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The map label for this gene is fabD [H]

Identifier: 157826192

GI number: 157826192

Start: 1036650

End: 1037594

Strand: Reverse

Name: fabD [H]

Synonym: A1C_05845

Alternate gene names: 157826192

Gene position: 1037594-1036650 (Counterclockwise)

Preceding gene: 157826193

Following gene: 157826191

Centisome position: 84.28

GC content: 34.07

Gene sequence:

>945_bases
ATGAAAACAGCTTTTATCTTCCCCGGTCAAGGTGCGCAATTGATCGGCATGGGGAAGGATTTTTATGATAATTTTAAACC
CGCCAAAGAAACTTTTCAAGTCGTTAATGAAGTACTAAATCGAAAGCTCACTAATATAATTTTTAATGGACCTTCTGCAG
AACTTACCTTAACCACTAACGCACAACCGGCATTAATGGCAGTATCTATGGCAATAATAAATATTATCAAAGCTGAAACA
GGTAAAAATTTGGATAGTTTTTGCGATTATGCTGCCGGTCATTCGCTAGGTGAATATAGTGCTTTATGTAGTACCGAAAG
TATTAGCCTTGAGACAGCAGCAAAGCTACTTCATATACGTAGTACATCTATGCAAGAAGCATGTCCCGAAGGTGAGGGAA
GCATGGCAGCTTGTATCAATATTCCGCTTCAAAAACTTGAAGAAATATTAGAAGATATCAACAAAATAAATGTATGCCAA
ATTGCCAACGATAATATCAAAGGACAAATAGTTATTAGCGGTAAAACCACAGCTATCGATCATGCTATTAGTATAATTAA
AGATTTAGGTTATAAAGCGATAAAACTGAAAGTCAGTGCTCCATTTCATTGTAGCTTAATGAAGCCTGCAGAAGAAAAAA
TGCGAGTAGCTCTTGATAAATCTGTAATTAATAAGCCTATAATACCGATAATCCAAAATTGTACTGCAAAACTTACTCTA
GATCCTACCGAAATCAAACAAAATTTAATTCTTCAGATATGTAGACGAGTTAGATGGCGTGAAACTTTAAAGCTATTTAA
TCAGCTAGATGTAACCCATATAGTAGAAATAGGGGCAGGAAACGTACTAACCAATATGCTACGGAAAATTAATTATCCAT
ATAAATTAAGTAATATTAGTAATTTAGAAGAACTACAGAATTTTTTAGAGAACGTTAGCAAATAA

Upstream 100 bases:

>100_bases
CGTCACAATTGAAAAACCGTTTTTAAATGCTTAAAATAATTTGACTATTTTAGAAAATTTTAATAATATCCATTAACAGA
CTCAATCGATAATACAAAAT

Downstream 100 bases:

>100_bases
CACCTCTAATAACTTCTGATTTATAAAGCTTTTAAATTAACTCAATAATATTATTATATGAAAATTAGTTGTAGTTTTTT
AAGCAATGGCTAGAATTATT

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKTAFIFPGQGAQLIGMGKDFYDNFKPAKETFQVVNEVLNRKLTNIIFNGPSAELTLTTNAQPALMAVSMAIINIIKAET
GKNLDSFCDYAAGHSLGEYSALCSTESISLETAAKLLHIRSTSMQEACPEGEGSMAACINIPLQKLEEILEDINKINVCQ
IANDNIKGQIVISGKTTAIDHAISIIKDLGYKAIKLKVSAPFHCSLMKPAEEKMRVALDKSVINKPIIPIIQNCTAKLTL
DPTEIKQNLILQICRRVRWRETLKLFNQLDVTHIVEIGAGNVLTNMLRKINYPYKLSNISNLEELQNFLENVSK

Sequences:

>Translated_314_residues
MKTAFIFPGQGAQLIGMGKDFYDNFKPAKETFQVVNEVLNRKLTNIIFNGPSAELTLTTNAQPALMAVSMAIINIIKAET
GKNLDSFCDYAAGHSLGEYSALCSTESISLETAAKLLHIRSTSMQEACPEGEGSMAACINIPLQKLEEILEDINKINVCQ
IANDNIKGQIVISGKTTAIDHAISIIKDLGYKAIKLKVSAPFHCSLMKPAEEKMRVALDKSVINKPIIPIIQNCTAKLTL
DPTEIKQNLILQICRRVRWRETLKLFNQLDVTHIVEIGAGNVLTNMLRKINYPYKLSNISNLEELQNFLENVSK
>Mature_314_residues
MKTAFIFPGQGAQLIGMGKDFYDNFKPAKETFQVVNEVLNRKLTNIIFNGPSAELTLTTNAQPALMAVSMAIINIIKAET
GKNLDSFCDYAAGHSLGEYSALCSTESISLETAAKLLHIRSTSMQEACPEGEGSMAACINIPLQKLEEILEDINKINVCQ
IANDNIKGQIVISGKTTAIDHAISIIKDLGYKAIKLKVSAPFHCSLMKPAEEKMRVALDKSVINKPIIPIIQNCTAKLTL
DPTEIKQNLILQICRRVRWRETLKLFNQLDVTHIVEIGAGNVLTNMLRKINYPYKLSNISNLEELQNFLENVSK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=302, Percent_Identity=26.8211920529801, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1787334, Length=288, Percent_Identity=36.1111111111111, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71984332, Length=296, Percent_Identity=28.0405405405405, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=304, Percent_Identity=24.0131578947368, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24665753, Length=302, Percent_Identity=32.1192052980132, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 34737; Mature: 34737

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAFIFPGQGAQLIGMGKDFYDNFKPAKETFQVVNEVLNRKLTNIIFNGPSAELTLTTN
CCCEEEECCCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECC
AQPALMAVSMAIINIIKAETGKNLDSFCDYAAGHSLGEYSALCSTESISLETAAKLLHIR
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
STSMQEACPEGEGSMAACINIPLQKLEEILEDINKINVCQIANDNIKGQIVISGKTTAID
CCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHH
HAISIIKDLGYKAIKLKVSAPFHCSLMKPAEEKMRVALDKSVINKPIIPIIQNCTAKLTL
HHHHHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEE
DPTEIKQNLILQICRRVRWRETLKLFNQLDVTHIVEIGAGNVLTNMLRKINYPYKLSNIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCEEECCCC
NLEELQNFLENVSK
CHHHHHHHHHHHCC
>Mature Secondary Structure
MKTAFIFPGQGAQLIGMGKDFYDNFKPAKETFQVVNEVLNRKLTNIIFNGPSAELTLTTN
CCCEEEECCCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECC
AQPALMAVSMAIINIIKAETGKNLDSFCDYAAGHSLGEYSALCSTESISLETAAKLLHIR
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
STSMQEACPEGEGSMAACINIPLQKLEEILEDINKINVCQIANDNIKGQIVISGKTTAID
CCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHH
HAISIIKDLGYKAIKLKVSAPFHCSLMKPAEEKMRVALDKSVINKPIIPIIQNCTAKLTL
HHHHHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEE
DPTEIKQNLILQICRRVRWRETLKLFNQLDVTHIVEIGAGNVLTNMLRKINYPYKLSNIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCEEECCCC
NLEELQNFLENVSK
CHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]