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The map label for this gene is pleC [H]

Identifier: 157825438

GI number: 157825438

Start: 318835

End: 320328

Strand: Direct

Name: pleC [H]

Synonym: A1C_01695

Alternate gene names: 157825438

Gene position: 318835-320328 (Clockwise)

Preceding gene: 157825437

Following gene: 157825439

Centisome position: 25.9

GC content: 28.71

Gene sequence:

>1494_bases
ATGAACCATAATAAGTATATAGTAAGATTGTCATTTATTATATTATTTCTTAATATTGTTATAAATATGATGTTTTATCG
TTATTTTATGATAAAAGAAATGATAGTAAAACAAGTGGCTTTGGAACATACTAAAATTGTAGAACTTTACACTGATAATA
TTTGGAATACTCATCAGAACGTAATCAGTAAATTACATAAATTCGATTATTTAAAATTATTACAAGATCAAGATTTTATT
AATTTTGCAAAGATTACCGCTCAATGGTTCACCAATCTTAATATTAATATTTCTCTCTACGATCTCAAAGGTAATAAATT
CATCACTAGTAATATGTTGCATATGTATAGTGTAGACAATTATAAAGATGATAGTTTGGTTGAGATATTTACCGCAAAAA
TCGATAAAATTTTTTTGAAATCCTTTACTTCAAAAGCTCCGCTTCACGATGCTTTTGATGGTATTACAAGTCATATATTA
TTACCAAGGGTAGTAATAGAAAATGAAAGTGATTTAACAGTGGAAGAAGCTTCTTTTGTTACTAGCTATATCCCTGTTAT
AGATAATAATTTAGATTTTCCCGTAGATGCAGTATTTGAGATTAACACTAATATTACCAGCCAGTGGCAAAATATAACCG
CTCTTGAGCAAAAGGTTTTTATAACTTTTATCATTATTTTTATAATATTCTGCACTATAATTATTAGTAATACTAATTAT
GCTAGACAAATTATTGAGGAACAGTTTGAAACAAATAGAAATTTAAAAGCTCAAATAGTAAAAGTAGAACAAACTAGCTC
TTCAAATACAAAGTTTTTTGCTAATATTAGTCATGAATTGCGTACACCGCTTAATGCTATAATAGGCTTTTCGGAAATTC
TTATGTCGGAAAGAGATGCAGAAAAAAGTAAAAATTATATTAAAGATATAAATGATGCCGGTAAACATTTGCTTAGTATG
ATTAATGATATTTTAGATCTTTCTAAAGCTTCTGCCGATAAATTAAAAGTAGATAGTATAGATCTTGATTTAAATAAATT
AATTAGTTCTTCGCTGGCACTTGTTAAGCCTCGTGCTGATCAAGCCGAAGTGGCTTTAATGAGTAGATTACCGAAAGAGC
ATGTGGTTATAAAGGCTGATCCAAAAAGGCTAAAACAAGTATTCTTAAATCTTTTATCAAATGCCGTGAAATTTACAAAT
TCCGGAGGAAGTGTTGCTATTACACTTGAAAAAGATGAGTTAGCAAAATTAGTATATATCAAAGTTATAGATACCGGTAT
CGGTATTGAGGAAAAAGATATTCCAAAAACTTTATCAGCGTTTGGCCAAATTGATAGTGAGCTTAGTAGAAAATATGAAG
GTACTGGTCTTGGGTTACCGCTTACTAAAAAGCTGGTTGAACTTATGAATGGTAAATTTGATTTGCAAAGTAAGATAAAT
GAAGGTACCACCATAACAATAACTTTTACATATGATGGTAGTATTGAAATATGA

Upstream 100 bases:

>100_bases
GGCTTTCCGCCTACGCGGGAATGACATCCAGAGCATTCATACAGTAGGGATGCAAGCTATAGGATGACTTGAGAGCTAAA
AATAACTACTAGGTCTCGTA

Downstream 100 bases:

>100_bases
TATTGCTACGTGGTTTGGTGCTTTCCATTGTCACCCCGTGACATGATCACGGGGTTCAGCCACGGTATGACATCGAGTGT
GTGTTTAAAGCGATGCAATA

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MNHNKYIVRLSFIILFLNIVINMMFYRYFMIKEMIVKQVALEHTKIVELYTDNIWNTHQNVISKLHKFDYLKLLQDQDFI
NFAKITAQWFTNLNINISLYDLKGNKFITSNMLHMYSVDNYKDDSLVEIFTAKIDKIFLKSFTSKAPLHDAFDGITSHIL
LPRVVIENESDLTVEEASFVTSYIPVIDNNLDFPVDAVFEINTNITSQWQNITALEQKVFITFIIIFIIFCTIIISNTNY
ARQIIEEQFETNRNLKAQIVKVEQTSSSNTKFFANISHELRTPLNAIIGFSEILMSERDAEKSKNYIKDINDAGKHLLSM
INDILDLSKASADKLKVDSIDLDLNKLISSSLALVKPRADQAEVALMSRLPKEHVVIKADPKRLKQVFLNLLSNAVKFTN
SGGSVAITLEKDELAKLVYIKVIDTGIGIEEKDIPKTLSAFGQIDSELSRKYEGTGLGLPLTKKLVELMNGKFDLQSKIN
EGTTITITFTYDGSIEI

Sequences:

>Translated_497_residues
MNHNKYIVRLSFIILFLNIVINMMFYRYFMIKEMIVKQVALEHTKIVELYTDNIWNTHQNVISKLHKFDYLKLLQDQDFI
NFAKITAQWFTNLNINISLYDLKGNKFITSNMLHMYSVDNYKDDSLVEIFTAKIDKIFLKSFTSKAPLHDAFDGITSHIL
LPRVVIENESDLTVEEASFVTSYIPVIDNNLDFPVDAVFEINTNITSQWQNITALEQKVFITFIIIFIIFCTIIISNTNY
ARQIIEEQFETNRNLKAQIVKVEQTSSSNTKFFANISHELRTPLNAIIGFSEILMSERDAEKSKNYIKDINDAGKHLLSM
INDILDLSKASADKLKVDSIDLDLNKLISSSLALVKPRADQAEVALMSRLPKEHVVIKADPKRLKQVFLNLLSNAVKFTN
SGGSVAITLEKDELAKLVYIKVIDTGIGIEEKDIPKTLSAFGQIDSELSRKYEGTGLGLPLTKKLVELMNGKFDLQSKIN
EGTTITITFTYDGSIEI
>Mature_497_residues
MNHNKYIVRLSFIILFLNIVINMMFYRYFMIKEMIVKQVALEHTKIVELYTDNIWNTHQNVISKLHKFDYLKLLQDQDFI
NFAKITAQWFTNLNINISLYDLKGNKFITSNMLHMYSVDNYKDDSLVEIFTAKIDKIFLKSFTSKAPLHDAFDGITSHIL
LPRVVIENESDLTVEEASFVTSYIPVIDNNLDFPVDAVFEINTNITSQWQNITALEQKVFITFIIIFIIFCTIIISNTNY
ARQIIEEQFETNRNLKAQIVKVEQTSSSNTKFFANISHELRTPLNAIIGFSEILMSERDAEKSKNYIKDINDAGKHLLSM
INDILDLSKASADKLKVDSIDLDLNKLISSSLALVKPRADQAEVALMSRLPKEHVVIKADPKRLKQVFLNLLSNAVKFTN
SGGSVAITLEKDELAKLVYIKVIDTGIGIEEKDIPKTLSAFGQIDSELSRKYEGTGLGLPLTKKLVELMNGKFDLQSKIN
EGTTITITFTYDGSIEI

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=34.251968503937, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=31.4741035856574, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=35.4978354978355, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=31.640625, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=30.5084745762712, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1790436, Length=279, Percent_Identity=26.8817204301075, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=26.7241379310345, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=29.7297297297297, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=26.6375545851528, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=25.3164556962025, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=23.5807860262009, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790551, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=26.3392857142857, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=217, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=22.4913494809689, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=204, Percent_Identity=28.4313725490196, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=146, Percent_Identity=36.986301369863, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56656; Mature: 56656

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHNKYIVRLSFIILFLNIVINMMFYRYFMIKEMIVKQVALEHTKIVELYTDNIWNTHQN
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCCHHHH
VISKLHKFDYLKLLQDQDFINFAKITAQWFTNLNINISLYDLKGNKFITSNMLHMYSVDN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCCEEEEECCC
YKDDSLVEIFTAKIDKIFLKSFTSKAPLHDAFDGITSHILLPRVVIENESDLTVEEASFV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCCCEEHHHHHH
TSYIPVIDNNLDFPVDAVFEINTNITSQWQNITALEQKVFITFIIIFIIFCTIIISNTNY
HHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ARQIIEEQFETNRNLKAQIVKVEQTSSSNTKFFANISHELRTPLNAIIGFSEILMSERDA
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHCCH
EKSKNYIKDINDAGKHLLSMINDILDLSKASADKLKVDSIDLDLNKLISSSLALVKPRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHEECCCCC
QAEVALMSRLPKEHVVIKADPKRLKQVFLNLLSNAVKFTNSGGSVAITLEKDELAKLVYI
HHHHHHHHHCCHHCEEEECCHHHHHHHHHHHHHHHHEEECCCCEEEEEEEHHHHHHEEEE
KVIDTGIGIEEKDIPKTLSAFGQIDSELSRKYEGTGLGLPLTKKLVELMNGKFDLQSKIN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCC
EGTTITITFTYDGSIEI
CCCEEEEEEEECCCCCC
>Mature Secondary Structure
MNHNKYIVRLSFIILFLNIVINMMFYRYFMIKEMIVKQVALEHTKIVELYTDNIWNTHQN
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCCHHHH
VISKLHKFDYLKLLQDQDFINFAKITAQWFTNLNINISLYDLKGNKFITSNMLHMYSVDN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCCEEEEECCC
YKDDSLVEIFTAKIDKIFLKSFTSKAPLHDAFDGITSHILLPRVVIENESDLTVEEASFV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCCCEEHHHHHH
TSYIPVIDNNLDFPVDAVFEINTNITSQWQNITALEQKVFITFIIIFIIFCTIIISNTNY
HHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ARQIIEEQFETNRNLKAQIVKVEQTSSSNTKFFANISHELRTPLNAIIGFSEILMSERDA
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHCCH
EKSKNYIKDINDAGKHLLSMINDILDLSKASADKLKVDSIDLDLNKLISSSLALVKPRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHEECCCCC
QAEVALMSRLPKEHVVIKADPKRLKQVFLNLLSNAVKFTNSGGSVAITLEKDELAKLVYI
HHHHHHHHHCCHHCEEEECCHHHHHHHHHHHHHHHHEEECCCCEEEEEEEHHHHHHEEEE
KVIDTGIGIEEKDIPKTLSAFGQIDSELSRKYEGTGLGLPLTKKLVELMNGKFDLQSKIN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCC
EGTTITITFTYDGSIEI
CCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]