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The map label for this gene is galM [H]

Identifier: 157960405

GI number: 157960405

Start: 705652

End: 706683

Strand: Reverse

Name: galM [H]

Synonym: Spea_0576

Alternate gene names: 157960405

Gene position: 706683-705652 (Counterclockwise)

Preceding gene: 157960406

Following gene: 157960403

Centisome position: 13.66

GC content: 46.8

Gene sequence:

>1032_bases
ATGGTACGCATTCGCCCTCTCGAGCCTTGGACCGATCCACGTGGTGGACAAATAGAGCGACTGCTCATCGATAACGGTAC
AATAGCGATAGAAGTGTTAAGCCTTGGCGGGATCATCCGCTCTTTATGGGCACCGGATCGAGATGGTGAGCGTGCAAACT
TAGTATTAGGCTGTGATAGCGCTGAAGATTATCTAGCCCAAGATGCCTACTTGGGCGCCATTGCTGGACGATACGCCAAC
CGTATTGCCAAGGGCCGTTTTAGTGTTGGTCAAACTCAGTACCAGCTCGATGTTAACCAGGCGATGAATTGTTTACATGG
TGGCAGTGAAGGGTTCCATCGAAAAAATTGGCAACTAGGGCCACTACCCGATGGTGTGCGTCTCAGTCTAAAAAGCTTAG
ATCAAGACATGGGCTTTCCCGGTAACTGTAACGTGCAGTTAGATTATCGTCTAGTCGGCAATAATCTCTATGTAGAGATC
TTAGCAAGCTCAGATAAACCTTGCCCGATTAGCCTGACTCAACACAGTTATTTTAATCTAGACTCCAGCAAGACAAGCCT
CAACCACCAACTGCAGATCGATGCAAAACAATACCTCAGCATAGATGATAGCGGGATCCCCAAGTCTGTTTGTTCAACCA
AGAGCAGTGACTTAGATCTTTCTATGCCGACAGAGTTACAGTCACTCATTGGGCGTGAAGAATTAACCGCAACCTCGGGA
ATCGATCATTGTTTCTTAATGCCTAACACAGAGTCAAAACTACAGCGATTTGGTCGTTTGAGCTCACCACTTAGCGGTCG
TAGCATGACTTTATATACCAATCAGCCAAGCGTGCAGGTATATGGAGGTAATGGCTTAGAAGGGGTAATAGGTAAAAGCC
AACAGGGATTAGGTCAATATCAGGGGGTGTGTTTAGAACCTCAACAGATCCCAGATGCGCCAAACCAGGCTCATATAGCT
GGAGATGCGATGATTAATCCTGGCGAGGTTTACCATCATATCAGTCGCTATCAATTTGAAGTGGACGCCTAA

Upstream 100 bases:

>100_bases
AGGCCTAGAAGCCGATATTTATCTCTGTACAGCTAGCGATGGTGCCAAGCGTATCGACGATTAGCTTAACGATTGATGTA
ACAATTAACAGGACTTAATT

Downstream 100 bases:

>100_bases
TACCAATTGGTATAGAACAAATAACAGCGCCTAGGCGCTGTTATTTAACTCTTATTGATTAATCATCGTAATCGTCTGAC
CAATCATCATCATAGTCATC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVRIRPLEPWTDPRGGQIERLLIDNGTIAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEDYLAQDAYLGAIAGRYAN
RIAKGRFSVGQTQYQLDVNQAMNCLHGGSEGFHRKNWQLGPLPDGVRLSLKSLDQDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDSSKTSLNHQLQIDAKQYLSIDDSGIPKSVCSTKSSDLDLSMPTELQSLIGREELTATSG
IDHCFLMPNTESKLQRFGRLSSPLSGRSMTLYTNQPSVQVYGGNGLEGVIGKSQQGLGQYQGVCLEPQQIPDAPNQAHIA
GDAMINPGEVYHHISRYQFEVDA

Sequences:

>Translated_343_residues
MVRIRPLEPWTDPRGGQIERLLIDNGTIAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEDYLAQDAYLGAIAGRYAN
RIAKGRFSVGQTQYQLDVNQAMNCLHGGSEGFHRKNWQLGPLPDGVRLSLKSLDQDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDSSKTSLNHQLQIDAKQYLSIDDSGIPKSVCSTKSSDLDLSMPTELQSLIGREELTATSG
IDHCFLMPNTESKLQRFGRLSSPLSGRSMTLYTNQPSVQVYGGNGLEGVIGKSQQGLGQYQGVCLEPQQIPDAPNQAHIA
GDAMINPGEVYHHISRYQFEVDA
>Mature_343_residues
MVRIRPLEPWTDPRGGQIERLLIDNGTIAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEDYLAQDAYLGAIAGRYAN
RIAKGRFSVGQTQYQLDVNQAMNCLHGGSEGFHRKNWQLGPLPDGVRLSLKSLDQDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDSSKTSLNHQLQIDAKQYLSIDDSGIPKSVCSTKSSDLDLSMPTELQSLIGREELTATSG
IDHCFLMPNTESKLQRFGRLSSPLSGRSMTLYTNQPSVQVYGGNGLEGVIGKSQQGLGQYQGVCLEPQQIPDAPNQAHIA
GDAMINPGEVYHHISRYQFEVDA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=331, Percent_Identity=36.5558912386707, Blast_Score=208, Evalue=7e-54,
Organism=Escherichia coli, GI1786971, Length=332, Percent_Identity=35.2409638554217, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17557428, Length=321, Percent_Identity=28.9719626168224, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533334, Length=321, Percent_Identity=28.9719626168224, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319493, Length=311, Percent_Identity=28.6173633440514, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322004, Length=355, Percent_Identity=27.6056338028169, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=311, Percent_Identity=26.3665594855305, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24659048, Length=353, Percent_Identity=30.5949008498584, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24668278, Length=337, Percent_Identity=28.486646884273, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583720, Length=345, Percent_Identity=27.8260869565217, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24668282, Length=355, Percent_Identity=27.3239436619718, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24641876, Length=339, Percent_Identity=27.1386430678466, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37613; Mature: 37613

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRIRPLEPWTDPRGGQIERLLIDNGTIAIEVLSLGGIIRSLWAPDRDGERANLVLGCDS
CEEEECCCCCCCCCCCCEEEEEEECCEEEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCC
AEDYLAQDAYLGAIAGRYANRIAKGRFSVGQTQYQLDVNQAMNCLHGGSEGFHRKNWQLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCC
PLPDGVRLSLKSLDQDMGFPGNCNVQLDYRLVGNNLYVEILASSDKPCPISLTQHSYFNL
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEECCCEEEC
DSSKTSLNHQLQIDAKQYLSIDDSGIPKSVCSTKSSDLDLSMPTELQSLIGREELTATSG
CCCCCCCCEEEEECHHHHEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHCC
IDHCFLMPNTESKLQRFGRLSSPLSGRSMTLYTNQPSVQVYGGNGLEGVIGKSQQGLGQY
CCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCHHH
QGVCLEPQQIPDAPNQAHIAGDAMINPGEVYHHISRYQFEVDA
CCEEECHHHCCCCCCCCEEECCCEECHHHHHHHHHHEEEEECC
>Mature Secondary Structure
MVRIRPLEPWTDPRGGQIERLLIDNGTIAIEVLSLGGIIRSLWAPDRDGERANLVLGCDS
CEEEECCCCCCCCCCCCEEEEEEECCEEEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCC
AEDYLAQDAYLGAIAGRYANRIAKGRFSVGQTQYQLDVNQAMNCLHGGSEGFHRKNWQLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCC
PLPDGVRLSLKSLDQDMGFPGNCNVQLDYRLVGNNLYVEILASSDKPCPISLTQHSYFNL
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEECCCEEEC
DSSKTSLNHQLQIDAKQYLSIDDSGIPKSVCSTKSSDLDLSMPTELQSLIGREELTATSG
CCCCCCCCEEEEECHHHHEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHCC
IDHCFLMPNTESKLQRFGRLSSPLSGRSMTLYTNQPSVQVYGGNGLEGVIGKSQQGLGQY
CCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCHHH
QGVCLEPQQIPDAPNQAHIAGDAMINPGEVYHHISRYQFEVDA
CCEEECHHHCCCCCCCCEEECCCEECHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]