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The map label for this gene is aaeR [H]

Identifier: 157373088

GI number: 157373088

Start: 5377288

End: 5378301

Strand: Direct

Name: aaeR [H]

Synonym: Spro_4856

Alternate gene names: 157373088

Gene position: 5377288-5378301 (Clockwise)

Preceding gene: 157373087

Following gene: 157373093

Centisome position: 98.69

GC content: 47.93

Gene sequence:

>1014_bases
ATGGAGAAAAGCGATGCTTTCAAAATATTTGCAATGGTCGGTGATCGGGGATCTATTTCTGGCGCAGCGCGTGCACTGGG
TGAGTCTAAAGTAACGGTAAGCCGGGCAGTATCTCGTTTGGAGTCCCTCTATAACGTCAGACTAGTCGAACGAACTACAC
GGCGGATAACACTCACCGAAGTGGGGAGTGTTTTACACGCACGTTGTATTCGCATACGAGAAGAAATGGAAGACGCTGAC
GCTGAGATTGCAACCTACAGGAGTAGTCCGGCCGGTATATTGCGCATAGGCTGTACCAGTGATGTCGCTAAAACGCTCCT
CACTCCCAACTTACCCGAGTTTCTGGCTAACTATCCAGAGATTGATGTTCGTGTACGAGTGGGGGAAAGATTACTCCCAG
AGTCTAACATTCTCGATGTCGTTCTCCATTGCGGATGGTTGTCGGATTCTCGTTTGACTGCTCGAAAAATCGCAGAGGTA
AAAAACATCCTGGTAGCAAGTCGAGAATACGTACAAGCCAACGGAATACCAACCTCTCCAGACGATCTCGAAGATCATGC
CATCATCGGTAATTTCTACCTCGACGCAGCGGCGATTGAGCCAGGCCCTTTGCCTGCTTATGTGCCCAGGCTTGAAATAT
CTCGGGGCCAGGAACGCTTTACGTTACCGACATACCGTAGATTTTTATCGACCGATCATTCGCAAATCCTCGAACTGGTG
AAACATGGCCGCGTCATTGCACCCATTACCGGTATTTGGGCACTGCCAGGACTACTCTCAGGAGAGTTAGTTCGTATATT
ACCCGATTATGAAATAAGCGAGTCGCCGCAACTTTATGCTTTATATCTCGATCGGCTGGCATCAATACCCAAGTTAAAAG
TATTTCTAGATTTCATTGAGGAAATCGTTAAGCGCCTTACAAAAGAGTGGCAACCCCAGGCCGATAAACTCTTTCCGAAA
CAGAACCTCGTCCTTTTCCCGTCTATAAACTTCCAAACCAGGAATGACTCCTGA

Upstream 100 bases:

>100_bases
GCATTAGAACATTAATCCGAGCCTTCGCTTTTATTGGTTTAATGTTAAATAGCACTCGAATTTCTTAATTAATGAGAATG
TTACAGCCAGAGGATAAAAA

Downstream 100 bases:

>100_bases
CGAGTGATTAAAACCTTAATGAATACTGGTTCTGTGATGTTGTTCATGCAAGAGAAATTATTAATGAATGGGGCAGGACT
ATAACGAATGTCGGCCCCAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MEKSDAFKIFAMVGDRGSISGAARALGESKVTVSRAVSRLESLYNVRLVERTTRRITLTEVGSVLHARCIRIREEMEDAD
AEIATYRSSPAGILRIGCTSDVAKTLLTPNLPEFLANYPEIDVRVRVGERLLPESNILDVVLHCGWLSDSRLTARKIAEV
KNILVASREYVQANGIPTSPDDLEDHAIIGNFYLDAAAIEPGPLPAYVPRLEISRGQERFTLPTYRRFLSTDHSQILELV
KHGRVIAPITGIWALPGLLSGELVRILPDYEISESPQLYALYLDRLASIPKLKVFLDFIEEIVKRLTKEWQPQADKLFPK
QNLVLFPSINFQTRNDS

Sequences:

>Translated_337_residues
MEKSDAFKIFAMVGDRGSISGAARALGESKVTVSRAVSRLESLYNVRLVERTTRRITLTEVGSVLHARCIRIREEMEDAD
AEIATYRSSPAGILRIGCTSDVAKTLLTPNLPEFLANYPEIDVRVRVGERLLPESNILDVVLHCGWLSDSRLTARKIAEV
KNILVASREYVQANGIPTSPDDLEDHAIIGNFYLDAAAIEPGPLPAYVPRLEISRGQERFTLPTYRRFLSTDHSQILELV
KHGRVIAPITGIWALPGLLSGELVRILPDYEISESPQLYALYLDRLASIPKLKVFLDFIEEIVKRLTKEWQPQADKLFPK
QNLVLFPSINFQTRNDS
>Mature_337_residues
MEKSDAFKIFAMVGDRGSISGAARALGESKVTVSRAVSRLESLYNVRLVERTTRRITLTEVGSVLHARCIRIREEMEDAD
AEIATYRSSPAGILRIGCTSDVAKTLLTPNLPEFLANYPEIDVRVRVGERLLPESNILDVVLHCGWLSDSRLTARKIAEV
KNILVASREYVQANGIPTSPDDLEDHAIIGNFYLDAAAIEPGPLPAYVPRLEISRGQERFTLPTYRRFLSTDHSQILELV
KHGRVIAPITGIWALPGLLSGELVRILPDYEISESPQLYALYLDRLASIPKLKVFLDFIEEIVKRLTKEWQPQADKLFPK
QNLVLFPSINFQTRNDS

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=315, Percent_Identity=29.2063492063492, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1786401, Length=304, Percent_Identity=31.9078947368421, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI87081978, Length=300, Percent_Identity=29, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693193, Length=308, Percent_Identity=27.9220779220779, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789440, Length=296, Percent_Identity=26.0135135135135, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787589, Length=187, Percent_Identity=30.4812834224599, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787128, Length=327, Percent_Identity=26.9113149847095, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787601, Length=127, Percent_Identity=27.5590551181102, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786448, Length=121, Percent_Identity=33.0578512396694, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37808; Mature: 37808

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSDAFKIFAMVGDRGSISGAARALGESKVTVSRAVSRLESLYNVRLVERTTRRITLTE
CCCCCCEEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEHHHHEEEHHH
VGSVLHARCIRIREEMEDADAEIATYRSSPAGILRIGCTSDVAKTLLTPNLPEFLANYPE
HHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCEEEECCCHHHHHHHHCCCCHHHHCCCCC
IDVRVRVGERLLPESNILDVVLHCGWLSDSRLTARKIAEVKNILVASREYVQANGIPTSP
EEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DDLEDHAIIGNFYLDAAAIEPGPLPAYVPRLEISRGQERFTLPTYRRFLSTDHSQILELV
CCCCCCEEEEEEEEEEECCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCHHHHHHHH
KHGRVIAPITGIWALPGLLSGELVRILPDYEISESPQLYALYLDRLASIPKLKVFLDFIE
HCCCEEEEHHHHHHHCCHHCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
EIVKRLTKEWQPQADKLFPKQNLVLFPSINFQTRNDS
HHHHHHHHHCCCCHHHCCCCCCEEEEECCCCEECCCC
>Mature Secondary Structure
MEKSDAFKIFAMVGDRGSISGAARALGESKVTVSRAVSRLESLYNVRLVERTTRRITLTE
CCCCCCEEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEHHHHEEEHHH
VGSVLHARCIRIREEMEDADAEIATYRSSPAGILRIGCTSDVAKTLLTPNLPEFLANYPE
HHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCEEEECCCHHHHHHHHCCCCHHHHCCCCC
IDVRVRVGERLLPESNILDVVLHCGWLSDSRLTARKIAEVKNILVASREYVQANGIPTSP
EEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DDLEDHAIIGNFYLDAAAIEPGPLPAYVPRLEISRGQERFTLPTYRRFLSTDHSQILELV
CCCCCCEEEEEEEEEEECCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCHHHHHHHH
KHGRVIAPITGIWALPGLLSGELVRILPDYEISESPQLYALYLDRLASIPKLKVFLDFIE
HCCCEEEEHHHHHHHCCHHCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
EIVKRLTKEWQPQADKLFPKQNLVLFPSINFQTRNDS
HHHHHHHHHCCCCHHHCCCCCCEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]