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The map label for this gene is gyrB [H]

Identifier: 157825960

GI number: 157825960

Start: 812158

End: 814581

Strand: Reverse

Name: gyrB [H]

Synonym: A1C_04510

Alternate gene names: 157825960

Gene position: 814581-812158 (Counterclockwise)

Preceding gene: 157825963

Following gene: 157825959

Centisome position: 66.17

GC content: 37.33

Gene sequence:

>2424_bases
ATGTCGGAAATTGAAGAAAAATTTAACGAGTCATCATACGGCGCTGATTCTATAAAGGTTTTAAAAGGTCTGGAAGCCGT
AAGAAAAAGACCGGGAATGTATATCGGGGACGTTGGAGATGGGTCCGGTCTACATCATATGATTTATGAAGTAGTCGACA
ACGCTATAGACGAGTCGCTTGCCGGTTATTGTGATCTAGTAAGAGTAACATTGAATAAAAATGGTTCGGTAACTGTATCT
GATAACGGGCGAGGTATCCCCGTTGAAATTCATGAAGAAGAAGGAACATCTGCAGCTGAAGTGATTATGACGCAACTTCA
CGCCGGCGGTAAGTTTGATCAGAACTCTTACAAGGTTTCAGGCGGGCTGCACGGTGTCGGAGTATCGGTTGTGAATGCTC
TTTCAGAGTGGCTTGAATTACGTATTTGGCGTAATAATAAGGAATATTTGATTAGATTTAATAATGGTATAACAGCAGCT
CCGATTGCGGTTGTCAAAGAAAATATTGATAAAAAAGGTACGGAAGTTACTTTTTTTCCGTCTGCAGAAACATTTACTAA
TATAGAATTTGATTTCGGTACTATAGAACATCGTCTTCGTGAGCTTGCTTTTTTAAATTCAGGCGTAAAGATTTTATTCG
TCGATAATCGCTTTGAAGAAGTTAAAGAAGTAGAGTTTTATTATATGGGCGGTATAGAAGCTTATGTAAAATATATAGAT
AGAGCTAAACACGCCATTCATCCATGTATAGTAGTTAATACAGAGAATGCTGACTCCGGTATAAGCCTTGAGCTTGCGAT
GCACTGGAACGATTCTTATCATGAGAATATCATGTGTTTCACTAACAATATTAGGCAGCGTGACGGCGGAACTCATCTTA
GTGCTTTCAAATCAGCAATAACACGTGTTATTACCTCGTACCTTGATACTACGGGTCTTAATAAAAAATTTAAAAATGAC
TTTAGCGGTGAGGATACTAGAGAAGGCTTATGTTGTGTACTTTCCGTTAAAGTTCCTGATCCTAAATTTTCCTCTCAAAC
GAAAGATAAGCTAGTAAGTTCCGAAGTGCGACCGGTTGTTGAAAATGCCGTTTATACAAAGGTTCTTGAGTGGTTTGAAG
AGCATCCGGCGGAATCAAAGGCAATTATAGCTAAGATTATGGAAGCAGCTAATGCTCGTGAAGCTGCTAGAAAAGCGAGG
GAGCTAACTCGAAGAAAATCAGCCTTAGAAGTCTCGAACTTACCCGGTAAGCTTGCCGATTGCCATGCAAAAGATCCGGC
AATTTCAGAATTGTTTATTGTTGAGGGAGACTCTGCGGGCGGTACTGCAAAACAGGGTAGGGATAGCAAAATTCAGGCTA
TATTGCCTTTGCGTGGTAAAATTTTGAATGTTGAGCGTGCAAGATTTGATAAAATGCTCGGTTCGGACCAAATTGGTACG
TTAATTACAGCTCTTGGGATTAGTGTTGAGCGAGAATTTTCCTTAGAAAAGCTTAGATACCATAAAGTTATTATTATGAC
CGATGCTGATGTTGACGGCTCGCACATTAGAACTTTATTGCTCACGTTTTTCTATCGTCATATGCCTGAGCTAATAAATA
AAGGTTATCTATATATAGCACAGCCACCGCTTTATAAGGTAAAAAAGGGTGCAGCTGAGCTTTATTTGAAGAATGAGCAA
GCTTTGCAGGATTATTTGATAAAATCAACTATCAATGATGCAACCTTAACTCTAGACGGTAAAGAGCAGTTAGTAGGTGA
TAATTTAGAAGAGCTAATTAATAAAGTAGTTAAGTTTAACGGCTTGCTTGAGCACGCTAGCAAAAAATTTAATCGCTCAA
TTACTGAAATTCTTGCGATTAATGACTTACTTAATAATAAAATATTTGAAGCTGAAAGTGACTTAAGACTCGAAAAAGCT
TTAGATGTGTTAAATAGCTTAGAAGAGTCACCTGATAAAACTAATTGGGAAATTTTAAAACATGAAAATAAAATAGAGTT
CTTTCGTTTTAGTATGGGTTTAAAAGAAAGTAAAATATTGTTGAAAGAGCAGTTGGAATCCTTTGAGTTTATACAAATAT
CAAAGCTTGCTTTAACGATTTTTGATATATTCAGTAAGAAATTAAAGCTTATAGTAAAAAGTCAGGAATGTGGTATTTTA
ACAGCAAGCCAGTTATTAAATACCATTATAGAATGTGGGAAAAAAGGGATAAACATTCAGCGTTTTAAGGGTCTTGGTGA
GATGAATTCCGACCAATTATGGGAAACTACTCTTGATCCTGCAAAAAGAACTTTGCTTCAGGTAAGAGTTGCGGAGGTCG
ATGAAGCGGAGGGCATTTTCTCTACTTTAATGGGTGATGTTGTTGAACCGCGTAGATTATTTATCCAAGAGAATGCGTTG
AATGTCATGAATTTGGATGTATAA

Upstream 100 bases:

>100_bases
ATGACGTAAACTTTTTAAATCAAGAAACTTTACTCTTCTAATAAGTTACGTTATAGTTATCTTTATTGTTTCTAGCAACA
AATAAATATTGTGTCGGATT

Downstream 100 bases:

>100_bases
TACAGAGTCATCTCACAATCACTTGATACAAGCGAATTTTGCGGGTATAGCATGTGCTCACGTACTTTTTGTATGCTGTG
CGTGGGCTATCCCTTAAAAT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVS
DNGRGIPVEIHEEEGTSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITAA
PIAVVKENIDKKGTEVTFFPSAETFTNIEFDFGTIEHRLRELAFLNSGVKILFVDNRFEEVKEVEFYYMGGIEAYVKYID
RAKHAIHPCIVVNTENADSGISLELAMHWNDSYHENIMCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKFKND
FSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKAR
ELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAELYLKNEQ
ALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFNGLLEHASKKFNRSITEILAINDLLNNKIFEAESDLRLEKA
LDVLNSLEESPDKTNWEILKHENKIEFFRFSMGLKESKILLKEQLESFEFIQISKLALTIFDIFSKKLKLIVKSQECGIL
TASQLLNTIIECGKKGINIQRFKGLGEMNSDQLWETTLDPAKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQENAL
NVMNLDV

Sequences:

>Translated_807_residues
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVS
DNGRGIPVEIHEEEGTSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITAA
PIAVVKENIDKKGTEVTFFPSAETFTNIEFDFGTIEHRLRELAFLNSGVKILFVDNRFEEVKEVEFYYMGGIEAYVKYID
RAKHAIHPCIVVNTENADSGISLELAMHWNDSYHENIMCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKFKND
FSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKAR
ELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAELYLKNEQ
ALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFNGLLEHASKKFNRSITEILAINDLLNNKIFEAESDLRLEKA
LDVLNSLEESPDKTNWEILKHENKIEFFRFSMGLKESKILLKEQLESFEFIQISKLALTIFDIFSKKLKLIVKSQECGIL
TASQLLNTIIECGKKGINIQRFKGLGEMNSDQLWETTLDPAKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQENAL
NVMNLDV
>Mature_806_residues
SEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSD
NGRGIPVEIHEEEGTSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITAAP
IAVVKENIDKKGTEVTFFPSAETFTNIEFDFGTIEHRLRELAFLNSGVKILFVDNRFEEVKEVEFYYMGGIEAYVKYIDR
AKHAIHPCIVVNTENADSGISLELAMHWNDSYHENIMCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKFKNDF
SGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKARE
LTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTL
ITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAELYLKNEQA
LQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFNGLLEHASKKFNRSITEILAINDLLNNKIFEAESDLRLEKAL
DVLNSLEESPDKTNWEILKHENKIEFFRFSMGLKESKILLKEQLESFEFIQISKLALTIFDIFSKKLKLIVKSQECGILT
ASQLLNTIIECGKKGINIQRFKGLGEMNSDQLWETTLDPAKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQENALN
VMNLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=576, Percent_Identity=25.1736111111111, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI19913406, Length=575, Percent_Identity=24.8695652173913, Blast_Score=124, Evalue=5e-28,
Organism=Escherichia coli, GI48994957, Length=812, Percent_Identity=51.9704433497537, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=658, Percent_Identity=35.4103343465046, Blast_Score=351, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI212645845, Length=520, Percent_Identity=25.3846153846154, Blast_Score=126, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17535065, Length=587, Percent_Identity=24.190800681431, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI212645657, Length=237, Percent_Identity=27.8481012658228, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=588, Percent_Identity=25.6802721088435, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17136538, Length=543, Percent_Identity=25.0460405156538, Blast_Score=132, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90626; Mature: 90495

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESL
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
AGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHEEEGTSAAEVIMTQLHAGGKFDQNSYKVS
HHHEEEEEEEECCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEC
GGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITAAPIAVVKENIDKKGTEVTFFP
CCCCHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEC
SAETFTNIEFDFGTIEHRLRELAFLNSGVKILFVDNRFEEVKEVEFYYMGGIEAYVKYID
CCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHEEEECCHHHHHHHHH
RAKHAIHPCIVVNTENADSGISLELAMHWNDSYHENIMCFTNNIRQRDGGTHLSAFKSAI
HHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCCCEEEEECCHHHCCCCCHHHHHHHHH
TRVITSYLDTTGLNKKFKNDFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVV
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLAD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
CHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHHHH
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIA
HHHHHCCCHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
QPPLYKVKKGAAELYLKNEQALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFN
CCCHHHHHCCCHHEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHCCCHHHHHHHHHHHH
GLLEHASKKFNRSITEILAINDLLNNKIFEAESDLRLEKALDVLNSLEESPDKTNWEILK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
HENKIEFFRFSMGLKESKILLKEQLESFEFIQISKLALTIFDIFSKKLKLIVKSQECGIL
CCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEE
TASQLLNTIIECGKKGINIQRFKGLGEMNSDQLWETTLDPAKRTLLQVRVAEVDEAEGIF
EHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
STLMGDVVEPRRLFIQENALNVMNLDV
HHHHHHHCCHHHHHEECCCCCEEECCC
>Mature Secondary Structure 
SEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESL
CHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
AGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHEEEGTSAAEVIMTQLHAGGKFDQNSYKVS
HHHEEEEEEEECCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEC
GGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITAAPIAVVKENIDKKGTEVTFFP
CCCCHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEC
SAETFTNIEFDFGTIEHRLRELAFLNSGVKILFVDNRFEEVKEVEFYYMGGIEAYVKYID
CCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHEEEECCHHHHHHHHH
RAKHAIHPCIVVNTENADSGISLELAMHWNDSYHENIMCFTNNIRQRDGGTHLSAFKSAI
HHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCCCEEEEECCHHHCCCCCHHHHHHHHH
TRVITSYLDTTGLNKKFKNDFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVV
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLAD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
CHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHHHH
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIA
HHHHHCCCHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
QPPLYKVKKGAAELYLKNEQALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFN
CCCHHHHHCCCHHEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHCCCHHHHHHHHHHHH
GLLEHASKKFNRSITEILAINDLLNNKIFEAESDLRLEKALDVLNSLEESPDKTNWEILK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
HENKIEFFRFSMGLKESKILLKEQLESFEFIQISKLALTIFDIFSKKLKLIVKSQECGIL
CCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEE
TASQLLNTIIECGKKGINIQRFKGLGEMNSDQLWETTLDPAKRTLLQVRVAEVDEAEGIF
EHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
STLMGDVVEPRRLFIQENALNVMNLDV
HHHHHHHCCHHHHHEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]