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The map label for this gene is ctrA [H]

Identifier: 157825231

GI number: 157825231

Start: 92212

End: 92925

Strand: Direct

Name: ctrA [H]

Synonym: A1C_00550

Alternate gene names: 157825231

Gene position: 92212-92925 (Clockwise)

Preceding gene: 157825230

Following gene: 157825232

Centisome position: 7.49

GC content: 33.05

Gene sequence:

>714_bases
ATGAGAGTTTTGTTAATTGAAGATGAGCTGGAAATGGCTAACTTAATTGAGCTAACTTTAGCTTCAGAAGGTATAGTTTG
CGATAAAGCTTCAGTTGGTGTGGAAGGTTTAAGGATTGGTAAAGTCTGTGGTTATGATCTAGTGATTTTAGACATTATGT
TACCGGATATTAATGGTTTTGAGATATTATTAAGATTGCGTGCTGCAAAAATAAAAACCCCAATCTTAATTTTATCTAGC
TTAACGGATACGGATCAAAAGATTAACGGTTTCTATTCTGGAGCCGATGATTATTTAACCAAGCCGTTTGTAAGAGAGGA
ATTAATTGCTAGAATTAAAGCTATAGTTAGACGTTCGAAAGGTCATGCAGCATCAATATTTATGTTTGATAAGGTTAGCG
TAAACCTAGATACTAGAACTGTAGAAGTTGACGGCAAAAAAGTACATTTGACGAACAAAGAATATGCTATTTTAGAGCTA
TTAATACTACGAAGAGGAACTATTTTAACTAAAGAAATGTTTTTAAATCACTTATATAGTAGTGTTGACGAACCGGAAAT
GAAAATTATTGACGTATTTATTTGTAAACTTCGTAAAAAGTTAAGTGATGCTGCTGGCGGTAGAGATTATATCGACACAG
TATGGGGACGCGGTTATATGCTAAAAGAATATGATGAATTACAACAAAAAGAAATTTTAGCACAAGGAGCATAA

Upstream 100 bases:

>100_bases
TGTATAAAGCACTAGATAAAAAATTATAATTTAGTTAACAATGATTAAGTGTAATTAAGTTATAGCACAATATAAAAATT
GAATTTTATGGAGAAAAATA

Downstream 100 bases:

>100_bases
TTAATGCCTTTATCTACTTCTTTGCTTGGTAAAACAAGTACCTATAAAGATAGTTATGATGCGACTTTATTATTTAAAAT
TCCACGTATAAATAATCGAA

Product: transcriptional activator protein CzcR

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MRVLLIEDELEMANLIELTLASEGIVCDKASVGVEGLRIGKVCGYDLVILDIMLPDINGFEILLRLRAAKIKTPILILSS
LTDTDQKINGFYSGADDYLTKPFVREELIARIKAIVRRSKGHAASIFMFDKVSVNLDTRTVEVDGKKVHLTNKEYAILEL
LILRRGTILTKEMFLNHLYSSVDEPEMKIIDVFICKLRKKLSDAAGGRDYIDTVWGRGYMLKEYDELQQKEILAQGA

Sequences:

>Translated_237_residues
MRVLLIEDELEMANLIELTLASEGIVCDKASVGVEGLRIGKVCGYDLVILDIMLPDINGFEILLRLRAAKIKTPILILSS
LTDTDQKINGFYSGADDYLTKPFVREELIARIKAIVRRSKGHAASIFMFDKVSVNLDTRTVEVDGKKVHLTNKEYAILEL
LILRRGTILTKEMFLNHLYSSVDEPEMKIIDVFICKLRKKLSDAAGGRDYIDTVWGRGYMLKEYDELQQKEILAQGA
>Mature_237_residues
MRVLLIEDELEMANLIELTLASEGIVCDKASVGVEGLRIGKVCGYDLVILDIMLPDINGFEILLRLRAAKIKTPILILSS
LTDTDQKINGFYSGADDYLTKPFVREELIARIKAIVRRSKGHAASIFMFDKVSVNLDTRTVEVDGKKVHLTNKEYAILEL
LILRRGTILTKEMFLNHLYSSVDEPEMKIIDVFICKLRKKLSDAAGGRDYIDTVWGRGYMLKEYDELQQKEILAQGA

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=36.283185840708, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.9649122807018, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=34.9775784753363, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.4324324324324, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=29.4372294372294, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=32.7272727272727, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.0175438596491, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=28.3783783783784, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=29.7777777777778, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=27.4774774774775, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=26.5486725663717, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=27.6150627615063, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=26.1682242990654, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=26.4705882352941, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26755; Mature: 26755

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIEDELEMANLIELTLASEGIVCDKASVGVEGLRIGKVCGYDLVILDIMLPDINGF
CEEEEEECCCCHHHHHHHEECCCCEEECCCCCCCCCEEECCCCCCCEEEEEECCCCCCHH
EILLRLRAAKIKTPILILSSLTDTDQKINGFYSGADDYLTKPFVREELIARIKAIVRRSK
HHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GHAASIFMFDKVSVNLDTRTVEVDGKKVHLTNKEYAILELLILRRGTILTKEMFLNHLYS
CCEEEEEEEEEEEEEECCEEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SVDEPEMKIIDVFICKLRKKLSDAAGGRDYIDTVWGRGYMLKEYDELQQKEILAQGA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVLLIEDELEMANLIELTLASEGIVCDKASVGVEGLRIGKVCGYDLVILDIMLPDINGF
CEEEEEECCCCHHHHHHHEECCCCEEECCCCCCCCCEEECCCCCCCEEEEEECCCCCCHH
EILLRLRAAKIKTPILILSSLTDTDQKINGFYSGADDYLTKPFVREELIARIKAIVRRSK
HHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GHAASIFMFDKVSVNLDTRTVEVDGKKVHLTNKEYAILELLILRRGTILTKEMFLNHLYS
CCEEEEEEEEEEEEEECCEEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SVDEPEMKIIDVFICKLRKKLSDAAGGRDYIDTVWGRGYMLKEYDELQQKEILAQGA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]