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The map label for this gene is yjcE [H]

Identifier: 157372663

GI number: 157372663

Start: 4902376

End: 4904025

Strand: Reverse

Name: yjcE [H]

Synonym: Spro_4430

Alternate gene names: 157372663

Gene position: 4904025-4902376 (Counterclockwise)

Preceding gene: 157372664

Following gene: 157372661

Centisome position: 90.0

GC content: 58.36

Gene sequence:

>1650_bases
ATGGAAATCTTTTTTACAATCCTCATTTTAATTTTGGTGGTCTCCCTGTCCGGGGTGGTGACGCGCATGTTGCCGTTCCA
GGTGCCATTACCGTTAATGCAGATCGGTATCGGGGCCTTGTTGGCCTGGCCGCATTTTGGGCTGCACGTCGACTTTGACC
CTGAATTGTTCCTGGTCCTGTTTATTCCGCCGTTGCTGTTTGCCGATGGCTGGAAAACGCCAACCCGTGAGTTTTTGCAC
CACGGCCGTGAAATCCTTGGTCTGGCACTGGTGCTGGTGCTGATTACCGTCGTCGGTGTCGGCTACCTGATTTACGCCAT
GGTACCGGGCATCCCGCTGGTGGCGGCGTTTGCCCTGGCGGCGGTACTGTCGCCAACCGATGCCGTGGCGCTGTCCGGCA
TCGTGGGTAAAGGGCGTATTCCCAAGTCGATCATGGGGGTGCTGGAAGGTGAGGCGCTGATGAACGACGCGTCCGGTCTG
GTCTCACTCAAATTCGCCATCGCAGTGGCGATGGGCACCATGGTGTTTACCGTGGGCGGAGCGACGCTGGAGTTTCTCAA
GGTGGCGATCGGCGGCCTGCTGGCCGGTGTGGCGATCACCTGGCTTTACAGTAAGTCGTTGCGCGTCATGAGCCGCTGGA
GTGGCGACGACCCGGCAACGCAAATTGTATTCCTGCTGCTGTTGCCGTTTGCCTCTTATCTGATTGCCGAACATATTGGC
GTCTCCGGCATCCTGGCCGCGGTTGCTGCGGGGATGACCATCAGCCAGTCCGGCGTGATCCGCAATGCCCCGCTGGCGAT
GCGTCTGCGTGCCAACAGCGTCTGGGCGATGCTGGAATTTGTGTTTAACGGCATGGTGTTCATCATGTTGGGGCTGCAGC
TGCCGGGGATCCTGGAGACCTCCATCTTCCAGGCGGAGCTGGATCCGACCATTCAGACCTGGTACCTGTTTGCCGATGTT
GCCATCATCTACGCCGCGTTGCTGGTGTTGCGCTTCACCTGGCTGTGGCTGATGAAAAACGCCAGCCGTCGCTTTATGAA
AAAACGGCCGTTGCAGTTTGGCGATTTCACCACGCGTGAACTGTGGGTGGCGTCGTTCGCCGGGGTGCGTGGGGCGATTA
CGCTGGCGGGTGTGCTGTCCATTCCGCTGTTGCTGAGTGACGGTTCTGCCTTCCCGGCGCGCTATCAACTGGTGTTTATC
GCCGCCGGAGTGATCCTGCTTTCGCTGATTGCCGGCGTCATGGCGTTGCCGCTGTTGCTGCGCGGCGTGCAGGTGGCAGA
CAAGAGCGTCAGCAAGAGTGAAGAGCGGATGGCGATTGCCATGGCGGCCGAAGTGGCGATCGAAAGCATCAACAAAATGG
AAGAACGCCTGGCCGTGGATACCGAGGAAAATATCGATCCGCAGATATTGAAAGAGATCAGTTCGCGGGTGGTCGGGACG
CTGCGGCGGCGCATCACCACTAAAGACGATATCGAAAATGCGCTGATGCTGGAAAACCTCGAACGGCGTTTTCGCCTGAC
GGCGCTGCGTGCCGAACGCGGTGAGTTATATCACCTGCGCGCCACGCAGAAAATCAGCAACGAGACGCTGCAAAAATTAT
TGCACGATCTCGACCTGCTGGAAGCGCTGTTGATAGAGCGCGAGGGGTAA

Upstream 100 bases:

>100_bases
GCATTTTGAATGGCACAACAAGCTTTAACCGCTGTAAAAAAAGTGATCTACTATCGGGCATATTCAGAGATATTTCTGAA
CCCTGGAGTCTAAGGAAAGC

Downstream 100 bases:

>100_bases
TGCCAATGGGGCCGCAGACGCGGCCCCGTTTATTTCATCGACGGCCAGTAGTCGCGACAACAGGCGATCCAGGCCTGGGC
GCTGTGTGACAGGTAGCTGC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIGIGALLAWPHFGLHVDFDPELFLVLFIPPLLFADGWKTPTREFLH
HGREILGLALVLVLITVVGVGYLIYAMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VSLKFAIAVAMGTMVFTVGGATLEFLKVAIGGLLAGVAITWLYSKSLRVMSRWSGDDPATQIVFLLLLPFASYLIAEHIG
VSGILAAVAAGMTISQSGVIRNAPLAMRLRANSVWAMLEFVFNGMVFIMLGLQLPGILETSIFQAELDPTIQTWYLFADV
AIIYAALLVLRFTWLWLMKNASRRFMKKRPLQFGDFTTRELWVASFAGVRGAITLAGVLSIPLLLSDGSAFPARYQLVFI
AAGVILLSLIAGVMALPLLLRGVQVADKSVSKSEERMAIAMAAEVAIESINKMEERLAVDTEENIDPQILKEISSRVVGT
LRRRITTKDDIENALMLENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEREG

Sequences:

>Translated_549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIGIGALLAWPHFGLHVDFDPELFLVLFIPPLLFADGWKTPTREFLH
HGREILGLALVLVLITVVGVGYLIYAMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VSLKFAIAVAMGTMVFTVGGATLEFLKVAIGGLLAGVAITWLYSKSLRVMSRWSGDDPATQIVFLLLLPFASYLIAEHIG
VSGILAAVAAGMTISQSGVIRNAPLAMRLRANSVWAMLEFVFNGMVFIMLGLQLPGILETSIFQAELDPTIQTWYLFADV
AIIYAALLVLRFTWLWLMKNASRRFMKKRPLQFGDFTTRELWVASFAGVRGAITLAGVLSIPLLLSDGSAFPARYQLVFI
AAGVILLSLIAGVMALPLLLRGVQVADKSVSKSEERMAIAMAAEVAIESINKMEERLAVDTEENIDPQILKEISSRVVGT
LRRRITTKDDIENALMLENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEREG
>Mature_549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIGIGALLAWPHFGLHVDFDPELFLVLFIPPLLFADGWKTPTREFLH
HGREILGLALVLVLITVVGVGYLIYAMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VSLKFAIAVAMGTMVFTVGGATLEFLKVAIGGLLAGVAITWLYSKSLRVMSRWSGDDPATQIVFLLLLPFASYLIAEHIG
VSGILAAVAAGMTISQSGVIRNAPLAMRLRANSVWAMLEFVFNGMVFIMLGLQLPGILETSIFQAELDPTIQTWYLFADV
AIIYAALLVLRFTWLWLMKNASRRFMKKRPLQFGDFTTRELWVASFAGVRGAITLAGVLSIPLLLSDGSAFPARYQLVFI
AAGVILLSLIAGVMALPLLLRGVQVADKSVSKSEERMAIAMAAEVAIESINKMEERLAVDTEENIDPQILKEISSRVVGT
LRRRITTKDDIENALMLENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEREG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=446, Percent_Identity=25.5605381165919, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI148727259, Length=524, Percent_Identity=22.7099236641221, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI27734935, Length=352, Percent_Identity=24.1477272727273, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI14211919, Length=270, Percent_Identity=22.962962962963, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI41872703, Length=534, Percent_Identity=21.9101123595506, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI294997330, Length=264, Percent_Identity=23.1060606060606, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=76.2773722627737, Blast_Score=840, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25150332, Length=406, Percent_Identity=23.1527093596059, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=417, Percent_Identity=22.5419664268585, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=335, Percent_Identity=24.4776119402985, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=335, Percent_Identity=24.4776119402985, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71999821, Length=352, Percent_Identity=24.1477272727273, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=409, Percent_Identity=23.960880195599, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999819, Length=409, Percent_Identity=23.7163814180929, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=397, Percent_Identity=21.6624685138539, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=397, Percent_Identity=21.6624685138539, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=367, Percent_Identity=22.3433242506812, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364513, Length=441, Percent_Identity=22.6757369614512, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221473222, Length=441, Percent_Identity=22.6757369614512, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221473215, Length=447, Percent_Identity=22.5950782997763, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221473212, Length=460, Percent_Identity=23.695652173913, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510734, Length=400, Percent_Identity=22.75, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510738, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60015; Mature: 60015

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCC
>Mature Secondary Structure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HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]