| Definition | Rickettsia akari str. Hartford, complete genome. |
|---|---|
| Accession | NC_009881 |
| Length | 1,231,060 |
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The map label for this gene is murE [H]
Identifier: 157825984
GI number: 157825984
Start: 840749
End: 842191
Strand: Reverse
Name: murE [H]
Synonym: A1C_04670
Alternate gene names: 157825984
Gene position: 842191-840749 (Counterclockwise)
Preceding gene: 157825985
Following gene: 157825983
Centisome position: 68.41
GC content: 31.53
Gene sequence:
>1443_bases ATGCGCTATAACCTAAAACAATTATTTAAACAATATAAAGTAAAAGGTTTGTCGATTAATTCTAAAACCGTTAAGGAGAA TGATGTCTTTTTTGTGCTTAAGGGACAAAATGTCGATGTAAATGATTTTATAAATGATGCTTTAAATCAGGCGGTAGCAT TAGTCATTACGGACAATAAAAAAAGTGCTACTATAGATAAAATAATCTACGTAGAAGATGTACAAGCAGCTTTATATGAA GCTATAGAAATTTTTTATCCTAAGAAACCAAAGAATTTGATAGCCGTAACCGGTACTAACGGCAAAAGCTCGGTAGTGTC CTATATAGCTCAAACATATTCATTACTTGGAAAAAAAGCCGCATCTATCGGCACGATAGGTGTAGAGATTTTTGGATGCG ATAATCTTATAAATGATGTGACGGAATTAACCACACTTGATTATTTAAGCTTTAGAAAAATTGCACATAATTTAGCTGAA AACAATATAGAATATTTGGCTTTTGAAGCTTCTAGTCATGGTCTTAATCAAGCAAGACTTGGGGAAATAAAAGTAAATAT CGCATGTTTTACTAGCTTTAGTCAGGATCATCTAGACTATCACTATACAAAAGAAAATTATTTATTAGCCAAACTGAAAT TATTTACTGAGCATTTATTACAAGGCGGTCTTGCAATATTAAATTCTGATATAGAAGAAATAGAGTTTATTAAAGATTAT CTGCTTAACCATAATATTAAATTTATCACTGTTGGAAAAAAAGGTGATGTACAAATAACTAAAATTAATGGTTCTTTAAA AGGACAAAATATTAGTTTTGCATTTAATAATAGAGAATGTAGTTTTAATACCTCTATAATCGGTAGTTTTCAGGCTAGCA ATTTGTTAATTGCCGCTCTTAGCATTCATTATATCGGATGTGATTTTAATAAAATAGTTGAAATTCTAACGCAAGTTAAA CCGGTAAAAGGCAGAATGGAAAGGATAGATAACACTAATATTTTCGTTGATTATTCCCATACTCCGGATGCTCTTGAAAA AGCTTTAACAGAGCTGAAAAATATTAAATTACGTGATAGTAAGTTAATCGTGGTTTTTGGTTGCGGCGGTAATCGTGATA AAACAAAGAGAAGTCTTATGGGGCAAATAGCCGCCAAACTTGCCGATACCGTAATAATTACCGATGACAACCCACGTCAT GAAGATCCAAAACTGATCAGAGCCGAAATCATAAGCTGTATAGAGAAAGCGGATTATATGGAAATTGCAAATAGAGAAGA GGCTATTAAATATGGTATAAATAATTTAAAACAAGATGATATTTTATTAATTGCCGGCAAAGGTCATGAAAATTACCAAA TTATAGGAGATAAGAAATTACCTTTTGATGATGCTGAAATTGTAGGGAAACTAACGTTATTGCAAGGAAAGGCAAAGCAT TGA
Upstream 100 bases:
>100_bases TAAAAAAATGCTGATTTACAGAATTTTTTACTGGATTGCTGTGTCGAATTACTACGTAATTCTTCTCGCAATGACAGTAA CATTTTTTAACATAATAAAC
Downstream 100 bases:
>100_bases CGCAGCAATCCCATGCCAAAATCCTGAGATTACCACGCTCCTTACAGTCGCTCGCAATGACGGGTTTGGCATCTACGTGG GCAATGCCATGCGGGCATGA
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 480; Mature: 480
Protein sequence:
>480_residues MRYNLKQLFKQYKVKGLSINSKTVKENDVFFVLKGQNVDVNDFINDALNQAVALVITDNKKSATIDKIIYVEDVQAALYE AIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTYSLLGKKAASIGTIGVEIFGCDNLINDVTELTTLDYLSFRKIAHNLAE NNIEYLAFEASSHGLNQARLGEIKVNIACFTSFSQDHLDYHYTKENYLLAKLKLFTEHLLQGGLAILNSDIEEIEFIKDY LLNHNIKFITVGKKGDVQITKINGSLKGQNISFAFNNRECSFNTSIIGSFQASNLLIAALSIHYIGCDFNKIVEILTQVK PVKGRMERIDNTNIFVDYSHTPDALEKALTELKNIKLRDSKLIVVFGCGGNRDKTKRSLMGQIAAKLADTVIITDDNPRH EDPKLIRAEIISCIEKADYMEIANREEAIKYGINNLKQDDILLIAGKGHENYQIIGDKKLPFDDAEIVGKLTLLQGKAKH
Sequences:
>Translated_480_residues MRYNLKQLFKQYKVKGLSINSKTVKENDVFFVLKGQNVDVNDFINDALNQAVALVITDNKKSATIDKIIYVEDVQAALYE AIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTYSLLGKKAASIGTIGVEIFGCDNLINDVTELTTLDYLSFRKIAHNLAE NNIEYLAFEASSHGLNQARLGEIKVNIACFTSFSQDHLDYHYTKENYLLAKLKLFTEHLLQGGLAILNSDIEEIEFIKDY LLNHNIKFITVGKKGDVQITKINGSLKGQNISFAFNNRECSFNTSIIGSFQASNLLIAALSIHYIGCDFNKIVEILTQVK PVKGRMERIDNTNIFVDYSHTPDALEKALTELKNIKLRDSKLIVVFGCGGNRDKTKRSLMGQIAAKLADTVIITDDNPRH EDPKLIRAEIISCIEKADYMEIANREEAIKYGINNLKQDDILLIAGKGHENYQIIGDKKLPFDDAEIVGKLTLLQGKAKH >Mature_480_residues MRYNLKQLFKQYKVKGLSINSKTVKENDVFFVLKGQNVDVNDFINDALNQAVALVITDNKKSATIDKIIYVEDVQAALYE AIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTYSLLGKKAASIGTIGVEIFGCDNLINDVTELTTLDYLSFRKIAHNLAE NNIEYLAFEASSHGLNQARLGEIKVNIACFTSFSQDHLDYHYTKENYLLAKLKLFTEHLLQGGLAILNSDIEEIEFIKDY LLNHNIKFITVGKKGDVQITKINGSLKGQNISFAFNNRECSFNTSIIGSFQASNLLIAALSIHYIGCDFNKIVEILTQVK PVKGRMERIDNTNIFVDYSHTPDALEKALTELKNIKLRDSKLIVVFGCGGNRDKTKRSLMGQIAAKLADTVIITDDNPRH EDPKLIRAEIISCIEKADYMEIANREEAIKYGINNLKQDDILLIAGKGHENYQIIGDKKLPFDDAEIVGKLTLLQGKAKH
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 RPE1 insert domain [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=495, Percent_Identity=33.7373737373737, Blast_Score=236, Evalue=3e-63,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005728 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 53725; Mature: 53725
Theoretical pI: Translated: 7.59; Mature: 7.59
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 0.8 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRYNLKQLFKQYKVKGLSINSKTVKENDVFFVLKGQNVDVNDFINDALNQAVALVITDNK CCCCHHHHHHHHCCCCEEECCCEEECCCEEEEEECCCCCHHHHHHHHHCCEEEEEEECCC KSATIDKIIYVEDVQAALYEAIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTYSLLGKKA CCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH ASIGTIGVEIFGCDNLINDVTELTTLDYLSFRKIAHNLAENNIEYLAFEASSHGLNQARL CCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEE GEIKVNIACFTSFSQDHLDYHYTKENYLLAKLKLFTEHLLQGGLAILNSDIEEIEFIKDY CEEEEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH LLNHNIKFITVGKKGDVQITKINGSLKGQNISFAFNNRECSFNTSIIGSFQASNLLIAAL HHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCEECCCEEECCCCCCEEEEEE SIHYIGCDFNKIVEILTQVKPVKGRMERIDNTNIFVDYSHTPDALEKALTELKNIKLRDS EEEEECCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCEEECC KLIVVFGCGGNRDKTKRSLMGQIAAKLADTVIITDDNPRHEDPKLIRAEIISCIEKADYM EEEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH EIANREEAIKYGINNLKQDDILLIAGKGHENYQIIGDKKLPFDDAEIVGKLTLLQGKAKH HHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCC >Mature Secondary Structure MRYNLKQLFKQYKVKGLSINSKTVKENDVFFVLKGQNVDVNDFINDALNQAVALVITDNK CCCCHHHHHHHHCCCCEEECCCEEECCCEEEEEECCCCCHHHHHHHHHCCEEEEEEECCC KSATIDKIIYVEDVQAALYEAIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTYSLLGKKA CCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH ASIGTIGVEIFGCDNLINDVTELTTLDYLSFRKIAHNLAENNIEYLAFEASSHGLNQARL CCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEE GEIKVNIACFTSFSQDHLDYHYTKENYLLAKLKLFTEHLLQGGLAILNSDIEEIEFIKDY CEEEEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH LLNHNIKFITVGKKGDVQITKINGSLKGQNISFAFNNRECSFNTSIIGSFQASNLLIAAL HHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCEECCCEEECCCCCCEEEEEE SIHYIGCDFNKIVEILTQVKPVKGRMERIDNTNIFVDYSHTPDALEKALTELKNIKLRDS EEEEECCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCEEECC KLIVVFGCGGNRDKTKRSLMGQIAAKLADTVIITDDNPRHEDPKLIRAEIISCIEKADYM EEEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH EIANREEAIKYGINNLKQDDILLIAGKGHENYQIIGDKKLPFDDAEIVGKLTLLQGKAKH HHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA