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The map label for this gene is yeiG [H]

Identifier: 157960099

GI number: 157960099

Start: 303077

End: 303916

Strand: Direct

Name: yeiG [H]

Synonym: Spea_0270

Alternate gene names: 157960099

Gene position: 303077-303916 (Clockwise)

Preceding gene: 157960098

Following gene: 157960100

Centisome position: 5.86

GC content: 46.43

Gene sequence:

>840_bases
ATGACCGTTGAAAATATCAGTGTAAATAAGAGCTTTGGTGGTTGGCATAAGCAGTACAGCCATCAATCTAAAACACTTAA
TTGCGCAATGCGATTTGCCATTTATTTACCGCCTCAAGCGTCAAATGGTAAAAAAGTGCCAGTGCTGTATTGGTTGTCAG
GTTTAACCTGCACCGATGAAAACTTTATGCAAAAAGCCGGTGCTCAGCGTATGGCTGCTGAGCTGGGTATTGCGATTGTT
GCCCCTGATACCAGCCCACGTGGTGACGATGTTGCCGATGACACGGGTTACGACTTAGGTAAGGGCGCAGGTTTCTATGT
TAACGCTACCCAAGCTCCTTGGAACCGTCATTATAGAATGTACGATTATGTGGTTAATGAATTGCCACAGCTGATTGAGT
CTATGTTCCCGGTTAGTGATAAGCGCTCAATAGCGGGCCATTCTATGGGCGGCCACGGTGCACTCGTAATTGCCATGCGT
AATCCACAGGCTTACCAGTCGGTGTCGGCATTTAGCCCAATTACGAACCCTGTTAACTGCCCTTGGGGCAAGAAGGCGTT
CACTGCTTATTTGGGTCGTGATACGACAACTTGGGTTGACTACGATGCGAGCTTATTAATGCGTCAAGCGACTGAGTTTG
TGCCAGCGCTAGTGGATCAAGGTGAAGCTGATGATTTTCTTATCGAACAGCTAAAGCCAGAGGTACTAGAGGCCGCAGCC
AAGATGAGTGGATATCCTTTAACGCTAAATATGCAAGAAGGCTTCGATCATAGCTACTACTTTATCTCTAGCTTTATCGA
AAACCACCTGCGTTTTCATGCTGAGCACTTAGTTAAGTAG

Upstream 100 bases:

>100_bases
CTGGCGCTTGTTATTTTTAAAGGCTTAATTTTTAAAGATAGAGCTTTAAAGGTTGAGCTTTACAGAATTAGTTTAAAGAA
TTTATAGGAGTCGGTATTAA

Downstream 100 bases:

>100_bases
TCGCTTATATAGGCGCGATTACTCGCTGACATTCCGACACGAGAAGCTGCCCACCAAGGCAGCTTTTTTTATTGCTAATG
TTCAGGCCTCAAAGAGATTA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTVENISVNKSFGGWHKQYSHQSKTLNCAMRFAIYLPPQASNGKKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIV
APDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPQLIESMFPVSDKRSIAGHSMGGHGALVIAMR
NPQAYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWVDYDASLLMRQATEFVPALVDQGEADDFLIEQLKPEVLEAAA
KMSGYPLTLNMQEGFDHSYYFISSFIENHLRFHAEHLVK

Sequences:

>Translated_279_residues
MTVENISVNKSFGGWHKQYSHQSKTLNCAMRFAIYLPPQASNGKKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIV
APDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPQLIESMFPVSDKRSIAGHSMGGHGALVIAMR
NPQAYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWVDYDASLLMRQATEFVPALVDQGEADDFLIEQLKPEVLEAAA
KMSGYPLTLNMQEGFDHSYYFISSFIENHLRFHAEHLVK
>Mature_278_residues
TVENISVNKSFGGWHKQYSHQSKTLNCAMRFAIYLPPQASNGKKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIVA
PDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPQLIESMFPVSDKRSIAGHSMGGHGALVIAMRN
PQAYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWVDYDASLLMRQATEFVPALVDQGEADDFLIEQLKPEVLEAAAK
MSGYPLTLNMQEGFDHSYYFISSFIENHLRFHAEHLVK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=54.0925266903915, Blast_Score=321, Evalue=5e-88,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=58.4229390681004, Blast_Score=353, Evalue=6e-99,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=55.2727272727273, Blast_Score=327, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=48.943661971831, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322393, Length=286, Percent_Identity=43.7062937062937, Blast_Score=231, Evalue=8e-62,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=51.7605633802817, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=51.7605633802817, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31094; Mature: 30963

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVENISVNKSFGGWHKQYSHQSKTLNCAMRFAIYLPPQASNGKKVPVLYWLSGLTCTDE
CCCCCEECCCCCCCHHHHHHCCHHHHEEEEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAQRMAAELGIAIVAPDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHCHHH
YDYVVNELPQLIESMFPVSDKRSIAGHSMGGHGALVIAMRNPQAYQSVSAFSPITNPVNC
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCC
PWGKKAFTAYLGRDTTTWVDYDASLLMRQATEFVPALVDQGEADDFLIEQLKPEVLEAAA
CCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHH
KMSGYPLTLNMQEGFDHSYYFISSFIENHLRFHAEHLVK
HHCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVENISVNKSFGGWHKQYSHQSKTLNCAMRFAIYLPPQASNGKKVPVLYWLSGLTCTDE
CCCCEECCCCCCCHHHHHHCCHHHHEEEEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAQRMAAELGIAIVAPDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHCHHH
YDYVVNELPQLIESMFPVSDKRSIAGHSMGGHGALVIAMRNPQAYQSVSAFSPITNPVNC
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCC
PWGKKAFTAYLGRDTTTWVDYDASLLMRQATEFVPALVDQGEADDFLIEQLKPEVLEAAA
CCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHH
KMSGYPLTLNMQEGFDHSYYFISSFIENHLRFHAEHLVK
HHCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA