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The map label for this gene is phaA [H]

Identifier: 157826187

GI number: 157826187

Start: 1031762

End: 1032940

Strand: Direct

Name: phaA [H]

Synonym: A1C_05820

Alternate gene names: 157826187

Gene position: 1031762-1032940 (Clockwise)

Preceding gene: 157826186

Following gene: 157826189

Centisome position: 83.81

GC content: 40.54

Gene sequence:

>1179_bases
ATGATAAAACCGGTTTATATAACTTATGCGAAAAGGACGGCGTTCGGCTCGTTTATGGGTAGTCTTAGCACGACTTCAGC
ACCAATGCTAGCTGCTCCTTTAATAAAAGATATGATACAAAACAGCAAAATCGATCCAGCTTTAGTAGGTGAGGTAATAC
TTGGACAAGTAATAACAGGTGGTAGCGGGCAGAATCCGGCGAGGCAAACTCTGATTCATGCGGGGATACCGAAAGAAGTG
CCGGGTTATACGATTAATAAAGTATGTGGCTCAGGTCTTAAAAGCGTAGCACTTGCAGCAAATGCGATTATGACTGGTGA
TAATGAGATAGTTATAGCAGGTGGGCAGGAAAATATGTCGCTCAGTATGCACGGTAGCTATATCAGAGCCGGAGCTAAAT
TCGGCGATATTAAAATGGTTGATCTCATGCAGTATGACGGACTAACTGATGTATTTTCAGGAGTATTTATGGGAATTACT
GCCGAAAATGTCTCGAAACAGTTTAATATTAGTAGACAAGAGCAAGATGAATTTGCTTTAAGTTCTCACAAGAAAGCAGC
TAAAGCACAGCTAGCCGGAATTTTTAAAGATGAAATTTTACCTATCGAAGTAACGGTTAAAAAAACTACTAGTTTGTTTA
AACATGATGAAACAATCAGACCTGATACAAGCCTTGAAATTCTGAGTAAATTATGTCCTGCTTTTGATAAAAACGGCGTA
GTTACGGCTGGTAATGCTTCTTCAATCAATGACGGTGCGGCATGCCTTATGGTAGTTTCTGAAGAAGCATTGAAAAAGCA
TAATTTGATGCCGCTAGCTCGTATTGTTTCTTATGCTTCAGCCGGTGTTGATCCAAGTATTATGTGTACTGCCCCCGTTC
CTGCCTCCCAAAAGGCTTTAAGTAAAGCAGGTTGGAGTGTTAATGATTTGGAAATTATCGAGGTTAATGAGGCGTTTGCT
GCTCAAAGTATTTATGTAAACCGTGAAATGAAATGGGATATGGATAAGGTTAACATAAATGGCGGTGCAATAGCCATCGG
GCATCCGATTGGTGCAAGCGGTGGACGTATTCTTATAACTCTGATACACTCTTTAAGAAGAGCTAAAGCTAAAAAAGGCT
TAGTCACCTTATGTATCGGCGGAGGTATTGGTATGGCTATGTGCGTTGAAGCAGTTTAA

Upstream 100 bases:

>100_bases
CGTATTACTATACGCTCCGATCCAAGGACTCTGCATGCCTAGTTCTTTTTGAAGTTGATCTTCGTATACCTATTATTCAT
TCACTTGGAGTATACACATT

Downstream 100 bases:

>100_bases
ATGTAAGTTAAATATGCTGTTACAGTTTTTTAATCAATAGCAAATTACGAGGTATTACTCAATAAATATAGATTTAGTCA
TTGCAAGCAACTGCAAGGAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MIKPVYITYAKRTAFGSFMGSLSTTSAPMLAAPLIKDMIQNSKIDPALVGEVILGQVITGGSGQNPARQTLIHAGIPKEV
PGYTINKVCGSGLKSVALAANAIMTGDNEIVIAGGQENMSLSMHGSYIRAGAKFGDIKMVDLMQYDGLTDVFSGVFMGIT
AENVSKQFNISRQEQDEFALSSHKKAAKAQLAGIFKDEILPIEVTVKKTTSLFKHDETIRPDTSLEILSKLCPAFDKNGV
VTAGNASSINDGAACLMVVSEEALKKHNLMPLARIVSYASAGVDPSIMCTAPVPASQKALSKAGWSVNDLEIIEVNEAFA
AQSIYVNREMKWDMDKVNINGGAIAIGHPIGASGGRILITLIHSLRRAKAKKGLVTLCIGGGIGMAMCVEAV

Sequences:

>Translated_392_residues
MIKPVYITYAKRTAFGSFMGSLSTTSAPMLAAPLIKDMIQNSKIDPALVGEVILGQVITGGSGQNPARQTLIHAGIPKEV
PGYTINKVCGSGLKSVALAANAIMTGDNEIVIAGGQENMSLSMHGSYIRAGAKFGDIKMVDLMQYDGLTDVFSGVFMGIT
AENVSKQFNISRQEQDEFALSSHKKAAKAQLAGIFKDEILPIEVTVKKTTSLFKHDETIRPDTSLEILSKLCPAFDKNGV
VTAGNASSINDGAACLMVVSEEALKKHNLMPLARIVSYASAGVDPSIMCTAPVPASQKALSKAGWSVNDLEIIEVNEAFA
AQSIYVNREMKWDMDKVNINGGAIAIGHPIGASGGRILITLIHSLRRAKAKKGLVTLCIGGGIGMAMCVEAV
>Mature_392_residues
MIKPVYITYAKRTAFGSFMGSLSTTSAPMLAAPLIKDMIQNSKIDPALVGEVILGQVITGGSGQNPARQTLIHAGIPKEV
PGYTINKVCGSGLKSVALAANAIMTGDNEIVIAGGQENMSLSMHGSYIRAGAKFGDIKMVDLMQYDGLTDVFSGVFMGIT
AENVSKQFNISRQEQDEFALSSHKKAAKAQLAGIFKDEILPIEVTVKKTTSLFKHDETIRPDTSLEILSKLCPAFDKNGV
VTAGNASSINDGAACLMVVSEEALKKHNLMPLARIVSYASAGVDPSIMCTAPVPASQKALSKAGWSVNDLEIIEVNEAFA
AQSIYVNREMKWDMDKVNINGGAIAIGHPIGASGGRILITLIHSLRRAKAKKGLVTLCIGGGIGMAMCVEAV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=48.0719794344473, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=44.4162436548223, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=41.4758269720102, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=39.1857506361323, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI4504327, Length=398, Percent_Identity=30.9045226130653, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=31.025641025641, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=50.5128205128205, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=52.6854219948849, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=42.3940149625935, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=39.2592592592593, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=31.0096153846154, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=43.6224489795918, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=39.3316195372751, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=37.3401534526854, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=393, Percent_Identity=31.2977099236641, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=30.6122448979592, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=39.0547263681592, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=37.6288659793814, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24655093, Length=386, Percent_Identity=47.6683937823834, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=44.7837150127226, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=39.6419437340153, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=30.8252427184466, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41430; Mature: 41430

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPVYITYAKRTAFGSFMGSLSTTSAPMLAAPLIKDMIQNSKIDPALVGEVILGQVITG
CCCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEC
GSGQNPARQTLIHAGIPKEVPGYTINKVCGSGLKSVALAANAIMTGDNEIVIAGGQENMS
CCCCCHHHHHHEECCCCCCCCCCCHHHHHCCCHHHHHHHHHEEEECCCEEEEECCCCCCE
LSMHGSYIRAGAKFGDIKMVDLMQYDGLTDVFSGVFMGITAENVSKQFNISRQEQDEFAL
EEECCCEEECCCCCCCEEEEEHHHHCCHHHHHHHHHEEEEHHHHHHHCCCCCHHHHHHHH
SSHKKAAKAQLAGIFKDEILPIEVTVKKTTSLFKHDETIRPDTSLEILSKLCPAFDKNGV
HHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCE
VTAGNASSINDGAACLMVVSEEALKKHNLMPLARIVSYASAGVDPSIMCTAPVPASQKAL
EEECCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
SKAGWSVNDLEIIEVNEAFAAQSIYVNREMKWDMDKVNINGGAIAIGHPIGASGGRILIT
HHCCCCCCCEEEEEECHHHHHEEEEECCCCCCCCEEEEECCCEEEECCCCCCCCCCHHHH
LIHSLRRAKAKKGLVTLCIGGGIGMAMCVEAV
HHHHHHHHHHHCCEEEEEECCCCCHHHHEECC
>Mature Secondary Structure
MIKPVYITYAKRTAFGSFMGSLSTTSAPMLAAPLIKDMIQNSKIDPALVGEVILGQVITG
CCCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEC
GSGQNPARQTLIHAGIPKEVPGYTINKVCGSGLKSVALAANAIMTGDNEIVIAGGQENMS
CCCCCHHHHHHEECCCCCCCCCCCHHHHHCCCHHHHHHHHHEEEECCCEEEEECCCCCCE
LSMHGSYIRAGAKFGDIKMVDLMQYDGLTDVFSGVFMGITAENVSKQFNISRQEQDEFAL
EEECCCEEECCCCCCCEEEEEHHHHCCHHHHHHHHHEEEEHHHHHHHCCCCCHHHHHHHH
SSHKKAAKAQLAGIFKDEILPIEVTVKKTTSLFKHDETIRPDTSLEILSKLCPAFDKNGV
HHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCE
VTAGNASSINDGAACLMVVSEEALKKHNLMPLARIVSYASAGVDPSIMCTAPVPASQKAL
EEECCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
SKAGWSVNDLEIIEVNEAFAAQSIYVNREMKWDMDKVNINGGAIAIGHPIGASGGRILIT
HHCCCCCCCEEEEEECHHHHHEEEEECCCCCCCCEEEEECCCEEEECCCCCCCCCCHHHH
LIHSLRRAKAKKGLVTLCIGGGIGMAMCVEAV
HHHHHHHHHHHCCEEEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]