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The map label for this gene is guaB [H]

Identifier: 157961141

GI number: 157961141

Start: 1599278

End: 1600750

Strand: Direct

Name: guaB [H]

Synonym: Spea_1313

Alternate gene names: 157961141

Gene position: 1599278-1600750 (Clockwise)

Preceding gene: 157961137

Following gene: 157961142

Centisome position: 30.91

GC content: 46.84

Gene sequence:

>1473_bases
ATGTTAAGATTGAAAAAAGAAGCGTTAACTTTTGATGATGTGTTGCTGGTTCCAGCGCACTCTACCGTCCTCCCAAATAC
AGCTGTTTTAAAAACACGCCTGACGAATAAGATTGAGTTGAATACTCCAATCGTTTCTGCTGCTATGGATACCGTTACTG
AAGCTCGCTTGGCAATTGCTATTGCTCAAGAAGGTGGCCTTGGCTTTATCCATAAGAACATGACGATTGAGCAACAAGCT
GAAGAAGTTCGCAAAGTAAAAATTTACGAAGCGGGTATCGTTCAGCAACCTGTGACAGTCACCCCTGCAACGACACTAGC
CGATGTTAAGGTTCTGACTGAAAGAAATGGTTTCGCAGGTTACCCAGTGGTAAATGAAGCAAACGAGTTAGTGGGTATTA
TCACTGGCCGTGACGTACGCTTTATCACTGACTGGTCGCGTACCGTTGATCAAGTGATGACACCAAAAGAGCGCCTTGTG
ACAGTGCCAGAAGGGACTAAGCTAGATGAAGTTCAAAAACTGATGCATTCTCACCGTGTTGAGAAAGTATTGGTTGTTGA
TGACAACTTCAAGCTAAAGGGTCTTATCACTGTAAAAGACTTCCAAAAAGCAGAGCGTAAGCCAAACGCATGTAAAGACG
AGTTAGGTCGTTTACGTGTAGGTGCGGCTGTTGGTGCAGGTCCAGGTAACGAAGAGCGTGTTGATGCACTTGTGCTAGCT
GGCGTTGACGTCTTACTTATCGACTCATCTCACGGCCATTCAGAAGGCGTTTTACAACGTATTCGTGATACTCGTGCTAA
ATACCCGGACTTACAAATCGTTGGCGGTAACGTTGCAACAGCTGAAGGTGCAATTGCACTCGTTGAAGCGGGCGTTAACG
CAGTTAAAGTCGGTATTGGCCCTGGTTCAATCTGTACCACGCGTATCGTAACGGGTGTGGGTGTACCACAAATTACAGCG
GTATCTGATGCCGCTGCTGCCGTTAAGCACTTAGACATTCCAGTTATTGCCGATGGCGGTATTCGCTTCTCTGGCGACCT
AGCAAAAGCATTGGCTGCTGGCGCGTCGTGCATCATGGCAGGCTCTATGTTTGCAGGTACCGATGAAGCGCCAGGTGAAA
CTGAGCTTTATAACGGCCGTGCTTATAAGTCATACCGCGGTATGGGTTCACTAGGCGCTATGACCCAAACTCAAGGTTCG
TCTGATCGTTATTTCCAAAGCGATAACGCTGCAGACAAGCTAGTACCTGAAGGTATTGAAGGTCGCGTTGCTTACAAAGG
TAAGCTAAAAGAGATCATTCACCAGCATATGGGCGGTCTACGTTCATGCATGGGTCTAACTGGCTGCGCAACGATTAAAG
AACTAAACGAGAAGGCTGAGTTTGTGAAAATCACTGCAGCGGGCATGGGCGAGTCTCATGTTCACGATGTGACGATTAGT
AAAGAAGCACCTAACTACAGCACTCGTTCTTAA

Upstream 100 bases:

>100_bases
CGAATTAGTGTCTATTTTCCATTTACCAACCCCGATATGCAAGGTATAATCTCGCCGCAATATTTCACCTCTAATTCCTA
ATCTCTTGGGGAGATGTTGC

Downstream 100 bases:

>100_bases
ATAGTGTTCTAAATCTTAAAGGCGACATATAATGTCGCCTTTAAATTAAGCCAAGTAGTAGATTCGCAGAGTACTCACTG
CTTGGTTAGTTAACAATAAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPATTLADVKVLTERNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVPEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEERVDALVLA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSTRS

Sequences:

>Translated_490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPATTLADVKVLTERNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVPEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEERVDALVLA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSTRS
>Mature_490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPATTLADVKVLTERNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVPEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEERVDALVLA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSTRS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.6639004149378, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=39.7119341563786, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=38.9583333333333, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=36.4583333333333, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=38.3064516129032, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=36.5461847389558, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=36.9477911646586, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=36.9477911646586, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=36.9477911646586, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=79.4238683127572, Blast_Score=724, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=35.4260089686099, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=36.0587002096436, Blast_Score=266, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.3886255924171, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=246, Percent_Identity=36.9918699186992, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=40.495867768595, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=40.2489626556017, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6322012, Length=482, Percent_Identity=37.9668049792531, Blast_Score=322, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.7573964497041, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=38.5245901639344, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.9233954451346, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.9233954451346, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.6825396825397, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52199; Mature: 52199

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEEE
IAQEGGLGFIHKNMTIEQQAEEVRKVKIYEAGIVQQPVTVTPATTLADVKVLTERNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCHHHHEEEEECCCCCCC
YPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLVTVPEGTKLDEVQKLMHSHRV
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHCCC
EKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEERVDALVLA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHEEEEE
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYNGRAYKSYRGMGSLGAMTQTQGSSDRYFQSDNAADKLVPEGIE
CCEECCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCC
GRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
CEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEE
KEAPNYSTRS
CCCCCCCCCC
>Mature Secondary Structure
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEEE
IAQEGGLGFIHKNMTIEQQAEEVRKVKIYEAGIVQQPVTVTPATTLADVKVLTERNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCHHHHEEEEECCCCCCC
YPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLVTVPEGTKLDEVQKLMHSHRV
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHCCC
EKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEERVDALVLA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHEEEEE
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYNGRAYKSYRGMGSLGAMTQTQGSSDRYFQSDNAADKLVPEGIE
CCEECCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCC
GRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
CEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEE
KEAPNYSTRS
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]