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The map label for this gene is tlyC

Identifier: 157826182

GI number: 157826182

Start: 1025841

End: 1026746

Strand: Direct

Name: tlyC

Synonym: A1C_05795

Alternate gene names: 157826182

Gene position: 1025841-1026746 (Clockwise)

Preceding gene: 157826181

Following gene: 157826186

Centisome position: 83.33

GC content: 31.35

Gene sequence:

>906_bases
ATGTTAAAATCTTCAAAAAAAGAAGATTCTAGTAAAAAAAATCAAAATAATAATTTAATTTTTACTGTACGAAAATTATT
CTCTCCGATAAAAAATTTTTTTAGAACAACAAAAACGCCTGATAATTTTTTTGGTGTCATCAAACGCCTTAAAATTAATA
TCCAAAAAATGACCCTAGACGAGCGTAATATTTTAGCTAATTTATTGGAGCTAGAAGATAAAACTATTGAAGATATAATG
GTACCGCGTTCTGATATTGTGGCAATAAAATTAACTGCGAATCTAGCAGAATTAAGTGAGTCTATTAAGTTAGAAGTCCC
ACATACACGCACTCTTATATATGACGGTACTTTGGACAATGTAGTAGGGTTCATTCATATCAAAGATTTGTTTAAAGCAT
TGGCTACAAAGCAAAATGGTCGTTTAAAAAAACTTATACGTAAGCATATAATTGCAGCTCCTTCTATGAAATTATTAGAT
TTGCTAGCAAAAATGCGTCGCGAGAGAACACATATTGCAATAGTTGTTGATGAGTATGGCGGTACTGACGGTTTAGTTAC
TATTGAAGATCTTATAGAAGAAATAGTAGGACGCATTGATGATGAGCATGATCAGCAATTAGATAGCGATAATTTCAAGG
TTATTAATAACTCAACAATTATTTCAAATGCACGTGTTGAAGTAGAAGTGCTTGAAGAAATAATAGGAGAAAAGCTAAAA
AATGATGATGATGAGTTTGATACAATAGGAGGACTTGTATTGACTAGAGTCAGTAGTGTTCCGGTTATCGGTACTAGAAT
AGATATTTCAGAAAATATTGAAATTGAAGTTACGGATGCAACTCCTCGTTCTTTAAAACAAGTCAAAATTAGACTAAAAA
ACGGTTTGCATAGCGATAAGATTTGA

Upstream 100 bases:

>100_bases
CATCAAAATGACACAGAAGCACACATTATGGAAAATCTAGAAATTGAAATATTATCATATTTCGGTATTTCTTCCCCTTA
TTAACTAAATAAAAAACTTT

Downstream 100 bases:

>100_bases
TTTTAAATAAATATGAATTTAGAGTGGTTGATACTCTAAGTTCATTAAAAATGTTTTGTTATTATGTTTCAGTATTGTAT
TCTACTGCTCCAATTAATCC

Product: hemolysin C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLKSSKKEDSSKKNQNNNLIFTVRKLFSPIKNFFRTTKTPDNFFGVIKRLKINIQKMTLDERNILANLLELEDKTIEDIM
VPRSDIVAIKLTANLAELSESIKLEVPHTRTLIYDGTLDNVVGFIHIKDLFKALATKQNGRLKKLIRKHIIAAPSMKLLD
LLAKMRRERTHIAIVVDEYGGTDGLVTIEDLIEEIVGRIDDEHDQQLDSDNFKVINNSTIISNARVEVEVLEEIIGEKLK
NDDDEFDTIGGLVLTRVSSVPVIGTRIDISENIEIEVTDATPRSLKQVKIRLKNGLHSDKI

Sequences:

>Translated_301_residues
MLKSSKKEDSSKKNQNNNLIFTVRKLFSPIKNFFRTTKTPDNFFGVIKRLKINIQKMTLDERNILANLLELEDKTIEDIM
VPRSDIVAIKLTANLAELSESIKLEVPHTRTLIYDGTLDNVVGFIHIKDLFKALATKQNGRLKKLIRKHIIAAPSMKLLD
LLAKMRRERTHIAIVVDEYGGTDGLVTIEDLIEEIVGRIDDEHDQQLDSDNFKVINNSTIISNARVEVEVLEEIIGEKLK
NDDDEFDTIGGLVLTRVSSVPVIGTRIDISENIEIEVTDATPRSLKQVKIRLKNGLHSDKI
>Mature_301_residues
MLKSSKKEDSSKKNQNNNLIFTVRKLFSPIKNFFRTTKTPDNFFGVIKRLKINIQKMTLDERNILANLLELEDKTIEDIM
VPRSDIVAIKLTANLAELSESIKLEVPHTRTLIYDGTLDNVVGFIHIKDLFKALATKQNGRLKKLIRKHIIAAPSMKLLD
LLAKMRRERTHIAIVVDEYGGTDGLVTIEDLIEEIVGRIDDEHDQQLDSDNFKVINNSTIISNARVEVEVLEEIIGEKLK
NDDDEFDTIGGLVLTRVSSVPVIGTRIDISENIEIEVTDATPRSLKQVKIRLKNGLHSDKI

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=194, Percent_Identity=35.5670103092784, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1786879, Length=236, Percent_Identity=31.3559322033898, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693175, Length=236, Percent_Identity=30.0847457627119, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082033, Length=229, Percent_Identity=28.82096069869, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788119, Length=234, Percent_Identity=26.0683760683761, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790664, Length=203, Percent_Identity=22.6600985221675, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLYC_RICAH (A8GPR9)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493902.1
- ProteinModelPortal:   A8GPR9
- SMR:   A8GPR9
- STRING:   A8GPR9
- GeneID:   5644786
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_05795
- NMPDR:   fig|293614.3.peg.1089
- eggNOG:   COG1253
- HOGENOM:   HBG673071
- OMA:   TRRMKGS
- ProtClustDB:   CLSK871055
- BioCyc:   RAKA293614:A1C_05795-MONOMER
- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC

EC number: NA

Molecular weight: Translated: 34118; Mature: 34118

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSSKKEDSSKKNQNNNLIFTVRKLFSPIKNFFRTTKTPDNFFGVIKRLKINIQKMTLD
CCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECC
ERNILANLLELEDKTIEDIMVPRSDIVAIKLTANLAELSESIKLEVPHTRTLIYDGTLDN
HHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCHHHHHHHEEEECCCCEEEEECCCHHH
VVGFIHIKDLFKALATKQNGRLKKLIRKHIIAAPSMKLLDLLAKMRRERTHIAIVVDEYG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GTDGLVTIEDLIEEIVGRIDDEHDQQLDSDNFKVINNSTIISNARVEVEVLEEIIGEKLK
CCCCEEEHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCEEEECCEEHHHHHHHHHHHHHC
NDDDEFDTIGGLVLTRVSSVPVIGTRIDISENIEIEVTDATPRSLKQVKIRLKNGLHSDK
CCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCCC
I
C
>Mature Secondary Structure
MLKSSKKEDSSKKNQNNNLIFTVRKLFSPIKNFFRTTKTPDNFFGVIKRLKINIQKMTLD
CCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECC
ERNILANLLELEDKTIEDIMVPRSDIVAIKLTANLAELSESIKLEVPHTRTLIYDGTLDN
HHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCHHHHHHHEEEECCCCEEEEECCCHHH
VVGFIHIKDLFKALATKQNGRLKKLIRKHIIAAPSMKLLDLLAKMRRERTHIAIVVDEYG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GTDGLVTIEDLIEEIVGRIDDEHDQQLDSDNFKVINNSTIISNARVEVEVLEEIIGEKLK
CCCCEEEHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCEEEECCEEHHHHHHHHHHHHHC
NDDDEFDTIGGLVLTRVSSVPVIGTRIDISENIEIEVTDATPRSLKQVKIRLKNGLHSDK
CCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA