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The map label for this gene is trxA [H]

Identifier: 157825127

GI number: 157825127

Start: 964

End: 1383

Strand: Direct

Name: trxA [H]

Synonym: A1C_00010

Alternate gene names: 157825127

Gene position: 964-1383 (Clockwise)

Preceding gene: 157825126

Following gene: 157825128

Centisome position: 0.08

GC content: 30.71

Gene sequence:

>420_bases
ATGATTTATAGTATTAATTATTTTAATATGTTTATTGGATCCCGGGATCAAGTTGCTGGATTACAACAGAAAAGCATCAT
CACGCAACACATAGAGGATAAAATGGCAAATAACGTAACGGATAGCTCTTTTAAAAAGGAAGTATTAGAATCGGATTTAC
CGGTATTGGTTGATTTTTGGGCAGAATGGTGTGGACCGTGCAAAATGTTAACACCGATAATAGATGAAATCAGTAAAGAA
TTAAAAGGCAAAGTAAAAGTACTTAAAATGAATATTGATGAAAATCCTAACATTTCTTCAGAATACGGTATTCGTAGTAT
TCCAACGATAATGTTATTTAAAAACGGTGAACAAAAAGATACTAAAATAGGTTTGCAGCAAAAAAACTCTCTTTTAGATT
GGATTAATAAATCTGTTTAA

Upstream 100 bases:

>100_bases
ATCTCTTATATTACTTCGTCATTGCAAGGAAAAATTGAAAATTTTGACGAAGCAAAATGTGCTCTAGGTTATACCGTGGC
TTGACCACGGTATCCAAAAA

Downstream 100 bases:

>100_bases
TAGTTATGTCACTTAGCCATTCAAAAGTATTTATAGAAATAACAAATGGTTATGTAGAAGGTGTAGATACTCATAAAAGA
GCTCAAGGTTTAAAGGCTTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MIYSINYFNMFIGSRDQVAGLQQKSIITQHIEDKMANNVTDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKE
LKGKVKVLKMNIDENPNISSEYGIRSIPTIMLFKNGEQKDTKIGLQQKNSLLDWINKSV

Sequences:

>Translated_139_residues
MIYSINYFNMFIGSRDQVAGLQQKSIITQHIEDKMANNVTDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKE
LKGKVKVLKMNIDENPNISSEYGIRSIPTIMLFKNGEQKDTKIGLQQKNSLLDWINKSV
>Mature_139_residues
MIYSINYFNMFIGSRDQVAGLQQKSIITQHIEDKMANNVTDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKE
LKGKVKVLKMNIDENPNISSEYGIRSIPTIMLFKNGEQKDTKIGLQQKNSLLDWINKSV

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=114, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=43.3734939759036, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI38505222, Length=100, Percent_Identity=39, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=52.9411764705882, Blast_Score=128, Evalue=1e-31,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=45.0980392156863, Blast_Score=103, Evalue=5e-24,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=32.3529411764706, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=40.2173913043478, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115532380, Length=86, Percent_Identity=43.0232558139535, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=90, Percent_Identity=41.1111111111111, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=82, Percent_Identity=37.8048780487805, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=41.7910447761194, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=104, Percent_Identity=37.5, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=39.7435897435897, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=92, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=40.2597402597403, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=30.1204819277108, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324862, Length=84, Percent_Identity=34.5238095238095, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=36, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639826, Length=69, Percent_Identity=44.9275362318841, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=37.5, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=43.2432432432432, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=43.2432432432432, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921434, Length=89, Percent_Identity=38.2022471910112, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664269, Length=100, Percent_Identity=32, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639068, Length=117, Percent_Identity=32.4786324786325, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 15901; Mature: 15901

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYSINYFNMFIGSRDQVAGLQQKSIITQHIEDKMANNVTDSSFKKEVLESDLPVLVDFW
CEEECCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
AEWCGPCKMLTPIIDEISKELKGKVKVLKMNIDENPNISSEYGIRSIPTIMLFKNGEQKD
HHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCH
TKIGLQQKNSLLDWINKSV
HHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIYSINYFNMFIGSRDQVAGLQQKSIITQHIEDKMANNVTDSSFKKEVLESDLPVLVDFW
CEEECCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
AEWCGPCKMLTPIIDEISKELKGKVKVLKMNIDENPNISSEYGIRSIPTIMLFKNGEQKD
HHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCH
TKIGLQQKNSLLDWINKSV
HHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]