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The map label for this gene is ruvC

Identifier: 157825294

GI number: 157825294

Start: 165101

End: 165574

Strand: Direct

Name: ruvC

Synonym: A1C_00880

Alternate gene names: 157825294

Gene position: 165101-165574 (Clockwise)

Preceding gene: 157825293

Following gene: 157825295

Centisome position: 13.41

GC content: 36.92

Gene sequence:

>474_bases
ATGATAGTACTTGGGATTGATCCAGCACTTGGGAGTCTTGGATGGGCAGTAGTTGCAAGGCAGTTGACAAAACTGAAATA
TTTAGCTAGCGGTATTATTAAAACAAATAGTAAAGATGAAATTCATAATAGACTTGCCTGTATTAACAGTACATTAGAAA
AAGTAATATTAGAATATCAACCAAATATGGCAGCGATTGAAGAAACATTTGTTAATACTAATAGCGTGACTTCGTTAAAG
CTCGGCTATGCTAGAGGTGCGATAATGTCGCTGTGCGGTAGGTATAATTTGGACATTCGGGAATTTAAACCAAATACGGT
CAAAAAAACCGTGACCGGTTATGGGCATGCAGAGAAAGATCAAATTTTGCATATGATAAAGCTTTTGCTGCCCGGCACTT
CCTTAATTACTAATTCCGATGAAGCTGATGCTATAGCAATCGCTTATACTTGTCATGTTATGAGAGTTAAATGA

Upstream 100 bases:

>100_bases
TGAAGCTGTCACCCCGTGGCTTGACTACGGGGTCCAGTATTTTTATAATTATTTTATGGACCCCGTAGTCAAGCCACGGG
GTGACACGGGATATATAATC

Downstream 100 bases:

>100_bases
ATCCGGTTATAATATTAGTTGTCCCGCAAATGGGTGAGAATATCGGTGCTACTGCAAGAGCCATGAAGAATTTTGGCTTA
AGTGAGCTGAGAATCGTAGC

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MIVLGIDPALGSLGWAVVARQLTKLKYLASGIIKTNSKDEIHNRLACINSTLEKVILEYQPNMAAIEETFVNTNSVTSLK
LGYARGAIMSLCGRYNLDIREFKPNTVKKTVTGYGHAEKDQILHMIKLLLPGTSLITNSDEADAIAIAYTCHVMRVK

Sequences:

>Translated_157_residues
MIVLGIDPALGSLGWAVVARQLTKLKYLASGIIKTNSKDEIHNRLACINSTLEKVILEYQPNMAAIEETFVNTNSVTSLK
LGYARGAIMSLCGRYNLDIREFKPNTVKKTVTGYGHAEKDQILHMIKLLLPGTSLITNSDEADAIAIAYTCHVMRVK
>Mature_157_residues
MIVLGIDPALGSLGWAVVARQLTKLKYLASGIIKTNSKDEIHNRLACINSTLEKVILEYQPNMAAIEETFVNTNSVTSLK
LGYARGAIMSLCGRYNLDIREFKPNTVKKTVTGYGHAEKDQILHMIKLLLPGTSLITNSDEADAIAIAYTCHVMRVK

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=129, Percent_Identity=38.7596899224806, Blast_Score=96, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_RICAH (A8GM81)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493014.1
- ProteinModelPortal:   A8GM81
- SMR:   A8GM81
- STRING:   A8GM81
- GeneID:   5645327
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_00880
- NMPDR:   fig|293614.3.peg.164
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   PMQIKLA
- ProtClustDB:   PRK00039
- BioCyc:   RAKA293614:A1C_00880-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 17278; Mature: 17278

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLGIDPALGSLGWAVVARQLTKLKYLASGIIKTNSKDEIHNRLACINSTLEKVILEYQ
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
PNMAAIEETFVNTNSVTSLKLGYARGAIMSLCGRYNLDIREFKPNTVKKTVTGYGHAEKD
CCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCCCCCHH
QILHMIKLLLPGTSLITNSDEADAIAIAYTCHVMRVK
HHHHHHHHHCCCCCEEECCCCCCEEEEEEEEEEEEEC
>Mature Secondary Structure
MIVLGIDPALGSLGWAVVARQLTKLKYLASGIIKTNSKDEIHNRLACINSTLEKVILEYQ
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
PNMAAIEETFVNTNSVTSLKLGYARGAIMSLCGRYNLDIREFKPNTVKKTVTGYGHAEKD
CCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCCCCCHH
QILHMIKLLLPGTSLITNSDEADAIAIAYTCHVMRVK
HHHHHHHHHCCCCCEEECCCCCCEEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA