Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 157372288

GI number: 157372288

Start: 4494141

End: 4495784

Strand: Direct

Name: luxQ [H]

Synonym: Spro_4054

Alternate gene names: 157372288

Gene position: 4494141-4495784 (Clockwise)

Preceding gene: 157372287

Following gene: 157372299

Centisome position: 82.48

GC content: 37.35

Gene sequence:

>1644_bases
ATGTATGAACAGTATTTTTCCACAAGCCATAATATTAACTCAGCTGGTCCACAAGAAAACTATGCGTGGGCTATAGCTAA
ATTCACGATCAGGCTGGCAGGATTTAATGCGAATATTGAGCGTCAGTTACGCCTGGGAAACTCTGATAAAGAAGAATTAC
AAACTGAGCTTGATCTCCTGTTCTCGAGCTCGAATGTTCTGCTACATAAAAGTGTATCAACCAGATACTTATTTGAAGAG
GCAGGATACGCTACGACTGTAGCACATATAAATGAAAATCTGGAAAAGATTGATGTCGAGCTAAATAAAGAGGTTCCTGA
TTACTCTATCATTCTTAAAAGCATTGAATTAATTGGACAAGACAATAAAAGTCTCGTTGTAATTTCAGACCATGCCGAAG
TAAGGCAACGAAATATTATCCAACAAGACTACATTAACAAAGGAAACTCCATGAAGTTTCCAATTGCGTCACTGTACTTC
CTATTCCTATTGATGCTATTTATTTCATATCGACAAGTGAAATCCATTAACAACCAATTAGAATCCGAAAAAAAGTCCTT
CAACAACAAAAACGCATTCCTTGGGATTTTGGGTCACGAATTAAGAACTTCACTCCAGGCAATAATTTCCTCCGTAGAGG
TCATTATACGAAAAAAAGATGACACGACATTCAACCATTTTGAACGTTTGGAAAATGCCGCCATGAAAATGGAACGTCAG
ATGAAAGACCTTGCTGAATTTGCAAAGGTTGATAATGGTAACGTCGAAATAAAAATAGCATCATTCAACTTACGTAAAAT
TGTGCAAGATACCGTTGAGCAAAGCATTTCGATATTAAATAAAAACTCTGTTTCTGTAAGTTTAGGTGACATCTCTGATG
TGTATATAAAGACTGATCCCTCGCGGACTATGCAAATAGTTGAAAACATTGTCACCAATGCCATCAAATACACAGAAAAC
GGTAATGTGCAGGTCAGTGCAGTTGTTCACGAAAAATCCAAACTAATTATTAAGGTCGAAGATTCGGGGCAGGGTATCCC
GAAAGATAAAATAGACACTATATTTTCGCCGTTTATCCGCGTCGGCAACGACAACAAGGTGCCCGGTTTTGGGATGGGGT
TAGCTATCGTCCATGGTGTTGTTAAAGCCATGAATGGGACTATTGATGTAAAAAGTGATGTTGGTAAAGGAACTGTATTT
ACCGTTTCATTACCTATTGAGCTGGCAACACCTGCTGAAATTGACATTATCACCTATATTGATGACAAACCGTTCTCAGC
TAAGGGCATCAGTATATTAATTATTGATGATAATGAAATGGCGTGCGAGTCATTAGTATCAATTCTTCAGCATGACTTTT
CAGTAGAGTATACAACATCTCCGGAAAGAGCATTGGAGAAGTTATATCGGAAATCATTTGATCTTGTTTTGAGTGATTTA
CAGATGCCTATTATCACTGGTGATGACTTATACAGAGAAGTCAAACAGAACAACGGCCCAAATAAAAACACACCGTTTAT
ATTCATTAGTGCATACACCAGTGAAAGCCCAATCAAAGATGTGGATATTTTAACAAAGCCAGTAAGATTAAATGATATTA
AAAAATCCATAGAATCCGTATTTGCGAGTCAACCCACTCTATAA

Upstream 100 bases:

>100_bases
GGCAAGTAGACGGCATAACGGTCATAGATAAATGAAACTAAAACGGATCCTGATCCAGTATATCGTCGGTTTTTTCATTC
TAACCGGTGGTTTCGTGTGG

Downstream 100 bases:

>100_bases
ATCGCACATTATATTTATAGAACCAAAAGATAACCGCCCATACTGGGCGGTTTTGGTCAATTACCTGAATGGTACTGCTG
TATTCTAAGCGGCCATTTTT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MYEQYFSTSHNINSAGPQENYAWAIAKFTIRLAGFNANIERQLRLGNSDKEELQTELDLLFSSSNVLLHKSVSTRYLFEE
AGYATTVAHINENLEKIDVELNKEVPDYSIILKSIELIGQDNKSLVVISDHAEVRQRNIIQQDYINKGNSMKFPIASLYF
LFLLMLFISYRQVKSINNQLESEKKSFNNKNAFLGILGHELRTSLQAIISSVEVIIRKKDDTTFNHFERLENAAMKMERQ
MKDLAEFAKVDNGNVEIKIASFNLRKIVQDTVEQSISILNKNSVSVSLGDISDVYIKTDPSRTMQIVENIVTNAIKYTEN
GNVQVSAVVHEKSKLIIKVEDSGQGIPKDKIDTIFSPFIRVGNDNKVPGFGMGLAIVHGVVKAMNGTIDVKSDVGKGTVF
TVSLPIELATPAEIDIITYIDDKPFSAKGISILIIDDNEMACESLVSILQHDFSVEYTTSPERALEKLYRKSFDLVLSDL
QMPIITGDDLYREVKQNNGPNKNTPFIFISAYTSESPIKDVDILTKPVRLNDIKKSIESVFASQPTL

Sequences:

>Translated_547_residues
MYEQYFSTSHNINSAGPQENYAWAIAKFTIRLAGFNANIERQLRLGNSDKEELQTELDLLFSSSNVLLHKSVSTRYLFEE
AGYATTVAHINENLEKIDVELNKEVPDYSIILKSIELIGQDNKSLVVISDHAEVRQRNIIQQDYINKGNSMKFPIASLYF
LFLLMLFISYRQVKSINNQLESEKKSFNNKNAFLGILGHELRTSLQAIISSVEVIIRKKDDTTFNHFERLENAAMKMERQ
MKDLAEFAKVDNGNVEIKIASFNLRKIVQDTVEQSISILNKNSVSVSLGDISDVYIKTDPSRTMQIVENIVTNAIKYTEN
GNVQVSAVVHEKSKLIIKVEDSGQGIPKDKIDTIFSPFIRVGNDNKVPGFGMGLAIVHGVVKAMNGTIDVKSDVGKGTVF
TVSLPIELATPAEIDIITYIDDKPFSAKGISILIIDDNEMACESLVSILQHDFSVEYTTSPERALEKLYRKSFDLVLSDL
QMPIITGDDLYREVKQNNGPNKNTPFIFISAYTSESPIKDVDILTKPVRLNDIKKSIESVFASQPTL
>Mature_547_residues
MYEQYFSTSHNINSAGPQENYAWAIAKFTIRLAGFNANIERQLRLGNSDKEELQTELDLLFSSSNVLLHKSVSTRYLFEE
AGYATTVAHINENLEKIDVELNKEVPDYSIILKSIELIGQDNKSLVVISDHAEVRQRNIIQQDYINKGNSMKFPIASLYF
LFLLMLFISYRQVKSINNQLESEKKSFNNKNAFLGILGHELRTSLQAIISSVEVIIRKKDDTTFNHFERLENAAMKMERQ
MKDLAEFAKVDNGNVEIKIASFNLRKIVQDTVEQSISILNKNSVSVSLGDISDVYIKTDPSRTMQIVENIVTNAIKYTEN
GNVQVSAVVHEKSKLIIKVEDSGQGIPKDKIDTIFSPFIRVGNDNKVPGFGMGLAIVHGVVKAMNGTIDVKSDVGKGTVF
TVSLPIELATPAEIDIITYIDDKPFSAKGISILIIDDNEMACESLVSILQHDFSVEYTTSPERALEKLYRKSFDLVLSDL
QMPIITGDDLYREVKQNNGPNKNTPFIFISAYTSESPIKDVDILTKPVRLNDIKKSIESVFASQPTL

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=381, Percent_Identity=26.246719160105, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI87081816, Length=345, Percent_Identity=25.2173913043478, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788713, Length=345, Percent_Identity=23.4782608695652, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.3109243697479, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=28.0701754385965, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=26.9961977186312, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=25.531914893617, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.4462809917355, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=25, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=26.0683760683761, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=22.2689075630252, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=24.4725738396624, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=23.8297872340426, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=220, Percent_Identity=20.4545454545455, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=115, Percent_Identity=31.304347826087, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=26.4840182648402, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=23.7704918032787, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61429; Mature: 61429

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEQYFSTSHNINSAGPQENYAWAIAKFTIRLAGFNANIERQLRLGNSDKEELQTELDLL
CCCCHHCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHEECCCCCHHHHHHHHHHH
FSSSNVLLHKSVSTRYLFEEAGYATTVAHINENLEKIDVELNKEVPDYSIILKSIELIGQ
CCCCCEEEEECCCHHHHHHHCCCEEEHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHHCC
DNKSLVVISDHAEVRQRNIIQQDYINKGNSMKFPIASLYFLFLLMLFISYRQVKSINNQL
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ESEKKSFNNKNAFLGILGHELRTSLQAIISSVEVIIRKKDDTTFNHFERLENAAMKMERQ
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
MKDLAEFAKVDNGNVEIKIASFNLRKIVQDTVEQSISILNKNSVSVSLGDISDVYIKTDP
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCC
SRTMQIVENIVTNAIKYTENGNVQVSAVVHEKSKLIIKVEDSGQGIPKDKIDTIFSPFIR
HHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHE
VGNDNKVPGFGMGLAIVHGVVKAMNGTIDVKSDVGKGTVFTVSLPIELATPAEIDIITYI
ECCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEECCCCCEEEEEEE
DDKPFSAKGISILIIDDNEMACESLVSILQHDFSVEYTTSPERALEKLYRKSFDLVLSDL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHC
QMPIITGDDLYREVKQNNGPNKNTPFIFISAYTSESPIKDVDILTKPVRLNDIKKSIESV
CCCEEECHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHH
FASQPTL
HCCCCCC
>Mature Secondary Structure
MYEQYFSTSHNINSAGPQENYAWAIAKFTIRLAGFNANIERQLRLGNSDKEELQTELDLL
CCCCHHCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHEECCCCCHHHHHHHHHHH
FSSSNVLLHKSVSTRYLFEEAGYATTVAHINENLEKIDVELNKEVPDYSIILKSIELIGQ
CCCCCEEEEECCCHHHHHHHCCCEEEHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHHCC
DNKSLVVISDHAEVRQRNIIQQDYINKGNSMKFPIASLYFLFLLMLFISYRQVKSINNQL
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ESEKKSFNNKNAFLGILGHELRTSLQAIISSVEVIIRKKDDTTFNHFERLENAAMKMERQ
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
MKDLAEFAKVDNGNVEIKIASFNLRKIVQDTVEQSISILNKNSVSVSLGDISDVYIKTDP
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCC
SRTMQIVENIVTNAIKYTENGNVQVSAVVHEKSKLIIKVEDSGQGIPKDKIDTIFSPFIR
HHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHE
VGNDNKVPGFGMGLAIVHGVVKAMNGTIDVKSDVGKGTVFTVSLPIELATPAEIDIITYI
ECCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEECCCCCEEEEEEE
DDKPFSAKGISILIIDDNEMACESLVSILQHDFSVEYTTSPERALEKLYRKSFDLVLSDL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHC
QMPIITGDDLYREVKQNNGPNKNTPFIFISAYTSESPIKDVDILTKPVRLNDIKKSIESV
CCCEEECHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHH
FASQPTL
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA