upstream 100 bases:

>100_bases
CGGTGTAATGTCCTAAAACCTAATCAATGTTGATTAGGTTTTATTTTACTTAAAAGTTAAGGAGTTCCGCTTGAAGCCTA
CTCAGTTATTTTTCCTACTT

Downstream 100 bases:

>100_bases
CACTGGCGTCTATTTCACTATCTTGTTTAGTACATTGATATTTTTTAGCAGAGTCTGGATCTGAGACTCGCTTATCCCCT
CAACTTGCTAAACCAATAAT

Product: kelch repeat-containing protein

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MPLVALVCGPALAVESQTKVPVQAKVSWVKAGQLPAPKGFNQSIGIAGAYSAFVGDYLVVAGGANFPKGHPFFDKGVKQY
YSDIFVFDTANNQFELVAHGHLPSARGHGATVVVGNSLYLVGGKNNDQAFDSILKLTLDDNSQPVVNAVNQLPFTWDSGA
AAWQDDSLFLFAGKHNGVVSNAVCQFSLKQQKCINKDKIAPIPGLARADFPSIKHHKQFYVFGGANVLAGKGRYVLTDAY
AFDFEALSWRTLTPITVKDQPYSVAGGGVAVINDEQFILLGGVNRQVFNDAIFQLTTSAQDRLSKFKQYYFSLNEQEVNF
SRQQLIYDLNKDNWSTLSKEVPFTGGAGPLAISQKENQIYWISGEIRPVIRTPNVYQATIEPVQ

Sequences:

>Translated_384_residues
MPLVALVCGPALAVESQTKVPVQAKVSWVKAGQLPAPKGFNQSIGIAGAYSAFVGDYLVVAGGANFPKGHPFFDKGVKQY
YSDIFVFDTANNQFELVAHGHLPSARGHGATVVVGNSLYLVGGKNNDQAFDSILKLTLDDNSQPVVNAVNQLPFTWDSGA
AAWQDDSLFLFAGKHNGVVSNAVCQFSLKQQKCINKDKIAPIPGLARADFPSIKHHKQFYVFGGANVLAGKGRYVLTDAY
AFDFEALSWRTLTPITVKDQPYSVAGGGVAVINDEQFILLGGVNRQVFNDAIFQLTTSAQDRLSKFKQYYFSLNEQEVNF
SRQQLIYDLNKDNWSTLSKEVPFTGGAGPLAISQKENQIYWISGEIRPVIRTPNVYQATIEPVQ
>Mature_383_residues
PLVALVCGPALAVESQTKVPVQAKVSWVKAGQLPAPKGFNQSIGIAGAYSAFVGDYLVVAGGANFPKGHPFFDKGVKQYY
SDIFVFDTANNQFELVAHGHLPSARGHGATVVVGNSLYLVGGKNNDQAFDSILKLTLDDNSQPVVNAVNQLPFTWDSGAA
AWQDDSLFLFAGKHNGVVSNAVCQFSLKQQKCINKDKIAPIPGLARADFPSIKHHKQFYVFGGANVLAGKGRYVLTDAYA
FDFEALSWRTLTPITVKDQPYSVAGGGVAVINDEQFILLGGVNRQVFNDAIFQLTTSAQDRLSKFKQYYFSLNEQEVNFS
RQQLIYDLNKDNWSTLSKEVPFTGGAGPLAISQKENQIYWISGEIRPVIRTPNVYQATIEPVQ

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=233, Percent_Identity=26.1802575107296, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013089
- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936 [H]

Pfam domain/function: PF01344 Kelch_1 [H]

EC number: NA

Molecular weight: Translated: 41920; Mature: 41789

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVALVCGPALAVESQTKVPVQAKVSWVKAGQLPAPKGFNQSIGIAGAYSAFVGDYLVV
CCEEEEEECCEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCEEEE
AGGANFPKGHPFFDKGVKQYYSDIFVFDTANNQFELVAHGHLPSARGHGATVVVGNSLYL
ECCCCCCCCCCCHHHHHHHHHCEEEEEECCCCEEEEEEECCCCCCCCCCEEEEECCEEEE
VGGKNNDQAFDSILKLTLDDNSQPVVNAVNQLPFTWDSGAAAWQDDSLFLFAGKHNGVVS
EECCCCHHHHHHEEEEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCEEE
NAVCQFSLKQQKCINKDKIAPIPGLARADFPSIKHHKQFYVFGGANVLAGKGRYVLTDAY
CCEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCEEEEEEE
AFDFEALSWRTLTPITVKDQPYSVAGGGVAVINDEQFILLGGVNRQVFNDAIFQLTTSAQ
EECCCCCCEEEECEEEECCCCEEECCCCEEEEECCCEEEEECCCHHHHHHHHHEEECCHH
DRLSKFKQYYFSLNEQEVNFSRQQLIYDLNKDNWSTLSKEVPFTGGAGPLAISQKENQIY
HHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCEEEECCCCEEE
WISGEIRPVIRTPNVYQATIEPVQ
EEECCEEEEEECCCEEEEEECCCC
>Mature Secondary Structure 
PLVALVCGPALAVESQTKVPVQAKVSWVKAGQLPAPKGFNQSIGIAGAYSAFVGDYLVV
CEEEEEECCEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCEEEE
AGGANFPKGHPFFDKGVKQYYSDIFVFDTANNQFELVAHGHLPSARGHGATVVVGNSLYL
ECCCCCCCCCCCHHHHHHHHHCEEEEEECCCCEEEEEEECCCCCCCCCCEEEEECCEEEE
VGGKNNDQAFDSILKLTLDDNSQPVVNAVNQLPFTWDSGAAAWQDDSLFLFAGKHNGVVS
EECCCCHHHHHHEEEEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCEEE
NAVCQFSLKQQKCINKDKIAPIPGLARADFPSIKHHKQFYVFGGANVLAGKGRYVLTDAY
CCEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCEEEEEEE
AFDFEALSWRTLTPITVKDQPYSVAGGGVAVINDEQFILLGGVNRQVFNDAIFQLTTSAQ
EECCCCCCEEEECEEEECCCCEEECCCCEEEEECCCEEEEECCCHHHHHHHHHEEECCHH
DRLSKFKQYYFSLNEQEVNFSRQQLIYDLNKDNWSTLSKEVPFTGGAGPLAISQKENQIY
HHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCEEEECCCCEEE
WISGEIRPVIRTPNVYQATIEPVQ
EEECCEEEEEECCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA