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The map label for this gene is ilvY [H]

Identifier: 157960172

GI number: 157960172

Start: 388225

End: 389097

Strand: Reverse

Name: ilvY [H]

Synonym: Spea_0343

Alternate gene names: 157960172

Gene position: 389097-388225 (Counterclockwise)

Preceding gene: 157960180

Following gene: 157960169

Centisome position: 7.52

GC content: 51.2

Gene sequence:

>873_bases
TTGGATATCCGCACTATCAAGCTTTATCTGCATTTAGCAGACAGTTTGCACTTTGCTAGAACAGCACAGGCGATGCATGT
CAGTCCATCGACCTTGAGCCGGACCATGCAGAGGCTGGAAGAGGAGGTTGGCGCGCAGCTGTTTCAACGTGACAACCGCA
GCGTGACCTTGACCAGCGCCGGAGTCGAGTACCGACACTTTGCCGAGTCCACACTTGAGCAGTGGGGAAAGCTGAAAACC
AAGCTAGATCCTAAGCAGGACTTTCTAAGAGGACGGCTCAACCTGTACTGCTCGGTAACCGCCGCCTACAGTCACCTCCC
AGGATTGTTGGATCGTTTTAGACGTGAGCATCCATTAGTAGAAATCGCCCTCACCACGGGTGATGCAGCCAATGCGGTGA
ATGAAGTACGCAACAATCGCGCCGATATTGCCATCGCCGCCCTACCCGATCCGTTTCCCGATAACCTGCATTTTGCAAAA
ATAGATGATGTGCCGCTATCGATCATTGCGCCGACGTTTAGGTGTCAGGTGCAAGAGCTGCTTACTGAGTCTTATATTCC
ATGGGATAGACTGCCCTTTATCGTGCCGGAGCACGGTCCGGGTCGAAAACGTATCGATAACTGGTTTAAGTCATTGGGAT
TAATTCCCAATATTTATGCGCAAGTGTCTGGCCAAGAAGCCATAACCTCTATGGTGGCATTGGGCTGCGGCGTGAGCATT
ACCCCAGAGGTGGTGATTAATAACAGCCCAGTACGAGATCGCATTCAGCTACTCACATCGCCTATCGACATTCCGCCGTT
TGAACTCGGCTGTTGTTGTAAGAGCAAACGCCTAGCCGAACCTGTTATAGAGGCATTTCTGCAGGCGATTTAA

Upstream 100 bases:

>100_bases
AGCTTTTCATTGCTTAAAATGATATATTCGGGATGTAGTGTTGCATCTTTTGCAACACCAACTAAATTAATGCCGTTTTA
TCAAACATGGAGAACTCAGC

Downstream 100 bases:

>100_bases
TTCGTCTTTGAAGCTCGCGTTTATACGATCGAGATCCAGTCATGCAGAGCTAGGCTGGGTTCTTTTCTTTAAAAGCTATA
AACCACGAAGCGCTCACTCC

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDIRTIKLYLHLADSLHFARTAQAMHVSPSTLSRTMQRLEEEVGAQLFQRDNRSVTLTSAGVEYRHFAESTLEQWGKLKT
KLDPKQDFLRGRLNLYCSVTAAYSHLPGLLDRFRREHPLVEIALTTGDAANAVNEVRNNRADIAIAALPDPFPDNLHFAK
IDDVPLSIIAPTFRCQVQELLTESYIPWDRLPFIVPEHGPGRKRIDNWFKSLGLIPNIYAQVSGQEAITSMVALGCGVSI
TPEVVINNSPVRDRIQLLTSPIDIPPFELGCCCKSKRLAEPVIEAFLQAI

Sequences:

>Translated_290_residues
MDIRTIKLYLHLADSLHFARTAQAMHVSPSTLSRTMQRLEEEVGAQLFQRDNRSVTLTSAGVEYRHFAESTLEQWGKLKT
KLDPKQDFLRGRLNLYCSVTAAYSHLPGLLDRFRREHPLVEIALTTGDAANAVNEVRNNRADIAIAALPDPFPDNLHFAK
IDDVPLSIIAPTFRCQVQELLTESYIPWDRLPFIVPEHGPGRKRIDNWFKSLGLIPNIYAQVSGQEAITSMVALGCGVSI
TPEVVINNSPVRDRIQLLTSPIDIPPFELGCCCKSKRLAEPVIEAFLQAI
>Mature_290_residues
MDIRTIKLYLHLADSLHFARTAQAMHVSPSTLSRTMQRLEEEVGAQLFQRDNRSVTLTSAGVEYRHFAESTLEQWGKLKT
KLDPKQDFLRGRLNLYCSVTAAYSHLPGLLDRFRREHPLVEIALTTGDAANAVNEVRNNRADIAIAALPDPFPDNLHFAK
IDDVPLSIIAPTFRCQVQELLTESYIPWDRLPFIVPEHGPGRKRIDNWFKSLGLIPNIYAQVSGQEAITSMVALGCGVSI
TPEVVINNSPVRDRIQLLTSPIDIPPFELGCCCKSKRLAEPVIEAFLQAI

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=51.877133105802, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1787601, Length=170, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=25.1063829787234, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787806, Length=266, Percent_Identity=19.9248120300752, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788887, Length=248, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788296, Length=239, Percent_Identity=26.3598326359833, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=256, Percent_Identity=23.828125, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790399, Length=258, Percent_Identity=23.2558139534884, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=25.0996015936255, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693105, Length=297, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI2367136, Length=257, Percent_Identity=22.1789883268482, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=158, Percent_Identity=31.6455696202532, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=24.7967479674797, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32495; Mature: 32495

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRTIKLYLHLADSLHFARTAQAMHVSPSTLSRTMQRLEEEVGAQLFQRDNRSVTLTSA
CCCEEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GVEYRHFAESTLEQWGKLKTKLDPKQDFLRGRLNLYCSVTAAYSHLPGLLDRFRREHPLV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCEE
EIALTTGDAANAVNEVRNNRADIAIAALPDPFPDNLHFAKIDDVPLSIIAPTFRCQVQEL
EEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHCHHHHHHHHHH
LTESYIPWDRLPFIVPEHGPGRKRIDNWFKSLGLIPNIYAQVSGQEAITSMVALGCGVSI
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCCCC
TPEVVINNSPVRDRIQLLTSPIDIPPFELGCCCKSKRLAEPVIEAFLQAI
CCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MDIRTIKLYLHLADSLHFARTAQAMHVSPSTLSRTMQRLEEEVGAQLFQRDNRSVTLTSA
CCCEEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GVEYRHFAESTLEQWGKLKTKLDPKQDFLRGRLNLYCSVTAAYSHLPGLLDRFRREHPLV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCEE
EIALTTGDAANAVNEVRNNRADIAIAALPDPFPDNLHFAKIDDVPLSIIAPTFRCQVQEL
EEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHCHHHHHHHHHH
LTESYIPWDRLPFIVPEHGPGRKRIDNWFKSLGLIPNIYAQVSGQEAITSMVALGCGVSI
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCCCC
TPEVVINNSPVRDRIQLLTSPIDIPPFELGCCCKSKRLAEPVIEAFLQAI
CCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]