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The map label for this gene is galK [H]

Identifier: 157960406

GI number: 157960406

Start: 706720

End: 707874

Strand: Reverse

Name: galK [H]

Synonym: Spea_0577

Alternate gene names: 157960406

Gene position: 707874-706720 (Counterclockwise)

Preceding gene: 157960407

Following gene: 157960405

Centisome position: 13.68

GC content: 50.82

Gene sequence:

>1155_bases
ATGTCCAATCCCGCTCTGCGAGCAAACAAACTGTTTGTGCAAACTTTTGGCACCCAAGCCGATGAGCTTTATTGTGCCCC
TGGACGCGTTAACCTGATTGGTGAACATACCGATTACAACGATGGCTTTGTGCTACCCGCCGCCATCAACTTCTATACGG
CTGTGGTTGTTAAACGCCGTGATGACTTGCGGTTTCGCGCCGTATCGGACGCCTTTCCCGGTGAAATTGAAGAGTGGGTT
TTCGGTGAAGAAGGCCTACCCACAGCCAATCATTGGTCGAACTACCTTAAAGGCTTTACCGCAGCGATGGCCACGTCAGG
CTTAGCGCCAAAAGGACTGGATGTCGCAGTTGTCAGTAATGTCCCTATGGGGGCAGGTCTGTCTTCTTCGGCCGCATTAG
AGATAGCCTTCGGTACCGCCGTCAATGATTGCAGCCAGATTAAACTGTCACCACTTGCTATCGCTCAACTGGCTCAGCGC
GGCGAAAACCAATTTGTCGGCTGCGCCTGCGGCATCATGGATCAGATGATCAGCGCTCTCGGTGAACAAGATCATGCACT
GCTTATCGACTGCCTAGATCTCGACAGTGAAGCAATTAGTATTCCCGACAGCTTAAGCCTGATCATTATCAACTCGAATG
TACAGCGTGGACTTGTTGAGTCGGAATATAACCTTCGCCGCGAACAGTGCGAGCAAGCTGCTGCTCATTTTGGCTTAGAG
TCACTGCGCGACCTTGACCTTGCCACCTTAGAGGCGGGAAAGGCGGACTTAAGCGACAACTGCTACAAACGTGCTAAACA
TGTTGTCACTGAAAACAGACGCACCCAAAATGCGGCGTGGGCACTTGAGTCTGGTGACATAGCCAAAGTTAGCCTTTTAA
TGGCACAGTCTCATAGGTCGATGCGAGATGACTTTGAGATCACCACCACAGAAATCGACTACCTAGTTGAGATAATCTCG
AATGTTATCGGTGAGCGCGGTGGCGTACGTATGACTGGCGGTGGCTTTGGCGGCTGCGTGGTCGCACTGGTCGATCATGC
GTTAACCGATGCTGTAGTTGAAGTTGTAGAAAAACAGTATGCCGAAAAAACAGGCCTAGAAGCCGATATTTATCTCTGTA
CAGCTAGCGATGGTGCCAAGCGTATCGACGATTAG

Upstream 100 bases:

>100_bases
CTGTTATTAAATTGGTCATCAGAATCAAACTCAGCTACCACTCAGTGTATTGCAATGCTTTTGTACTGAACGAACATATT
AACATTCGGAAATTTTGATT

Downstream 100 bases:

>100_bases
CTTAACGATTGATGTAACAATTAACAGGACTTAATTATGGTACGCATTCGCCCTCTCGAGCCTTGGACCGATCCACGTGG
TGGACAAATAGAGCGACTGC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSNPALRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFYTAVVVKRRDDLRFRAVSDAFPGEIEEWV
FGEEGLPTANHWSNYLKGFTAAMATSGLAPKGLDVAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIKLSPLAIAQLAQR
GENQFVGCACGIMDQMISALGEQDHALLIDCLDLDSEAISIPDSLSLIIINSNVQRGLVESEYNLRREQCEQAAAHFGLE
SLRDLDLATLEAGKADLSDNCYKRAKHVVTENRRTQNAAWALESGDIAKVSLLMAQSHRSMRDDFEITTTEIDYLVEIIS
NVIGERGGVRMTGGGFGGCVVALVDHALTDAVVEVVEKQYAEKTGLEADIYLCTASDGAKRIDD

Sequences:

>Translated_384_residues
MSNPALRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFYTAVVVKRRDDLRFRAVSDAFPGEIEEWV
FGEEGLPTANHWSNYLKGFTAAMATSGLAPKGLDVAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIKLSPLAIAQLAQR
GENQFVGCACGIMDQMISALGEQDHALLIDCLDLDSEAISIPDSLSLIIINSNVQRGLVESEYNLRREQCEQAAAHFGLE
SLRDLDLATLEAGKADLSDNCYKRAKHVVTENRRTQNAAWALESGDIAKVSLLMAQSHRSMRDDFEITTTEIDYLVEIIS
NVIGERGGVRMTGGGFGGCVVALVDHALTDAVVEVVEKQYAEKTGLEADIYLCTASDGAKRIDD
>Mature_383_residues
SNPALRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFYTAVVVKRRDDLRFRAVSDAFPGEIEEWVF
GEEGLPTANHWSNYLKGFTAAMATSGLAPKGLDVAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIKLSPLAIAQLAQRG
ENQFVGCACGIMDQMISALGEQDHALLIDCLDLDSEAISIPDSLSLIIINSNVQRGLVESEYNLRREQCEQAAAHFGLES
LRDLDLATLEAGKADLSDNCYKRAKHVVTENRRTQNAAWALESGDIAKVSLLMAQSHRSMRDDFEITTTEIDYLVEIISN
VIGERGGVRMTGGGFGGCVVALVDHALTDAVVEVVEKQYAEKTGLEADIYLCTASDGAKRIDD

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=383, Percent_Identity=42.8198433420365, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI48527957, Length=420, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503897, Length=420, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786972, Length=374, Percent_Identity=49.1978609625668, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71989053, Length=414, Percent_Identity=27.2946859903382, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319494, Length=339, Percent_Identity=29.2035398230088, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=31.1203319502075, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24661292, Length=421, Percent_Identity=28.2660332541568, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355577, Length=421, Percent_Identity=28.2660332541568, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24661285, Length=421, Percent_Identity=28.2660332541568, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41418; Mature: 41287

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPALRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFYTAVVVKRR
CCCCCCCHHEEEEEECCCCCCEEEECCCCEEEEECCCCCCCCEEEHHHHHHEEEEEEECC
DDLRFRAVSDAFPGEIEEWVFGEEGLPTANHWSNYLKGFTAAMATSGLAPKGLDVAVVSN
CCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VPMGAGLSSSAALEIAFGTAVNDCSQIKLSPLAIAQLAQRGENQFVGCACGIMDQMISAL
CCCCCCCCCCCEEEEEECCCCCCCHHCEECHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GEQDHALLIDCLDLDSEAISIPDSLSLIIINSNVQRGLVESEYNLRREQCEQAAAHFGLE
CCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHCHH
SLRDLDLATLEAGKADLSDNCYKRAKHVVTENRRTQNAAWALESGDIAKVSLLMAQSHRS
HHHCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
MRDDFEITTTEIDYLVEIISNVIGERGGVRMTGGGFGGCVVALVDHALTDAVVEVVEKQY
HCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEKTGLEADIYLCTASDGAKRIDD
HHHHCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SNPALRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFYTAVVVKRR
CCCCCCHHEEEEEECCCCCCEEEECCCCEEEEECCCCCCCCEEEHHHHHHEEEEEEECC
DDLRFRAVSDAFPGEIEEWVFGEEGLPTANHWSNYLKGFTAAMATSGLAPKGLDVAVVSN
CCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VPMGAGLSSSAALEIAFGTAVNDCSQIKLSPLAIAQLAQRGENQFVGCACGIMDQMISAL
CCCCCCCCCCCEEEEEECCCCCCCHHCEECHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GEQDHALLIDCLDLDSEAISIPDSLSLIIINSNVQRGLVESEYNLRREQCEQAAAHFGLE
CCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHCHH
SLRDLDLATLEAGKADLSDNCYKRAKHVVTENRRTQNAAWALESGDIAKVSLLMAQSHRS
HHHCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
MRDDFEITTTEIDYLVEIISNVIGERGGVRMTGGGFGGCVVALVDHALTDAVVEVVEKQY
HCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEKTGLEADIYLCTASDGAKRIDD
HHHHCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]