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The map label for this gene is alr [H]

Identifier: 157372681

GI number: 157372681

Start: 4921051

End: 4922130

Strand: Reverse

Name: alr [H]

Synonym: Spro_4448

Alternate gene names: 157372681

Gene position: 4922130-4921051 (Counterclockwise)

Preceding gene: 157372682

Following gene: 157372679

Centisome position: 90.33

GC content: 60.19

Gene sequence:

>1080_bases
ATGAAAGCGGCAACCGCTGTAATCGACCGCCGCGCTCTGCGACATAATCTGCAACAGGTGCGCCGTCAGGCGCCGCAAAG
TCGCCTGATTGCCGTTGTGAAAGCAAACGCTTATGGACATGGCCTGCTGGAAACAGCGCACACCCTGCAAGACGCCGACT
GCTACGGCGTGGCGCGCATTGGCGAGGCATTGATGCTGCGCTCCGGCGGTATCGTCAAACCGATCCTGATGCTGGAAGGT
TTCTTCTGTGCCGAAGACCTGCCGGTGTTGGTGGCCAATAACATCGAAACCGCGGTGCACAGCATCGAACAGCTCGAAGC
GCTGGAGCAGGCCACGTTGGCGCGCCCGGTGCCGGTGTGGATGAAGCTCGATACCGGCATGCATCGCCTGGGCGTGCGCC
CGGAGCAGGCGGAGGCGTTCTATCAGCGTCTGAGCGCCTGCCGTAACGTGGTGCAGCCGGTTAATATCATGAGCCATTTC
AGCCGCGCCGATGAGCCTGAGTCGGACACTACGCTCAAGCAAATACAGTGTTTCGAAAGCTTTGCCGCCGGCAAACCGGG
GCAGCGTTCGATCGCCGCCTCCGGTGGCACTCTGCTGTGGCCGGATGCGCACAACGAGTGGGTACGCCCAGGCATTATCC
TGTACGGTGTTTCACCGATGGAAGGCTCTCAGGGCTGTCAGTACGACCTGCAACCGGCGATGACGCTTAAATCCAACCTG
ATCGCGGTGCGTGAACACAAAGCCGGTGAATCTGTGGGCTACGGCGGCACCTGGGTTAGCGCAGGTGATACCCGTTTGGG
CGTGGTGGCAATGGGTTATGGCGACGGCTACCCGCGCAGCGCACCTACGGGAACGCCTGTATGGCTTAACGGCCGTGAAG
TGCCGATAGTGGGTCGGGTGTCGATGGACATGATGTCGGTCGATCTGGGGCCGGAGGCCACCGATAAGGTTGGCGATGAA
GTGGTGCTGTGGGGCCAGGCTTTACCGGTCGAACGAATTGCCGACTGTACCGGCATCAGCGCTTATGAACTGATTACCAA
ACTAACGCAGCGCGTGTCGATGGAATACATCGGCGAATAG

Upstream 100 bases:

>100_bases
CGATCGGTTCCGTGCGGCTGACCTTTAACGGCCAGTGGTCGCGTTTCGATAACTACGCGGGGCCACAATATGATGACGAA
TAATCAGCTAAGGAACTGAA

Downstream 100 bases:

>100_bases
CCTGTGAGGGGCCAGCGCCTGCCGGCCCCAATCAATAACGCGTTATTTCTTTACCGCCAGCCATTGATCGATAATGCTCT
GATACTCGCCGGTCGCTTTG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKAATAVIDRRALRHNLQQVRRQAPQSRLIAVVKANAYGHGLLETAHTLQDADCYGVARIGEALMLRSGGIVKPILMLEG
FFCAEDLPVLVANNIETAVHSIEQLEALEQATLARPVPVWMKLDTGMHRLGVRPEQAEAFYQRLSACRNVVQPVNIMSHF
SRADEPESDTTLKQIQCFESFAAGKPGQRSIAASGGTLLWPDAHNEWVRPGIILYGVSPMEGSQGCQYDLQPAMTLKSNL
IAVREHKAGESVGYGGTWVSAGDTRLGVVAMGYGDGYPRSAPTGTPVWLNGREVPIVGRVSMDMMSVDLGPEATDKVGDE
VVLWGQALPVERIADCTGISAYELITKLTQRVSMEYIGE

Sequences:

>Translated_359_residues
MKAATAVIDRRALRHNLQQVRRQAPQSRLIAVVKANAYGHGLLETAHTLQDADCYGVARIGEALMLRSGGIVKPILMLEG
FFCAEDLPVLVANNIETAVHSIEQLEALEQATLARPVPVWMKLDTGMHRLGVRPEQAEAFYQRLSACRNVVQPVNIMSHF
SRADEPESDTTLKQIQCFESFAAGKPGQRSIAASGGTLLWPDAHNEWVRPGIILYGVSPMEGSQGCQYDLQPAMTLKSNL
IAVREHKAGESVGYGGTWVSAGDTRLGVVAMGYGDGYPRSAPTGTPVWLNGREVPIVGRVSMDMMSVDLGPEATDKVGDE
VVLWGQALPVERIADCTGISAYELITKLTQRVSMEYIGE
>Mature_359_residues
MKAATAVIDRRALRHNLQQVRRQAPQSRLIAVVKANAYGHGLLETAHTLQDADCYGVARIGEALMLRSGGIVKPILMLEG
FFCAEDLPVLVANNIETAVHSIEQLEALEQATLARPVPVWMKLDTGMHRLGVRPEQAEAFYQRLSACRNVVQPVNIMSHF
SRADEPESDTTLKQIQCFESFAAGKPGQRSIAASGGTLLWPDAHNEWVRPGIILYGVSPMEGSQGCQYDLQPAMTLKSNL
IAVREHKAGESVGYGGTWVSAGDTRLGVVAMGYGDGYPRSAPTGTPVWLNGREVPIVGRVSMDMMSVDLGPEATDKVGDE
VVLWGQALPVERIADCTGISAYELITKLTQRVSMEYIGE

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=71.5083798882682, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1787439, Length=348, Percent_Identity=43.3908045977011, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 39026; Mature: 39026

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATAVIDRRALRHNLQQVRRQAPQSRLIAVVKANAYGHGLLETAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
GEALMLRSGGIVKPILMLEGFFCAEDLPVLVANNIETAVHSIEQLEALEQATLARPVPVW
HHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEE
MKLDTGMHRLGVRPEQAEAFYQRLSACRNVVQPVNIMSHFSRADEPESDTTLKQIQCFES
EEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FAAGKPGQRSIAASGGTLLWPDAHNEWVRPGIILYGVSPMEGSQGCQYDLQPAMTLKSNL
HHCCCCCCCCEECCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCE
IAVREHKAGESVGYGGTWVSAGDTRLGVVAMGYGDGYPRSAPTGTPVWLNGREVPIVGRV
EEEEECCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECC
SMDMMSVDLGPEATDKVGDEVVLWGQALPVERIADCTGISAYELITKLTQRVSMEYIGE
CCEEEEECCCCCCHHHCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAATAVIDRRALRHNLQQVRRQAPQSRLIAVVKANAYGHGLLETAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
GEALMLRSGGIVKPILMLEGFFCAEDLPVLVANNIETAVHSIEQLEALEQATLARPVPVW
HHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEE
MKLDTGMHRLGVRPEQAEAFYQRLSACRNVVQPVNIMSHFSRADEPESDTTLKQIQCFES
EEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FAAGKPGQRSIAASGGTLLWPDAHNEWVRPGIILYGVSPMEGSQGCQYDLQPAMTLKSNL
HHCCCCCCCCEECCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCE
IAVREHKAGESVGYGGTWVSAGDTRLGVVAMGYGDGYPRSAPTGTPVWLNGREVPIVGRV
EEEEECCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECC
SMDMMSVDLGPEATDKVGDEVVLWGQALPVERIADCTGISAYELITKLTQRVSMEYIGE
CCEEEEECCCCCCHHHCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]