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The map label for this gene is trxA [H]

Identifier: 157960227

GI number: 157960227

Start: 480827

End: 481153

Strand: Reverse

Name: trxA [H]

Synonym: Spea_0398

Alternate gene names: 157960227

Gene position: 481153-480827 (Counterclockwise)

Preceding gene: 157960234

Following gene: 157960226

Centisome position: 9.3

GC content: 43.43

Gene sequence:

>327_bases
ATGAGCGACAAGATTGTATACCTAAGCGATGACAGCTTTGAAAATGACGTAATTAACTCAGAACTGCCAGTTCTTGTTGA
TTTCTGGGCTGAGTGGTGTGGTCCATGTAAGATGATTGCCCCAATCTTAGACGACGTAGCTGAAGAGTACGAAGGTAAGA
TCAAAATCGCTAAGCTTAATGTTGACCAAAACAACGTATCACCAGCTAAATACGGCGTTCGTGGCATCCCGACTCTATTG
CTTTTTAAAGCCGGTGAGCTTGCTGCGACTAAAGTTGGCGCACTATCAAAGACTCAGCTTAAAGAGTTTATCGACGCTCA
GCTTTAA

Upstream 100 bases:

>100_bases
AATATTTGCATAACTTTTAGCTTGAAAAGTTATTTTACCGACCCAATATACAGGTTAAGCCATTAACAAACCAGCAATGG
CAACCAAACTGGAGAACAAC

Downstream 100 bases:

>100_bases
TCACCAAATTACCGTTTAATCGCAGATCCGACGGTATATAAGTGACTCCCGACACAGCTTCAATAAGAAAATGTGTCGGG
TTAAGCTAAACTTCTAGACG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIVYLSDDSFENDVINSELPVLVDFWAEWCGPCKMIAPILDDVAEEYEGKIKIAKLNVDQNNVSPAKYGVRGIPTLL
LFKAGELAATKVGALSKTQLKEFIDAQL

Sequences:

>Translated_108_residues
MSDKIVYLSDDSFENDVINSELPVLVDFWAEWCGPCKMIAPILDDVAEEYEGKIKIAKLNVDQNNVSPAKYGVRGIPTLL
LFKAGELAATKVGALSKTQLKEFIDAQL
>Mature_107_residues
SDKIVYLSDDSFENDVINSELPVLVDFWAEWCGPCKMIAPILDDVAEEYEGKIKIAKLNVDQNNVSPAKYGVRGIPTLLL
FKAGELAATKVGALSKTQLKEFIDAQL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=39.1304347826087, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=35, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=38.4615384615385, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=71.2962962962963, Blast_Score=171, Evalue=1e-44,
Organism=Escherichia coli, GI1788936, Length=116, Percent_Identity=35.3448275862069, Blast_Score=92, Evalue=8e-21,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=40.625, Blast_Score=63, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=40.2061855670103, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17556044, Length=107, Percent_Identity=31.7757009345794, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=46.4788732394366, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532254, Length=113, Percent_Identity=35.3982300884956, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=35.3982300884956, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=37.3493975903614, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=39.7727272727273, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=115, Percent_Identity=33.0434782608696, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=115, Percent_Identity=33.0434782608696, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=35, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=32.5581395348837, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=37.9310344827586, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=37.9310344827586, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=42.0454545454545, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=38.3720930232558, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324862, Length=89, Percent_Identity=33.7078651685393, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=36.9565217391304, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=42.4657534246575, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=39.7727272727273, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=57, Percent_Identity=42.1052631578947, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11919; Mature: 11788

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIVYLSDDSFENDVINSELPVLVDFWAEWCGPCKMIAPILDDVAEEYEGKIKIAKLN
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKAGELAATKVGALSKTQLKEFIDAQL
CCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDKIVYLSDDSFENDVINSELPVLVDFWAEWCGPCKMIAPILDDVAEEYEGKIKIAKLN
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKAGELAATKVGALSKTQLKEFIDAQL
CCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]