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The map label for this gene is hutH [H]

Identifier: 157960167

GI number: 157960167

Start: 382112

End: 383764

Strand: Reverse

Name: hutH [H]

Synonym: Spea_0338

Alternate gene names: 157960167

Gene position: 383764-382112 (Counterclockwise)

Preceding gene: 157960168

Following gene: 157960164

Centisome position: 7.42

GC content: 46.22

Gene sequence:

>1653_bases
ATGAAGAAAAGTGTATTTGCATTACTCGTTGCTGCAAGCCTACCTTTGTCCGCTAATGCTGCAACACATACCCTAGATGG
TCGCTCGCTTACTGTTGACCAATTATGGGAAATCGCCCAACCAGGTGAAGATGTCACCATTGCTAAAGCAGGTTGGCAGC
GCATTAACGCAGGTTACAAGGCGCCTATTCACGCTGCAGCAGATGGCCGTTCAATTTACGGTTTAACCGTTAACTACGGC
GCCTTAAAGGATCAACGTGTTGCAGGTACATCTGTTGAAGATGAGCCAAACTTCACTGCATCGATAAAGTTCAACGAACG
CCAGATGCGCATTCAAGCCGCAGGTGTTGAACCGTTCATCTCTGAGCGCGAATCAAAGATGGCGATGATTATTCGCCTTA
ACCAAATGGCTGCTGGCTACACGGCAATGAGTACCGAAGGTGCGCAAGCATTTATGGATTACATCAACGCAGACGTCACA
CCACTCATTCCAAGTCGAGGCTCATCTGGTGCTAACGATTTAAGTTTAGCGACCCATATTGGTTTATCGTTAATGGGAGA
ATGGGACGTAATGTACAAAGGCGAGCGCCGTGACTCGAAAGAAGTTCGCGAAGAGCTAGGCCTTGAGCCATACAGACCGT
TCGGTTTAGACGGTATTTCTATCCTATCAAACGGTAACGTAGCCGAAGCGCAGAACATCGCAGCGGTTAAGAAAGCCGAA
CATTTACTCGATATTTCACCTGTGATTATTGCCTCTTCACTAGAAGCACTGAACGGTAACGTATCGCCATTCCTTTGGCA
CACTGTTGACACAAAAGGCTGGCCACAAGGTCATGAAGCTGCAGAAGGCATTCTTGGCGCATTAAAGGGCTCATACTTAT
GGGAATTAGATAACAAGCGTAACCTACAGGACCCGCTATCATTCCGTTCATCGGGCTACATTTTAGCGACCGCAAAAGAA
GAGCTACGCCAAGCAAAAGAGCTACTTAACACAGCGATTAATCACACCACTGATAACCCTATTGTGAATACTGAAGCTCG
TGATGACTTATGGTATAGCAACACACCAGCCGTTAATGCATTACGTGTCGGCGATGACAATGTCTTTGTAAACTCTGGCG
CTAACTTCGACAACACTCAACTAGCCGTACAGATGGAGTCTTTAGGCCGTGCACTTGCACAAGTTATCCATATTTCGGCT
TGGCGTACTACTCAGCTTGACGATGGACACCGTACTAACCTACCGACTTACCTTATCGCGAAAGAGAATGTCGGCGGCGA
TGGTTTTGCTAATATCGCCCAGTCAATGTCGGGTCTATATGCCGAAGCGATGACTCTAACTAATAGCGCTACACTATACG
GCATCCCAACTTCAGTCGGTATTGAAGAGACCTTTAGTAACGTGAACTTAATTGCTTCTCGCGTTGCAAAAATGGCTGAT
ATTGGTTACGAAATCTATGCCTATGAGGTGTTACATACCACGCAAGGTATGGAGATCCGTATGAGAGATCAAGATAAGAA
AATGGGTCAAGGTACCAGTCACCTTATCGAGCAATACCGTAAAGTGGTGCCATTTGTTGATTTAGACCGGACTTACACGC
CAGATATTAATAATGGCATCAAGTTCCTTAAGACTTACTCTGCGGCCAAGTAA

Upstream 100 bases:

>100_bases
CCATTCAGAGCACCAACCTTCGAAAGATATTTGTTCCGACTGTCATAAAGTCGAATTTAACAACCTTAAGTAGATGTACT
ACCAATTAGAGAATTGAACA

Downstream 100 bases:

>100_bases
GGACCCATGGCTTAGTTAATTAAGCCTGACTCCCCCACTGCAATAAAAAAGGTGTTTAGCCAATCGCTAAACACCTTTTC
ATTTTCTTACAATAGTACTA

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKKSVFALLVAASLPLSANAATHTLDGRSLTVDQLWEIAQPGEDVTIAKAGWQRINAGYKAPIHAAADGRSIYGLTVNYG
ALKDQRVAGTSVEDEPNFTASIKFNERQMRIQAAGVEPFISERESKMAMIIRLNQMAAGYTAMSTEGAQAFMDYINADVT
PLIPSRGSSGANDLSLATHIGLSLMGEWDVMYKGERRDSKEVREELGLEPYRPFGLDGISILSNGNVAEAQNIAAVKKAE
HLLDISPVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAEGILGALKGSYLWELDNKRNLQDPLSFRSSGYILATAKE
ELRQAKELLNTAINHTTDNPIVNTEARDDLWYSNTPAVNALRVGDDNVFVNSGANFDNTQLAVQMESLGRALAQVIHISA
WRTTQLDDGHRTNLPTYLIAKENVGGDGFANIAQSMSGLYAEAMTLTNSATLYGIPTSVGIEETFSNVNLIASRVAKMAD
IGYEIYAYEVLHTTQGMEIRMRDQDKKMGQGTSHLIEQYRKVVPFVDLDRTYTPDINNGIKFLKTYSAAK

Sequences:

>Translated_550_residues
MKKSVFALLVAASLPLSANAATHTLDGRSLTVDQLWEIAQPGEDVTIAKAGWQRINAGYKAPIHAAADGRSIYGLTVNYG
ALKDQRVAGTSVEDEPNFTASIKFNERQMRIQAAGVEPFISERESKMAMIIRLNQMAAGYTAMSTEGAQAFMDYINADVT
PLIPSRGSSGANDLSLATHIGLSLMGEWDVMYKGERRDSKEVREELGLEPYRPFGLDGISILSNGNVAEAQNIAAVKKAE
HLLDISPVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAEGILGALKGSYLWELDNKRNLQDPLSFRSSGYILATAKE
ELRQAKELLNTAINHTTDNPIVNTEARDDLWYSNTPAVNALRVGDDNVFVNSGANFDNTQLAVQMESLGRALAQVIHISA
WRTTQLDDGHRTNLPTYLIAKENVGGDGFANIAQSMSGLYAEAMTLTNSATLYGIPTSVGIEETFSNVNLIASRVAKMAD
IGYEIYAYEVLHTTQGMEIRMRDQDKKMGQGTSHLIEQYRKVVPFVDLDRTYTPDINNGIKFLKTYSAAK
>Mature_550_residues
MKKSVFALLVAASLPLSANAATHTLDGRSLTVDQLWEIAQPGEDVTIAKAGWQRINAGYKAPIHAAADGRSIYGLTVNYG
ALKDQRVAGTSVEDEPNFTASIKFNERQMRIQAAGVEPFISERESKMAMIIRLNQMAAGYTAMSTEGAQAFMDYINADVT
PLIPSRGSSGANDLSLATHIGLSLMGEWDVMYKGERRDSKEVREELGLEPYRPFGLDGISILSNGNVAEAQNIAAVKKAE
HLLDISPVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAEGILGALKGSYLWELDNKRNLQDPLSFRSSGYILATAKE
ELRQAKELLNTAINHTTDNPIVNTEARDDLWYSNTPAVNALRVGDDNVFVNSGANFDNTQLAVQMESLGRALAQVIHISA
WRTTQLDDGHRTNLPTYLIAKENVGGDGFANIAQSMSGLYAEAMTLTNSATLYGIPTSVGIEETFSNVNLIASRVAKMAD
IGYEIYAYEVLHTTQGMEIRMRDQDKKMGQGTSHLIEQYRKVVPFVDLDRTYTPDINNGIKFLKTYSAAK

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=541, Percent_Identity=21.4417744916821, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17567831, Length=537, Percent_Identity=22.1601489757914, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 60128; Mature: 60128

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSVFALLVAASLPLSANAATHTLDGRSLTVDQLWEIAQPGEDVTIAKAGWQRINAGYK
CCHHHHHHHHHHCCCCCCCCCEEECCCCEEEHHHHHHHHCCCCCEEEECCCHHHHCCCCC
APIHAAADGRSIYGLTVNYGALKDQRVAGTSVEDEPNFTASIKFNERQMRIQAAGVEPFI
CCEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCHHH
SERESKMAMIIRLNQMAAGYTAMSTEGAQAFMDYINADVTPLIPSRGSSGANDLSLATHI
HHCCCCEEEEEEEEHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
GLSLMGEWDVMYKGERRDSKEVREELGLEPYRPFGLDGISILSNGNVAEAQNIAAVKKAE
CCCEEECEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHH
HLLDISPVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAEGILGALKGSYLWELDNKR
HHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
NLQDPLSFRSSGYILATAKEELRQAKELLNTAINHTTDNPIVNTEARDDLWYSNTPAVNA
CCCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCEE
LRVGDDNVFVNSGANFDNTQLAVQMESLGRALAQVIHISAWRTTQLDDGHRTNLPTYLIA
EEECCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
KENVGGDGFANIAQSMSGLYAEAMTLTNSATLYGIPTSVGIEETFSNVNLIASRVAKMAD
ECCCCCCHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IGYEIYAYEVLHTTQGMEIRMRDQDKKMGQGTSHLIEQYRKVVPFVDLDRTYTPDINNGI
CCEEEEEEEEEECCCCCEEEECCCHHHCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCH
KFLKTYSAAK
HHHHHHCCCC
>Mature Secondary Structure
MKKSVFALLVAASLPLSANAATHTLDGRSLTVDQLWEIAQPGEDVTIAKAGWQRINAGYK
CCHHHHHHHHHHCCCCCCCCCEEECCCCEEEHHHHHHHHCCCCCEEEECCCHHHHCCCCC
APIHAAADGRSIYGLTVNYGALKDQRVAGTSVEDEPNFTASIKFNERQMRIQAAGVEPFI
CCEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCHHH
SERESKMAMIIRLNQMAAGYTAMSTEGAQAFMDYINADVTPLIPSRGSSGANDLSLATHI
HHCCCCEEEEEEEEHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
GLSLMGEWDVMYKGERRDSKEVREELGLEPYRPFGLDGISILSNGNVAEAQNIAAVKKAE
CCCEEECEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHH
HLLDISPVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAEGILGALKGSYLWELDNKR
HHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
NLQDPLSFRSSGYILATAKEELRQAKELLNTAINHTTDNPIVNTEARDDLWYSNTPAVNA
CCCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCEE
LRVGDDNVFVNSGANFDNTQLAVQMESLGRALAQVIHISAWRTTQLDDGHRTNLPTYLIA
EEECCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
KENVGGDGFANIAQSMSGLYAEAMTLTNSATLYGIPTSVGIEETFSNVNLIASRVAKMAD
ECCCCCCHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IGYEIYAYEVLHTTQGMEIRMRDQDKKMGQGTSHLIEQYRKVVPFVDLDRTYTPDINNGI
CCEEEEEEEEEECCCCCEEEECCCHHHCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCH
KFLKTYSAAK
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]