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The map label for this gene is mltC

Identifier: 157372279

GI number: 157372279

Start: 4481385

End: 4482461

Strand: Direct

Name: mltC

Synonym: Spro_4045

Alternate gene names: 157372279

Gene position: 4481385-4482461 (Clockwise)

Preceding gene: 157372278

Following gene: 157372285

Centisome position: 82.24

GC content: 55.06

Gene sequence:

>1077_bases
ATGAAGAAAATTTTAGCTCTGCTAGTGATAGCGCCTTTGCTGATTTCCTGTTCCGGCAAAAAAAATACTGAAGTCAACGA
AGCCCTGGTCAAAGACACCAACGGCTTTGAGATCCTGATGGGCCAATTCGCCCACAACATCGAGAATATCTGGGGTCTGA
ACGAAGTTCTGATCGCCGGGCCAAAAGATTACGTTAAATACACCGACCAGTATCAGACTCGTAGCCACATCAACTTTGAT
TCTGGTGCCATCACCATTGAAACCATCGCCACCACCGATCCTGCCGCCCACCTGCGCCAGGCGATTATCAGCACCTTGCT
GATGGGGGACGATCCGGGTTCTATCGATCTGTATTCCGACGTCAACGATATCCAGATCAGTAAAGAGCCGTTCCTGTACG
GCCAGGTGCTGGATAACAAAGGCGCGCCGATCCGTTGGGAATGGCGTGCGGCGCATTTCGCCGACTATCTGGTGCAGACC
AAACTGCAAAAACGCACCTCCGGCCTGCACGTGATTTACTCGGTCACCATTCAACTGGTACCGAACCACCTGGACAAGCG
TGCGCATAAATACCTGCCGATGGTCCGCAAGGCGTCCGAGAAGTACGGGGTGGAAGAATCGCTGATCCTGGCGATTATGC
AGACCGAATCGAGCTTTAACCCCTATGCGGTGAGCGGTTCGGATGCGTTGGGCCTGATGCAGGTGGTACAACACACCGCC
GGTAAGGACGTGTTCCAGATGCGTGGCAAATGGGGCAAACCAAGCCGCAGTTACCTGTTCGATCCGGAGAACAACATCGA
CACCGGTACCGCCTATCTGGCCATTTTGCAGAACAACTATTTGGGCGGCATCCAGAACCCAACCTCGCGTCGCTACGCGG
TAATCACCGCCTATAACGGCGGGGCGGGCAGCGTGCTGAGGGTGTTCTCCAGCGACAGAACCCGCGCGGTCGGCATCATC
AACGGCATGCAACCGGGCGACGTCTACCAAACGCTGACCACCAAGCATCCGGCCAGTGAGTCGCGCCACTATCTGGTGAA
GGTGAACAACGCGCAGAAGAGCTATCGACGCCGTTAA

Upstream 100 bases:

>100_bases
GGGCACGACGTGCACATCGAAGGCTATACGCCACCAAGCGAATAACGCTGTTGGGGCCAGGCGCTGGCCCTCTTCAACAC
TTCCCGTATACGGCTTTAAG

Downstream 100 bases:

>100_bases
TCACCCGGTCAGGGCGGTCTTTCCCGTCGCCCTGACCACCAGCATCCTTAAGCAATACTGTAGCCATTACGGCCAAGCTC
CTTGGCGCGGTACAGAGCCT

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKKILALLVIAPLLISCSGKKNTEVNEALVKDTNGFEILMGQFAHNIENIWGLNEVLIAGPKDYVKYTDQYQTRSHINFD
SGAITIETIATTDPAAHLRQAIISTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNKGAPIRWEWRAAHFADYLVQT
KLQKRTSGLHVIYSVTIQLVPNHLDKRAHKYLPMVRKASEKYGVEESLILAIMQTESSFNPYAVSGSDALGLMQVVQHTA
GKDVFQMRGKWGKPSRSYLFDPENNIDTGTAYLAILQNNYLGGIQNPTSRRYAVITAYNGGAGSVLRVFSSDRTRAVGII
NGMQPGDVYQTLTTKHPASESRHYLVKVNNAQKSYRRR

Sequences:

>Translated_358_residues
MKKILALLVIAPLLISCSGKKNTEVNEALVKDTNGFEILMGQFAHNIENIWGLNEVLIAGPKDYVKYTDQYQTRSHINFD
SGAITIETIATTDPAAHLRQAIISTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNKGAPIRWEWRAAHFADYLVQT
KLQKRTSGLHVIYSVTIQLVPNHLDKRAHKYLPMVRKASEKYGVEESLILAIMQTESSFNPYAVSGSDALGLMQVVQHTA
GKDVFQMRGKWGKPSRSYLFDPENNIDTGTAYLAILQNNYLGGIQNPTSRRYAVITAYNGGAGSVLRVFSSDRTRAVGII
NGMQPGDVYQTLTTKHPASESRHYLVKVNNAQKSYRRR
>Mature_358_residues
MKKILALLVIAPLLISCSGKKNTEVNEALVKDTNGFEILMGQFAHNIENIWGLNEVLIAGPKDYVKYTDQYQTRSHINFD
SGAITIETIATTDPAAHLRQAIISTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNKGAPIRWEWRAAHFADYLVQT
KLQKRTSGLHVIYSVTIQLVPNHLDKRAHKYLPMVRKASEKYGVEESLILAIMQTESSFNPYAVSGSDALGLMQVVQHTA
GKDVFQMRGKWGKPSRSYLFDPENNIDTGTAYLAILQNNYLGGIQNPTSRRYAVITAYNGGAGSVLRVFSSDRTRAVGII
NGMQPGDVYQTLTTKHPASESRHYLVKVNNAQKSYRRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family

Homologues:

Organism=Escherichia coli, GI87082191, Length=359, Percent_Identity=79.6657381615599, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=41.566265060241, Blast_Score=141, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MLTC_SERP5 (A8GJ50)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480268.1
- ProteinModelPortal:   A8GJ50
- SMR:   A8GJ50
- STRING:   A8GJ50
- GeneID:   5606036
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4045
- eggNOG:   COG0741
- HOGENOM:   HBG563263
- OMA:   NEVLIAG
- ProtClustDB:   PRK11671
- BioCyc:   SPRO399741:SPRO_4045-MONOMER
- HAMAP:   MF_01616
- InterPro:   IPR008258
- InterPro:   IPR000189

Pfam domain/function: PF01464 SLT

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39925; Mature: 39925

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00922 TRANSGLYCOSYLASE; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILALLVIAPLLISCSGKKNTEVNEALVKDTNGFEILMGQFAHNIENIWGLNEVLIAG
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEC
PKDYVKYTDQYQTRSHINFDSGAITIETIATTDPAAHLRQAIISTLLMGDDPGSIDLYSD
CHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECC
VNDIQISKEPFLYGQVLDNKGAPIRWEWRAAHFADYLVQTKLQKRTSGLHVIYSVTIQLV
CCCEEECCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHH
PNHLDKRAHKYLPMVRKASEKYGVEESLILAIMQTESSFNPYAVSGSDALGLMQVVQHTA
HHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHC
GKDVFQMRGKWGKPSRSYLFDPENNIDTGTAYLAILQNNYLGGIQNPTSRRYAVITAYNG
CCHHHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEECC
GAGSVLRVFSSDRTRAVGIINGMQPGDVYQTLTTKHPASESRHYLVKVNNAQKSYRRR
CCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCCHHHHCCC
>Mature Secondary Structure
MKKILALLVIAPLLISCSGKKNTEVNEALVKDTNGFEILMGQFAHNIENIWGLNEVLIAG
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEC
PKDYVKYTDQYQTRSHINFDSGAITIETIATTDPAAHLRQAIISTLLMGDDPGSIDLYSD
CHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECC
VNDIQISKEPFLYGQVLDNKGAPIRWEWRAAHFADYLVQTKLQKRTSGLHVIYSVTIQLV
CCCEEECCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHH
PNHLDKRAHKYLPMVRKASEKYGVEESLILAIMQTESSFNPYAVSGSDALGLMQVVQHTA
HHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHC
GKDVFQMRGKWGKPSRSYLFDPENNIDTGTAYLAILQNNYLGGIQNPTSRRYAVITAYNG
CCHHHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEECC
GAGSVLRVFSSDRTRAVGIINGMQPGDVYQTLTTKHPASESRHYLVKVNNAQKSYRRR
CCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA