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The map label for this gene is hemA [H]

Identifier: 157826315

GI number: 157826315

Start: 1167736

End: 1168980

Strand: Direct

Name: hemA [H]

Synonym: A1C_06520

Alternate gene names: 157826315

Gene position: 1167736-1168980 (Clockwise)

Preceding gene: 157826314

Following gene: 157826316

Centisome position: 94.86

GC content: 35.42

Gene sequence:

>1245_bases
ATGTCTTATTACGATACTATATTTAGCAAACATATAGACAAAATTAAGGGCGAAGGAAGGTATCGAGAATTTAAAGCCTT
AAAAAGACAAGCCGATAATTTTCCTTTTGCAGAACATGCTAATAAACAAATAGTTATGTGGTGCATTAATGACTATTTAG
GTATGAGTAAACATGCAAAAGTAATGCAAGCTTCTATAGAGACATTGCTAAAATACGGTGTTGGATCAGGCGGAACTCGC
AATATCGGCGGCAATAATATTGCCATTCTTGAGCTTGAAAAAGAACTTGCAGATTTACACAAAAAGCAAGCAGCTTTAGT
TTTTACATCTGGTTTTGTTGCAAATGATACAACGCTTGCAAGTCTTGCTAAAATCATGCCGGATATAGTATTTTTCTCCG
ATGAGCTAAATCATGCATCAATCATTGCAGGAATTACAAGTTCAAGAGCCGAGAAATATATATATAGACATTTAGATGTT
AAACATCTAGAAGAGCTTTTGCAATCAATCGATATTAATAGGCCGAAAATTATTGTTTTTGAATCGGCTTACTCTATGGA
CGGTTTCTTCTCACCTATCAAAGATATAATCAACTTAGCCAAAAAATATAATGCTTTAACCTTTATCGACGAAGTCCATA
CGGTCGGTTTGTACGGTAAACAAGGCGGCGGTATGGCTGAGCTTCTTAATTGTAGCGATCAAATCGATATTATTCAAGGA
ACGCTTGCCAAAGCATACGGCACTATCGGCGGTTATATCACTAGCACCCATAATTTAGTCAATGCTATAAGATTAACCGC
TCCAGGATTTATTTTCACTACTTCATTACCGCCGGTAATTTCTACCGCTGCAACGCATAGTATTAGACATCTTAAAGAAT
CAAATGAAGAACGAATAACACATCAAGAAGTAGTGATAAAACTTAAAAACTCTTTTGAAAATTTTAATATACCTTATTTG
AAAAATGAAAGTCATATAGTGCCAATAATTATTGGTGATCCGATTAAAGCGGCGAGAGCCTCAAATATGCTCCTTAATGA
GTACAGTATTTACGTTCAACATATCAATTTTCCAACCGTACCGAGAGGTACGGAACGCCTCCGAATCATACCAACCCCTG
CCCATACCAATAAAATGATCAATGATTTGTCTATAGCCTTAGTGCATATATTTGCCGAACTTGATATAGAATTATCTTCT
ACAAAAGAACTAAACGAAGAAGTACGTTTGAATCTTATTGCATAA

Upstream 100 bases:

>100_bases
AGTATTTTTTATTGTTTTTATGGATCCCATGGTCAAGCCACGGGATGACACAGTATATTTTACAATTCACATAAAAAACT
TCAAACAAATAATAGTTCTA

Downstream 100 bases:

>100_bases
AGTCATTGTGAGGGAAATTACGAAGTAATTGACAAAGCAAGTAAGAAAAAAAATTCTGATTTACCGAATTTTTTTAATTA
TTTTCTGGATTGCCACGTCG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSYYDTIFSKHIDKIKGEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMQASIETLLKYGVGSGGTR
NIGGNNIAILELEKELADLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDV
KHLEELLQSIDINRPKIIVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGMAELLNCSDQIDIIQG
TLAKAYGTIGGYITSTHNLVNAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERITHQEVVIKLKNSFENFNIPYL
KNESHIVPIIIGDPIKAARASNMLLNEYSIYVQHINFPTVPRGTERLRIIPTPAHTNKMINDLSIALVHIFAELDIELSS
TKELNEEVRLNLIA

Sequences:

>Translated_414_residues
MSYYDTIFSKHIDKIKGEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMQASIETLLKYGVGSGGTR
NIGGNNIAILELEKELADLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDV
KHLEELLQSIDINRPKIIVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGMAELLNCSDQIDIIQG
TLAKAYGTIGGYITSTHNLVNAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERITHQEVVIKLKNSFENFNIPYL
KNESHIVPIIIGDPIKAARASNMLLNEYSIYVQHINFPTVPRGTERLRIIPTPAHTNKMINDLSIALVHIFAELDIELSS
TKELNEEVRLNLIA
>Mature_413_residues
SYYDTIFSKHIDKIKGEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMQASIETLLKYGVGSGGTRN
IGGNNIAILELEKELADLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVK
HLEELLQSIDINRPKIIVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGMAELLNCSDQIDIIQGT
LAKAYGTIGGYITSTHNLVNAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERITHQEVVIKLKNSFENFNIPYLK
NESHIVPIIIGDPIKAARASNMLLNEYSIYVQHINFPTVPRGTERLRIIPTPAHTNKMINDLSIALVHIFAELDIELSST
KELNEEVRLNLIA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=45.9057071960298, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=45.9057071960298, Blast_Score=380, Evalue=1e-106,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=45.9057071960298, Blast_Score=380, Evalue=1e-106,
Organism=Homo sapiens, GI4502025, Length=412, Percent_Identity=46.8446601941748, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI40316939, Length=412, Percent_Identity=46.8446601941748, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=33.2474226804124, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI284448556, Length=351, Percent_Identity=35.6125356125356, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI119220554, Length=421, Percent_Identity=29.2161520190024, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4758668, Length=379, Percent_Identity=28.2321899736148, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI5454084, Length=246, Percent_Identity=30.8943089430894, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=28.9340101522843, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=28.4122562674095, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=32.1608040201005, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=349, Percent_Identity=28.080229226361, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=351, Percent_Identity=27.6353276353276, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=351, Percent_Identity=27.6353276353276, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=238, Percent_Identity=32.3529411764706, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=233, Percent_Identity=32.618025751073, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320438, Length=417, Percent_Identity=45.5635491606715, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320267, Length=378, Percent_Identity=27.2486772486773, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=26.1818181818182, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=46.8827930174564, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24662918, Length=394, Percent_Identity=31.9796954314721, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24653280, Length=256, Percent_Identity=31.25, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24653276, Length=256, Percent_Identity=31.25, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24653278, Length=256, Percent_Identity=31.25, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136286, Length=376, Percent_Identity=27.1276595744681, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46288; Mature: 46157

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYDTIFSKHIDKIKGEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAK
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEEHHHHCCHHHHH
VMQASIETLLKYGVGSGGTRNIGGNNIAILELEKELADLHKKQAALVFTSGFVANDTTLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCEEEEEECCCEECCHHHH
SLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVKHLEELLQSIDINRPKIIVF
HHHHHHHHHEEECCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
ESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGMAELLNCSDQIDIIQG
ECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCCCCHHHHHCCCCCHHHHHH
TLAKAYGTIGGYITSTHNLVNAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIT
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
HQEVVIKLKNSFENFNIPYLKNESHIVPIIIGDPIKAARASNMLLNEYSIYVQHINFPTV
HHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCC
PRGTERLRIIPTPAHTNKMINDLSIALVHIFAELDIELSSTKELNEEVRLNLIA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHCCCHHEEEECC
>Mature Secondary Structure 
SYYDTIFSKHIDKIKGEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAK
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEEHHHHCCHHHHH
VMQASIETLLKYGVGSGGTRNIGGNNIAILELEKELADLHKKQAALVFTSGFVANDTTLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCEEEEEECCCEECCHHHH
SLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVKHLEELLQSIDINRPKIIVF
HHHHHHHHHEEECCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
ESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGMAELLNCSDQIDIIQG
ECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCCCCHHHHHCCCCCHHHHHH
TLAKAYGTIGGYITSTHNLVNAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIT
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
HQEVVIKLKNSFENFNIPYLKNESHIVPIIIGDPIKAARASNMLLNEYSIYVQHINFPTV
HHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCC
PRGTERLRIIPTPAHTNKMINDLSIALVHIFAELDIELSSTKELNEEVRLNLIA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]