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The map label for this gene is pgi [H]

Identifier: 157960901

GI number: 157960901

Start: 1296964

End: 1298601

Strand: Reverse

Name: pgi [H]

Synonym: Spea_1073

Alternate gene names: 157960901

Gene position: 1298601-1296964 (Counterclockwise)

Preceding gene: 157960902

Following gene: 157960900

Centisome position: 25.1

GC content: 44.81

Gene sequence:

>1638_bases
ATGACAGAACTCACTCAACAAGCTAGCTGGCAAGCACTTGAGAAGCACAGTAAATCGCTTCCTCATATGCGCGAACTCTT
TTCTACTGAACCTGAACGCTTCGGTAATATGTCGACTCAGGCATGCGGCCTATTTTTAGATTATTCTAAAAACCGTGCTT
CACAAGAGACGATGTCATTACTGTTTAATCTAGCCAAAGACTCTCAGCTTGAATCGAAAATTAAGGCGATGTTTGCAGGA
CACGTGATAAACAACACAGAACAACGTGCAGTTTTGCACACAGCTCTGCGTGCCCCTGCTGACAAAGTTATTAATGTCGA
TGGCAATAATATTGTCGCCGAAGTTCAGCAGACATTGGCAAAAATGGGTGAGTTCGTCGAGTCGCTGACTTCTGGTCAGT
GGAAAGGTTATACAGGTAAAACCATTACTGATGTGGTAAGCATAGGTATTGGAGGTTCCTTCTTAGGCCCAAAAATCGTT
TCTCAAGCCCTGCGTCCTTATTGGACAGGTGAGCTAAATTGTCACTTTGTGGCAAACGTGGACGGTACTTCTATCACTGA
AAAACTTAAAGGGCTCGATCCACAAACCACCCTGTTTGTGATGTCTTCTAAGTCTTTCGGTACCCAAGAAACCTTAACCA
ATACGCTAACCGCAAAAGAGTGGTTTTTAAGCCAAGGTGCATCACAGTCTGATGTGGCAAAGCATTTTGTCGCCGTGAGC
TCGAACGTCTCTAAAGCTACTGAGTTTGGTATCGATGCTAACAACATCTTCCCAATGTGGGATTGGGTCGGTGGACGTTA
CTCATTATGGTCTGCTATTGGCTTACCTATCGCCCTGCTAATCGGTATGGATAACTTCCGTCAATTATTGGCTGGCGCTC
ATGAGATGGATGAACATTTTGCCAATACCCCATTAGAGAGCAATATGCCGGTGATTATGGGTATGTTCTCGCTTTGGTAT
GGCAACTTTTTCAATGCACAGTCTCATGTCGTGCTTACCTATGATCATTACCTGAGAGGTCTACCAGCTTACTTCCAACA
ACTCGATATGGAAAGTAATGGTAAATCTGTCACCCTAAACGGTACTGATGTTGATTACAGCACTGGCCCGATTATTTGGG
GAGGTGAAGGCACCAATGGCCAGCATGCATACCACCAGCTACTGCATCAAGGTACAGCGCTTATCCCGGCTGACTTTATT
ATGCCGCTAAATAGCCACAACCCAGTGGGTGAGCATCATGTACAACTTGCTTCAAATTGCTTCGGACAAACCCAAGCATT
GATGCAGGGCAGAACATTCGATGAGGCATTAGCTGAGCTTAACCAAAGTGGATTAGCTGAGGAGCAGAAGCTGCTTATCG
CTAAGCATAAGGTGATGCCAGGTAATAAGCCAAGCAATACTATTTTGATGGATAAGCTAACACCGTCGACCTTAGGTTCA
CTTATTGCCCTTTACGAGCACAGAACCTTTGTTCAAGGCGCTATCTGGCAGATAAACTCTTTCGACCAGTGGGGTGTAGA
GCTAGGTAAACAACTCGGTAATGATGTACTAGAACGTCTGGTCGCTGATACTGAAGCCAAAGAGCTCGACTCATCGAGCA
ATGGTTTAATTAACCTGTTTAAGCAGGGCAAAATTTAA

Upstream 100 bases:

>100_bases
AGAAGCTAGCCGAAGGTATTCGCAACTTCGCTATCGACCAGGGTAAGCTCGAAGTTATGCTAAAAGAAAAGCTTTCGTCT
TAACGGAATAGGACAAGACT

Downstream 100 bases:

>100_bases
TACTGCTCAGCACACGGCTTTCCATGCCTAACAAAAAAAGCCAGTTTCTACTGGCTTTTTTGTTTTTCACTAGCTAATAC
CAATCAGTATAAGAAGTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTELTQQASWQALEKHSKSLPHMRELFSTEPERFGNMSTQACGLFLDYSKNRASQETMSLLFNLAKDSQLESKIKAMFAG
HVINNTEQRAVLHTALRAPADKVINVDGNNIVAEVQQTLAKMGEFVESLTSGQWKGYTGKTITDVVSIGIGGSFLGPKIV
SQALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKEWFLSQGASQSDVAKHFVAVS
SNVSKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRQLLAGAHEMDEHFANTPLESNMPVIMGMFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPIIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLNSHNPVGEHHVQLASNCFGQTQALMQGRTFDEALAELNQSGLAEEQKLLIAKHKVMPGNKPSNTILMDKLTPSTLGS
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLERLVADTEAKELDSSSNGLINLFKQGKI

Sequences:

>Translated_545_residues
MTELTQQASWQALEKHSKSLPHMRELFSTEPERFGNMSTQACGLFLDYSKNRASQETMSLLFNLAKDSQLESKIKAMFAG
HVINNTEQRAVLHTALRAPADKVINVDGNNIVAEVQQTLAKMGEFVESLTSGQWKGYTGKTITDVVSIGIGGSFLGPKIV
SQALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKEWFLSQGASQSDVAKHFVAVS
SNVSKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRQLLAGAHEMDEHFANTPLESNMPVIMGMFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPIIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLNSHNPVGEHHVQLASNCFGQTQALMQGRTFDEALAELNQSGLAEEQKLLIAKHKVMPGNKPSNTILMDKLTPSTLGS
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLERLVADTEAKELDSSSNGLINLFKQGKI
>Mature_544_residues
TELTQQASWQALEKHSKSLPHMRELFSTEPERFGNMSTQACGLFLDYSKNRASQETMSLLFNLAKDSQLESKIKAMFAGH
VINNTEQRAVLHTALRAPADKVINVDGNNIVAEVQQTLAKMGEFVESLTSGQWKGYTGKTITDVVSIGIGGSFLGPKIVS
QALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKEWFLSQGASQSDVAKHFVAVSS
NVSKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRQLLAGAHEMDEHFANTPLESNMPVIMGMFSLWYG
NFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPIIWGGEGTNGQHAYHQLLHQGTALIPADFIM
PLNSHNPVGEHHVQLASNCFGQTQALMQGRTFDEALAELNQSGLAEEQKLLIAKHKVMPGNKPSNTILMDKLTPSTLGSL
IALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLERLVADTEAKELDSSSNGLINLFKQGKI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=553, Percent_Identity=50.994575045208, Blast_Score=584, Evalue=1e-167,
Organism=Homo sapiens, GI296080693, Length=553, Percent_Identity=47.1971066907776, Blast_Score=526, Evalue=1e-149,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=53.3333333333333, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71996708, Length=547, Percent_Identity=52.8336380255942, Blast_Score=579, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71996703, Length=547, Percent_Identity=52.8336380255942, Blast_Score=578, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319673, Length=550, Percent_Identity=50.1818181818182, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24651916, Length=551, Percent_Identity=53.3575317604356, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651914, Length=551, Percent_Identity=53.3575317604356, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17737445, Length=551, Percent_Identity=53.3575317604356, Blast_Score=581, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 60057; Mature: 59926

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTQQASWQALEKHSKSLPHMRELFSTEPERFGNMSTQACGLFLDYSKNRASQETMSL
CCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCHHHHEEEEECCCCCCHHHHHHH
LFNLAKDSQLESKIKAMFAGHVINNTEQRAVLHTALRAPADKVINVDGNNIVAEVQQTLA
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHH
KMGEFVESLTSGQWKGYTGKTITDVVSIGIGGSFLGPKIVSQALRPYWTGELNCHFVANV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECC
DGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKEWFLSQGASQSDVAKHFVAVS
CCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
SNVSKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRQLLAGAHEMDEHF
CCHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANTPLESNMPVIMGMFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEC
GTDVDYSTGPIIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLNSHNPVGEHHVQLASNC
CCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHHHHHHHHHH
FGQTQALMQGRTFDEALAELNQSGLAEEQKLLIAKHKVMPGNKPSNTILMDKLTPSTLGS
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHH
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLERLVADTEAKELDSSSNGLINLF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEHH
KQGKI
CCCCC
>Mature Secondary Structure 
TELTQQASWQALEKHSKSLPHMRELFSTEPERFGNMSTQACGLFLDYSKNRASQETMSL
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCHHHHEEEEECCCCCCHHHHHHH
LFNLAKDSQLESKIKAMFAGHVINNTEQRAVLHTALRAPADKVINVDGNNIVAEVQQTLA
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHH
KMGEFVESLTSGQWKGYTGKTITDVVSIGIGGSFLGPKIVSQALRPYWTGELNCHFVANV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECC
DGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKEWFLSQGASQSDVAKHFVAVS
CCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
SNVSKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRQLLAGAHEMDEHF
CCHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANTPLESNMPVIMGMFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEC
GTDVDYSTGPIIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLNSHNPVGEHHVQLASNC
CCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHHHHHHHHHH
FGQTQALMQGRTFDEALAELNQSGLAEEQKLLIAKHKVMPGNKPSNTILMDKLTPSTLGS
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHH
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLERLVADTEAKELDSSSNGLINLF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEHH
KQGKI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA